师资队伍
各类人才
研究生导师
课题组长（PI）
首席教师
陈红专
  作者：  2018-12-31

基本信息 >>>

                       
 陈红专
  化学生物学和系统药理学研究组
  电话：63846590-778015
  邮箱：yaoli@shsmu.edu.cn

研究方向>>>

主要研究方向包括神经退行性病（阿尔茨海默病和青光眼）和肿瘤等重大疾病的新靶点和创新药物研究，临床药物动力学和药物代谢组学研究和基于疾病功能基因组学信息的化学生物学研究。

个人简历 >>>

陈红专，现任欧洲杯竞猜平台副院长，二级教授，博士生导师，药物研究所所长，基础欧洲杯竞猜平台“化学生物学和系统药理学”课题组长（PI），欧洲杯竞猜平台-中国科学院神经科学所脑疾病研究中心主任，上海市转化医学协同创新中心主任，上海市高校系统药理学重点实验室主任，上海市“药学”一流学科带头人。

1983年7月毕业于浙江大学欧洲杯竞猜平台（原浙江医科大学）临床医学本科，获医学学士学位。1983年9月和1990年2月毕业于欧洲杯竞猜平台（原上海第二医科大学）药理学研究生，获医学硕士和医学博士学位。1993年至1995年法国国立健康与卫生研究院（INSERM）神经生物学博士后研究。1998年至1999年法国里昂第一大学临床药理学和临床试验设计高级访问学者。

担任国务院学科评议组成员、国家药品审评专家、国家自然科学基金委二审专家、中国神经药理学常委理事、上海市药理学会名誉理事长、上海市药学会副理事长、上海市药学会药理专业委员会主任和新药临床评价专业委员会顾问、上海市学位委员会（药学）召集人等，同时担任国际著名专业期刊Mol Pharmacol、CNS Neuroscience and Therapeutics、Acta Pharmacol Sin等编委和欧洲杯竞猜平台学报（医学版）执行主编等。现为上海市人大常委、上海市人大教科文卫委员会委员、浦东新区人大副主任；民盟上海市委副主委、民盟浦东新区主委；上海市第三检察院特邀监督员。

在同事们和国内外合作者共同努力下，胆碱受体药理学和神经退行性病新药研究；纳米脑靶向和肿瘤靶向治疗的药理学研究；新药临床试验和临床药学等领域取得一系列创新发现和成果。先后主持国家重点基础研究发展计划（973计划）课题，国家“重大新药创制”科技重大专项，科技部国际合作项目和国家自然科学基金，上海市重点和国际合作项目等30余项。作为通讯作者和共同作者在Nature系列期刊和国际药学专业期刊等发表SCI论文200余篇，引用近3000次。申请或授权国际和国家发明专利20余项.获国家教育部科技进步一等奖、教育部自然科学二等奖、中华医学奖二等奖、上海科技进步奖一等奖各1项、上海医学科技奖二等奖2项、上海市优秀学科带头人。完成国内外药厂新药如氯雷他定、左甲状腺素钠（优甲乐）、氨氯地平、西他普兰、N乙酰半胱氨酸等临床前评价、生物等效性和I期临床研究10余项，自主开发新药专利许可转让1项。

主编或副主编《临床药理学教程》、《药理学》、《药理学前沿》、《临床用药大全》、《生物医学科研基本知识和技能》教材或专著等7部。获国家级教学成果奖特等奖1项、全国优秀医药教材一等奖、上海市教委教学成果奖二等奖1项、上海市研究生优秀成果(导师)2项。获全国优秀教师、国家教委优秀青年教师基金、国家教委宝钢教育基金会优秀教师奖、国家教委霍英东教育基金会青年教师奖、上海市优秀青年教师、欧洲杯竞猜平台校长奖、欧洲杯竞猜平台院长奖、瑞金医院红烛奖等。享受国务院政府特殊津贴。

