研究组长介绍
童雪梅，欧洲杯竞猜平台基础欧洲杯竞猜平台研究员，细胞代谢研究组长，博士生导师。
2006年毕业于美国约翰霍普金斯大学欧洲杯竞猜平台，获生物化学博士。2006-2010年在美国宾夕法尼亚大学欧洲杯竞猜平台博士后期间开始细胞代谢领域研究。2010年起在欧洲杯竞猜平台基础欧洲杯竞猜平台工作，研究方向为肿瘤、脂肪肝和糖尿病等代谢性疾病的调控机制。在PNAS、Genes & Development、Cancer Research、Diabetes、JBC等期刊发表SCI收录通讯作者和第一作者论文多篇。国家优青、教育部 “新世纪优秀人才支持计划”、上海高层次人才、上海市青年科技启明星等获得者。担任中国抗癌协会肿瘤代谢专委会青委会副主任委员。
研究方向与进展
本研究组致力于研究肿瘤、脂肪肝和糖尿病等代谢性疾病的调控机制。研究进展包括以下两方面：
1）研究包括转酮醇酶（TKT）在内的磷酸戊糖途径（PPP）代谢酶在肿瘤和代谢性疾病中的作用和机制；
2）研究Mondo家族转录因子（MondoA和ChREBP）在肿瘤微环境代谢中的作用和机制。
科研项目
1. 童雪梅，国家自然科学基金面上项目，81972210，转录因子MondoA调控结直肠肿瘤微环境中调节性T细胞代谢和功能的机制研究，2020.01-2023.12，在研，主持。
2. 童雪梅，国家自然科学基金“糖脂代谢的时空网络调控“重大研究计划培育项目，92057117，转酮醇酶TKT调控NASH中糖脂代谢重塑和免疫细胞浸润的机理研究，2021.01-2023.12，在研，主持。
3. 童雪梅，国家重点研发计划合成生物学重点专项，2019YFA0906100 设计构建靶向实体瘤的新一代免疫细胞，2019年12月-2024年12月，在研，子课题骨干。
4. 童雪梅，上海市“科技创新行动计划”基础研究领域项目，19JC1410204，基因突变导致的异常代谢调控结直肠癌发生发展的机制，2019.11-2022.10，在研，子课题负责人。
5. 卢颖，国家自然科学基金青年项目，82003012，转录因子MondoA负调控肿瘤微环境CD8阳性T细胞功能的机制研究，2021.01-2023.12，在研，主持。
代表性论文、专著与专利
1. Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L*, Tong X*. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis. Diabetes. 2020 Jul;69(7):1355-1367.
2. Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J*, Tong X*, Bai J*. The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines. Cell Death Dis. 2020 Jan 16;11(1):31. (*co-corresponding authors)
3. Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH*, Tong X*. Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides. Cancer Res. 2019 Jul 15;79(14):3689-3701.
4. Li Y, Yang D, Tian N, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L*, Tong X*. The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. J Biol Chem. 2019 Oct 4;294(40):14745-14756.
5. Sun Q, Wang W, Wu L, Cheng L, Tong X*, Xu X*. Unexpected ABCC6 mRNA splicing in a Chinese family with pseudoxanthoma elasticum. Acta Ophthalmol. 2019 May;97(3):e381-e389. (*co-corresponding authors)
6. Wang J, Tan M, Ge J, Zhang P, Zhong J, Tao L, Wang Q, Tong X*, Qiu J*. Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression. Cell Prolif. 2018 Aug;51(4):e12452. (*co-corresponding authors)
7. Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X*, Su Q*. Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN. J Exp Clin Cancer Res. 2018 Mar 12;37(1):54. (*co-corresponding authors)
8. Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ET, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 Mar 16;293(11):3965-3980.
9. Mao JY, Sun JT, Yang K, Shen WF, Lu L, Zhang RY, Tong X*, Liu Y*. Serum amyloid A enrichment impairs the anti-inflammatory ability of HDL from diabetic nephropathy patients. J Diabetes Complications. 2017 Oct;31(10):1538-1543. (*co-corresponding authors)
10. Meng J, Feng M, Dong W, Zhu Y, Li Y, Zhang P, Wu L, Li M, Lu Y, Chen H, Liu X, Lu Y, Sun H, Tong X*, Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose. Sci Rep. 2016 Mar 31;6:23944.
11. Wang J, Zhang P, Zhong J, Tan M, Ge J, Tao L, Li Y, Zhu Y, Wu L, Qiu J*, Tong X*, The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma. Oncotarget. 2016 Mar 25.
12. Zhang X, Li M, Sun K, Chen XJ, Meng J, Wu L, Zhang P, Tong X*, Jiang WW*. Decreased expression of GRIM-19 by DNA hypermethylation promotes aerobic glycolysis and cell proliferation in head and neck squamous cell carcinoma. Oncotarget. 2015 Jan 1;6(1):101-115.
13. Chen H, Wu L, Li Y, Meng J, Lin N, Yang D, Zhu Y, Li X, Li M, Xu Y, Wu Y, Tong X*, Su Q*. Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation. Mol Cell Endocrinol. 2014 Sep;395(1-2):69-78. (*co-corresponding authors)
14. Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X. Flightless I homolog negatively regulates ChREBP activity in cancer cells. Int J Biochem Cell Biol. 2013 Nov;45(11):2688-97.
15. Tang S, Huang G, Tong X, Xu L, Cai R, Li J, Zhou X, Song S, Huang C, Cheng J. Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism. PLoS One. 2013 May 14;8(5):e63965.
16. Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012 May 1;109(18): 6904-9.
17. Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprogramming. Oncogene. 2010 May 20;29(20):2962-72.
18. Tong X, Zhao F, Mancuso A, Gruber JJ and Thompson CB. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21660-5.
19. Tong X*, Zhao F*, Thompson CB*. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Current Opinion in Genetics & Development. 2009 Feb;19(1):32-7. (*co-corresponding authors)
20. Larouche D, Tong X, Fradette J, Coulombe PA, Germain L. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile. FASEB J. 2008 May;22(5):1404-15.
21. Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFa-dependent fashion. Genes & Development 2006 May;20(10):1353-64.
22. Coulombe PA, Tong X, Mazzalupo S, Wang Z, Wong P. Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo. European Journal of Cell Biology 2004 Dec;83(11-12):735-46.
23. Tong X, Coulombe PA. A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. Journal of Investigative Dermatology 2004 Apr;122(4):965-70.
24. Tong X, Coulombe PA. Mouse models of alopecia: identifying structural genes that are baldly needed. Trends in Molecular Medicine 2003 Feb;9(2):79-84.
25. McGowan KW*, Tong X*, Colucci-Guyon E, Langa F, Babinet C, Coulombe PA. Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes & Development 2002 Jun;16(11):1412-22. (*co-first authors)
团队介绍
童雪梅，博士，研究员，PI，邮箱：xuemeitong@shsmu.edu.cn
张萍，副教授，邮箱：ssmuzp@139.com
吴丽芳，助研，邮箱：wulifang@shsmu.edu.cn
朱晔敏，高级实验师，邮箱：kringsley2004@aliyun.com
李亚葵，高级实验师，邮箱：chessyk@live.cn
卢颖，博士后，邮箱：ntuluying@163.com
刘琪，博士生，邮箱：liuqi0325@163.com
童灵锋，博士生，邮箱：lingfeng_tong@163.com
胡蕾，硕士生，邮箱：19921893259@163.com
季迎宁，硕士生，邮箱：peacenene@sjtu.edu.cn
