师资队伍
姚玉峰
  作者:  2018-12-31

基本信息 >>>

               


  病原细菌学研究组
  电话:63846590-776523
  邮箱:yfyao@sjtu.edu.cn

研究方向>>>

1、 大肠埃希菌VI型分泌系统(T6SS)分泌蛋白质组学研究

2、 细菌蛋白乙酰化修饰与功能

3、 结核分枝杆菌的基因组变异进化规律、探索结核分枝杆菌致病机制并利用组学手段探索新的结核病快速诊断技术

个人简历 >>>

    姚玉峰,博士,研究员,博士生导师。目前主要从事病原菌致病机制及宿主天然免疫方面的研究,在ScienceTrends MicrobiolPLoS PathogJ Infect DisInfect & ImmunJ Biol Chem、等国际知名期刊上发表论文50多篇。科研工作获得科技部973计划课题、重点研发专项、传染病重大专项、国家自然科学基金委和上海市科委、教委的资助。曾获上海高层次人才、上海市青年科技启明星、欧洲杯竞猜平台晨星青年学者奖励计划以及欧洲杯竞猜平台首届青年十杰等荣誉称号。

科研项目 >>>

2016YFA0500600 病原菌核糖体调节因子的发现、鉴定及调控机制研究 国家重点研发计划 2016-01~2020-12  300万元   课题参与人

上海高层次人才 上海市教委  2015-01~2017-12  100万元   课题负责人

15GWZK0102 传染病与卫生微生物学 上海市公共卫生三年行动计划重点学科建设项目 2015-01~2017-12  22万元   课题参与人

2015CB554203 表观修饰与病原细菌适应性进化 科技部973计划 2015-01~2019-12  300万元   课题负责人

81361120383 细胞壁脂类与耐利福平结核分枝杆菌致病性关系的研究 国家自然科学基金委 2014-01~2016-12  180万元   课题负责人

31270173 肠出血型大肠埃希菌VI型分泌系统分泌蛋白鉴定及功能研究 国家自然科学基金委 2013-01~2016-12  82万元   课题负责人

12QH1401300 结核分枝杆菌未知功能ABC超家族转运蛋白的研究 上海市科委,青年科技启明星(跟踪) 2012-01~2014-12  20万元   课题负责人

31070114 结核分枝杆菌DnaA乙酰化修饰与DNA复制调控的研究 国家自然基金委 2011-01~2013-12  35万元   课题负责人

上海高层次人才 上海市教委 2010-01~2012-12  50万元   课题负责人

09QA1403600 结核分枝杆菌MazG功能研究及其与无毒株H37Ra表型的关系 上海市科委,青年科技启明星A 2009-07~2011-06  15万元   课题负责人

30870100 细胞毒素坏死因子(CNF1)的分泌及其作用机制 国家自然基金委 2009-01~2011-12  30万元   课题负责人

2009CB522605 结核杆菌微进化的研究 科技部973计划 2009-01~2013-12  320万元   课题负责人

论文与专著 >>>

Ren J, Sang Y, Lu J, Yao YF (通讯作者)   Protein acetylation and its role in bacterial virulence   Trends Microbiol   2017   XX:XX-XX    

Li S, Zhang Q, Xu Z, Yao YF (通讯作者)   Acetylation of lysine 243 inhibits the oriC binding ability of DnaA in Escherichia coli   Front Microbiol   2017   8:699   

Wan B, Zhang Q, Ni J, Li S, Wen D, Li J, Xiao H, He P, Ou H, Tao J, Teng Q, Lu J, Wu W, Yao YF (通讯作者)   Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)   PLoS Pathog   2017   e1006246   

Sang Y, Ren J, Qin R, Liu S, Cui Z, Cheng S, Liu X, Lu J, Tao J, Yao YF (通讯作者)   Acetylation regulates protein stability and DNA-binding ability of HilD to modulate Salmonella Typhimurium virulence   J Infect Dis   2017   XX:XX-XX   

Ren J, Sang Y, Lu J, Yao YF   6S RNA is involved in acid resistance and invasion of epithelial cells in Salmonella enterica serovar Typhimurium   Future Microbiol   2017   XX:XX-XX    

Sang Y, Ren J, Ni J, Tao J, Lu J, Yao YF (通讯作者)   Protein acetylation is involved in Salmonella enterica serovar Typhimurium virulence.   J Infect Dis   2016   213(11):1836-45   

Qin R, Sang Y, Ren J, Zhang Q, Li S, Cui Z, Yao YF (通讯作者)   The bacterial two-hybrid system uncovers the involvement of acetylation in regulating of Lrp activity in Salmonella Typhimurium   Front Microbiol   2016   7:1864   

Ren J, Sang Y, Tan Y, Tao J, Ni J, Liu S, Fan X, Zhao W, Lu J, Wu W, Yao YF (通讯作者)   Acetylation of lysine 201 inhibits the DNA-binding ability of PhoP to regulate Salmonella virulence   PLoS Pathog   2016   e1005458   

