基本信息 >>>
 曾凡一
组织胚胎学与遗传发育学系
电话：63846590-776667
邮箱：fzeng@sjtu.edu.cn
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研究方向>>>
医学遗传学和发育生物学，尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究。 |
个人简历 >>>
曾凡一，美国宾夕法尼亚大学医学/理学双博士，研究员，博导。现任欧洲杯竞猜平台基础欧洲杯竞猜平台，组织胚胎学与遗传发育学系PI，欧洲杯竞猜平台特聘教授、欧洲杯竞猜平台特聘教授。 曾凡一教授主要从事医学遗传学和发育生物学，尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究，在国际著名期刊《Nature》、《PNAS》等杂志发表SCI论文90 余篇，研究成果多次入选“中国基础研究十大新闻”以及“中国十大科技进展新闻”。近年来获得国家自然科学奖二等奖、教育部自然科学奖一等奖、首届第三世界女青年科学家奖、谈家桢生命科学奖创新奖等奖项。担任国际干细胞组织（ISCF）秘书长及伦理委员会中国代表、中国遗传学会第十届理事会常务理事以及人类与医学遗传专业委员会主任委员等职务。 |
科研项目 >>>
2019YFA0801402 国家重点研发计划子课题“胚层形成过程细胞分子调控机制”2019-12~2024-11 383.5万 课题负责人 31871484 克隆牛重编程的表观遗传机理研究 国家自然科学基金(面上项目) 2019-01~2022-12 59万元 课题负责人 17-163-12-ZT-005-051-01 新发病原体感染胚胎嵌合体修饰技术 国防科技创新特区课题 2017-07~2020-06 346万元 课题负责人 2016YFC1000503 出生缺陷表观遗传异常模式及防控靶点 国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项 2016-07~2021-07 150万元 课题参与人 2014CB964700 多能干细胞向中胚层细胞分化的机制研究 973计划 2014-01~2018-08 910万元 课题负责人 31371486 克隆牛重编程中核质互作分子机理的探讨 国家自然科学基金(面上项目) 2014-01~2017-12 80万元 课题负责人 12XD1406500 遗传病的个体化基因治疗研究 上海市科学技术委员会优秀学术带头人 2012-07~2014-06 20万元 课题负责人 81125003 重编程技术在遗传病个体化基因治疗领域的应用研究 国家杰出青年科学基金 2012-01~2015-12 240万元 课题负责人 10GG10 几种常见出生缺陷（先心、神经管缺陷）的分子机理研究 上海市教委曙光跟踪项目 2011-01~2013-12 25万元 课题负责人 / 重大遗传性疾病的诊断、治疗和干预的新技术研究 卫生部国家临床重点专科建设项目 2011-01~2015-12 500万元 课题负责人 2011AA020116 安全高效iPS诱导体系的建立 863计划 2011-01~2015-12 157.9万元 课题参与人 / 干细胞体内组织模型对药物性肝损伤修复的系统生物学研究 欧洲杯竞猜平台“理工交叉研究基金”重点项目 2011-01~2012-12 25万元 课题负责人 10140900200 应用囊胚注射技术制备并研究β654地贫小鼠转基因干细胞嵌合体动物模型 上海市科委实验动物研究项目 2010-05~2012-09 15万元 课题负责人 30871379 表观遗传修饰对不同线粒体DNA单倍型来源胚胎发育的机理研究 国家自然科学基金(面上项目) 2009-01~2011-12 29万元 课题负责人 08dj1400502 iPS细胞诱导的新方法和新材料 上海市科学技术委员会 2008-09~2011-09 50万元 课题参与人 30770242 线粒体DNA单倍型及表观遗传对牛克隆胚发育影响的机理 国家自然基金委(面上项目) 2008-01~2010-12 30万元 课题负责人 2006BAI05A08 重大遗传病产前筛查、诊断技术规范化研究 国家十一五支撑计划 2008-01~2010-12 42万元 课题参与人 2007CB947800 干细胞表面分子特征与功能 国家科技部重大科学研究计划 2007-07~2011-08 744.17万元 课题负责人 06SG16 应用MLPA-微阵列芯片技术对常见遗传病进行基因诊断 上海市教育曙光计划 2007-01~2009-12 12万元 课题负责人 |
论文与专著 >>>
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Shuo Tan, Yuan Chen, Yue Gao, Jiaping He, Xinbing Guo, Simin Zhang, Jingzhi Zhang, Fanyi Zeng（通讯作者） |
β-Galactosidase gene codon optimization results in post-transcriptional enhancement of expression. |
Gene |
2020 |
748: 144676 |
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Yudan Fang, Yan Cheng, Dan Lu, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng（通讯作者） |
Treatment of β654-thalassaemia by TALENs in a mouse model. |
Cell Proliferation |
2018
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51(6): e12491 |
| Zhijuan Gong, Qingwen Ma, Xujun Wang, Qin Cai, Xiuli Gong, Georgi Z. Genchev, Hui Lu and Fanyi Zeng（通讯作者） |
A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals. |
Genes |
2018 |
9(8): 380, 2018 |
| Jingzhi Zhang, Jingbin Yan, Fanyi Zeng（通讯作者） |
Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World. |
Human Gene Therapy |
2018 |
29(2): 197-203 |
| Chuanliang Guo, Yan Xue, Guanheng Yang, Shang Yin, Wansheng Shi, Yan Cheng, Xiaoshuang Yan, Shuyue Fan, Huijun Zhang, |
Nanog RNA binding proteins YBX1 and ILF3 affect pluripotency of embryonic stem cells |
Cell Biology International |
2016 |
40(8): 847-860 |
| Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, |
Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia |
Haematologica |
2014 |
99(8):1304-1311 |
| Xuesong Chen, Qi Gu, Xiang Wang, Qingwen Ma, Huixiang Tang, Xiaoshuang Yan, Xinbing Guo, Hao Yan, Jie Hao, |
Directed neuronal differentiation of mouse embryonic and induced pluripotent stem cells and their gene expression profiles |
Int J Mol Med |
2013 |
32(1):25-34 |
| Chenmin Yang, Chuanliang Gong, Jin Qiu, Huixiang Tang, Zhijuan Gong, Shuzhen Huang, |
Engraftment of genetically modified human amniotic fluid-derived progenitor cells to produce coagulation factor IX after in utero transplantation in mice |
Cell Biol Int |
2013 |
37(5):420-429 |
| , Shu-Zhen Huang, Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan, Juan Wang, Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen Eaves, Connie Eaves and Xiaoyan Jiang# |
Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin?CD34+ cord blood cells |
Cell Res |
2013 |
23:859-862 |
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Studying Stem Cell Biology Using In Utero Transplantation in Animal Models |
Regenerative Medicine in China |
2012 |
14-15 |
| Fei Xie, Qingwen Ma, Shizhong Jiang, Zhaorui Ren, Juan Wang, Shuzhen Huang,, Yitao Zeng |
Adjusting the attB Site in Donor Plasmid Improves the Efficiency of ΦC31 Integrase System |
DNA and Cell Biology |
2012 |
31(7): 1335-1340 |
| Z.-J. Gong, Y.-Y. Zhou, M. Xu, Q. Cai, H. Li, J.-B. Yan, J. Wang, H.-J. Zhang, S.-Y. Fan, Q. Yuan, S.-Z. Huang, |
Aberrant expression of imprinted genes and their regulatory network in cloned cattle |
Theriogenology |
2012 |
78: 858-866 |
| Xiang Wang, Xuesong Chen, Huijun Zhang, Wenyi Qin, Yan Xue, |
Shared Gene Regulation during Human Somatic Cell Reprogramming |
J Genet Genomics |
2012 |
39(12):613-623 |
| Linlin Wang, Yan Xue, Yihang Shen, Wei Li, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, |
Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cell |
Cell Res |
2012 |
22: 1082-1085 |
| Shu-Yang Xie, Wei Li, Zhao-Rui Ren, Shu-Zhen Huang,, Yi-Tao Zeng |
Correction of β654-thalassaemia mice using direct intravenous injection of siRNA and antisense RNA vectors |
Int J Hematol |
2011 |
93(3): 301-310 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Xiang Wang, Liu Wang,, Qi Zhou |
Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium |
Cell research |
2010 |
20(3):383-386 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Xiang Wang, Liu Wang,, Qi Zhou |
Viable Fertile Mice Generated from Fully Pluripotent iPS Cells Derived from Adult Somatic Cells |
Stem Cell Rev and Rep |
2010 |
6: 390-397 |
| Yan Z, Zhou Y, Fu J, Jia F, Zhao L, Guan P, Huang S, Zeng Y, |
Donor-host mitochondrial compatibility improves efficiency of bovine somatic cell nuclear transfer |
BMC Dev Biol |
2010 |
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| Jing-bin Yan, Hong-ping Xu, Can Xiong, Zhao-rui Ren, Guo-li Tian,, Shu-zhen Huang |
Rapid and Reliable Detection of Glucose-6-Phosphate Dehydrogenase (G6PD) Gene Mutations in Han Chinese Using High-Resolution Melting Analysis |
Journal of Molecular Diagnostics |
2010 |
12(3): 305-311 |
| Zhao XY, Li W, Lv Z,, Zhou Q |
Production of mice using iPS cells and tetraploid complementation |
Nat Protoc |
2010 |
5(5): 963-971 |
