科学研究
衰老与代谢课题组
  作者:  2022-09-21

基本信息 >>>

贺明                                                                                  B42  

衰老与代谢课题组

研究方向: 衰老及代谢疾病的病理生理学研究

电话:021-63846590-776403

邮箱:heming@shsmu.edu.cn


研究方向与进展>>>

课题组主要围绕蛋白质修饰在衰老、肝脏代谢性疾病及肿瘤等发生发展中的作用及机制开展研究,包括:糖脂代谢重塑对肝脏内不同细胞命运决定及其在ALDNAFLDHCC中的病理生理学作用;衰老及代谢重塑时组织器官间信息交流机制;同时研发相应的生物标记物检测方法和相应靶向治疗手段。


研究组长介绍 >>>


贺明,教授,博导,病理生理学系PI。“上海市五一劳动奖章”、“上海市青年五四奖章”、“上海市浦江人才计划”、“上海市教学能手”、 “黄浦区青年岗位能手”、“欧洲杯竞猜平台教书育人奖”、“欧洲杯竞猜平台教学能手”、欧洲杯竞猜平台“上药杏林育才奖”、“九龙医学优秀青年人才奖” 、“优秀青年教师”、“大学生创新训练计划优秀指导教师”;基础欧洲杯竞猜平台“优秀共产党员”、“杰出员工(2017和2018)”、“RBL 优秀指导教师”等获得者;入选教育部“全国万名优秀创新创业导师人才库”。先后获得“全国高校青年教师教学竞赛”二等奖、“上海高校青年教师教学竞赛”特等奖。贺明教授长期从事衰老与代谢疾病机制研究,共主持5项国自然课题,4项上海市课题,在Cell Metabolism、Cell Discovery、Cell Death & Differentiation、Cell Reports等期刊发表论文40余篇,其中的一些文章入选高被引论文。




工作经历 >>>

2020/12-至今, 欧洲杯竞猜平台,病理生理学系,细胞分化与凋亡教育部重点实验室,教授

2017/12-至今, 欧洲杯竞猜平台,病理生理学系,细胞分化与凋亡教育部重点实验室,研究员

2012/6-2015/1, 加州大学伯克利分校,营养与毒物学系,博士后

2009/12-2017/11,欧洲杯竞猜平台,病理生理学系,细胞分化与凋亡教育部重点实验室,副研究员

2007/7-2009/11, 欧洲杯竞猜平台,病理生理学系,细胞分化与凋亡教育部重点实验室,讲师

2017/9-2022/08,渥太华大学欧洲杯竞猜平台(加拿大),医学教育创新系,Adjunct Professor



科研项目 >>>

1. 国家自然科学基金委员会重大研究计划培育项目,2021.01-2023.129205711878万元,NAFLD-HCC转化中胆固醇代谢调控机制及作用研究

2. 国家自然科学基金(面上项目),2021.01-2024.128207060355万元,SIRT2抑制酒精性肝病发生发展的机制研究

3. 国家自然科学基金(面上项目) ,2015.01-2018.128147084173万元,SIRT7 抑制非酒精性脂肪肝病发生发展的机制研究。

4. 国家自然科学基金(面上项目),2012.01-2015.1281170505 60万元,MiR-17 miR-20a在低氧诱导因子-1α诱导白血病细胞分化中的作用。

5. 国家自然科学基金(青年基金),2009.01-2011.123080038020万元,温度敏感性TRP离子通道在哮喘大鼠气道平滑肌表型转化中的作用 。

6. 上海市科委自然科学基金,2019.07-2022.0619ZR142840020万元,SIRT2NLRP3炎症小体活性的调控及其在衰老相关胰岛素抵抗中的作用。

7. 上海市浦江人才计划(A类),2016.07-2018.0616PJ140540020万元,SIRT7在非酒精性脂肪肝病发生发展中的作用及机制。

8. 上海市教委科研创新项目,2009.01-2011.1209YZ968万元,肾素受体在大鼠肾小球系膜细胞中表达的调节机制的研究。

9. 上海市教委优秀青年教师科研专项基金,2008.01-2010.12jdy070043万元,温度敏感性TRP 离子通道在高反应性气道组织中表达的变化及意义。

10. 欧洲杯竞猜平台青年教师提升计划,2008.12-2010.1120万元,MicroRNA在白血病细胞分化中的表达和作用。



论文与专著 >>>



论文*第一作者;#通讯作者)

1. Wo L, Zhang X, Ma C, Zhou C, Li J, Hu Z, Gong X, Zhan M, He M#, Zhao Q#. LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening. Cell Death Discov. 2022;8(1):171. doi: 10.1038/s41420-022-00917-6.

