转化医学国家重大科技基础设施（上海）项目（简称大设施）于2013年7月经国家发展和改革委员会正式批准立项，2016年9月启动建设,2020年12月正式运行。
作为国家级转化医学研究机构，大设施由国家教育部和上海市共同管理，是我国首个综合性国家级转化医学重大科技基础设施。大设施以国家创新战略和国家中长期科技发展规划为导向，以促进前沿技术和基础医学研究成果向临床应用转化为目标，结合欧洲杯竞猜平台和瑞金医院的研究基础和学科优势，选择严重危害中国人群健康的肿瘤、代谢性疾病和心脑血管疾病等“三大类疾病”作为主要研究对象。大设施将重点建设转化医学核心设施、资源深度开发与共享设施和关键技术支撑设施三大板块，与三大类疾病形成“三纵三横”的建设格局。
重点建设标准化临床生物样本库、临床资源深度分析与挖掘平台、生物标记物与药物研发及新药创制平台、诊断试剂与仪器开发平台、分子病理与影像技术研究平台和临床研究型病房六大平台，通过搭建系统化、规模化、集成化的科学设施，开展从临床实践到基础研究、医药产品和技术开发再回到临床实践的循环往复的转化医学研究。
新建成的瑞金医院转化医学大楼拥有300张研究型病床（含50张万级层流病床），按照国际一流标准进行设计和配置，是转化医学核心设施，用于开展大规模、前瞻性、规范化0-IV期临床试验，促进创新性疗法、技术、诊断试剂在临床的实践。
目前大设施已初步建立起一支具有转化医学相关背景和工作经验、能胜任学科交叉融合的高层次专业技术人员队伍。
National Center for Translational Medicine·Shanghai
——National Key Scientific Infrastructure for Translational Medicine
National Center for Translational Medicine·Shanghai (the Center for short hereinafter), which is a national key scientific infrastructure, was approved to be founded by National Development and Reform Commission in July 2013 and put into full operation in December 2020. As a national academic institution, the Center is co-administrated by Ministry of Education and Shanghai Municipal Government.
With an aim to promote the translation of frontier technologies and the findings of basic medical research into clinical practices, the Center has adopted a “systematic three by three” research scheme. Guided by the National Innovation Strategies and National Mid- and Long-Term Guidelines for Scientific Development, and to make the best of the advantages of Shanghai Jiao Tong University and Rui-Jin Hospital, the research of the Center is focused on three major types of life-threatening diseases: cancer, cardiovascular and cerebrovascular diseases, and metabolic diseases. To carry out the research, the Center prioritized building three main systems: translational research core facilities, a resource sharing system, and a key technical supporting system.
Through the building-up of 6 platforms, namely, biobank, in-depth clinical resources analysis platform, biomarker and new drug discovery platform, diagnostic reagents and new medical instrument development platform, pathological study and molecular imaging platform, the Center serves as a systematic and integrated platform for bed-bench-bed translational research.
The core facility of the Center, the newly inaugurated clinical research building of Rui-Jin Hospital, accommodates 300 research wards of international standard which are designed for large-scale, prospective and standard Phase 0-IV clinical trials to promote the application of new therapies, technologies and agents in clinical practices.
Presently, a high-level and multidisciplinary research team has been established in the Center.
