师资队伍
刘俊岭
  作者:  2018-12-31

基本信息 >>>

 刘俊岭
  生物化学与分子细胞生物学系
  电话:63846590-776345
  邮箱:liujl@shsmu.edu.cn

研究方向>>>

1. 粘附受体介导的信号传导在血小板激活中的作用。

2. 动脉粥样硬化发生发展机制。

3. 基质细胞在肿瘤转移微环境形成中的作用研究。

个人简历 >>>

刘俊岭研究员博士生导师。美国血液学会会员,中华医学会细胞生物专业青年委员,教育部新世纪优秀人才、上海市高层次人才

教育经历:

19936月毕业于新疆欧洲杯竞猜平台药学本科专业;

1995-1998年在新疆欧洲杯竞猜平台天然药物化学教研室攻读硕士学位,师从堵年生教授,课题内容为中草药化学成分提取、分离以及结构鉴定,获得天然药物化学硕士学位;

1998-2001年在北京大学医学部药学院药物化学系攻读博士学位,师从彭师奇教授,课题内容为具有生物活性小分子化合物合成及其活性评价。

工作经历:

2001-2006年在美国孟菲斯大学微生物及细胞分子生物学系进行博士后研究,主要从事血小板粘附受体及其介导信号在血栓性疾病中的作用研究;

2006-2008在美国伊利诺伊大学芝加哥分校欧洲杯竞猜平台药理系任研究助理教授,从事血栓止血分子机制的研究。2008回国在欧洲杯竞猜平台任研究员,获上海市浦江人才计划支持。

科研项目 >>>

1. 国家自然科学基金重点项目

项目编号:82030004

项目名称:糖代谢调控血小板生成和凋亡的作用机制研究

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2021年1月至2025年12月

资助金额:297万

2. 国家自然科学基金重点项目

项目编号:31830050

项目名称:代谢调控血小板衰老死亡的分子机制

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2019年1月至2023年12月

资助金额:288万

3. 国家自然科学基金重大研究计划集成项目

项目编号:91739302

项目名称:危重血管性疾病血栓事件的发生、发展及干预研究

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2018年1月至2020年12月

资助金额:210万

4. 国家自然科学基金国家杰出青年基金

项目编号:81525001

项目名称:血小板活化的分子调控机制研究

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2016年1月至2020年12月

资助金额:350万

5. 国家自然科学基金重大研究计划培育项目

项目编号:91439115

项目名称:血小板内皮聚集受体1调控血管稳态作用机制研究

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2015年1月至2017年12月

资助金额:150万

6. 科技部973子课题

项目编号:2012CB518001

项目名称:GPCR介导的血管炎症和损伤

项目负责人:刘俊岭

资助部门:科技部

起始年限:2012年1月至2016年12月

资助金额:289万

7. 国家自然科学基金重点项目

项目编号:81030039

项目名称:血小板介导预转移微环境的形成及其在肺癌转移中的作用

项目负责人:刘俊岭

资助部门:国家自然科学基金委

起始年限:2011年1月至2014年12月

资助金额:200万

8. 国家自然科学基金面上项目

项目编号:81170479

项目名称:整合素αIIb亚基介导信号在血小板活化和血栓形成中的作用

项目负责人:刘俊岭

资助部门:国家自然科学基金委BMCB 2011 56

起始年限:2012年1月至2015年12月

资助金额:60万

9. 上海市教委和教育发展基金会曙光学者

项目编号:10SG21

项目名称:血小板在肺癌预转移微环境形成中的作用研究

项目负责人:刘俊岭

资助部门:上海市科委

起始年限:2011年1月至2013年12月

资助金额:15万


论文与专著 >>>

1. Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y, Liu J. The role of AGK in thrombocytopoiesis and possible therapeutic strategies.Blood. 2020 Jul 2;136(1):119-129. doi: 10.1182/blood.2019003851.Blood. 2020. PMID: 32202634

2. Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H, Liu J. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.  Circulation. 2020 Jul 7;142(1):49-64. doi: 10.1161/CIRCULATIONAHA.119.043581. Epub 2020 Mar 23.Circulation. 2020. PMID: 32200651

3. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B, Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Jun 11. pii: S1550-4131(19)30256-6. doi: 10.1016/j.cmet.2019.05.016. [Epub ahead of print]

4. Hu Z1, Qu G1, Yu X1, Jiang H2, Teng XL1, Ding L1, Hu Q1, Guo X1, Zhou Y1, Wang F1, Li HB1, Chen L1, Jiang J3, Su B4, Liu J5, Zou Q6.(2019)Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Jun 11. pii: S1550-4131(19)30256-6. doi: 10.1016/j.cmet.2019.05.016. [Epub ahead of print]

5. Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan , Liu J*.(2018)Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. Hepatology. 2018 Dec;68(6):2239-2253.

6. Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J*. (2018)Sin1 (Stress-Activated Protein Kinase-Interacting Protein)Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2793-2805.

7. Fan Xuemei, Wang Conghui, Shi Panlai, Gao Wen, Gu Jianmin, Geng Yan, Yang Wenlong, Wu Ningbo, Wang Yang, Xu Yanyan, Chen Xue, Zhang Lin, Wang Kemin, Su Bin, Liu Junling.(2018)Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. Blood Adv. 2018 Jun 26;2(12):1439-1448.

8. Shi P, Zhang L, Zhang M, Yang W, Wang K, Zhang J, Otsu K, Huang G, Fan X, Liu J*. Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e185-e196.

9. Gao W, Shi P, Chen X, Zhang L, Liu J, Fan X, Luo X. Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading. Platelets. 2017 Sep 29:1-12.

10. Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L, Liu J, Wu X. Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression. Mol Pharmacol. 2017;92(3):285-296.

11. Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J, Luo X, Hu Y. Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway. J Thromb Haemost. 2017;15(8):1679-1688.

12. Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. 2017;130(6):817-828.

13. Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C. Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cell Mol Immunol. 2017;14(6):557-567.

14. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017;28(2):194-202.

15. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S, Jiang W. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017;62:245-255.

16. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017;149:1-8.

17. Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang C, Liu J, Chen Q. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016 Dec 20;5. pii: e21407.

18. Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J*, Chen GQ, Zheng J. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016 Dec 1;126(12):4537-4553. doi: 10.1172/JCI87105. Epub 2016 Oct 31.

19. Dai J, Lu Y, Wang C, Chen X, Fan X, Gu H, Wu X, Wang K, Gartner TK, Zheng J, Chen G, Wang X, Liu J*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. J Pathol. 2016;240(1):108-19.

20. Cheng Z, Liu J. Receptor-mediated inhibitory mechanisms and the regulation of platelet function. Sci China Life Sci. 2015;58(12):1299-301.

21. Fan X, Chen X, Wang C, Dai J, Lu Y, Wang K, Liu J, Zhang J, Wu X. Drospirenone enhances GPIb-IX-V-mediated platelet activation. J. Thromb. Haemost., 2015;13(10):1918-24.

22. Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. PLoS One., 2015;10(8):e0135738.

23. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015;126(7):905-14.

24. Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T, Liu J, Xia Z. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. J. Biol. Chem., 2015;290(20):12523-36

25. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J, He B. Vitamin D Receptor Activation Protects against Myocardial Reperfusion Injury through Inhibition of Apoptosis and Modulation of Autophagy. Antioxid. Redox. Signal., 2015;22(8):633-50.

26. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 2014;124(12):1957-67.

27. Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J*. Paired immunoglobulin-like receptor B regulates platelet activation. Blood, 2014;124(15):2421-30.

28. Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ. Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler. Thromb. Vasc. Biol., 2014;34(9):1961-7.

29. Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, Hämmerling G, Liu J, Essex DW. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood, 2013;122(22):3642-50. 10

30. Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y, Liu J*. PDK1 regulates platelet activation and arterial thrombosis. Blood, 2013;121(18): 3718-26.

31. Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, and Ding Z. P2Y(12) protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J. Thromb. Haemost., 2013;11(1):149-60.

32. Delaney MK, Liu J, Zheng Y, Berndt MC, and Du X. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler. Thromb. Vasc. Biol., 2012;32(11):2761-8.

