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S?@ABCDEGHIJKLIAIAIAI&AEAE AIA    30Bm]~ހRhKm(function): Bm]~ހXk(proliferation)Ջ n@zze(hemolytic plaque)Ջ vTMQueplELISPOT SOQՋvՋ (`!/c!) &f}C$        406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQvc@g$Ov~ހR NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) bˆ}v[e()5 $ C$ $ C$$C$ $C$    ϞDRP[vR( p10MQu~ހƋ+R-NvRSSOTOS T ;mSOS0 20puǏ z-N}v~ހT@{Qv~ހ ϞD0 30m]~ހR_]0 $98$$6 ϞDRP[Nuu  ( ϞDRP[N$v  ( Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S Φ   `}   r  S ۦ  `   H  0޽h ? gg380___PPT10.`r:M? PΕ( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvܼ(function) õƬ 42 õƬ 43 õƬ 44 õƬ 45Bܰϸ־ õƬ 47Bܰϸܼ(function): õƬ 49 õƬ 50 õƬ 51飨Ƥԣ飨Ƥԣ: õƬ 54 õƬ 55 õƬ 56!ϸصҪϸӼ⣺ϸӵࣺϸӼⷽ IL-2/ IL-2R_GlenovolenovoyF|A<IL-4IL-6IL-8ϸ𤸽 ϸ𤸽ӷ(cl_A0lenovolenovo hp    $,(˾ϸDZȾϵĽչ Ji YuhuaGlobelenovo660Microsoft PowerPoint@`le@+ID@SaGGSg    -- @ !--'--$AP!W!]"b$h&m(r+w/{37<AFKQW]ciouz{wrmhb]WPJD?94/*&"zuoic]WQKFA<"7&3*//+4(9&?$D"J!P!--'--$Ay!!"$&(+/37<AFKQW]ciouzysmgb\WSOKGDzBu@o>i=c=]=W>Q@KBFDAG<K7O3S/W+\(b&g$m"s!y!--'--$A!!"$&(+/37<AFLQW]djouz|zyuwovjudu]uWvQwLyF|A<73/+(&$"!!--'--%A!!"$& (+/37"<%A'F)K+Q,W,],c+i)o'u%z" zuoic]WQKFA<73/+(&$"!!--'--%A>!D!J"P$U&[(`+d/i3l7p<sAuFxKyQzWz]zcyixouuszplid`[UPJD>82,&!  zuoic]WQKF A <73/+!(&&,$2"8!>!--'-. 2 %ٴѧ8887878."System--. 32 V[(clinical immunological test).-՜.+,08    Ļʾ eF OTimes New RomanArial Wingdings DotN0SOmMQuhKm(^test)"A$N @nMQutˆ}vhKm (human serum immunoglobulin ^) N @neSOhKm (human serum complement ^)  N SOmMQuvsQvQNhKm (others ^)   $ C$ $C$$C$  N @nMQutˆ}vhKm  MQutˆ}vImmunoglobulins, Ig /fwQ gbSO;m'`bSf[~gNbSOvfWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) bˆ}v[e()5 $ C$ $ C$$C$ $C$~    "ϞDRP[vR(function)&( C( p10MQu~ހƋ+R-NvRSSOTOS T ;mSOS0 20puǏ z-N}v~ހT@{Qv~ހ ϞD0 30m]~ހR_]0 $98$$6 ϞDRP[Nuu  ( ϞDRP[N$v  ( Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S Ȧ   `}   r  S P  `   H  0޽h ? gg380___PPT10.P!rLP"? (PN8( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~ht chain disease 50JSRP[uhalf-molecule immunoglobulin disease 60v`'`m]$v(malignant ^) 70o'`Mˆ}v@u(benign ^).%)A" 2 N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$ eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) bˆ}v[e()5 $ C$ $ C$$C$ $C$~    "ϞDRP[vR(function)&( C( p10MQu~ހƋ+R-NvRSSOTOS T ;mSOS0 20puǏ z-N}v~ހT@{Qv~ހ ϞD0 30m]~ހR_]0 $98$$6 *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B L   L(   r  S    `}     0 NA v? T, v  H  0޽h ? gg380___PPT10.4L   L(   r  S    `}     0 NA ? j,   H  0޽h ? gg380___PPT10.r~? fr8( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) bˆ}v[e()5 $ C$ $ C$$C$ $C$~    "ϞDRP[vR(function)&( C( p10MQu~ހƋ+R-NvRSSOTOS T ;mSOS0 20puǏ z-N}v~ހT@{Qv~ހ ϞD0 30m]~ހR_]0 $98$$6 *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B r? Z( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin)5 $ C$ $ C$ $C$ $ C$     "ϞDRP[vR(function)&( C( p10MQu~ހƋ+R-NvRSSOTOS T ;mSOS0 20puǏ z-N}v~ހT@{Qv~ހ ϞD0 30m]~ހR_]0 $98$$6 *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S Φ   `}   r  S ۦ  `   H  0޽h ? gg380___PPT10.`r*? ( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|~8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$      "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] 0 ,TSC$C$Z   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S Φ   `}   r  S ۦ M `   H  0޽h ? gg380___PPT10.