2. Zhang Y, Long X, Ruan X, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q#, He M#. SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury. Cell Discov. 2021; 7 (9). doi: 10.1038/s41421-021-00326-6.

3. Ma C*, Wo L*, Wang D, Zhou C, Li J, Zhang X, Gong X, Wang C, Chen G, He M#, Zhao Q#. (2021) Hypoxia activated long non-coding RNA HABON regulates the growth and proliferation of hepatocarcinoma cells by binding to and antagonizing HIF-1 alpha. RNA Biol. doi: 10.1080/15476286.2020.1871215.

4. Wei Q, Zhang Y, Lin L, He E, He Y, Su Y, Duan C, Wang S, Zhao Q, Zhao Q, He M#. Haptoglobin suppresses hepatocyte ferroptosis via inhibition of the ERK1/2 signaling pathway. Journal of Shanghai Jiaotong University (Medical Science). 2021 (8): 999-1008. doi: 10.3969/j.issn.1674-8115.2021.08.002.

5. He M#, Zhang Y, Wei Q, Ruan X, An X, Sun Y. LPS induces acute liver injury by down-regulating SIRT2 in hepatocyte. Current Immunology. 2021; 41(1):8-13;55.

6. Wang CL, Li JC, Zhou CX, Ma CN, Wang DF, Wo LL, He M, Yin Q, He JR, Zhao Q. Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein. Breast Cancer Res Treat. 2021;189(3):607-619. doi: 10.1007/s10549-021-06286-5.

7. He M#, Wei Q, Zhang Y. Research progress on the mechanism of ferroptosis and its role in liver related diseases. Journal of Shanghai Jiaotong University (Medical Science). 2020, 40(12): 1519-1523.

8. He M*, Chiang H*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu W, Zhao S, Wu H, Chen D. (2020) An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance. Cell Metab. 31(3): 580-591.e5. doi: 10.1016/j.cmet.2020.01.009.

9. Ruan X, Zhang Y, Han K, Lin L, Chen C, Yue M, Wang C, Sun Y, Zhao Q, He M#. (2019) SIRT7 protects hepatocytes from LPS or D-GalN/LPS-induced apoptosis by attenuating endoplasmic reticulum stress via inactivation of GRP78. Journal of Shanghai Jiaotong University (Medical Science). 39(8):928-935.

10. Peng Y, Han K, Ruan X, Zhang Y, Wei Q, Zhao Y, An X, He M#. (2019) Expression of p53, TGFβ1 and inflammatory cytokines in a novel alcoholic renal injury mouse model.Current Immunology. 39(5):26-31.

11. Zhang Y, Wu Y, He M#. (2019) Application of CD229 in immunophenotyping of plasma cell diseases. Laboratory Medicine.34(7):605-609.

12. Lin S, Xing H, Zang T, Ruan X, Wo L, He M#. (2018) Sirtuins in mitochondrial stress: indispensable helpers behind the scenes. Ageing Res Rev. 44:22-32. doi: 10.1016/j.arr.2018.03.006.

13. Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018). MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

14. Gong X, Yu A, Tang J, Wang C, He J, Chen G, Zhao Q, He M#, Zhou C#. (2018) MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res. 362(2):378-385. doi: 10.1016/j.yexcr.2017.11.039.

15. Han K, Ruan X, He M#. (2018) The roles of SIRT2 in the tumorigenesis and development of hepatocellular carcinoma. Journal of Shanghai Jiaotong University (Medical Science). 10:1247-1251.

16. Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018) MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

17. Zang T, Liu H, Wo L, Lin S, Xing H, He M#. (2017) Roles of SIRT2 in glucose lipid metabolism. Sheng Li Ke Xue Jin Zhan. 48(6): 458-462.

18. Zhang L, An X, Ruan X, Huang D, Zhou L, Xue H, Lu L#, He M#. (2017) Inhibition of (pro)renin receptor contributes to renoprotective effects of angiotensin II type 1 receptor blockade in diabetic nephropathy. Front. Physiol. 8:758. doi: 10.3389/fphys.2017.00758. eCollection 2017.

19. An X, Zhang L, Yuan Y, Wang B, Yao Q, Li L, Zhang J#, He M#, Zhang J#. (2017) Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression. Sci Rep. 7(1):6413. doi: 10.1038/s41598-017-06844-2.

20. An X, Zhang L, Yao Q, Li L, Wang B, Zhang J#, He M#, Zhang J#. (2017) The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway. Mol Cell Endocrinol. 470:14-25. doi: 10.1016/j.mce.2017.05.004.

21. Huang D, Wo L, Ruan X, Xu Y, Gong Y, Yang L, Li X, Kang Y, He M#. (2017) Construction of a new alcoholic liver disease mouse model. Journal of Shanghai Jiaotong University (Medical Science). 37(7):906-913.

22. Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ, Zhao Q. (2017). Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis. 6(10):e387. doi: 10.1038/oncsis.2017.85.

23. Zhan MN, Yu XT, Tang J, Zhou CX, Wang CL, Yin QQ, Gong XF, He M, He JR, Chen GQ, Zhao Q. (2017) MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Cell Death Dis. 8(1):e2529. doi: 10.1038/cddis.2016.440.

24. Zhang L, An XF, Wang QY, He M#. (2016) Activation of cold-sensitive channels TRPM8 and TRPA1 inhibits the proliferative airway smooth muscle cell phenotype. Lung. 194(4):595-603. doi: 10.1007/s00408-016-9901-4.

25. Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, Zhao Q. (2016) MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 7(2):1288-99. doi: 10.18632/oncotarget.6339.

26. Zhang L, He M#. (2015) Roles of Sirtuins in occurrence and development of chronic kidney disease. Journal of Shanghai Jiaotong University (Medical Science). 35(4):594-600.

27. He M*, Wang QY*, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ, Zhao Q. (2013) HIF-1a down-regulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 20(3):408-418. doi: 10.1038/cdd.2012.130.

28. Shin J*, He M*, Liu Y*, Paredes S*, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. (2013) SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 5(3): 654-665. doi: 10.1016/j.celrep.2013.10.007.

29. Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q. (2013). MiR-124 targets slug to regulate epithelial-to-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34(3):713-722. doi: 10.1093/carcin/bgs383.

30. Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q. (2011). MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett. 585(9):1363-1367. doi: 10.1016/j.febslet.2011.04.018.

31. Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q. (2011) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis. 32(1):2-9. doi: 10.1093/carcin/bgq209.

32. Ten SC, Gu SY, Niu YF, An XF, Yan M, He M. (2010) Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocr Res. 35(3):128-136.

33. Han X, Yan M, An XF, He M, Yu JY. (2010) Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats. Acta Pharmacol Sin. 31(2):145-149.

34. He M, Zhang L, Shao Y, Zhou L, Wang XF, Yao T, Lu LM. (2010) Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal renin/prorenin receptor expression. Mol Cell Endocrinol. 315(1-2):188-194. doi: 10.1016/j.mce.2009.10.008.

35. He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L. (2009) Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 606(1-3):155-161. doi: 10.1016/j.ejphar.2008.12.050.

36. Chen L, He M, Wang WQ. (2009) High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis. Acta Physiologica Sinica. 61(6):559-566.

37. An XF, He M, Feng Y, Feng H, Yu JY. (2009) Central administration of Orphanin FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats. Neurosci Bull. 25(1):1-6.

38. Shao Y, He M, Zhou L, Yao T, Lu LM. (2008) Chronic Angiotensin (1-7) injection accelerated STZ-induced diabetic renal injure. Acta Pharmacol Sin. 29(7):829-837.

39. An XF, Niu YF, Ten SC, Liu JS, Feng H, He M, Shen XJ. (2008) Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats. Neurosci Lett. 440(2):109-112. doi: 10.1016/j.neulet.2008.05.059.

40. He M, Huang YL, Zhang L, Yao T, Lu LM. (2008). Expression of renin/prorenin receptor in rat kidney and cultured mesangial cells. Acta Physiologica Sinica. 59 (6): 796-804.

41. He M, Lu LM, Yao T. (2004). Effects of renin-angiotensin system on the regulation of renal function and chronic renal insufficiency. Sheng Li Ke Xue Jin Zhan. 35(2):188-192.




团队介绍 >>>

贺明 教授 

何玮 硕士研究生

黄永娇 硕士研究生

邹智慧 博士研究生