姓名：沈玉娟     

性别: 女        

出生年月：1969.10

学位/学历：硕士      

职称：研究员、硕士生导师

现任职务：药物室副主任（主持工作）

电子邮件：shenyj@nipd.chinacdc.cn; amyshyj12@163.com

办公地址：上海市瑞金二路207号

办公电话：电话：13564694660，021-64723472   传真：021-64376308

教育经历

1988.09-1992.07 欧洲杯竞猜平台农业与生物学院，兽医专业，学士学位

2004.09-2007.12苏州大学，病原生物学，硕士学位

工作经历

1992年7月至今    中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），研究员，硕士研究生导师

2014年9月至2015年8月  美国克瑞顿大学，访问学者

2015年4月至2021年3月 中国疾病预防控制中心寄生虫病预防控制所寄生虫病原与媒介生物学重点实验室副主任

2021年3月-至今  中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）药物室副主任（主持工作）

社会/学术任职和活动

中国女医师协会公共卫生专业委员会委员

中华预防医学会旅行卫生分会委员会委员

中国微生物学会人兽共患病分会委员兼病原学专业委员会原虫学科组副组长

上海市免疫学会理事

上海市免疫学会感染与免疫专委会委员

上海市实验动物生物安全委员会委员

《中国人兽共患病学报》编委。

研究方向/主要研究内容

1.   寄生虫感染免疫及包虫病免疫致病机制

2.   新发肠道原虫病原学、分子流行病学、高通量检测技术、溯源和风险评估

科研/教学研究项目

1.       2021.1-2023.12，原头节外泌体miR-4989促细粒棘球蚴寄生部位血管生成作用及其机制研究，82072307，国家自然科学基金面上项目

2.       2018.1-2021.12，原头节外泌体lncRNAs对细粒棘球蚴感染小鼠MDSCs免疫下调作用及其机制研究，81772224，国家自然科学基金面上项目

3.       2014.1-2017.12，细粒棘球蚴感染小鼠Mo-MDSC源免疫抑制相关分子的研究，81371842，国家自然科学基金面上项目

4.       2008.1-2010.12，日本血吸虫雌雄合抱相关分子的研究，30771880，国家自然科学基金面上项目

5.       2018.1-2021.6自然疫源性传染病症候群寄生虫病原谱构成及流行规律研究，2018ZX10713001-004，国家科技重大专项（子课题）

6.       2008.11-2011.12，我国介水传播隐孢子虫病病源溯源及对策研究，200802012，国家公益性卫生行业科研专项

7.       2013.6-2015.6，饮水安全检测、监测、风险评估和预警预测关键技术研究，201302004，国家公益性卫生行业科研专项（子课题）

8.       2012.1-2013.12，新发肠道原虫病病原检测及风险评估，GWDTR201214，上海市公共卫生优秀学科带头人培养项目

9.       2008.10-2011.6重要寄生虫病原标本显微图像计算机实时自动鉴定系统的研究传染病病原体诊断和组合检测技术研究，2008ZX10004-002，国家科技重大专项（子课题）

主要学术成果

期刊论文

1.        Wu   Y ^†, Gong B^†, Liu X, Jiang Y, Cao J, Yao L, Li H, Liu A^*, Shen   Y^*. Identification of uncommon Cryptosporidium viatorum   (a novel subtype XVcA2G1c) and Cryptosporidium andersoni as well as   common Giardia duodenalis assemblages A and B in humans in Myanmar. Front   Cell Infect Microbiol, 2020,10:614053 

2.        ZhaoW, XuJ, XiaoM, CaoJ, JiangY, HuangH, Zheng B*, ShenY*.   Prevalence and Characterization of Cryptosporidium Species and   Genotypes in Four Farmed Deer Species in the Northeast of China. Front Vet   Sci,2020,7:430. doi: 10.3389/fvets.2020.00430

3.        Zheng M, Wang L, Jiang B, Ren X, Shen Y*, Liu H*. A case report human thelaziasis from Zunyi, China. TheSoutheast Asian Trop Med Public Health, 2020, 51(3):385-386

4.        Xu J, Wang   X, Jing   H, Cao S, Zhang   X, Jiang   Y, Yin J, Cao J*, Shen   Y*.Identification and genotyping of Enterocytozoon bieneusi   in wild Himalayan marmots (Marmota himalayana) and Alashan ground   squirrels (Spermophilus alashanicus) in the Qinghai-Tibetan Plateau   area (QTPA) of Gansu Province, China. Parasit Vectors, 2020,13:367

5.      Zhang X,   Gong W, Cao S, