师资队伍
路丽明
  作者:  2018-12-31

基本信息 >>>


                                                                 

 

 路丽明

 免疫调节研究组

 电话: 63846590-776723

 邮箱lulunew2003@163.com

研究方向>>>

免疫调节,具体课题围绕 同种异体器官免疫耐受的诱导;细胞免疫治疗的基础和临床;干细胞的临床应用研究;中药天花粉蛋白(Tk)负向调控及其衍生肽作为免疫调节药物的研究

个人简历 >>>

路丽明,教授,博士生导师

免疫调节研究组 课题组长

《现代免疫学》杂志执行主编

SHC (shanghai chest , 国际标准刊号 ISSN 2521-3768) 副主编

上海市免疫学会常务理事

上海市免疫遗传学会副主任委员

教育部学位中心全国博士论文评审专家

中华免疫生物治疗学会理事,常务委员

上海市浦江人才,上海市曙光学者

上海市科技启明星人才计划

上海市教委骨干教师

上海市卫生系统优青


1994-1998 厦门大学 学士

1998-2001 欧洲杯竞猜平台 硕士

2003-2006 欧洲杯竞猜平台 博士


2001-2003 组织工程研发中心 部门主管

2006-2008 欧洲杯竞猜平台 讲师

2009-2014 欧洲杯竞猜平台,副研究员,硕士生导师, RBL导师

2014-至今 欧洲杯竞猜平台上海市免疫学研究所课题组长,研究员,教授,博士生导师,《现代免疫学》杂志执行主编

2012-2020 欧洲杯竞猜平台附属胸科医院 实验中心 主任

2013-2014 英国剑桥大学 高级访问学者

2018.03-2018.06 国家自然基金委医学四处 项目评审专家

科研项目 >>>

主持课题

1. 国家自然科学基金面上项目,中药天花粉蛋白作为A群流脑疫苗免疫增效剂的应用基础研究,82071856,项目负责人

2. 国家重点研发计划,单倍型相合移植(北京方案)后适应性免疫重建及调控机制,2017YFA0104600,项目3负责人

3. 国家自然科学基金面上项目,Tk衍生肽通过Treg细胞抑制同种异体肺移植慢性排斥的应用基础研究,81671579,项目负责人

4. 国家自然科学基金面上项目,II类反式激活因子通过NLR信号调控Th2应答的分子免疫学机制,31370904,项目负责人

5. 国家自然科学基金面上项目,天花粉蛋白衍生肽诱导的IL-9+IL-10+T细胞与Th9的免疫生物学特性比较研究,30972691,项目负责人

6. 国家自然科学基金青年项目,构建CIITA突变体转基因小鼠功能性剔除MHC及作用机制研究,30700766,项目负责人

7. 上海市科委实验动物项目,肺癌双人源化PDX模型的构建与临床患者药物治疗方案评估的探索,18140903800,项目负责人

8. 上海市科委生药研究重点项目,TK有效组分作为免疫调节细胞专一诱导剂的药效学研究,15401900500,项目负责人

9. 上海市教委,中药天花粉蛋白衍生肽通过Treg细胞延缓肺移植术后闭塞性细支气管炎综合症的可行性研究,16SG14,项目负责人

10. 上海市浦江人才计划项目,中药天花粉蛋白来源的生物活性多肽治疗Th1细胞主宰疾病的药效及作用机理研究,15PJD021,项目负责人

11. 上海市科委产学研项目,自体免疫细胞治疗肺癌的医学转化研究,14DZ1931003,项目负责人

12. 上海市中医药局面上项目,组蛋白去甲基化酶LSD1对天花粉蛋白诱导的CD8+Treg谱系维持的作用,2020JP009,项目负责人


参与课题:

1. 重点研发计划项目,人脐带间充质干细胞治疗视神经脊髓炎谱系疾病的临床研究, 2020YFA010045,课题骨干,2021-2025

2. 国家973重点基础研究项目,组织干细胞的干性维持、分化控制和免疫调节研究, 2010CB945600,课题骨干

3. 国家自然科学基金重点项目,MHCTh1/Th2分化相关基因转录激活调控的表观遗传学研究,30530690,第一参与人



论文与专著 >>>

1. RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the  MKK/p38MAPK signaling pathway. Hum Cell. Rui Guo, Shun-Yuan Lu, Jin-Xia Ma, Qian-Lan Wang, Lu Zhang, Ling-Yun Tang, Yan Shen, Chun-Ling Shen, Jin-Jin Wang, Li-Ming Lu, Zhu-GangWang, Hong-Xin Zhang:2022 Apr 13,(Accepted.

