本团队综合运用化学、生物学、分子影像学等多学科交叉的技术和方法，开发高灵敏度、高选择性、诊治同步的“可视化药物递送体系”，用于疾病诊断和治疗的转化医学研究。具体内容为：

1.基于活体光学影像的可视化递送体系用于术中诊断和清除残余微小肿瘤、逆转靶向药物耐药；

2.基于核医学影像的可视化递送体系用于肿瘤早期诊断、靶向用药指导及疗效评估；

3.口服裸眼可视化递送体系用于结肠部位疾病的早期诊断及治疗

肖泽宇，欧洲杯竞猜平台教授，博导，课题组长。国家高层次青年人才计划获得者。北京大学医学部药学院学士；中国科学院化学所与美国佛罗里达大学联合培养博士；美国麻省理工学院与哈佛大学欧洲杯竞猜平台癌症纳米交叉研究中心Robert Langer实验室博士后；2015年起在欧洲杯竞猜平台任现职至今。肖泽宇教授团队长期致力于可视化药物递送领域的研究，在Chem.Soc.Rev., Nature Comm. Angew.Chem., Nano Lett, ACS Nano等杂志发表论文40余篇，总引用达4500多次，其中单篇引用>1000次1篇、单篇引用>200次5篇、单篇引用>100次7篇，3篇入选ESI高被引论文。其中研发的1种可视化药物载体已进入临床试验阶段。申请或授权国际专利2件、国内专利1件，参编英文专著3本。研究成果多次被美国著名专业网络杂志C&E News, Science Daily,等转载报道。曾获哈佛大学欧洲杯竞猜平台授予的哈佛大学生命科学领域杰出研究工作奖，美国癌症研究协会授予的青年女性学者奖等。作为课题负责人主持科技部国家重点研发计划课题1项、主持国家自然科学基金4项等。

1.国家重点研发计划子课题，多模块可编程纳米药物的活体动态可视化研究，2020.11 ～ 2025.10，212万元，课题负责人；

2.欧洲杯竞猜平台附属仁济医院基础临床协同研究中心合作项目，分子影像与药物递送，2018.11 ～ 2023.11，300万元，课题负责人；

3.国家自然科学基金面上项目，拉曼纳米探针用于活性氧异常疾病的医学分析研究，2019.01 ～ 2022.12，64万元，课题负责人；

4.国家自然科学基金面上项目，核酸识体纳米药物在组织脏器的三维精准分布及靶向识别，2017.01 ～ 2020.12，62万元，课题负责人；

5.国家自然科学基金面上项目，DNA自主装纳米诊疗系统：构建及术中成像介导下前列腺癌细胞清除的问题研究，2015.01 ～ 2018.12，73万元，课题负责人；

6.国家自然科学基金应急管理项目，SP-A核酸适体拉曼纳米探针用于胎肺发育及异常的产前诊断研究，2018.01 ～ 2018.12，20万元，课题负责人；

7.国家重点研发计划，新型冠状病毒（2019-nCoV）核酸现场快速检测设备及试剂的研发，2020.01 ～ 2020.04，100万元，学术骨干；

8.欧洲杯竞猜平台医工交叉研究基金重点项目，家庭简易式新型冠状病毒感染自查技术与试剂盒，2020.02 ～ 2021.01，100万元，学术骨干.

代表性论文：

1. Zhao N, Chen Y, Chen G, Xiao Z*(Corresponding Author). Artificial cells based on DNA nanotechnology. ACS Applied Bio Materials 2020,3,7,3928-3934.

2. Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z*(Corresponding Author), Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019,10(1):2206.

3. Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W, Xiao Z*(Corresponding Author). CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019,19(5):3344-3352.

4. Qiu Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X*, Xiao Z*(Corresponding Author). Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019, 11(26):23436-23444.

5. Zheng B, Xu J, Chen G, Zhang S, Xiao Z*(Corresponding Author), Lu W*. Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019, 29(33):1901437.

6. Wu W, Xiao Z*(Corresponding Author). A deep learning “ticket” for single-molecule analysis of protein stoichiometry. Sci China Chem 2019. 62(10): 1269-1270.

7. Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*(Corresponding Author), Lu W*. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019, 13,10242-10260.

8. Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z*(Corresponding Author) Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018, 12(8):7974-7985.

9. Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z*(Corresponding Author). para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem. 2018, 90, 12137-12144.

10. Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z*(Corresponding Author) Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018, 8(3):381-389.

