研究组长介绍

沈蕾

电话：63846590-776365

邮箱：lshen@shsmu.edu.cn

个人简历

1990- 1995  南京医科大学 临床医学学士

1995- 2000  南京医科大学 医学博士

2001-2005  美国贝勒欧洲杯竞猜平台 博士后

2006-2011  美国斯坦福大学 助理研究员, 助理研究教授

2012.09-至今 欧洲杯竞猜平台上海市免疫学研究所 课题组长(PI)，研究员，博士生导师

研究方向

脂肪组织代谢稳态的免疫调控；天然淋巴细胞发育及功能的调控机制及其与炎症性疾病的关系。

科研项目

2020-2025：科技部国家重点研发计划“蛋白质机器与生命过程调控”重点专项，参与人，肠道重要致病菌感染与宿主关键因子互作促进结直肠癌发生发展中的蛋白质机器研究，项目编号： 2020YFA0509200

2020-2023: 国家自然科学基金面上项目，负责人，肝激酶B1(LKB1)调控脂肪2型天然淋巴细胞(ILC2)的功能影响肥胖及2型糖尿病发生，项目编号#81971487

2020-2023: 上海市自然科学基金项目，负责人，SUMO特异性蛋白酶1(SENP1)调控B细胞生发中心反应和抗体类别转换的作用及机制，项目编号：20ZR1430200

2020-2022: 上海市“科技创新行动计划”科学仪器领域项目，负责人，FACSymphony高参数流式分析仪用于全景式免疫监测的开发和应用研究，项目编号：20142202300

2020-2022：碧迪医疗器械（上海）横向课题，负责人，应用scRNAseq和high-parameter flow cytometry解析结肠癌肿瘤微环境中固有淋巴细胞的免疫应答特征，项目编号：2020HX009

2016-2019: 国家自然科学基金面上项目，负责人，SUMO特异性蛋白酶1 对脂肪组织巨噬细胞的调控作用以及与2型糖尿病发生的关系，项目编号：#81571533

2016-2019: 国家自然科学基金面上项目，负责人，PLZF对3型天然淋巴细胞(ILC3)发育和功能的调控作用及机制研究，项目编号：#31570921

2016-2018：国自然重大研究计划，参与者，Dermo+ 间质细胞在肠道免疫反应中的作用机制，项目编号：# 91542120

2014-2017:国家自然科学基金面上项目，负责人，B淋巴细胞调节肥胖诱导胰岛素抵抗的作用机制，项目编号：#81373210

2014-2017:国家海外高层次人才计划，负责人，适应性免疫应答与2型糖尿病

2013-2015: 上海浦江人才计划，负责人，B细胞亚群在胰岛素抵抗中的作用机制，项目编号：#13PJ1405400

论文与专著

1. Wang L, Zhang H, Sun L, Gao W, Xiong Y, Ma A, Liu X, Shen L*, Li Q, Yang H. Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury. J Nanobiotechnology. 2020 Feb 26;18(1):38.

2. Ji Z, Wu S, Xu Y, Qi J, Su X, Shen L*. Obesity promotes EAE through IL-6 and CCL-2-mediated T cells infiltration. Front Immunol. 2019 Aug 27;10:1881.

3. Wang H, Shen L, Sun X, Liu F, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D, Bi Y. Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity. Nat Commun. 2019, 10(1):3254

4. Cai T, Qiu J, Ji Y, Li W, Ding Z, Suo C, Chang J, Wang J, He R, Qian Y, Guo X, Zhou L, Sheng H, Shen L*, Qiu J*. IL-17-producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation. J Allergy Clin Immunol 2019 Jan; 143(1):229-244

5. Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L*, Cheng J*. SENP1 regulates IFN-g-STAT1 signaling through STAT3-SOCS3 negative feedback loop. J Mol Cell Biol. 2017 Apr;9(2):144-153

6. McLaughlin T, Ackerman SE, Shen L, Engleman E. Role of innate and adaptive immunity in obesity-associated metabolic disease. J Clin Invest 2017 Jan 2; 127(1): 5-13

7. Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG. B-1a Lymphocytes Attenuate Insulin Resistance.Diabetes. 2015 Feb; 64(2):593-603

8. Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG. Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production. Eur J Immunol. 2015 Feb; 45(2):612-623.

9. McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E.T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2637-43.

10. Winer DA, Winer S, Chng MH, Shen L, Engleman EG. B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance.Cell Mol Life Sci. 2014 Mar;71(6):1033-43.

11. (Co-first author) Winer D* Winer S*, Shen L*, Wadia P, Yantha J, Paltser G, Tsui H, Wu P, Davidson M, Alonso M, Leong H, Glassford A, Caimol M, Tedder T, McLaughlin T, Miklos D, Dosch HM, Engleman EG. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nature Medicine. 2011, May; 17(5):610-7

12. Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder J. The role of Vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood. 2011 Apr 28;117(17):4569-79

13. Song XT, Evel-Kabler K, Shen L, Rollins L, Huang XF, Chen SY. A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell-mediated suppression. Nature Medicine. 2008; 14(3):258-65

14. Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nature Biotechnology. 2004; 22:1546-1553

15. Shen L, Schroers R, Hammer J, Huang XF, Chen SY. Identification of a MHC class II-restricted epitope in Carcinoembryonic antigen (CEA). Cancer Immunology and Immunotherapy. 2004; 53(5):391-403

16. Schroers R, Shen L*, Rollins L, Rooney CM, Slawin K, Sonderstrup G, Huang XF, Chen SY. Human telomerase reverse transcriptase-specific T helper responses induced by promiscuous MHC Class II-restricted Epitopes. Clinical Cancer Research. 2003; 9(13): 4743-4755

17. Schroers R, Shen L*, Rollins L, Xiao Z, Sonderstrup G, Slawin K, Huang XF, Chen SY. Identification of MHC class II-restricted epitopes in prostate-specific membrane antigen (PSMA). Clinical Cancer Research. 2003; 9(9):3260-3271

专利与技术许可

Modulation of cytokine signaling regulators and applications for immunotherapy. (2006). Inventors: Lei Shen and Si-Yi Chen. Licensing to ImmunoVac on April, 2007. US Serial # 11/165091; US Patent Application# 20060269519; European Patent # EP1781338.

荣誉与奖励

国家海外青年高层次人才 上海市浦江人才

团队介绍

本课题组围绕代谢与免疫两大系统在生理和病理状态下相互作用的调控网络进行研究, 在整体水平，聚焦免疫细胞尤其淋巴细胞对系统性代谢疾病如2型糖尿病的调控作用及临床意义; 在细胞水平，研究代谢因素以及胞内代谢通路对免疫细胞功能的影响和机理。主要研究方向为：

1、探究肥胖诱导的胰岛素抵抗免疫机制

2、天然淋巴细胞ILC发育和功能的代谢调控机制