`$   $(   r  S Ȧ   `}   r  S P  `   H  0޽h ? gg380___PPT10.P!rLI? в>N"( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$      "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$Sn'`ϞDRP[   cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0^^>ϞDRP[vhKm(10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S Ȧ   `}   r  S P  `   H  0޽h ? gg380___PPT10.P!rN? ^N( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` @ <           $   #           "# ()*+-./0 1 234 7 9:"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$      "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S x   `}   r  S 8  `   H  0޽h ? gg380___PPT10.o$   $(   r  S h   `}    r  S (  `   H  0޽h ? gg380___PPT10.|U^r?  ( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` H >           $   #           "# ()*+-./0 1 234 7 9:;<"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S U   `}   r  S pV z `   H  0޽h ? gg380___PPT10.mi$  D $(  D r D S x^   `}   r D S  `  H D 0޽h ? gg380___PPT10.Y0d$  H $(  H r H S :  `}   r H S  `  H H 0޽h ? gg380___PPT10.YP!IrdR ~ "? @$( / \ ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` L  ?           $        !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ #           "# ()*+-./0 1 234 7 9:;<="$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  H $(  H r H S  L  `}   r H S L `  H H 0޽h ? gg380___PPT10.YP!I$  L $(  L r L S Q   `}  Q  r L S Q  ` Q  H L 0޽h ? gg380___PPT10.YY_r% ,X? $( / \  ech Word.Document.80"Microsoft Word echYech Word.Docassified)𤸽ӵĹ(function)𤸽뼲(and disease) 𤸽 (and tumour)𤸽ӣdissolved 𤸽ӵļ⣨test  õʾĸģǶ OLE  õƬFG õƬGument.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` P @           $   #           "# ()*+-./0 1 234 7 9:;<=>"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNOb$Ӛ-N gePibXv_8^Fm~ހe"15% :N;Nutyr_ ~~[ gFm~ހ$vc$ gn'`_c[0L    N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$ eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  L $(  L r L S @U  `}   r L S VM `  H L 0޽h ? gg380___PPT10.YY_$  P $(  P r P S    `}   r P S DH)  `   H P 0޽h ? gg380___PPT10.Y#^r f i? 6kƦ( / \ $ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` T A           $   #           "# ()*+-./0 1 234 7 9:;<=>?"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNOb$Ӛ-N gePibXv_8^Fm~ހe"15% :N;Nutyr_ ~~[ gFm~ހ$vc$ gn'`_c[0L   N T{|WvYS'`Ӛ$v  f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *f  N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$ eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  P $(  P r P S c  `/   r P S d/  H P 0޽h ? gg380___PPT10.Y#^$  T $(  T r T S    `}   r T S   `   H T 0޽h ? gg380___PPT10.Y1rvk D p ? Rk &( / \ (ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` X B           $   #           "# ()*+-./0 1 234 7 9:;<=>?@"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|} z[ 0ppp@  <4ddddL< 0|\g42d2d z[ 0\p@ pp<4!d!dL 0.R ʚ;p8ʚ;<4ddddL|- 08___PPT10D[SOal0z[ 0DArial0z[ 0" pp? %O =2n 4N^MQuf[h (clinical immunological test).8 (C($ tu(category)C( Z10ag'`uu(infection disease) 20ꁫMQu'`uu(autoimmune ^) 30OeS^'`uu(hypersensitivity ^ ) 40MQu:w/Xk'`uu (immunoabnormal ^ deficiency/proliferation) 50$v(tumour) 60y i(transplantation)L_,#_A,C#A 4Kbk(measure)Nvv(objective)C$.  8^(uMQuf[vt(theory)Nb/g (technique) xvzuuvuV(u) (pathogenesis)0Su(occur)0SU\ (develop)TlR_(turn) v^[uuۏL ʋe(diagnosis)0uHevKm(curative effect monitor)T2(prevent)0 &C$     Q[(content) C(   10SOmMQuhKm(humoral^) 20~ހMQuhKm(cellular ^) 30vsQ4N^uuvMQuhKm ag'`uu ꁫMQu'`uu OeS^'`uu MQu:w/Xk0$vNy i 0BE$C$~ G N0SOmMQuhKm(^test)"A$N @nMQutˆ}vhKm (human serum immunoglobulin ^) N @neSOhKm (human serum complement ^)  N SOmMQuvsQvQNhKm (others ^)   $ C$ $C$$C$  N @nMQutˆ}vhKm  MQutˆ}vImmunoglobulins, Ig /fwQ gbSO;m'`bSf[~gNbSOvfWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N      N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$ eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  D $(  D r D S l@  `}  @ r D S @@ ` @ H D 0޽h ? gg380___PPT10.Y0d$  H $(  H r H S @  `}  @ r H S @< @ H H 0޽h ? gg380___PPT10.YP!I$  L $(  L r L S `@  `}  @ r L S @M ` @ H L 0޽h ? gg380___PPT10.YY_$  P $(  P r P S ̼@  `/  @ r P S @/ @ H P 0޽h ? gg380___PPT10.Y#^$  T $(  T r T S Pz  `}   r T S zj  H T 0޽h ? gg380___PPT10.Y1$  X $(  X r X S '   `}  '  r X S '  ` '  H X 0޽h ? gg380___PPT10.Yj^r$ ` 6 b ?   ( / \ (ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` X B           $   #           "# ()*+-./0 1 234 7 9:;<=>?@"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     <,ghTˆ}vbence-jones protein :  8 N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$ eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  X $(  X r X S '   `}  '  r X S '  ` '  H X 0޽h ? gg380___PPT10.Yj^rb *{ ? > V} ( / \ (ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@``  \ C           $   #           "# ()*+-./0 1 234 7 9:;<=>?@A"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$   eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . 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A6b6(& ԤoեZb0 ջ ʋrP Dձ"+=U"۟VԥUgm$0}i?T7Xԓ/ŏ]4ft ԧ 9&''neXd `(J9uzG&"dVW ɠɕ6`D|}z: LДO4JNj4ԽR=}UߟW F,h)m;=K0A7@s7x'~V3@b^'x0Vj t˗NAF\ 3TSv=G\\ט iإpa0 ik n&wLOtmPgm@_vd-m d/}rvyס4 &>hWA|rtɇbuk/>tVT\O@t#Ke &<ǖT'G9<1}sw:]w?ep㫷{>>o}`Z&ԑ ?@A"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B P  \ P(  \ r \ S    `}    \ ^A b179-n2_ 2   H \ 0޽h ? gg380___PPT10.Y ŀrN/ \ ? */ ( / \ 0ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` d D           $   #           "# ()*+-./0 1 234 7 9:;<=>?@AB"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7  N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   d $(  d r d S d(   `}  (  r d S (  ` (  H d 0޽h ? gg380___PPT10.YP  \ P(  \ r \ S ؒ  `}    \ ^A b179-n2z H \ 0޽h ? gg380___PPT10.Y ŀr  ڎ ?  2 ( / \ 0ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` d D           $   #           "# ()*+-./0 1 234 7 9:;<=>?@AB"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M      !"#$%5'()*+,-./012346789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|~' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm  G"  N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   d $(  d r d S d(   `}  (  r d S (  ` (  H d 0޽h ? gg380___PPT10.Yrr p? ? 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C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . 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A n( / \ 4ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 00DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` ,$l E           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABD"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G"0  N @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B 4   d 4(  d r d S   `}    d BA jY  H d 0޽h ? gg380___PPT10.Y$  @l $(  l r l S    `}    r l S   `   H l 0޽h ? gg380___PPT10.Yp'fEr8  ?   X( / \ 8ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` 4,p  F           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDE"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  @l $(  l r l S   `}   r l S  `  H l 0޽h ? gg380___PPT10.Yp'fE$  Pp $(  p r p S za   `}   r p S ga  ` a  H p 0޽h ? gg380___PPT10.YrV UW? 2Z( / \ <ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` 4,p  F           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDE"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz|}~ el:MQukJml0USTMQuibcel&*C Z eSOUS*NbRhKmvaIN: C$ @nC3+TϑXؚ 1uNC3/f%`'`evS^ˆ }v (W%`'`pu0 Ogueg0%`'`~~_c$O0v` '`$v0y iirceS^eXؚ0FO/feSO+TϑX ؚv4N^aIN N'Y0 @nC3+TϑMNO NTbRNO N Yba'` uTbSe N Y%{Q NoeSOmb"N 1YXY Y|~'`~eru;mRg0}v@uSu T0'Yϑ1Y@0'Ybyp$O0 @nC4+TϑMNO NYS'`Ӛ$v0W O'`@ {'`4l0W