2. Tumor-infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis. Journal of Inflammation Research. Di Tang#, Duo Zhang#, Yu Heng, Xiao-ke Zhu, Han-qing Lin, Jian Zhou, Lei Tao*, and Li-ming Lu* 2022 Feb. 16;15:1079-1097

3. Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR- targeted therapy in lung cancer. Sci Transl Med 2021 Oct 6;13(614):eabg6428. Ke-Ren Zhang , Yu-Fei Zhang , Hui-Min Lei , Ya-Bin Tang , Chun-Shuang Ma , Qian-Ming Lv , Shi-Yi Wang , Li-Ming Lu , Ying Shen , Hong-Zhuan Chen , Liang Zhu.

4.Prognostic Impact of Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients. Laryngoscope. 2020 Oct 27. doi: 10.1002/lary.29196. Duo Zhang; Di Tang; Yu Heng; Xiao-Ke Zhu; Liang Zhou; Lei Tao; Li-Ming Lu*

5.A systematic analysis identifies key regulators involved in cell proliferation and potential drugs for the treatment of human lung adenocarcinoma. Frontiers in Oncology-Thoracic Oncology. 2021 Sep 28;11:4-15. Kai Wang, Man Zhang, Jiao Wang, Jizhuang Luo, Pan Sun, Haizhen Jing, Rong Li, Changqing Pan, Li-Ming Lu*.

6. Dysregulation of DPP4-CXCL12 balance by TGF-β1/SMAD pathway promotes CXCR4+ inflammatory cell infiltration in keloid scars. Journal of Inflammation Research. 2021 Aug 26; 14:4169-4180. ZongAn Chen, Zhen Gao, LingLing Xia, XiaoQing Wang, Li-Ming Lu* XiaoLi Wu *..

7. BCL11A promotes the progression of laryngeal squamous cell carcinoma. Frontiers in Oncology. 2020 Mar 20;10:375. doi: 10.3389/fonc.2020.00375. Jian Zhou, Liang Zhou, Duo Zhang, Wei-Jing Tang, Di Tang, Xiao-Ling Shi, Yue Yang, Lin Zhou, Fei Liu, Yong Yu, Pentao Liu, Lei Tao, Li-Ming Lu*.

8. CXCL8high inflammatory B cells in the peripheral blood of patients with biliary atresia are involved in disease progression. Immunology & Cell Biology. 2020; 1–11. Zhang Yu; Zhou Lin; Gu Xiang; Feng Xuan; Ding Ping; Xia Qiang; Li-Ming Lu*

9.Chidamide combined with paclitaxel effectively reverses the expression of histone deacetylase in lung cancer. Anti-Cancer Drugs. 2020 August; 31(7):702-708. Zhang, Na; Sun, Pan; Jin, Haizhen; Yang, Yuqin; Zhao, Qingya; Zhou, Lin; Guo, Lili; Yang, Xiaohua; Li-Ming Lu*

10. Link Between CIITA rs3087456 Polymorphism and the Risk of Laryngeal Squamous Cell Carcinoma in a Chinese Population. Pathol Res Pract. 2020 Jan;216(1):152793. Yi Xue , Di Tang , Sheng-Jie Li , Jian Zhou , Chi-Yao Hsueh , Dan-Dan Zhao , Yu Heng , Lei Tao, Li-Ming Lu*

11. IL-33 promotes the progression of nonrheumatic aortic valve stenosis via inducing differential phenotypic transition in valvular interstitial cells. Journal of cardiology. 2019 Aug 12. HeYu-Bin; GuoJiang-Hong; WangChong; Zhu Dan; Lu Li-Ming*.

12. PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies. Trends Mol Med.2020 Nov 13;S1471-4914(20)30266 -5. Christopher D Nishimura, Marc C Pulanco, Wei Cui, Liming Lu, Xingxing Zang.

13. Mesothelin-targeted second generation CAR-T cells inhibit growth of mesothelin-expressing tumors in vivo. Exp Ther Med. 2019 Jan;17(1):739-747. Lin Ye, Yuqing Lou, Liming Lu* and Xiaohong Fan.

