张晶

氧化应激坏死课题组

电话：021-63846590-776935

邮箱：jingzhang@shsmu.edu.cn

研究组长介绍

张晶，2004年本科毕业于南开大学生命科学学院，2009年于中国科学院上海研究生院获得博士学位，先后在UC Berkley和西南医学中心从事博士后研究，2015年起在西南医学中心担任助理讲师。2019年加盟欧洲杯竞猜平台基础欧洲杯竞猜平台病理生理系担任课题组长。2020年入选上海市浦江人才，目前兼任上海市病理生理学会监事会成员。系列研究成果在Genes & Development、Haemotologica、Oncogene等国际优秀学术期刊。

研究方向与进展

本课题组运用生物化学，分子和细胞生物学，模式动物小鼠，化合物筛选等手段研究氧化应激引起的细胞坏死的前沿重大问题，并探索延缓缺血性疾病，纤维化疾病等的新方式。主要包括以下方面：

（1）铁死亡的发生机制以及对急性肝损伤的影响；

（2）一种新型的氧化应激坏死的机制探讨以及对急性肾损伤的影响。

科研项目

(1) E3泛素连接酶Mule调控铁死亡的分子机制及其在肝损伤中的意义

项目编号：NSCF 32070734

项目来源：国家自然科学基金面上项目

项目负责人：张晶

起止时间：2021年1月-2024年12月

(2) 线粒体氧化应激坏死与急性肾损伤

项目编号：20PJ1409500

项目来源：上海市浦江人才

项目负责人：张晶

起止时间：2020年11月-2022年10月

(3) E3泛素连接酶Mule通过降解铁调节蛋白调控铁死亡的研究

项目编号：20ZR1430800

项目来源：上海市“科技创新行动计划”自然科学基金

项目负责人：张晶

起止时间：2020年7月-2023年6月

代表性论文、专著与专利

1. Diao Jiajie, Liu Rong, Rong Yueguang, Zhao Minglei, Zhang Jing, Qing Zhong. et al. (2015) ATG14 Promotes Membrane Tethering and Fusion of Autophagosomes to Endolysosomes. Nature. 520:563-566.

2. Zhang Jing and Zhong Qing. (2014) Histone deacetylase inhibitor and cell death. Cellular and Molecular Life Sciences 71, 3885-3901.

3.  Zhang Jing, Kan Shu, Huang Brian, Hao Zhenyue, Mak Tak W., Zhong Qing. (2011) Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. Genes Dev. 25, 2610-2618.

4.  Huang Ying, Hou Jia-Kai, Chen Ting-Ting, Zhao Xu-Yun, Yan Zhao-Wen, Zhang Jing, Chen Guo-Qiang et al. (2011) PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy. 7, 1132-1144.

5.  Sun Qiming, Zhang Jing, Fan Weiliang, Wong Kwun Ngok, Ding Xiaojun, Chen She and Zhong Qing. (2011) The RUN domain of Rubicon is important for hVPS34 binding, lipd kinase inhibition and autophagy suppression. Journal of Biological Chemistry. 286, 185-191.

6.  Wu Shao-Fang, Huang Ying, Hou Jia-Kai, Yuan Ting-Ting, Zhou Ci-Xiang, Zhang Jing, and Chen Guo-Qiang. (2010) The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation. Leukemia 24, 544-551.

7. Zhang Jing and Chen Guo-Qiang. (2009) Hypoxia-HIF-1a-C/EBPa/Runx1 signaling in leukemic cell differentiation. Pathophysiology. 16, 297-303.

8.  Liao Shi-Hua, Zhao Xu-Yun, Han Yu-Hui, Zhang Jing, Wang Li-Shun, Xia Li, Chen Guo-Qiang et al. (2009) Proteomics-based identification of two novel direct targets of hypoxia- inducible facotor-1a and their potential roles in migration/invasion of cancer cells. Proteomics. 9, 3901-3912.

9. Chen Guo-Qiang, Zhang Jing and Zhao Qian. (2009) Active Compounds-based discoveris about the differentiation and apoptosis of leukemic cells. Chinese Sci Bull. 54, 4094-4101.

10.  Zhang Jing, Song Li-Ping, Huang Ying, Zhao Qian, Zhao Ke-Wen and Chen Guo-Qiang. (2008) Accumulation of hypoxia-inducible factor-1a protein and its role in differentiation induction of myeloid leukemic cells by all-trans retinoic acid. Haematologica, 93, 1480-1487.

11.  Song Li-Ping*, Zhang Jing*, Wu Shao-Fang, Huang Ying, Zhao Qian, Cao Jing-Ping, Wu Ying-Li, Wang Li-Shun and Chen Guo-Qiang. (2008) Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene, 27, 519-527. (* Co-first author)

12.  Xu Ya-Bei, Zhang Jing., Segal- Bendirdjian Evelyne, Wu Ying-Li and Chen Guo-Qiang. (2008) Downregulation of telomerase in CoCl₂-induced apoptosis of myeloid leukemic cells. The Open Hematology Journal, 2, 74-80.

团队介绍

1. 焦慧科，助理研究员 huike.jiao@shsmu.edu.cn

2. 张婧，技术员 Ginngzhang@126.com

3. 吴妍，博士研究生 wuyancqmu@163.com

4. 杜玉婷，硕士研究生 duduyuting@sjtu.edu.cn