11. Qi Q, Lu L, Li H, Yuan Z, Chen GX, Lin M, Ruan Z, Ye X*, Xiao Z* (Corresponding Author), Zhao Q* Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction. Int J Nanomedicine 2017, 12:4835-4848.

12. Zhang Y, Qiu Y, Lin L, Gu H, Xiao Z*(Corresponding Author), Ye J* Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging. ACS Appl Mater Interfaces 2017, 9(4):3995-4005.

13. Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z*(Corresponding Author) Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016, 61(9):670-681.

14. Xiao Z*(Corresponding Author) CuS Nanoparticles: clinically-translational materials for photothermal therapy. Nanomedicine, 2014, 9(3),373-375.

15. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW et al. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl 2014, 53(34):8975-8979.

16. Xiao Z, Levy-Nissenbaum E, Alex F, Luptak A, Teply B, Chan J, Shi J, Diggar E, Cheng J, Langer R, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano 2012, 6 (1), 696-704.

17. Xiao Z, Ji C, Shi J, Pridgen E, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl 2012, 51(47):11853-11857.

18. Xiao Z, Farokhzad OC, Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano 2012, 6(5), 3670-3676.

19. Kamaly N*, Xiao Z*(Co-First Author), Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 2012, 41(7), 2971-3010.

20. Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC.  Progress in siRNA Delivery: A Multifunctional Approach by Polymeric Nanoparticles. Methods in Mol Biol 2010, 629, 53-67

21. Shi J, Xiao Z, Votruba AR, Viols C, Farokhzad OC. Differently Charged Hollow Core/shell Lipid-polymer-lipid Hybrid Nanoparticles for Small Interfering RNA Delivery. Angew Chem Int Ed Engl 2011, 50, 7027-7031.

22. Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation. Acc Chem Res 2011, 44, 1123-34.

23. Liu Q, Chen B, Wang Q, Shi X, Xiao Z, Lin J, Fang X. Carbon Nanotubes as Molecular Tansporters for Walled Plant Cells. Nano Lett 2009, 9(3), 1007-1010.

24. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen Y. Single Molecule Imaging Reveals Transforming Growth Factor-β-induced Type II Receptor Dimerization. Proc Natl Acad Sci U S A 2009,106(37):15679-15683.

25. Xiao Z, Shangguan D, Cao ZC, Fang X, Tan W. Cell-specific Internalization Study of an Aptamer from Whole Cell Selection. Chemistry 2008, 14, 1769-1775.

26. Xiao Z, Zhang W, Yang Y, Xu L, Fang X. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway. Biochem Biophys Res Commun 2008, 369, 730-734.

27. Xiao Z, Ma X, Jiang Y, Liao J, Yue J, Fang X. Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation. J Phys Chem B 2008, 112, 4140-4145.

28. Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek RP, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells. Anal Chem 2008, 80(3), 721-728.

29. Yang R, Jin J, Chen Y, Shao N, Kang H, Xiao Z, Tang Z, Wu Y, Zhu Z, Tan W. Carbon. Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization. J.Am.Chem.Soc 2008, 130, 8351–8358.

专著（英文书章节）：

1. Qiu Y, Lu L, Hu D, Xiao Z*(Corresponding Author) Copper Sulfide nanoparticles: from synthesis to biomedical applications. Nano Based Drug Delivery, IAPC Publishing, 2015, 516-534, ISBN 978-953-56942-2-9

2. Guo L, Li Y, Xiao Z, Lu W. Photothermal Properties of Hollow Gold Nanostructures for Cancer Theranostics. Handbook of Nanomaterials Properties, Springer-Verlag Berlin Heidelberg 2014, ISBN 978-3-642-31107-9_50

3. Xiao Z, Frieder J, Teply B, Langer R, Farokhzad OC Aptamer conjugates: emerging delivery platforms for targeted cancer therapy. Drug Delivery in Oncology: From Basic Research to Cancer Therapy, Wiley-VCH, 2011, 1690 p., Hardcover, ISBN-13: 978-3-527-32823-9

专利

1. Shi J, Xiao Z, Vilos C, Votruba, A, Langer R, Farokhzad OC. Lipid-polymer hybrid particles. PCT/US2011/050334. （2017年1月24日已授权 Patent NO: US9549901B2；保护期至2034年1月12日）

2. Xiao Z, Lu L, Chen G, Lin M. Orally colon-targeted drug delivery systems. PCT/CN2016/106175

3. 肖泽宇，蔺淼，崔凯. 活性氧响应的聚合物、载体及其应用 201811592907.6