14. A Pathologic Complete Response to Neoadjuvant Chemotherapy and Immunotherapy Followed by Surgery in a Patient With NSCLC. Journal of Thoracic Oncology, 2019, 14(5): E104-E106.Ma, Xiao; Li, Bin; Li, Yuan; Lu, Liming; Chen, Haiquan

15. Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC. FRONTIERS IN ONCOLOGY , 2019 , Jul 2;9:588. Yi xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao and Li-ming Lu*.

16. CXCL16/CXCR6 Is Involved in LPS-induced Acute Lung Injury via P38 Signaling. Cell Physiol Biochem. 2019; 00; 1-10. Guo-wei Tu ,Min-jie Ju, Yi-jun zheng, Guang-wei Hao,Guo-guang Ma, Jun-yi Hou, Xue-peng Zhang, Zhe Luo, Li-ming Lu*.

17. Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for non-small cell lung cancer therapy. European Respiratory Journal . 2019 Mar 1;53(3). pii: 1801562. doi: 10.1183/13993003.01562-2018. Jun Lu, Hua Zhong, Tianqing Chu, Xueyan Zhang, Rong Li, Jiayuan Sun, Runbo Zhong, Yuqin Yang, Mohammad Shah Alam, Yuqing Lou, Jianlin Xu, Yanwei Zhang, Jun Wu, Xiaowei Li, Xiaodong Zhao, Kai Li, Liming Lu*, Baohui Han.

18. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease. Journal of J Neuroinflammation. 2019;16(1):263. Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu* and Jun Liu*.

19. Establishment of porcine and human expanded potential stem cells. Nature cell biology, 2019, 21(6): 687. Gao, Xuefei; Nowak-Imialek, Monika; Chen, Xi; Chen, Dongsheng; Herrmann, Doris; Pei, Duanqing; Zhang, Yi; Lu, Liming; Yang, Fengtang; Kimber, Susan J; Ahmed, Asif; Yeung, William Shu Biu; Teichmann, Sarah A; Niemann, Heiner; Liu, Pentao.

20. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature communications, 2018, 9(1): 3157. Xiaoyan Yu, Yimin Lao, Xiao-Lu Teng, Song Li, Yan Zhou, Feixiang Wang, Xinwei Guo,  Siyu Deng,  Yuzhou Chang,  Xuefeng Wu,  Zhiduo Liu,  Lei Chen,  Liming Lu,  Jinke Cheng, Bin Li,  Bing Su,  Jin Jiang,  Hua-Bing Li,  Chuanxin Huang,  Jing Yi & Qiang Zou .

21. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med .2018 Sep 3;215(9):2463-2476. doi: 10.1084/jem.20180397. Xiaoyan Yu, XiaoLu Teng, Feixiang Wang, Yuhan Zheng, Guojun Qu, Yan Zhou, Zhilin Hu, Zhongqiu Wu, Yuzhou Chang, Lei Chen,HuaBing Li, Bing Su, Liming Lu*, Zhiduo Liu, ShaoCong Sun, and Qiang Zou.

22. Trichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy. Scientific Reports,2018,8(1):3917 Dongfang Tang, Ruyong Yao, Dandan Zhao, Lin Zhou, Yun Wu, Yang Yang, Yifeng Sun, Liming Lu, Wen Gao

23. The miR-3127-5p/p-STAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22(8): 3847-3856.Tang, Dongfang; Zhao, Dandan; Wu, Yun; Yao, Ruyong; Zhou, Lin; Lu, Liming*; Gao, Wen*; Sun, Yifeng*

24. Peptede TK-PQ induces immunosuppression in skin allogeneic transplantation via increasing Foxp3+ Treg and impeding nuclear translocation of NF-κB. Molecular Immunology. 2018 Sep;101:597-607. doi: 10.1016/j.molimm. Yue Wang, Qing Li, Lin Zhou, Xueping Ding, Li-ming Lu*.

25. Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility. Frontiers in Physiology, 2018, 8:1117. doi: 10.3389/fphys. Weimin Fan, Yali Xu, Yue Liu , Zhengqing Zhang , Liming Lu* and Zhide Ding.