Wan B, Zhang Q, Tao J, Zhou A, Yao YF (通讯作者), Ni J   Global tranional regulation by H-NS and its biological influence on the virulence of Enterohemorrhagic Escherichia coli   Gene   2016   588(2):115-23   

Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F, Yao YF. (通讯作者)   Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli   Sci Rep   2016   6:30837   

Zhang Q, Wan B, Zhou A, Ni J, Xu Z, Li S, Tao J, Yao YF (通讯作者)   Whole genome analysis of a multiple drug-resistant Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions   Gene   2016   582(2):128-36   

Tan Y, Xu Z, Tao J, Ni J, Zhao W, Lu J, Yao YF (通讯作者)   A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis   Acta Biochim Biophys Sin (Shanghai)   2016   48(2):145-52   

Zhou A, Ni J, Xu Z, Wang Y, Lu S, Wu W, Karakousis PC, Yao YF (通讯作者)   Metabolomics specificity of tuberculosis plasma revealed by 1H-NMR spectroscopy   Tuberculosis   2015   95(3):294-302   

Ren J, Sang Y, Lu J, Zhao M, Yao YF (通讯作者)   Acetylation regulates survival in acid stress of Salmonella Typhimurium   Appl Environ Microbiol   2015   81(17):5675-82   

Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S, Yao YF (通讯作者)   Differential expression of miRNAs and their relation to active tuberculosis   Tuberculosis   2015   95(4):395-403   

Tao J, Sang Y, Teng Q, Ni J, Yang Y, Tsui S, Yao YF (通讯作者)   Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli.   Front Microbiol   2015   6:51   

Zhou A, Ni J, Xu Z, Wang Y, Lu S, Sha W, Karakousis PC, Yao YF (通讯作者)   Application of 1H-NMR spectroscopy-based metabolomics to sera of tuberculosis patients   J Proteome Res   2013   12(10):4642-9   

Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo XK, Yao YF (通讯作者)   Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells   Infect & Immun   2012   80(3):1243-51   

Zhou A, Nawaz M, Duan Y, Moore J, Millar C, Xu J, Yao YF (通讯作者)   Molecular characterization of isoniazid resistant Mycobacterium tuberculosis isolates from Xi’an, China   Microb Drug Resist   2011   17(2):275-81   

Zhou A, Nawaz M, Xue X, Karakousis P, Yao YF (通讯作者), Xu J   Molecular genotyping study of Mycobacterium tuberculosis in Xi’an, China using MIRU-VNTR typing system   Int J Tuberc Lung Dis   2011   15(4):517-22   

Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao YF, Ning Z, Zeng R, Xiong Y, Guan K, Zhao S, Zhao G   Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux   Science   2010   327(5968):1004-7   

Lu LD, Sun Q, Fan XY, Zhong Y, Yao YF (通讯作者), Zhao GP   Mycobacterial MazG Is A Novel NTP Pyrophosphohydrolyase Involved in Oxidative Stress Response   J Biol Chem   2010   285(36):28076-85   

Yao YF, Xie Y, Perace D, Zhong Y, Lu J, Tao J, Guo X, Kim KS   The type III secretion system is involved in the invasion and intracellular survival of Escherichia coli K1 in human brain microvascular endothelial cells   FEMS Microbiol Lett   2009   300(1):18-24   

Parthasarathy G, Yao YF, Kim KS   Flagella promote Escherichia coli K1 association with and invasion of human brain microvascular endothelial cells (HBMEC)   Infect & Immun   2007   75(6):2937-45   

Yao YF, Xie Y, Kim KS   Genomic comparison of E. coli K1 strains isolated from the cerebrospinal fluid of patients with meningitis   Infect & Immun   2006   74(4):2196-206   

Yao YF, Vuong C, Kocianova S, Villaruz A, Lai Y, Sturdevant D, Otto M   Characterization of the Staphylococcus epidermidis accessory-gene regulator response: Quorum-sensing regulation of resistance to human innate host defense   J Infect Dis   2006   193(6):841-8   

Yao YF, Sturdevant D, Villaru A, Xu L, Gao Q, Otto M   Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics   Infect & Immun   2005   73(3):1856-60   

Kocianova S, Vuong C, Yao YF, Carmody A, Otto M   Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis   J Clin Invest   2005   115(3):688-94   

Yao YF, Sturdevant D, Otto M   Genome-wide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into S. epidermidis biofilm pathophysiology   J Infect Dis   2005   191(2):289-98   

Vuong C, Kocianova S, Yao YF, Carmody AB, Otto M   Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo   J Infect Dis   2004   190(8):1498-505   

Yao YF, Zhang WW, Jiao RS, Zhao GP, Jiang WH   Efficient isolation of total RNA from antibiotic-producing bacterium Amycolatopsis mediterranei U32   J Microbiol Meth   2002   51(2):191-5   

专利与技术许可 >>>

 

 

教学工作 >>>

 

 

荣誉与奖励 >>>