33. Niu H, Chen X, Gruppo RA, Li D, Wang Y, Zhang L, Wang K, Chai W, Sun Y, Ding Z, Gartner TK, and Liu J*. Integrin αIIb-mediated PI3K/Akt activation in platelets. PLoS One., 2012;7(10):e47356. 8

34. Li D, Wang Y, Zhang L, Luo X, Li J, Chen X, Niu H, Wang K, Sun Y, Wang X, Yan Y, Chai W, Gartner TK, and Liu J*. Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 2012;32(8):e81-9. 15

35. Niu H, Xu Z, Li D, Zhang L, Wang K, Taylor DB, Liu J*, and Gartner TK*. Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets. Thromb. Res., 2012;130(2):203-9.

36. Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, and Liu J*. PTEN Regulates Collagen Induced Platelet Activation. Blood, 2010;116(14):2579-81.21

37. Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J, Liu J, Zhang X, Kunapuli SP, and Ding Z. BF0801, a novel adenine derivative, inhibits platelet activation via PDE inhibition and P2Y12 antagonism. Thromb. Haemost., 2010;104(4):845-57. 9

38. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, and Li Z. A Gi-independent mechanism mediating Akt phosphorylation in platelets. J. Thromb. Haemost., 2010;8(9):2032-41. 19

39. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, and Du X. An important role of the SRC family kinase LYN in stimulating platelet granule secretion. J. Biol. Chem., 2010;285(17):12559-70. 13

40. Guerrero JA, Kyei M, Russell S, Liu J, Gartner TK, Storrie B, and Ware J. Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Blood, 2009;114(27): 5541-6. 11

41. Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, and Du X. Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK- dependent integrin outside-in retractile signaling pathway. Blood, 2009;113(4):893-901. 52

42. Liu J*, Joglekar M, Ware J, Fitzgerald MEC, Lowell CA, Berndt MC, and Gartner TK. Evaluation of the physiological significance of botrocetin/von Willebrand factor in vitro signaling. J. Thromb. Haemost., 2008;6(11):1915-22.

43. Liu J*, Jackson CW, and Gartner TK. The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J. Thromb. Haemost., 2008;6(6):1035-7.

44. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, and Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood, 2008;112(4):1139-46. 35

45. Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Bäumler W, Jarvis GE, and Ware J. In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation. J. Thromb. Haemost., 2008;6(4):684-91.

46. Jain S, Zuka M, Liu J, Russell S, Dent J, Forsyth J, Maruszak B, Gartner TK, Habermann BF, and Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc. Natl. Acad. Sci. USA., 2007;104(21):9024-8. 96

47. Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain dependent alphallbbeta3 elicited outside-in signaling. J. Thromb. Haemost., 2007;5(2):426-8.

48. Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain signals in the absence of GPVI. J. Thromb. Haemost., 2007;5(1):201-3.

49. Liu J, Fitzgerald MEC, Berndt MC, Jackson CW, and Gartner TK. Bruton’s tyrosine kinase is essential for botrocetin/ vWf-induced signaling and GPIb-dependent thrombus formation in vivo. Blood, 2006;108(8):2596-603. 45

50. Zhao M, Liu J, Wang C, Wang L, Liu H, and Peng S. Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J. Med. Chem., 2005;48(13),4285 -92.

51. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. Botrocetin/vWf-induced signaling through GPIb-IX-V produces TxA2 in a Ca2+ and aggregation-independent manner without utilizing other receptors. Blood, 2005;106:2750-2756. 43

52. Liu J, Jackson CW, Gruppo RA, Jennings LK, and Gartner TK. The β3 Subunit of the Integrin αIIbβ3 Regulates αIIb-mediated Outside-in Signaling. Blood, 2005;105:4345-4352. 23

53. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. The roles of ADP and TXA2 in botrocetin/vWf- induced aggregation of washed platelets. J. Thromb. Haemost., 2004;2:2213-2222.

54. Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, and Gartner TK. The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood, 2003;101(7):2646-51. 60

55. Cho MJ, Liu J, Pestina TI, Steward SA, Jackson CW, and Gartner TK.  AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J. Thromb. Haemost., 2003;1(2):363-73.

56. Liu J, Zhao M, Wang C, and Peng S. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides. Bioorg Med Chem Lett., 2003;13(22):4065-4069. 12

     

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