26. Characterization of Memory T Lymphocytes in Keloid Disease. Br J Dermatol. 2018 Apr;178(4):940-950. ZongAn Chen*, Lin Zhou*, TaeHao Won, Zhen Gao, XiaoLi Wu, Li-ming Lu*.

27. Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma. PloS one, 2017 Feb 22;12(2):e0171116. Zhou, J., Yang, Y., Zhang, D., Zhou, L., Tao, L., & Lu L*.

28. Regulatory T Cells may Play an Protection Role in Lung Injury after Operation in Rheumatic Heart Disease. Journal of Thoracic Disease, 2018 Jun;10(6):3196-3205. Xiao-yang Zhang, Lin Zhou, Zhen Guo, Ye Kong, Wei Zhang, Li-ming Lu*Xin Li*.

29. Establishment of mouse expanded potential stem cells.[J] .Nature, 2017, 550(7676): 393-397. Yang Jian,Ryan David J,Wang Wei, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu,  Zhexin Zhu, Juexuan Wang, Aleksandra A. Kolodziejczyk, Lia S. Campos, Patrick P. L. Tam, Hiromitsu Nakauchi,  Xiangang Zou, Liming Lu & Pentao Liu*.

30. Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma.[J] .Oncol Lett, 2017, 14(1): 561-568. Tang Wei-Jing,Tao Lei, Li-ming Lu* .

31. Association of the recurrence of vocal leukoplakia with MDM2-309 variants over a 2-year period: a prospective study. Acta Otolaryngol, 2016.136, 95-9. Zhou, J, Y. Yang, D. Zhang, L. Zhou, F. Liu, L. Tao, Lu L*.

32. Objective measurement and significance of PD-L1, B7-H3, B7-H4 and TILs in small cell lung cancer (SCLC). Journal of Clinical Oncology, 2016, 34: 8566-8566. Kurt Alex, Schalper; Daniel E., Carvajal-Hausdorf; Joseph Francis, McLaughlin; Mehmet, Jie, Zhang, Liming Lu, Baohui, Han, Hui, Lu.

33. Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period. Acta Otolaryngol, 2016. 136, 1147-1153. ZhouJ, D.Zhang, L. Zhou, Y. Yang, F. Liu, L. Tao, Lu L*

34. New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk. J Reprod Immunol. 2015 Nov 10;113:35-41. doi: 10.1016/j.jri.2015.11.001. Zhao AM, Xu HJ, Kang XM, Zhao AM, Lu. L* ..

35. The ratio of CD4/CD8 T-cells in human papillomavirus-positive laryngeal squamous cell carcinoma accounts for improved outcome. Acta Otolaryngol, 2016.136, 826-33. Zhang, D, W. J. Tang, D. Tang, J. Zhou, L. Chou, L. Tao &Lu L*

36. Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance. Clinical Immunology, 2017, 175: 34-40. Zhang D, Zhou J, Tang D, Lei Tao, Lu L*.

37. Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its developmental pathway. Nature. 2016 Sep; 539(7627). Yu, Y, Tsang, C-H. J, Wang, C, Simon Clare, Juexuan Wang,Xi Chen, CordeliaBrandt, Leanne Kane, Lia S. Campos, Lu Lu*, Gabrielle T. Belz, Andrew N. J. McKenzie,Sarah A.Teichmann, Gordon Dougan& Pentao.

38. Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma. Acta Otolaryngol, 2016. 136, 806-11. Tang, D, W. J. Tang, X. L. Shi, W. P. Li, H. Zhou, Lu L*, L. Tao.

39. Low concentration of Trichosanthin induces apoptosis and cell cycle arrest through JNK/MAPK activation. Molecular Medicine Report. 2015 Jan;11(1):349-56. doi: 10.3892/mmr. Zhang D, Chen B, Zhou J, Zhou L, Li Q, Liu F, Chou KY, Tao L, Lu L*.

40. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. The Journal of experimental medicine 2015; 212:865-74. Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S1, Lu L*, He D, Jenkins NA, Copeland NG, Dougan G, Liu P..

41. Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells. Stem Cells. 2015 May 33(5):1390-404. doi: 10.1002/stem.1926. Yang J, Wang W, Ooi J, Campos LS, Lu L*, Liu P

42. A peptide tetramer Tk-tPN induces tolerance of cardiac allografting by conversion of type 1 to type 2 immune responses via the Toll‐like receptor 2 signal‐promoted activation of the MCP1 gene. Immunology, 2016, 147(3): 355-366. Li Z, Yang N, Zhou L, Lu L*, Chou KY.

43. Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells. Genome Biol. 2015 Sep 21;16(1):178. doi:10.1186/s13059-015-0739-5. Tsang JC, Yu Y, Burke S, Buettner F, Wang C, Kolodziejczyk , Teichmann SA, Lu L*, Liu P,

44. Significance of MDM2-309 polymorphisms and induced c orresponding plasma MDM2 levels in susceptibility to laryngeal squamous cell carcinoma.DNA Cell Biol. 2014 Feb;33(2):88-94. Zhou J, Liu F, Zhang D, Chen B, Li Q, Zhou L, Lu L*, Tao L.

45. Association of interleukin‑10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma ONCOLOGY LETTERS 2014,7:1721-1727. Jian Zhou, Duo Zhang, Bin Chen, Qing Li, Lin Zhou, Fei Liu, Kuang-Yen Chou, Lei Tao, Lu L*.

46. A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8+CD28Tregs Clinic immunology (2013), 153, 277–287. Neng Yang, Zuoqing Li, Zhijun Jiao, Peng Gu, Yun Zhou, Lu.L*, Kuang-Yen Chou

47. Genetic polymorphism and plasma levels of interleukin-22 contribute to the development of nonsmall lung cancer. DNA and CellBiology. 2014 Oct;33(10):705-14. doi: 10.1089/dna. F. Liu, X. Pan, L. Zhou, B. Chen, J. Shi, W. Gao and Lu. L*.

48. Cellular reprogramming by transcription factor engineering. Current Opinion in Genetics & Development 2014, 28:1–9. Tsang JC, Xuefei Gao, Lu. L*, Pentao Liu

49. Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Research, 2014 doi: 10.1093/nar/gku836. Xuefei Gao, Jason C.H. Tsang, Fortis Gaba, Donghai Wu, Lu L*, Pentao Liu

50. High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma. ONCOLOGY REPORTS 2013 30: 1380-1390. Bin Chen, Duo Zhang, Jian Zhou, Qing Li, Lin Zhou, Shi-Min Li, Li Zhu, Kuang-Yen Chou, Liang Zhou, Lei Tao, Lu L*,

51. Mutated MHC class II transactivator upregulates IL-33-dependent differentiation of Th2 subset through Nod2 binding for NLR signaling initiation. Journal of Biological Chemistry, 2012 Mar 23;287(13) :9972-9981. Yang ZQ, Yang N, Zhou Y, Xin LJ, Lu L*, Chou KY.

52. Con A-binding protein Zn-α2-glycoprotein on human sperm membrane is related to acrosome reaction and sperm fertility. International Journal of Andrology. 2012 Apr;35(2):145-157. Liu Y, Qu F, Cao X, Chen G, Guo Q, Ying X, Guo W, Lu L*, Ding Z.

53. Human PD-L1-overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4+CD25hiFoxp3+ Treg cells. Journal ofLeukocyte Biology , 2011 Jul, 90 (1):77-86. Ding Q, Lu L, Xiaorong Zhou, Zhou Y, Chou KY. Co-first author

54. Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells. Journal of Immunology. 2010 Jul 1: 185(1):79-88. Wang B, Jiao Z, Shao X, Lu L, Yang N, Zhou X, Xin L, Zhou Y, Chou KY.

55. High level expression of B7H1 molecules by keratinocytes suppresses xeno- and allo- eactions by inducing type I regulatory T cells TransplantImmunology, 2009, 21: 192-197. Zhou XR, Zhou Y, Ding Q, Lu L, Yang N, Chou KY.

56. Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immuno- suppression. Immunol Let 2007, 74-81. Zhou XR, Yang N, Lu L, Ding Q, Jiao ZJ, Zhou Y, Chou KY.

57. MHC class II transactivator represses human IL-4 gene transcription by interruption of promoter binding with CBP/p300, STAT6 and NFAT1 via histone hypoacetylation. Immunol, 2007,122,476-485. Xiaorong Zhou,YangJiang, Lu L, Qing Ding,Kuang-Yen Chou.

