欧洲杯竞猜平台药物化学与生物信息学中心是我院精准医药科研、教学和对外合作的主要基地。中心成立于2013年，由张健教授担任主任，并于2020年5月与化学教研室整合。中心一直聚焦精准医学和药学创新技术的发展及其在临床诊疗中的应用，自主研发的变构药物设计技术在国际上具有重要影响力，近5年获得国内外100多个国家60000余名医药用户的使用。同时，中心承担了国内外多项医学大数据及人工智能的研究与转化项目，培养了一批精准与转化医学大数据人才，为生物医药与人工智能时代的对接提供了支撑。
中心具有优秀的师资队伍，目前已有教师22人，其中75%具有博士学历，其中正高1人，副高8人，博导和硕导4人。中心主任张健担任欧洲杯竞猜平台特聘教授，国务院学位委员会学科评议组成员，国家自然科学基金委杰出青年基金、国家高层次人才计划及国家高层次人才计划青年项目获得者，国家自然科学基金委创新研究群体成员，以通讯作者在包括Nat Chem Biol, Chem Rev, Chem Soc Rev等国际学术杂志上发表SCI论文100余篇。中心教师主要从事药物设计、生物信息学、化学生物学及化学材料等研究方向，在精准靶标识别和First-in-class原创药物发现等方向做出了一系列突破性成果。中心自成立以来已承担国家重大研究计划，国家新药创制，上海市分子影像学重点实验室项目、上海市科委扬帆人才计划和基础欧洲杯竞猜平台前沿研究青年支持等项目，发表新靶标和创新药物相关工作120余篇。
在教学育人方面，中心的生物信息学及医用化学教学团队，每年承担了研究生、本科生、留学生等各专业的教学工作。其中生物信息学团队开设了“生物信息学”、“医学图像处理与分析”、“生物医学数据挖掘”、“VB程序设计”、“计算机应用基础”等课程。同时，医用化学教学团队开设课程有“医用基础化学”、“医用有机化学”、“分析化学与仪器分析”、“色谱分析在医药上应用”等课程。中心每年共完成近1500学时的本科及研究生理论教学，同时辅助完成本科实验教学约260学时，同时开展双语教学课程。主编《有机化学》英文改编版，主持各级教学课题4项，发表高水平教学论文3篇，有多名教师担任RBL及大创项目指导老师，其中1项大创获得上海市级课题。
中心在学术交流发展方面，致力于与各界合作伙伴共同构建全球生物医药的创新生态。从原创科学研究到高效的成果转化，与合作伙伴形成良好的互动与交流。中心先后与中国科学院上海药物研究所、上海生物信息技术研究中心、中国科学院上海有机化学研究所、美国国家癌症研究所实验免疫学实验室癌症研究中心、上海市第九人民医院、上海市第六人民医院、新华医院等开展了深入的合作与广泛的学术交流，取得了一系列科研进展。
中心在本科生及青少年科创培养方面也取得了多项成果。作为交医本科生创新基地，目前指导的5名学生获各类奖项及基金资助20余项，多次获得全国大学生生命科学竞赛及上海市“挑战杯”等重要奖项，发表多篇SCI文章。同时，中心作为上海市药学会青少年科学种子辅导站、上海市医学科学实践工作站，成功举办科普夏令营，为未来的生物医药人才培养提供了前瞻性实践。
Center for Pharmaceutical Chemistry and Bioinformatics
The Center for Pharmaceutical Chemistry and Bioinformatics in School of Medicine of Shanghai Jiao Tong University, is the main base for research, education and international cooperation of precision medicine. The Center was established in May 2013, headed by Professor Zhang Jian, and further integrated with the Medical Bioinformatics Center and Chemistry Teaching Department in May 2020. The Center has been focusing on the development of precision medicine and pharmaceutical innovation technology and its application in clinical diagnosis and treatment. The independently developed technology of allosteric drug design has an important influence in the world, and has been used by more than 60,000 medical users from more than 100 countries in the past five years. At the same time, the Center has undertaken a number of research and transformation projects of medical big data and artificial intelligence in the domestic and overseas, and cultivated a group of precision and translational medicine talents. It provides support for the docking of biomedicine and artificial intelligence era.
The Center has an excellent faculty. At present, there are 22 teachers in the Center, 75% of whom have doctor's degree. Among them, 1 is a senior, 8 are associate senior, and 4 are doctoral and master supervisors. Zhang Jian, director of the Center, is a distinguished professor of the School of Medicine of Shanghai Jiao Tong University, excellent doctoral supervisor of Shanghai Jiao Tong University, who has obtained the Outstanding Youth Fund of The National Natural Science Foundation of China, National High-level Talent Plan, National High-level Youth Talent Plan, and is also the member of the Innovative Research Group of the National Natural Science Foundation of China. As the corresponding author, he has published more than 100 SCI papers in international academic journals including Nat Chem Biol, Chem Rev, Chem Soc Rev and so on. Faculty members of the Center mainly participate in studies of drug design, bioinformatics, chemical biology and chemical materials, and have made a series of breakthrough achievements in precision target identification and first-in-class original drug discovery. Since establishment, the Center has undertaken one Shanghai Key Laboratory of Molecular Imaging, one Sailing Talent Program of Shanghai Science and Technology Commission, and one Frontier Research Youth Support Program of Basic Medical School, and published 120 papers associated with the identification of new target and drug discovery.
In terms of teaching, both the bioinformatics team and medical chemistry teaching team of the Center have undertaken teaching work for graduate students, undergraduate students and international students each year. The bioinformatics team offers courses such as "Bioinformatics", "Medical Image Processing and Analysis", "Biomedical Data Mining", "VB Programming" and "Computer Application Basis". At the same time, the medical chemistry teaching team offers courses such as "Medical basic Chemistry", "Medical Organic Chemistry", "Analytical Chemistry and Instrumental Analysis", "chromatographic analysis in medicine" and other courses. The Center has completed nearly 1500 credit hours of undergraduate and graduate theoretical courses every year, and assisted in 260 hours of undergraduate experimental courses, and it also offers bilingual courses. He is the chief editor of the English adaptation of Organic Chemistry. The teaching team has edited the English version of "Organic Chemistry", presided over 4 teaching projects, and published 3 high-level teaching papers. Many teachers have been the advisers of RBL and Great Innovation Projects, among which 1 project was awarded the Shanghai Municipal Level Project.
In terms of academic communication, the Center is committed to building a global biomedical innovation ecosystem together with partners from all fields. From original scientific research to efficient achievement transformation, it has formed good interaction and communication with partners. The Center deeply cooperates and communicates with the Shanghai Institute of Medicine of Chinese Academy of Sciences, Shanghai Biological information technology research center, Shanghai Institute of Organic Chemistry of Chinese Academy of Sciences, the Experimental Immunology Laboratory Cancer Research Center of National Cancer Institute of the U.S.A., Shanghai Ninth People's Hospital, Shanghai Sixth People's Hospital and Xinhua Hospital, which has made a series of scientific research progress.
The Center has also made many achievements in the scientific innovation cultivation of undergraduates and teenagers. As the innovation base for undergraduate students of the school, 5 students under our guidance have won more than 20 awards and funds, such as the National College Students Life Science Competition and the Challenge Cup Competition of Shanghai, they have published many SCI articles. At the same time, as the teenagers’ science training station of Shanghai Pharmaceutical Association and Shanghai Medical Science Practice Workstation, the Center successfully held popular science summer camp, providing prospective practice for the cultivation of biomedical talents in the future.