O'`C4:ONuI{0ZZ8ZZ;ZZZdDO&N0~ހMQu(cellular^)hKmF(C( C*C(. SN:gSO~ހMQuS^v~ހ Tm]~ހ Bm]~ހ NK~ހ6q@g$O -N'`|~ހ [~ހvpeϑ(amount)0;m'`R function 0hbh_ir(membrane molecules )h(express) z^^0HZ}ZyC$AC$ 4N^8^v~ހMQuhKmyv( 10T~ހhbh_irhKm (membrane molecules of T lymphocytes^) ǏhKmTm]~ހhbyr gvh_ir Ƌ+R pe~ހ;`peRg~ހN0 elEsptsb_bՋ (Erythrocyte rosette forming cell test) T~ހRSbSCD Km[ (Cluster Differentiation of T cells^ )p  C$'A2C$(AC$'A $" ,#   >20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 ZpZ"C$G$;C$G$ C$K$C$##  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  Pp $(  p r p S   `}   r p S HM `  H p 0޽h ? gg380___PPT10.Y$  P4 $(  4 r 4 S q   `}   r 4 S r  `   H 4 0޽h ? gg380___PPT10.DrNZ|P ? *Z( / \ <ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 00DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0 C(0.  @n?" dd@  @@`` 4,p  F           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDE"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^S20Tm]~ހRhKm(function^) Tm]~ހSOYW{Q,(W gNRˆS\O(u N ~ހQ8hxNˆ}v(TbXR,~ހSuk~ ހS(transformation )^,b~mT(mixed) m]~ހW{QI{eg.^R~ހMQuRċ0O0 elb_`f[(morphologic counting ) 3H-z'VvU8hceQl (3H-thymidine incorporation) MTTl(MTT colorimetry) Mixed lymphocyte culture (one-way/two-way)dZ ZAIAIpA   ! & ;  (3H-thymidine incorporation): T~ހ~ gNRˆS:Ro Tk~ހl SeހQDNATb;mÍ 3H-z'VvU8h \O:NSeDdeQ 3H-z'VvU8hv ceQϑN~ހXkvsQSI2 ck8^ qC$K$+C$G$O$G$C$K$C$l! *MTTl(colorimetry): ~ހXkN";mÍ ~ހQ~|SO1 "lv;m'`Xؚ Ǐ~|SOϑN" O_MTTN"b_b+}r2u\o ~~ހn Rg8TIQ^ 0O~ހXk z^(SI2)0 methyl thiazolyte trazolium;MTT V2uWvP.lUv,:NNyge.X/C$G$C$1A &   mTm]~ހW{Q(mixed culture) \$N*NesQvm]~ހmTW{Q 1uN N T*NSOMHCv]_ |_dkN[e :NbSSuS^ [T~ހlS0 T~ހlSRSǏ3H-z'VvU 8hceQl0MTTl hKmRg0 {C$G$'C$G$C$K$C$v     B30Bm]~ހhbh_irhKm Bm]~ހhbh_ir hbMQutˆ}vSmIg RSbSCD19^22TCD29 FcSSO(Fc receptor) eSOSSO(complement receptor) EBukSSOI{(EB virus receptor) n%C$G$ C$G$`C$  hKmel(method) 10MQugIQ(fluorescence immunoassay) lKmSmIg(u5ybIgbSO+B~ހ  gIQ>f _\ Npe . Ses0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $   $(   r  S ¼   `}   r  S ¼    H  0޽h ? gg380___PPT10.?r? 2D( / \ @ech ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echecWord.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` D<x &H           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFG"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . Ses0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  `t $(  t r t S m   `}  v r t S m  ` m  H t 0޽h ? gg380___PPT10.Y%E$  P4 $(  4 r 4 S (W  `}  W r 4 S W ` W H 4 0޽h ? gg380___PPT10.D$  h $(  h r h S 04   `}   r h S -  `   H h 0޽h ? gg380___PPT10.z $   $(   r  S @ov  `}  v r  S Wz9  v H  0޽h ? gg380___PPT10. t$   $(   r  S (v  `}  v r  S ̊v/ ` v H  0޽h ? gg380___PPT10.yZ$  px $(  x r x S Lá Z `   r x S v ` v H x 0޽h ? gg380___PPT10.Yr4n>j ? JŒ&( / \ @ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` D<x &H           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFG"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . Ses0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  px $(  x r x S Lá Z `   r x S v ` v H x 0޽h ? gg380___PPT10.Yr"PE? |G޺( / \ Dech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` LD| )I           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFGH"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . Ses0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  | $(  | r | S dK  `}  #  r | S @ `  H | 0޽h ? gg380___PPT10.Ys<rG? G( / \ Hech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` LD| )I           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFGH"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . Ses0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  