58. 宣彬彬,丁旭苹,侯亚菲,王雪,武娇祥,孙寒晓,谭美玉,盛慧明,路丽明.天花粉蛋白通过影响Foxp3的泛素化水平增强CD4+Treg的体外诱导的初步研究. 现代免疫学. 2022, 423:185-192

59. 林瀚青,陶磊,路丽明. CD4+调节性T细胞:功能异质性、分群与疾病. 现代免疫学. 202202488-492.

60. 杨晓华,郭莉莉,路丽明*.耐紫杉醇肺原位小鼠移植瘤模型的建立和鉴定.中国实验动物学报202103:275-283

61. 丁旭萍,王雪,路丽明*.中药天花粉蛋白增强诱导CD4+CD25+Foxp3+调节性 T细胞数量和功能的初探. 世界科学技术-中医药现代化. 网络首发时间:2021-12-15.

62. 汤成捷,疏龙强,吴缘开,赵良娟,张亦凡,侯亚菲,路丽明*.中性粒细胞的免疫抑制亚群及功能和机制研究进展.细胞与分子免疫学杂志, 202009:833-842

63. 费腾,李从镇,路丽明*.TIM-3分子与肿瘤免疫抑制. 中国肿瘤生物治疗杂志 2020,27(02),199-203 DOI:10.3872/j.issn.1007-385x.2020.02.015

64. 薛乙,汤迪,翟长文,袁存存,衡宇,周梁,陶磊, 路丽明* CⅡTA表达与喉鳞状细胞癌(LSCC)患者预后的关系.复旦学报(医学版). 202002 192-196.

65. 商占仙, 路丽明*中性粒细胞在肿瘤发生、发展中的研究进展. 现代免疫学. 201806488-492.

66. 李健,郭震, 路丽明*,李欣.无血预充大鼠体外循环模型的建立[J].中国体外循环杂志,2018,16(03):184-188.

67. 陈广洁, 谢长宜, 钮晓音, 蒋黎华, 聂红, 路丽明, 席晔斌, 葛海良. 机体防御与免疫整合课程的实践与研究[J]. 中国高等医学教育, 2018 (4): 16-17.

68. 衡宇, 查亚芳, 顾燕妮, 沈朝斌,路丽明*. 2018 年美国儿童预防接种最新指南解读及其与我国现状比较. 现代免疫学, 2018, 38(04): 350-353.

69. 张晓阳,路丽明*,李 调节性T 细胞和辅助性T细胞与体外循环后肺损伤相关性的研究 中国体外循环杂志 2017,15:81-85

70. 万建伟,周琳,赵丹丹,杨玉琴,路丽明* 联烯化合物 PHPO 对肺癌细胞株 A549 增殖及凋亡的影响 欧洲杯竞猜平台学报(医学版)2017,37:1433-1439

71. 那君 杨小茜 胡婧雯胡敏娟 衡宇 路丽明* 细胞因子来源的天然蛋白质作为人类疫苗佐剂的研究进展 现代免疫学 2016, 36:337-340

72. 周琳 高文 路丽明* 肺移植后闭塞性细支气管炎免疫学发病机制及治疗新策略 现代免疫学 2016, 36:67-71

73. 杨小茜 胡婧雯 那君 胡敏娟 衡宇 路丽明* 非细胞因子来源的天然蛋白质作为人类疫苗佐剂的研究进展 现代免疫学 2016, 36:245-249

74. 胡敏娟 那君 胡婧雯 杨小茜 衡宇 路丽明* 病原生物相关蛋白作为人类疫苗佐剂的研究进展 现代免疫学 2016, 36:242-244

75. 邵晓轶, 马妍慧, 路丽明*. B7H1-lg 诱导 Tr1 细胞向 CD4+CD25+ Foxp3+ Treg 细胞转化的研究. 现代免疫学, 2012, 6: 001.

76. 周琳,刘菲,周光炎,路丽明* 天花粉蛋白对结肠癌细胞株 CMT-93 凋亡及增殖的影响 欧洲杯竞猜平台学报(医学版) 2014,34(3):257-262. 通讯作者

77. 刘菲, 潘旭峰, 周琳, 路丽明* 肺腺癌患者血浆 microRNA-10b 表达及临床意义. 中华实用诊断与治疗杂志, 2014, 28(9): 846-848.

78. 刘菲, 周光炎, 路丽明*. 胞内模式识别受体 NLR 的生物学特性及其在疾病中的作用[J]. 中国免疫学杂志, 2014, 12: 032.