科研项目 >>>

81573415 乙酰胆碱酯酶新基序AChE7-20非酶活性依赖的海马神经元毒性调控机制 国家自然科学基金面上项目 2016-01~2019-12  72万元 课题负责人

81173084 乙酰胆碱受体及亚型在肺腺癌干细胞中的信号网络调控和代谢组学研究 国家自然科学基金面上项目  2012-01~2015-12  55万元 课题负责人

2011DFA33180 AMPA受体和M1受体协同调控机制及靶标药物研究 科技部国际合作专项(中美合作) 2012-01~2014-12  180万元 课题负责人

2012ZX09303-003 精神药物新药临床评价研究技术平台-精神药物转化医学研究 国家“新药创制”科技重大专项 2012-01~2015-12  50万元 课题负责人

81173084 乙酰胆碱受体及亚型在肺腺癌干细胞中的信号网络调控和代谢组学研究 国家自然科学基金面上项目 2012-01~2015-12  55万元 课题负责人

11430702200 基于老年性痴呆早期诊疗的仿生高密度脂蛋白纳米载体构建和药理学研究 上海市科委（中加合作） 2011-01~2013-12  50万元 课题负责人

30973509 分子伴侣AChE诱导Aβ寡聚体形成的动力学和膜离子通道改变的研究 国家自然基金面上项目 2010-01~2012-12  32万元 课题负责人

2010CB529806 重要药用前景动物多肽毒素的临床应用基础研究 国家重点基础研究（973计划子项目） 2010-01~2014-12  427万元 课题负责人

2009ZX09103-077 具有多靶点作用抗老年性痴呆候选药物XQ509的研究 国家“新药创制”科技重大专项 2009-06~2011-06  150万元 课题负责人

200802480058 具有多靶点作用抗老年性新型美普他酚系列双配基衍生物治疗阿尔茨海默病的化学生物学研究 教育部博士点基金 2009-01~2010-12  8万元 课题负责人