px $(  x r x S @۠ Z `   r x S ܠ `  H x 0޽h ? gg380___PPT10.Yr? N( / \ Lech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 0"0DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` TL ,J           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFGHI"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B $  px $(  x r x S 0 Z `   r x S  `  H x 0޽h ? gg380___PPT10.Y$   $(   r  S    `}   r  S  z'g   H  0޽h ? gg380___PPT10.Yrp? ȅ N( / \ Pech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word echN/ 0|DTimes New Roman0z[ 0D[SOes New Roman0z[ 0 DArialNew Roman0z[ 00DWingdingsRoman0z[ 0@DDotumCheRoman0z[ 01 C(0.  @n?" dd@  @@`` TL ,J           $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFGHI"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZB   N T{|WvYS'`Ӛ$v: $ f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  $Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G". Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm ( eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm ( X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| ( 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel ( 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C(&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C(&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C(IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C(IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  ( (~ހϞDRP[R{|(classified)&( C(  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&( C( 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0( C((ϞDRP[N$v (and tumour)(C(A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &(C($ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B   w0 (   r  S 1  `}     VA? 'g,   6O YB  Y  0CH  0޽h ? gg380___PPT10.pr bD? yG( / \ T      @      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~|      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~     $   #           "# ()*+-./0 1 234 7 9:;<=>?@ABDEFGHIK,L,"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|@Q=TTx 0xDArialdx}0`>@Q=TTx 0x" pp? %O = 4N^MQuf[hg D #<#BcB "N'Yf[;Sf[bh| c[NS Yec! tu(category)C- Z10ag'`uu(infection disease) 20ꁫMQu'`uu(autoimmune ^) 30OeS^'`uu(hypersensitivity ^ ) 40MQu:w/Xk'`uu (immunoabnormal ^ deficiency/proliferation) 50$v(tumour) 60y i(transplantation)L_,#_A,C#A 4Kbk(measure)Nvv(objective)C*.  8^(uMQuf[vt(theory)Nb/g (technique) xvzuuvuV(u) (pathogenesis)0Su(occur)0SU\ (develop)TlR_(turn) v^[uuۏL ʋe(diagnosis)0uHevKm(curative effect monitor)T2(prevent)0 &C$     Q[(content) C-   10SOmMQuhKm(humoral^) 20~ހMQuhKm(cellular ^) 30vsQ4N^uuvMQuhKm ag'`uu ꁫMQu'`uu OeS^'`uu MQu:w/Xk0$vNy i 0BE$C$~ G N0SOmMQuhKm(^test)"A$N @nMQutˆ}vhKm (human serum immunoglobulin ^) N @neSOhKm (human serum complement ^)  N SOmMQuvsQvQNhKm (others ^)   $ C$ $C$$C$  N @nMQutˆ}vhKm  MQutˆ}vImmunoglobulins, Ig /fwQ gbSO;m'`bSf[~gNbSOvfWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgEfMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZJ   N T{|WvYS'`Ӛ$v: * f{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y44     )M' *fMMvSu:g6R  *Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G(. Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm - eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm - X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| - 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel - 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C-&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C-&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C-IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C-IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  - (~ހϞDRP[R{|(classified)&- C-  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&- C- 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0- C-(ϞDRP[N$v (and tumour)(C-A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &-C-$ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0 " " "B E7  0` b!