79. 沈玥, 路丽明* 钱盈盈. Klotho 基因真核表达载体的构建及其 TCMK-1 细胞中的稳定表达. 欧洲杯竞猜平台学报(医学版) , 2014,34(5):567-572.

80. 刘菲 徐艺 周光炎 路丽明* CD8+Treg 的免疫生物学特征及其与疾病的关系 现代免疫学 2014, 34:61-66 通讯作者

81. 周琳,周光炎, 路丽明*.辅助性T细胞亚群的多样性与分化的可塑性研究[J].中国免疫学杂志,2013,29(06):653-656.

82. 邵晓轶, 路丽明*, 周芸, . 小鼠膜型 B7-H1 分子激活同种异体 Tr1 细胞介导免疫抑制. 南通大学学报: 医学版, 2012, 32(5): 333-337.

83. 李青 周光炎 路丽明* 天花粉蛋白抑制同种异体混合淋巴细胞反应与诱导 IL9+IL10+IL24+Th9 细胞间关系的初步探讨。现代免疫学 2012, 32(2): 94-98 通讯作者

84. 张铎,陶磊,路丽明* 天花粉蛋白诱导肿瘤细胞凋亡和其它抗肿瘤作用机制及研究进展。复旦大学学报(医学版)。 2012 39 6): 663-667 通讯作者

85. 邵晓轶, 周芸, 路丽明*. p38 MAPK 信号通路在 B7H1-Ig 融合蛋白诱导 Tr1 细胞分化中的作用.欧洲杯竞猜平台学报 (医学版), 2012, 32(11): 1448.

86. 周琳 周光炎路丽明* IL-10 的双向免疫调节作用 细胞与分子免疫学杂志,2012,28(10):1100-1102.

87. 陈斌 陶磊 周梁 周光炎 路丽明* CD4+CD25+Foxp3+Treg 细胞与喉癌发病的相关研究 现代免疫学 2012, 32: 40-46 通讯作者

88. 李青 周光炎 路丽明* Th9:亚群特征、相关转录因子及其分化的可塑性。现代免疫学 2011,31:340-343 通讯作者

89. 李青 周光炎 路丽明* IL-9 的研究进展。中国免疫学杂志 2011, 27:848-850 通讯作者

90. 陈斌,路丽明,陶磊,周梁,李诗敏,朱莉.趋化因子受体CCR6CCR7在喉鳞状细胞癌中表达的研究[J].临床耳鼻咽喉头颈外科杂志,2010,24(21):975-979.

91. 路丽明 丁庆 扬能 周芸 周光炎,应用 RNA 干扰阻抑小鼠 L929 细胞 MHC II 类基因表达及功能的研究,现代免疫学 2009, 28(6): 387-392

92. 周芸,焦志军,辛利军,汪四七,路丽明,丁庆,周晓荣,杨能,周光炎.自体角朊细胞通过B7-H1介导对异种混合淋巴细胞增殖的抑制作用[J].现代免疫学,2009,29(06):486-490.

93. 王慧,杨能,周佩军,邵琨,赵菊平,徐达,王祥慧,沈周俊, 路丽明,刘世雄 混合培养的供、受者骨髓细胞过继回输延长小鼠移植心脏存活时间 , 中华器官移植杂志 2009, 30:604-607

94. 周芸 焦志军 路丽明 丁庆 扬能 周光炎 自体角朊细胞通过诱导分泌 IL-10 T 细胞亚群抑制异种混合淋巴细胞增殖反应,现代免疫学 2009, 29:387-391

95. 路丽明 丁庆 扬能 周芸 周光炎 膜型 B7-H1 分子诱导产生的 T 细胞及其免疫学特性的初步研究,现代免疫学 2008, 28(6):465-469

96. 杨能,路丽明,周芸,周晓荣,焦志军,马妍慧,周光炎 天花粉蛋白合成肽通过激活抑制性 CD8+T细胞诱导免疫抑制现代免疫学 2008,28(1). 16-20

97. 杨能,史桂英,路丽明,周芸,马妍慧,周光炎.天花粉蛋白合成肽通过诱导CD8抑制性T细胞治疗实验性自身反应性脑脊髓炎[J].现代免疫学,2008(03):199-202.

