摘要：Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

本文概述了脂肪组织在代谢平衡中的作用，评估了靶向脂肪组织的新型策略。并列出了目前美国批准的肥胖治疗药物，美国批准的降糖药物，正在开发的治疗肥胖相关糖尿病的药物及潜在治疗策略。

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靶向脂肪组织治疗肥胖相关糖尿病