+fl` ii_EEfL u` f;v3ff` XVΟ` _V?" dd@,?n<d@ " d n<@" d`n< n?" dd@   @@``PR    @ ` `6p>> 22++ 2(   -T    "   c TBCDE`Fjd @ Hes>9Na }  ZaI9HH24@`"B *   c ByC DE,F6d @  y%f  ryyy@`"    c BTCfDE F*d @ ff0<TT*6ff@`"0vb     # "     c BHCDEF"d @ <H @`" -    c BCDEFd @   *H`xT ~ l N* 6Zx N lT6BD@`"    c BOCDEFd @ $$I=%N Bx1=C =0 1[   x  % =[ I0 O IIJL@`" o   c BCDEFd @ $$mI Z T =a  m I 7~7U y   JL@`"\   c B,CDEFd @ $$,=~ r1   H s   7frC  s H , ,,JL@`"j   c BCDEFd @ $$&z>% 2n&@ Z hs ,  sr~ 8 ty ` @ &&JL@`"Hj   c ,B]CDEFd @ 33WP?*(u[ba UVa{ "3*EKPQK| ? 3 1  W  J O[V  ]  (7 ? 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S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| - 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel - 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C-&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C-&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C-IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C-IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  - (~ހϞDRP[R{|(classified)&- C-  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&- C- 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0- C-(ϞDRP[N$v (and tumour)(C-A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &-C-$ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0  0 *" (   r  S g' }     ZA  + b66-N#    6=M  2d\O_h@n + b@nIgG IgA IgM   I bSbSO[^lm v^V[ grI{20`C :c   6pM  v~g(result) 0 C H  0޽h ? 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%O = 4N^MQuf[hg H '<#BcB  NwmN'Yf[;Sf[b c[NS Yec! tu(category)C- Z10ag'`uu(infection disease) 20ꁫMQu'`uu(autoimmune ^) 30OeS^'`uu(hypersensitivity ^ ) 40MQu:w/Xk'`uu (immunoabnormal ^ deficiency/proliferation) 50$v(tumour) 60y i(transplantation)L_,#_A,C#A 4Kbk(measure)Nvv(objective)C*.  8^(uMQuf[vt(theory)Nb/g (technique) xvzuuvuV(u) (pathogenesis)0Su(occur)0SU\ (develop)TlR_(turn) v^[uuۏL ʋe(diagnosis)0uHevKm(curative effect monitor)T2(prevent)0 &C$     Q[(content) C-   10SOmMQuhKm(humoral^) 20~ހMQuhKm(cellular ^) 30vsQ4N^uuvMQuhKm ag'`uu ꁫMQu'`uu OeS^'`uu MQu:w/Xk0$vNy i 0BE$C$~ G N0SOmMQuhKm(^test)"A$N @nMQutˆ}vhKm (human serum immunoglobulin ^) N @neSOhKm (human serum complement ^)  N SOmMQuvsQvQNhKm (others ^)   $ C$ $C$$C$  N @nMQutˆ}vhKm  MQutˆ}vImmunoglobulins, Ig /fwQ gbSO;m'`bSf[~gNbSOv?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz|}~ SR:NRlWTW$Ny MR;N X[(WN@nI{SOm-N YAbTy WMQutˆ}vmembrane Ig mIg /fB~ހ NvbSSSO(receptor)0 vPnPC$C$G$iC$C$8     bSOantibodies, Ab /fB~ހƋ+R bSTXkRS:NFm~ހ@bNuv Nv^bSyr_'`(specific)~T (recognize antigen and binding)v^ S%cMQuR(antigen and antibody reaction)vtˆ}v0 vPtPC$*C$[G$C$C$n   4N^hKmv@nMQutˆ}v  2eP^N@n;NIg+Tϑ(content)g/L C(B t^ IgG IgM IgA eu?Q 6.6^17.5 0.01^0.06 0.06^0.21 6*Ng 2.6^6.9 0.08^0.57 0.26^1.00 1 \ 3.0^9.5 0.14^0.91 0.37^1.50 2 \ 4.7^12.3 0.21^1.45 0.41^1.75 8 \ 6.3^15.0 0.46^2.51 0.47^2.20 12\ 7.0^15.5 0.58^2.91 0.49^2.40 18\ 7.3^15.5 0.70^3.21 0.51^2.61 bN 7.0^16.0 0.70^3.00 0.40^2.80 B^ A AC AC AC AC AC AC AC!A                  hKmKbk(method)" A      $ce\MQukJm~pce\/sce\ G$ &4N^aINsignificance 2- C--  1.@nYKQIg4ls^Xؚ `@n-NTWIgGWGSؚ 8^NTy agyr+R/fba'`(chronic)~̃ag Y~ 8h0ba'`/el{p0ba'`uꁫMQu'` (autoimmune)uu0SLE`NIgG0IgAGSؚ Y {|Θn'`sQp  IgMXؚ:N;N0$xA   YKQbSO(polyclonal antibody): 1u N TvB~ހKQNuvbSO. USKQbSO(monoclonal antibody): 1uN*N~ހKQ@bNuvSƋ+RUSN bSQ[|v~vbSO.