98. 辛利军,焦志军,丁庆,路丽明,周芸,周光炎.B7-H1协同刺激淋巴细胞增殖并诱导产生抑制性T细胞[J].中国免疫学杂志,2007(08):680-683+687.

99. 路丽明,丁庆,江阳等 一种新的 CIITA 显性负向突变体的构建和功能研究 现代免疫学 2006,26:116-120

100. 丁庆,路丽明,江阳等  小鼠B7H1-Ig融合蛋白诱导免疫抑制的机制研究。现代免疫学 2006,24(6). 460-463

101. 焦志军,王保龙,路丽明,丁庆,周晓荣,江阳,周芸,辛利军,周光炎,天花粉蛋白对不同小鼠品系 T 细胞亚群分化的影响现代免疫学 2006,24(1). 12-16

102. 焦志军,周芸,辛利军,路丽明,丁庆,周晓荣,杨能,周光炎天花粉蛋白及其肽段诱导的免疫抑制依赖 APC 表面 Notch 配体的表达现代免疫学 2006,26(6). 448-453

103. 焦志军 周芸 路丽明 丁庆 周晓荣 杨能 辛利军 周光炎 天花粉蛋白免疫抑制作用的功能性肽段筛选及其作用机制现代免疫学 2006,26(5). 362-366

104. 曹聪 董英海 董宇启 路丽明 崔磊 刘伟 曹谊林 人血源性间充质干细胞培养与体外成骨研究中国修复重建外科杂志 2005,19(8).642-647

105. 周洪语 路丽明 王勇 江基尧 罗其中榄香烯抑制脑胶质瘤细胞增殖的比较研究 中国实验外科杂志 2004,21(10).1241-1243

106. 陈炜 刘伟 刘德莉 吴娟娟 路丽明 曹谊林 FasL 基因转染 Hela 细胞体外诱导淋巴细胞凋亡的作用上海第二医科大学学报 2004,24(4).279-283

107. 范华骅 郭荣 崔磊 刘伟 路丽明 曹谊林 CIITA 反义基因体外转染对 HLA-Ⅱ类抗原表达的抑制作用的研究中国临床医学.2004,11(2).174-176

108. 江阳 路丽明 丁庆等类反式激活因子基因新变异体的克隆、鉴定和功能测定 现代免疫学2004,24(6).-460-463

109. 李宁丽 路丽明 等重组人可溶性 TRAIL 分子诱导细胞凋亡机理探讨。 上海第二医科大学学报2003,23(1).10-14

110. 路丽明 李宁丽 沈佰华等 TRAIL 分子胞外区基因工程蛋白的制备与鉴定,中国实验诊断学2003,7 477-479

111. 周洪语 路丽明 罗其中 SD大鼠星形胶质细胞的原代培养 中华神经医学杂志.2003,2(5). 346-347

112. 路丽明 李宁丽等 人可溶性TRAIL 基因的克隆及表达 上海免疫学杂志 2002, 22308-312

教学论文

1. Improvement of clinical medical students' comprehensive quality by the undergraduate innovative experimentation program; a teaching exploration. Clin Med Educ. Vol 3. No3,4. June 2016. Jinwen Hu, Xiaoqian Yang, Jun Na, Liming Lu.

2. RBL教学对临床医学本科生综合能力培养的作用,中华医学教育探索杂志,201610月,第15卷,第10. 于浩然,张柳蕙,刘威,周琳,丁旭苹,蒋黎华,路丽明。

3. 机体防御与免疫整合课程的实践与研究,中国高等医学教育,20184


参编教学专著

1. 《人体健康与免疫科普丛书》婴幼儿篇,人民卫生出版社,副主编。

2. 《免疫学原理》-教育部指定研究生教材,科学出版社,参编

3. Medical Immunology-国家级规划教材,清华大学出版社,参编

4. 《医学免疫学与免疫学检验》国家级规划教材,科学出版社,参编

5. 《口腔临床免疫学》第二版 国家级规划教材,人民卫生出版社,参编

6. Immunobiology》中文版,科学出版社,副主编


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5. 天花粉蛋白在增强疫苗特异性抗体中的应用(受理号:ZL201610049358.2)。

6. CD8+抑制性T细胞在免疫调节中的应用及诱导方法(受理号:202010965416.2)。

7. 具有免疫抑制作用的天花粉蛋白有效表位肽段及其应用(受理号:ZL201210390572.6)。

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