30772553 新型双配基AChE抑制剂的结构、性质和效应的关系 国家自然基金委面上项目 2008-01~2010-12  37万元 课题负责人

论文与专著 >>>

Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH,, Qiu Y.  Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12.  CNS Neurosci Ther  2015  21(7):591-8 
Jiang S, Yang W, Qiu Y,, Alzheimer's Disease Neuroimaging Initiative (ADNI)  Identification of Novel Quantitative Traits-Associated Susceptibility Loci for APOE ε 4 Non-Carriers of Alzheimer's Disease   Curr Alzheimer Res  2015  12(3):218-27 
Wang Y, Wang YX, Liu T, Law PY, Loh HH, Qiu Y,  μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling.  CNS Neurosci Ther  2015  21(1):8-14 
Song Y, Lu HZ, Xu JR, Wang XL, Zhou W, Hou LN, Zhu L, Yu ZH,, Cui YY.  Carbocysteine restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner  Pharmacol Res  2015  91:88-98 
Zhao Q, Gu X, Zhang C, Lu Q,, Xu L  Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC)  Cancer Biol Ther  2015  16(4):634-43 
Guan YY, Liu HJ, Luan X, Xu JR, Lu Q, Liu YR, Gao YG, Zhao M,, Fang C.  Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling  Phytomedicine  2015  22(1):103-10 
Yu DH, Liu YR, Luan X, Liu HJ, Gao YG, Wu H, Fang C,  Nanoparticles with IF7-conjugated annexin 1 targets tumor vasculature against P-gp mediated multidrug resistance  Bioconjug Chem  2015  26(8):1702-12 
Zhao Q, Yue J, Zhang C, Gu X,, Xu L   Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)   Oncotarget   2015  6(30):29335-46  
Huang M, Hu M, Song Q, Song H, Huang J, Gu X, Wang X, Chen J, Kang T, Feng X, Jiang D, Zheng G,, Gao X  GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease  ACS Nano  2015  9(11):10801-16 
Yu F, Gong P, Hu Z, Qiu Y, Cui Y, Gao X,, Li J.  Cu (II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation  J Neuroinflammation  2015  12:122 
Xu J, Zhao H, Zheng Z, Wang Y, Niu Y, Wang H, Xu J, Lu Y,  Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors  J Mol Recognit  2015  28(4):239-52 
Liu YR, Guan YY, Luan X, Lu Q, Wang C, Liu HJ, Gao YG, Yang SC, Dong X,, Fang C.  Delta-like ligand 4-targeted nanomedicine for antiangiogenic cancer therapy  Biomaterials  2015  42:161-71 
Gong Y, Li X, Kang L, Xie Y, Rong Z, Wang H, Qi H,  Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC–MS/MS: Application in tumor-bearing mice  J Pharm Biomed Anal  2015  111:57-63 
Li B, Li H, Bai Y, Kirschner-Schwabe R, Yang JJ, Chen Y, Lu G, Tzoneva G, Ma X, Wu T, Li W, Lu H, Ding L, Liang H, Huang X, Yang M, Jin L, Kang H, Chen S, Du A, Shen S, Ding J,, Chen J, von Stackelberg A, Gu L, Zhang J, Ferrando A, Tang J, Wang S, Zhou BB  Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL  Nat Med  2015  21(6):563-71 
Wang X, Gu X, Song H, Song Q, Gao X, Lu Y,  Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis  Anal Chim Acta  2015  893:77-83 
Sun F, Ding XP, An SM, Tang YB, Yang XJ, Teng L, Zhang C, Shen Y,, Zhu L  Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.  Sci Rep  2015  5:15950 
Sun F, Yang XJ, Lv HY, Tang YB, An SM, Ding XP, Li WB, Teng L, Shen Y,, Zhu L  β2‐adrenoreceptor–mediated proliferation inhibition of embryonic pluripotent stem cells  J Cell Physiol  2015  230(11):2640-6 
Zhao WS, Wang J, Ma XJ, Yang Y, Liu Y, Huang LD, Fan YZ, Cheng XY,, Wang R, Yu Y   Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation   Nat Commun   2014  5:4189-5189 
Song Q, Huang M, Yao L, Wang X, Gu X, Chen J, Chen J, Huang J, Hu Q, Kang T, Rong Z, Qi H, Zheng G,, Gao X.  Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer's disease by accelerating the clearance of amyloid-beta.  ACS Nano  2014  8(3):2345-59 