`!XC$G$C$Z  2.@nUSKQIg4ls^Xؚ `@n-NQs_8^XYvUSKQˆ}v monoclonal protein MPsSMˆ}v 30g/LN N ck8^IgSbNMP T{|Igv+Tϑ R>fWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE(NMˆ}vhKmvsQ(related)uuC-. 10YS'`Ӛ$vmultiple myeloma 20]tˆ}v@umacroglobulinemia 30͑uheavy chain disease 40{ulight chain disease 50JSRP[uhalf-molecule immunoglobulin disease 60v`'`m]$v(malignant ^) 70o'`Mˆ}v@u(benign ^).%)A" 2 O: YS'`Ӛ$v multiple myeloma,MM /fFm~ހ_8^Xkvv`'`$v _NyFm~ހ$vplasmocytoma 0/fIPD-Ng8^vNy{|W01873t^1uButzkyHQv^}T T04]dr    MMv;N4N^yr_ * `$ۏL'`v(4xOW Y(u~gTn'`uS 8^ gu0fb :NMMgxQWyr_ a$'YϑvMˆ}v[@m|^Xؚ,HTؚ|@ubly N\{-N \{ Nv~ހm|7hS'` Suu ~T_0_c[-Ng^y~|~ SQs^y~Rx b$Ӛ_c$OS_w+@0|~ހT@\gQ\ c$Fm~ހxmmvQN~~ Y ӚT^y~9hSSe_w ЏRRxI{ d$7u'`YS s^GWSut^46\]S e$v`'` z^ؚ T No f$fag0Z  9   MMv;NMQuf[yr_ " *( @`$@n-NQs'YϑvMˆ}vIgG35g/L, IgA20g/L, IgM15g/L, IgD2.0g/L IgE 2.0g/Lb?\-N g,ghTˆ}v1.0g/24h ?\  a$@n-Nck8^Ig 4ls^f>fMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZJ   N T{|WvYS'`Ӛ$v:   &{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y2      ![' "[MMvSu:g6R  *Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G(. Qtˆ}vv[ϑRg t[lm-Nˆ}v({|W S\lm(uQQ mmmT QnN]kYQm-N V[5u lbMQu5ult[0 Qtˆ}vhKmvlaNy Ǒ@Ǐ zO)n (uT(u)n 4! N>ene NhT ck8^N@n_NS+T gQtˆ}v Ype(W80g/L N N0\ 2 7A7A<.VN @neSOhKm - eSOcomplement /fc@n-NwQ gv;m'`vN~ Nptˆ}v0 A. C1^C9(C1q0r0s) B. BVP[0DVP[0PVP[0HVP[ C. C1b6Rir0C4~Tˆ}v0OpSVP[ I{0&#CfC$  n@ z^NeSO+TϑvsQ|: eSOvsQv[[hKm - X10;`eSOn@;m'`Km[CH50 S f;NeSOC1^C9bRv~T4ls^0 Ջ{lck8^Sf _\ Npe . S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| - 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel - 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C-&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C-&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C-IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C-IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  - (~ހϞDRP[R{|(classified)&- C-  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&- C- 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0- C-(ϞDRP[N$v (and tumour)(C-A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &-C-$ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0$  0 $(  r  S  @' c   @ r  S P,+  'ga @ H  0޽h ? gg380___PPT10.@r%/w/1J( / \ \ech Word.Document.80"Microsoft Word echYech Word.Document.80"Microsoft Word echvech Word.Document.80"Microsoft Word echech Word.Document.80"Microsoft Word ech/ 0DTimes New RomanTT4.ܖ 0ܖD[SOes New RomanTT4.ܖ 0ܖ DArialNew RomanTT4.ܖ 0ܖ0DWingdingsRomanTT4.ܖ 0ܖ@DDotumCheRomanTT4.ܖ 0ܖ1PDVerdanaRomanTT4.ܖ 0ܖ"`DўSOdanaRomanTT4.ܖ 0ܖ C0.  @n?" dd@  @@`` tl0 fI           $   #           "# ()*+-.0 1 234 7 9:;<=>?@ABDEFGHIK,L,"$M; os0b$ <)Ki^0b$رℤ+;uz]Eb$ǜ|YATTx 0xDArialdx}0>YATTx 0x pp? %O = 4N^MQuf[hg H '<#BcB  NwmN'Yf[;Sf[b c[NS Yec! tu(category)C- Z10ag'`uu(infection disease) 20ꁫMQu'`uu(autoimmune ^) 30OeS^'`uu(hypersensitivity ^ ) 40MQu:w/Xk'`uu (immunoabnormal ^ deficiency/proliferation) 50$v(tumour) 60y i(transplantation)L_,#_A,C#A 4Kbk(measure)Nvv(objective)C*.  8^(uMQuf[vt(theory)Nb/g (technique) xvzuuvuV(u) (pathogenesis)0Su(occur)0SU\ (develop)TlR_(turn) v^[uuۏL ʋe(diagnosis)0uHevKm(curative effect monitor)T2(prevent)0 &C$     Q[(content) C-   10SOmMQuhKm(humoral^) 20~ހMQuhKm(cellular ^) 30vsQ4N^uuvMQuhKm ag'`uu ꁫMQu'`uu OeS^'`uu MQu:w/Xk0$vNy i 0BE$C$~ G N0SOmMQuhKm(^test)"A$N @nMQutˆ}vhKm (human serum immunoglobulin ^) N @neSOhKm (human serum complement ^)  N SOmMQuvsQvQNhKm (others ^)   $ C$ $C$$C$  N @nMQutˆ}vhKm  MQutˆ}vImmunoglobulins, Ig /fwQ gbSO;m'`bSf[~gNbSOvfWMNO0dk{|_8^XYIgYeMQu;m'`, ;NNMQuXk'`(immunoproliferative) uu YYS'`Ӛ$v(multiple myeloma, MM),SS'`]tˆ}v@u(primary macro- globulinemia)0͑(heavy chain)u0{ (light chain)uI{0 dZZC$A&AEAf        4eu?Q0tZ|^?Q1uNSOmMQuR\ Nb q MQutˆ}vv+TϑbNNO ct^ ~ۏLRgN$Re0 sQN@nIgETIgDvKm[ @n;`IgE:N0.13^0.92mg/L; @n;`IgD:N0.6^2.0mg/L; IgE(NMˆ}vhKmvsQ(related)uuC-. 