刘智多

  免疫微环境课题组

  电话：021-63846590-776749

  邮箱：zhiduo.liu@shsmu.edu.cn

1.阐明巨噬细胞如何通过调控基质细胞的活化来影响局部的免疫反应;

2.揭示组织中调控巨噬细胞炎性基因表达的新机制，这些局部的炎症反应在介导组织损伤及肿瘤发生方面至关重要。

期待我们的工作为理解免疫反应的精细调控以及相应的免疫治疗开发提供新的视角。

1997-2001 武汉大学 学士

2001-2009 中国科学院上海生命科学研究院 博士

2009-2010 中国科学院上海生命科学研究院 研究助理

2010-2016 美国国立健康研究院(National Institutes of Health) 博士后

2016-至今 欧洲杯竞猜平台上海市免疫学研究所 研究员

1. 科技部重点研发项目， 240万元， 2021-12至2024-11，在研，参与

2. 国家自然科学基金委面上项目，58万元，2021-01至2024-12，主持

3. 国家自然科学基金委面上项目，60万元，2019-01至2022-12，主持

4. 上海市“浦江人才计划” ，20万元，2017-07至2019-06，主持

5. 上海市自然基金项目，20万元，2017-05至2020-04，主持

1. Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015, 528(7581):225-30. (First author)

2. Yu X^#, Teng XL^#, Wang F^#, Zheng Y^#, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L*, Liu Z*, Sun SC*, Zou Q*. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med. 2018, 215(9):2463-2476. (Co-correspondence)

3. Wu N^#, Sun H^#, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B.MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 2021 Apr;592(7855): 606-610.

4. Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J*, Cheng J*, Wu X*. SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation. Theranostics. 2021 Feb 15; 11(8):3981-3995.

5. Jin F^#, Li J^#, Zhang YB^#, Liu X^#, Cai M, Liu M, Li M, Ma C, Yue R, Zhu Y, Lai R, Wang Z, Ji X, Wei H, Dong J, Liu Z, Wang Y*, Sun Y*, Wang X*. A functional motif of long noncoding RNA Nron against osteoporosis. Nat Commun. 2021 Jun 3; 12(1):3319.

6. Yang XD^#*, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B*. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020, 39(2):e102201.

7. Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B*, Ginhoux F*. Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell. 2019, 178(6):1509-1525.e19.

8. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. 2017 Apr 18;46(4):609-620.

9. Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. J Immunol. 2017 Jan 15;198(2):895-907.

10.Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB. AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015 Jul 24;349(6246):436-40.

11.Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, Mao K, Wang J, Lin G, Tian L, Ji Y, Qin M, Sun S, Zhu X, Sun B. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 2011 Feb;12(2):178-85.