研究组长介绍

  王锋

  电话：63846590-776798
  邮箱：wangfeng16@sjtu.edu.cn

个人简历

2001-2005 北京师范大学 学士

2005-2010 北京生命科学研究所  生物化学与分子生物学 博士

2010-2016 斯坦福大学欧洲杯竞猜平台 博士后

2016-至今 欧洲杯竞猜平台上海市免疫学研究所 研究员 课题组长  

研究方向

主要研究T淋巴细胞的免疫识别，信号转导和代谢调节机制，以及其在肿瘤、感染和自身免疫疾病中的作用。我们将应用免疫学、分子细胞生物学、生物物理和生物化学等多种技术手段对以下三个方向进行探索：（1）天然代谢产物调控T细胞识别和信号的分子机理和生理功能；（2）T细胞信号和免疫受体组库在肿瘤和感染免疫中的作用；（3）T细胞免疫检验点抑制剂引起的抗肿瘤和自身免疫反应机制。

科研项目

论文与专著

1. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

2. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

3. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

4. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

5. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

6. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

7. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

8. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

9. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

10. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

11. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

12. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

13. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

14. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

15. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.

     

     

专利与技术许可

2019101191437，微生物在治疗和或预防免疫介导的肠道疾病中的应用

2019105339382(PCT/CN2020/096054)，肿瘤新抗原多肽及其用途

2019111645949，调节T细胞所处微环境中CS的量以及应用

2019111651371，突变型CD3及其应用

荣誉与奖励

2018: 上海市青年拔尖人才

2018: 美国免疫学会-Early Career Faculty Travel Award

2017: 上海市浦江人才计划

2017: 蒙民伟国际交流基金

2014: 中国科学院-Global Vision Lectures of the SKIPER College

2013: 美国免疫学会-Trainee Abstract Award

2012: 国际生物化学和分子生物学学会，欧洲生物化学学会－青年科学家奖

2010: 戈登会议委员会-Carl Storm International Diversity Fellowship

2010: 北京师范大学优秀博士毕业生

2009: 北京师范大学年度优秀学术奖

2008: 北京生命科学研究所－先正达奖学金

团队介绍

罗凌杰-助理研究员

王为芳-技术员

王秦兰-博士后

杨翠霞-博士后

梁文华-博士研究生

庞建峰-硕士研究生

王欣-硕士研究生