Hu Z, Yu F, Gong P, Qiu Y, Zhou W, Cui Y, Li J,  Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS  Toxicol Appl Pharmacol  2014  276(2):95-103 
Yao L, Song Q, Bai W, Zhang J, Miao D, Jiang M, Wang Y, Shen Z, Hu Q, Gu X, Huang M, Zheng G, Gao X, Hu B, Chen J,  Facilitated brain delivery of poly (ethylene glycol)-poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound  Biomaterials  2014  35(10):3384-95 
Tan PP, Yuan HH, Zhu X, Cui YY, Li H, Feng XM, Qiu Y,, Zhou W.   Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models  CNS Neurosci Ther  2014  20(3):227-36 
Hou LN, Xu JR, Zhao QN, Gao XL, Cui YY, Xu J, Wang H,  A New Motif in the N-Terminal of Acetylcholinesterase Triggers Amyloid-β Aggregation and Deposition  CNS Neurosci Ther  2014  20(1):59-66 
Shao BY, Xia Z, Xie Q, Ge XX, Zhang WW, Sun J, Jiang P, Wang H, Le WD, Qiu ZB, Lu Y,  Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice  CNS Neurosci Ther  2014  20(2):165-71 
Teng L, Tang YB, Sun F, An SM, Zhang C, Yang XJ, Lv HY, Lu Q, Cui YY, Hu JJ, Zhu L,  Non-neuronal release of gamma-aminobutyric Acid by embryonic pluripotent stem cells.  Stem Cells Dev  2013  22(22):2944-53 
Song Q, Wang X, Hu Q, Huang M, Yao L, Qi H, Qiu Y, Jiang X, Chen J,, Gao X  Cellular internalization pathway and transcellular transport of pegylated polyester nanoparticles in Caco-2 cells  Int J Pharm  2013  445(1-2):58-68 
Liu T, Xia Z, Zhang WW, Xu JR, Ge XX, Li J, Cui Y, Qiu ZB, Xu J, Xie Q, Wang H,  Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice  Pharmacol Biochem Behav  2013  104:138-43 
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL,, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ  Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells   Nat Chem Biol   2012  8(5):486-93 
Ge XX, Wang XL, Jiang P, Xie Y, Jiang T, Rong ZX, Zhang QZ, Xie Q, Qiu ZB, Wang H,  Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study  J Chromatogr B  2012  881-882:126-30 
Wang Y, Xia Z, Xu JR, Wang YX, Hou LN, Qiu Y,  α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.  Neuropharmacology  2012  62(2):871-81 
Xia H, Gao X, Gu G, Liu Z, Hu Q, Tu Y, Song Q, Yao L, Pang Z, Jiang X, Chen J,  Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery.  Int J Pharm  2012  436(1-2):840-50. 
Song Q, Yao L, Huang M, Hu Q, Lu Q, Wu B, Qi H, Rong Z, Jiang X, Gao X, Chen J,  Mechanisms of transcellular transport of wheat germ agglutinin-functionalized polymeric nanoparticles in Caco-2 cells  Biomaterials  2012  33(28):6769-82 
Zheng W, Li J, Qiu Z, Xia Z, Li W, Yu L, Chen H, Chen J, Chen Y, Hu Z, Zhou W, Shao B, Cui Y, Xie Q,  Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.  Toxicol Appl Pharmacol  2012  264(1):65-72. 
Peng L, Jiang T, Rong Z, Liu T, Wang H, Shao B, Ma J, Yang L, Kang L, Shen Y, Li H, Qi H,  Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry.  J Chromatogr B  2011  879(32):3927-31 
Qiu Y, Wang Y, Law PY,, Loh HH.  Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts.  Mol Pharmacol.  2011  80(1):210-8 
Gao X, Yao L, Song Q, Zhu L, Xia Z, Xia H, Jiang X, Chen J,  The association of autophagy with polyethylenimine-induced cytotoxity in nephritic and hepatic cell lines.   Biomaterials  2011  32(33):8613-25. 
Jiang T, Rong Z, Peng L, Chen B, Xie Y, Chen C, Sun J, Xu Y, Lu Y,  Simultaneous determination of citalopram and its metabolite in human plasma by LC-MS/MS applied to pharmacokinetic study.  J Chromatogr  2010  878(5-6):615-9 