10YS'`Ӛ$vmultiple myeloma 20]tˆ}v@umacroglobulinemia 30͑uheavy chain disease 40{ulight chain disease 50JSRP[uhalf-molecule immunoglobulin disease 60v`'`m]$v(malignant ^) 70o'`Mˆ}v@u(benign ^).%)A" 2 O: YS'`Ӛ$v multiple myeloma,MM /fFm~ހ_8^Xkvv`'`$v _NyFm~ހ$vplasmocytoma 0/fIPD-Ng8^vNy{|W01873t^1uButzkyHQv^}T T04]dr    MMv;N4N^yr_ * `$ۏL'`v(4xOW Y(u~gTn'`uS 8^ gu0fb :NMMgxQWyr_ a$'YϑvMˆ}v[@m|^Xؚ,HTؚ|@ubly N\{-N \{ Nv~ހm|7hS'` Suu ~T_0_c[-Ng^y~|~ SQs^y~Rx b$Ӛ_c$OS_w+@0|~ހT@\gQ\ c$Fm~ހxmmvQN~~ Y ӚT^y~9hSSe_w ЏRRxI{ d$7u'`YS s^GWSut^46\]S e$v`'` z^ؚ T No f$fag0Z  9   MMv;NMQuf[yr_ " *( @`$@n-NQs'YϑvMˆ}vIgG35g/L, IgA20g/L, IgM15g/L, IgD2.0g/L IgE 2.0g/Lb?\-N g,ghTˆ}v1.0g/24h ?\  a$@n-Nck8^Ig 4ls^f>fMNO b$Ӛ-N gePibXv_8^Fm~ހ e"15% :N;Nutyr_ ~~[ gFm ~ހ$v c$ gn'`_c[0ZJ   N T{|WvYS'`Ӛ$v:   &{| W Sus% ,ghTˆ}v?\3'`% 4N ^ yr p IgG 50^60 50^70 xQWur IgA 20^25 50^70 ؚ|~T_Y IgD 1^2 90 ӚYuS0nu SY 44%m|7hS IgE 0.01 \ IgM 1 90 ؚ|~T_g8^ ^RlW 1^5 e nuS\ ^y ~|~_c[Y2      ![' "[MMvSu:g6R  *Su:g6R Nf N NRV } gsQ0 1 /fW ONsXV }~T\O(uv~g0;NSu (W1S011S014SgrSO OFm~ހSSu8luS 2 @r^~ހv_8^ 0b_bFm~ހ$v0 3 ~ހVP[v_8^ 0MM`S gIL-6_8^Xؚ SOYQ[fIL-6SOOMM~ހXk0uTX[ ;m OMM~ހXY0IL-6XؚvcHe^/fb6RIL-4v Nu N b6RNck8^vSOmMQuR0 4 N|DRP[0IL-6I{OS OSSOTB~ހ1^2 I{b6RQNvSSOؚh gsQ0N     ,ghTˆ}vbence-jones protein : 1847t^1uBence-Jones(WuNv?\m-NhQ }T T0]wMˆ}v NwQ gMQu;m'` eck8^MQutˆ}vvR vQ{RP[\SǏ\tnǏN?\cd0 ,ghTˆ}v/fN?\-NhQvMˆ}v{  b}x  7Qtˆ}vvhKm(['`) G(. 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S !  406q@g$O~ހNK MQuhKm NK:NN{|'Y|m]~ހ vQhbeN 蕄vƋ+Rh_ wQ g~ހN[v~ހk \O(uvc@g$Ov~ހ0 NKwQ gb$v0bagTMQuI{R He ؏SNy ice0OeS^I{^ NKRKm[SbsNx1"lvʑ>es0 51Crʑ>eI{I{ 0 Z}Z"C$G$GC$G$ C$K$C$.#  50TlV~ހphagocytes RhKm TlV~ހ  -N'`|~ހneutrophils US8h-TlV~ހ mononuclear ^/macrophages TlV~ހvTlV;mR  Strend TlVphagocytosis ހQmSelimination ZC$          V  ~ހMQuvsQv;N~ހVP[hKm  A ~ހVP[vy{| - 10}v~ހN } IL-1^18 20Ɩ=:RoVP[CSF |0]lV~ ހTmT^ 30r^pb }IFN 00 40$vOW{kVP[TNF  0  50lSuVP[[e/ SGF 60SVP[[e 70vQNhvu0@\gMu^ 8ZZC$C$8^~ހVP[hKmel - 10uirf[hKmlO~ހXkTXkb6R0 ~ހk;m'`0buk;m'`0S;m'`I{ 0 20MQuf[hKmlELISA0RIA0MQupS0 MQuep 0 30RP[uirf[lRNApS0PCRI{ 0 40US*N~ހNu~ހVP[Km[lSTn@ zze0STELISAep 0 0AA( IL-2/ IL-2R C-&IL-2;N1u;mSvCD4+~ހNu ǏRlTeRl\O(uNRlIL-2v~ހ,gbяvCD4+T CD8+~ހ /f:gSOMQuQ~-Ng͑vVP[0 :NċN:gSOMQuRv͑chKNN0 SOm-N+TϑNONvchKm0 8^hKm1u:RoSPHA/ConA [US*N8h~ހ(WSOYNuvQvRegS f0JE;AE7Av >IL-4C-&;N1uTh~ހ~bSbNˆS:RoTNuSB~ހSvQNYyMQu~ހvR0 IL-4XRNBRϑIgMbSO[B~ހv:Ro IL-4NLPSqQ:RoB~ހRlIgG1TIgE IL-4OۏB~ހhbCD23RP[h IL-4;eIFN[L929~ހvOb\O(u HT>fbbIFNvbuk;m'`0 RG$+C$G$=C$8  IL-6C-IL-61uYym]{|T^m]{|~ހUS8h-]lV~ހ0@{Qv~ހ0T/B~ހ0gN$v~ހ Nu wQ gYyuirf[R (W:gSOvMQu^T{0Ӛ @0puS^-Nw͑\O(u0 IL-6:RogN~ހRSCESS~ހ0SKW6-CL4~ހ0B~ހI{ R|0G$C$ G$'C$~ 1 IL-8C-IL-81uUS8h/]lV~ހ0b~~~ހ0 Nv~ހTQv~ހvYy~ހNu vQ;Nuir;m'`/fo;m-N'`|~ހ0 IL-8/f-N'`|~ހvo;mBRTSVP[ IL-8:RoYW8h}v~ހʑ>eӚǏ'lSirv R_#G$C$G$C$H-~ހϞDRP[  - (~ހϞDRP[R{|(classified)&- C-  teT }[e(integrin) b }[e(selectin) MQutˆ}v[e (immunoglobulin superfamily) |ˆ}v[e(cadherin) |ˆ}v7h[e0I{I{ mucin-like family H1$C$    "ϞDRP[vR(function)&- C- 10MQu~ހƋ+Rdistinguish -NvRSSOTOS T;mSOS0 20puinflammatory Ǐ z-N}v~ހT@{Qv~ހϞD0 30m]~ހR_] lymphocyte homing 0 ,gfC$C$l   *ϞDRP[Nuu(and disease) 0- C-(ϞDRP[N$v (and tumour)(C-A$(Sn'`ϞDRP[dissolved^ 6 A cN~ހhb1=v^vcۏeQ@mv^ ]wgNϞDRP[1uvQmRNAыTSvcRlۏeQ@m^ 4N^Ss(W m0y4l0nmTlLpmm-NhKm0Rv^NSS f@\ϞDRP[hNN"v`Q0,^>A >ϞDRP[vhKm^test &-C-$ 10~ހhbϞDRP[vhKm >e\MQuKm[ MQugIQKm[ vMQuKm[ELISA Sf[SIQMQuKm[ 20Sn'`ϞDRP[vhKm ELISAl:8 _AH0r11