欧洲杯竞猜平台神经科学学科组成立于2014年，目前共有10位PI研究员，其中国家高层次人才计划2人、国家杰出青年基金获得者1人、中国科学院“百人计划”1人、国家高层次青年人才2人、国家优秀青年基金获得者1人。在教学上，学科组承担了欧洲杯竞猜平台本科生和研究生《神经生物学》、《神经科学前沿》、《神经生物学基础与进展》、《神经科学文献精读》共4门课程的教学工作。在科研上，学科组围绕脑认知、脑疾病和脑调控，布局感知认知、神经与精神性疾病在分子、细胞和环路机制上的前瞻性基础研究。近五年，承担科技部“中国脑计划”项目、重大科学研究计划973项目和国家自然科学基金重点项目、重大研究计划重点支持项目、集成项目、培育项目、国际（地区）合作与交流重点项目、面上项目、青年科学基金等50余项，并在Science、Neuron、Molecular Psychiatry、Molecular Biology and Evolution、Nature Communications、Science Advances、PNAS、Cell Reports、eLife、Journal of Cell Biology、Journal of Neuroscience等国际期刊发表论文60余篇。
作为欧洲杯竞猜平台“以疾病为导向的脑科学交叉集成平台”建设的脑科学研究计划的重要组成部分，学科组建设脑科学研究中心（Center for Brain Science），依托上海市教委重点支持建设的“脑认知原理解析”创新团队，积极对接“中国脑计划”，以认识脑、解析脑为核心，致力于解析脑疾病发病机制，发现药物新靶点，正在发展成为认知相关脑疾病药物研发及神经调控干预机制的策源地。脑科学研究中心聚焦“脑认知原理解析及认知障碍相关疾病机理”总体研究方向，细分为1）神经环路发育与行为；2）学习记忆原理与调控；3）脑疾病药物靶标发现等关键科学问题。脑科学研究中心在整合基础欧洲杯竞猜平台脑科学相关研究力量的基础上，以基础神经生物学平台建设为基础，致力于深化与附属医院若干脑科学相关临床科室的交叉合作，积极探索脑科学多学科整合发展新模式，为上海建设具有全球影响力的科创中心提供重要支撑和推动力。
为更好地开展脑科学研究中心的研究，学科组公共技术平台通过整合原有平台资源，形成了以四个专业平台为基础的技术支撑体系，包括：1）脑解剖-连接组学技术平台：主要涵盖多种离体和活体成像系统，用于全脑水平连接图谱的构建；2）脑生理-功能检测技术平台：主要包括丰富的离体、在体电生理记录系统，以及光遗传学刺激/调制系统和钙活动记录系统；3）脑行为-表型分析技术平台：现有设备涵盖感觉与运动、本能行为、学习与记忆、情感与社交等小鼠行为检测仪器，并配备有病毒注射、给药管/光纤埋植的手术室等；4）脑疾病-精准干预技术平台：与欧洲杯竞猜平台附属精神卫生中心等附属医院共建，现有仪器既包含多种临床样品的制备、检测和保存设备，还涵盖经颅磁刺激系统和同步脑电记录、多通道脑电记录系统等精准干预和诊断设备。
Discipline of Neuroscience
The Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, was founded in 2014. The discipline now has 10 faculty members leading independent research groups. Among them, two are winners of the National High-level Talent Plan, one is the winner of “Distinguished Young Scholars” sponsored by the National Natural Science Foundation of China, one is the member of Hundred people plan sponsored by Chinese Academy of Sciences, two are members of the National High-level Youth Talent Plan, and one is the winner of “Excellent Young Scholars” sponsored by the National Natural Science Foundation of China. The discipline conducts teaching of 4 main courses, including Neurobiology, Frontiers in Neuroscience, Basics and Progress of Neurobiology, and Neuroscience Journal Club for undergraduate and graduate students of medical school. In scientific research, the discipline aims to understand mechanisms of sensation, perception, cognition, neurological and mental diseases at molecular, cellular, and circuitry levels, with the focus on brain cognition, brain diseases and brain regulation. In the past five years, the discipline has received and completed more than 50 national funds from the Ministry of Science and Technology of China (the China Brain Project and 973 National Key Basic Research Program) and National Natural Science Foundation of China (Major Program, Key Program, Integration Program, Training Program, Key Program of International Cooperation and Exchange, General Program, and Youth Science Program). Over 60 papers have been published in international prestigious journals such as Science, Neuron, Molecular Psychiatry, Molecular Biology and Evolution, Nature Communications, Science Advances, PNAS, Cell Reports, eLife, Journal of Cell Biology, and Journal of Neuroscience.
Being part of the Strategic Plan of Brain Science Development at Shanghai Jiao Tong University School of Medicine entitled with “A crossing and integration brain science platform based on the population cohort and guided by the study of brain diseases”, the Discipline of Neuroscience has initiated and sponsored the Center for Brain Science, which mainly relies on the key Innovation Team of “Principle Analysis of Brain Cognition” supported by Shanghai Municipal Education Commission. The center is aimed at actively docking with the China Brain Project, and dedicated to understanding and resolving the brain function, deciphering the mechanisms underlying pathogenesis of brain diseases, discovering novel drug targets, and growing into one of the cradles for drug development and novel neural modulation ways targeting cognitive-related brain diseases. The center focuses on “Principle Analysis of Brain Cognition and Mechanistic Study of Cognitive Impairment” as the overall research direction, which can be further categorized into three key scientific questions: 1) development of neural circuit and behavior, 2) principles and regulation of learning and memory, 3) drug target discovery for brain diseases. The center was established by integrating the research teams on brain science at Shanghai Jiao Tong University College of Basic Medical Sciences and grounded as the development of basic neurobiology platform. It has been longing for collaborating with brain science-related clinical departments from hospitals affiliated to Shanghai Jiao Tong University School of Medicine and exploring novel mode for multidisciplinary integration development of brain science, providing an important support and driving force for Shanghai city to grow into the technological innovation center with global impact.
To provide technical support for the Center for Brain Science, the Discipline of Neuroscience has been actively running the brain research core facility with the goal to accelerate cutting-edge research into anatomical, functional, and physiological studies in neuroscience. The facility is composed of 4 main centers: 1) center for brain anatomy and connectome that includes in vitro and in vivo imaging workstations, 2) center for brain physiology and function that includes a large variety of instruments for electrophysiological recording, calcium imaging, and optogenetic stimulation, 3) center for behavior and phenotype analysis that includes behavioral paradigms covering sensation, motion, instinctive behaviors, learning, memory, emotion, and social behaviors as well as surgical suites for virus injection and cannula/optical fiber implantation, 4) center for brain diseases and precision treatment that includes equipment for preparation, detection, and preservation of clinical samples as well as systems for transcranial magnetic stimulation and electroencephalogram recording in collaboration with affiliated hospitals such as Shanghai Mental Health Center.