Cui Y, Devillier P, Kuang X, Wang H, Zhu L, Xu Z, Xia Z, Zemoura L, Advenier C,  Tiotropium reduces lung inflammation in a model of chronic gastro-oesophageal reflux.  Eur Respir J.  2010  35(6):1370-6 
Yu DH, Lu Q, Xie J, Fang C,  Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature  Biomaterials  2010  31(8):2278-2292 
Liu F, Fang C, Ye X, Lu Q, Yu DH, Zhang WW, Qi H, Xie J, Lieber A,  Anti-4-1BB scFv immunogene therapy and low dose cyclophosphamide exhibit a synergistic antitumor effect in established murine lung tumors  Cancer Biol Ther  2009  8(8):707-713 
Qi H, Ma J, Liu YM, Yang L, Peng L, Wang H,  Allostatic tumor-burden induces depression-associated changes in hepatoma-bearing mice.  J Neurooncol  2009  94(3):367-372 
Zhu X, Zhou W, Cui YY, Zhu L, Li J, Xia Z, Shao B, Wang H,  Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells  Biochem Biophys Res Commun  2009  384(1):110-113 
Lu Q, Yu DH, Fang C, Liu F, Ye X, Zhao Y, Qin J, Guo XK, Liang M, Hu F,  Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells.  Cancer Biol Ther  2009  8(12):1125-1132 
Miezan Ezoulin JM, Shao BY, Xia Z, Xie Q, Li J, Cui YY, Wang H, Dong CZ, Zhao YX, Massicot F, Qiu ZB, Heymans F,  Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice  Int J Neuropsychopharmacol  2009  12(10):1409-1419 
Fu J, Feng X, Yuan H, Yan L, Kuang X, Xia Z, Gao X, Yu C, Lu Y,  Study of ocular pharmacokinetics of in situ gel system for S(-)-satropane evaluated by microdialysis  J Pharm Biomed Anal  2008  48(3):840-843 
Xie Q, Wang H, Xia Z, Lu MY, Zhang WW, Wang XH, Fu Wei, Tang Y, Sheng W, Li W, Zhou W, Zhu X, Qiu ZB,  Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on Amyloid-β aggregation.  J Med Chem  2008  51(7):2027-2036 
Ren Z, Ye X, Fang C, Lu Q, Zhao Y, Liu F, Liang M, Hu F,  Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response.immunocompetent mice.  Cancer Biol Ther.  2008  7(2):191-195 
Song MK, Liu H, Jiang HL, Yue JM, Hu GY,  Discovery of talatisamine as a novel specific blocker for the delayed rectifier K(+) channels in rat hippocampal neurons.  Neuroscience.  2008  155(2):469-475 
Liu F, Lu Q, Ye X, Fang C, Zhao Y, Liang M, Hu F, Lieber A,  Cancer gene therapy of adenovirus-mediated anti-4-1BB scFv in immunocompetent mice.  Cancer Biol Ther.  2008  7(3):448-453 
Gao X, Chen J, Chen J, Wu B,, Jiang X.  Quantum dots bearing lectin-functionalized nanoparticles as a platform for in vivo brain imaging  Bioconjug Chem.  2008  19(11):2189-2195 
Gao X, Wang T, Wu B, Chen J, Chen J, Yue Y, Dai N,, Jiang X  Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles.  Biochem Biophys Res Commun  2008  377(1):35-40 
Fang C, Liu Y, Ye X, Rong ZX, Feng XM, Jiang CB,  Synergistically enhanced transdermal permeation and topical analgesia of tetracaine gel containing menthol and ethanol in experimental and clinical studies.  Eur J Pharm Biopharm.  2008  68(3):735-740 
Li J, Shao B, Zhu L, Cui Y, Dong C, Miezan Ezoulin JM, Gao X, Ren Q, Heymans F,  PMS777, A Bis-interacting Ligand for PAF Receptor Antagonism and AChE Inhibition, Attenuates PAF-induced Neurocytotoxicity in SH-SY5Y Cells.  Cell Mol Neurobiol  2008  28(1):125-136 
Zhou W, Zhu X, Zhu L, Cui YY, Wang H, Qi H, Ren QS,  Neuroprotection of Muscarinic Receptor Agonist Pilocarpine Against Glutamate-induced Apoptosis in Retinal Neurons  Cell Mol Neurobiol  2008  28(2):263-275 

荣誉与奖励 >>>

获国家级教学成果奖特等奖1项、全国优秀医药教材一等奖、上海市教委教学成果奖二等奖1项、上海市研究生优秀成果(导师)2项。获全国优秀教师、国家教委优秀青年教师基金、国家教委宝钢教育基金会优秀教师奖、国家教委霍英东教育基金会青年教师奖、上海市优秀青年教师、欧洲杯竞猜平台校长奖、欧洲杯竞猜平台院长奖、瑞金医院红烛奖等。