| Jai-Yoon Sul, Chia-wen K. Wu,, Jeanine Jochems, Miler T. Lee, Tae Kyung Kim, Tiina Peritz, Peter Buckley, David J. Cappelleri, Margaret Maronski, Minsun Kim, Vijay Kumar, David Meaney, Junhyong Kim1, and James Eberwine1 |
Tranome transfer produces a predictable cellular phenotype |
PNAS |
2009 |
106(18):7624-7629. |
| Chen X, Gong XL, M. Katsumata, Zeng YT, Huang SZ, |
Hematopoietic stem cell engraftment by early-stage in utero transplantation in a mouse model |
Exp Mol Pathol |
2009 |
87(3): 173-177 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang,, Qi Zhou |
iPS cells produce viable mice through tetraploid complementationnear |
Nature |
2009 |
461(7260):86-90 |
| Lei-Wen Zhao,Xiao-Yu Yang,Peng-Fei Guan,Jing Fu,Hua Li, Yi-Ye Zhou,Shu-Zhen Huang,Yi-Tao Zeng, |
Improved efficiency of bovine somatic cell nuclear transfer by optimizing operational procedures |
Journal of reproduction and development |
2009 |
55(5):542-546 |
| Wei Li, Shuyang Xie, Xinbing Guo, Xiuli Gong, Shu Wang, Dan Lin, Jingzhi Zhang, Zhaorui Ren, Shuzhen Huang,, Yitao Zeng |
A novel transgenic mouse model produced from lentiviral germline integration for the study of beta-thalassemia gene therapy |
Haematologica |
2008 |
933:356-362 |
| Shuyang Xie, Wei Li, Zhaorui Ren, Jingzhi Zhang, Xinbin Guo, Shu Wang, Shuzhen Huang,, Yi-Tao Zeng |
Amelioration of beta(654)-thalassemia in mouse model with the knockdown of aberrantly spliced beta-globin mRNA |
J. Genet. Genomics, |
2008 |
35(10):595-601. |
| Jing Fu, Pengfei Guan, Leiwen Zhao, Hua Li, Shuzhen Huang,, Yitao Zeng |
Effects of donor cells on in vitro development of cloned bovine embryos |
Journal of Genetics and Genomics |
2008 |
35(5):273-278 |
| , Zhao-Rui Ren, Shang-Zhi Huang, Margot Kalf, Monique Mommersteeg, Maarten Smit, Stefan White, Chun-Lian Jin, Miao Xu, Da-Wen Zhou, Jing-Bin Yan, Mei-Jue Chen, Rinie van Beuningen, Shu-Zhen Huang, Johan den Dunnen, Yi-Tao Zeng, Ying Wu |
Array-MLPA: Comprehensive Detection of Deletions and Duplications and Its Application to DMD Patients |
Human Mutation |
2008 |
29(1):190-197. |
| FEI JIAO, JING-BIN YAN, XIAO-YU YANG, HUA LI, QINGXUE WANG, SHU-ZHEN HUANG,, YI-TAO ZENG |
Effect of Oocyte Mitochondrial DNA Haplotype on Bovine Somatic Cell Nuclear Transfer Efficiency |
Molecular Reproduction and Development |
2007 |
74(10):1278-1286 |
| Chia-wen K.Wu,, James Eberwine |
mRNA transport to and translation in neuronal dendrites |
Anal Bioanal Chem |
2007 |
387:59-62. |
| Chunli Zhao, Ruqiang Yao, Jie Hao, Chenhui Ding, Yong Fan, Xiangpeng Dai, Wei Li, Tang Hui, Zichuan Li, Yang Yu, Yingying Wang, Xiaojun Hou, Wei zhi Ji, Qi Zhou, Alice Jouneau,, Lin Wang |
Establishment of customized mouse stem cell lines by sequential nuclear transfer |
Cell Research |
2007 |
17(1):80-87 |
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专利与技术许可 >>>
一种建立人/山羊造血干细胞异种移植模型的方法 ZL 0113 2 231.4
一种多能干细胞表面标志物及其用途 ZL 2012 1 0082520.2 一种小鼠宫内干细胞移植工具 ZL 2008 2 0154065.1 一种细胞核移植方法 ZL 2006 1 0029674.X |
荣誉与奖励 >>>
国家自然科学奖二等奖 首届妇幼健康科学技术奖自然科学奖一等奖 教育部自然科学奖一等奖 教育部自然科学奖二等奖 上海市科技进步奖二等奖 上海医学科技奖一等奖 上海医学科技奖二等奖 首届第三世界妇女科学组织女青年科学家奖 第六届中国青年女科学家奖 第十届中国青年科技奖 第五届谈家桢生命科学奖创新奖 教育部新世纪优秀人才支持计划 上海市“曙光学者” 上海市“浦江人才” 上海市领军人才 上海市优秀学术带头人 上海市卫生系统第十一届银蛇奖 上海科普教育创新奖科普贡献奖（个人）一等奖 上海市第一届医树奖医学科普创新奖 全国巾帼建功标兵 第六届上海市巾帼创新奖 上海市统一战线（工作）先进个人 中国侨界（创新成果）贡献奖 |
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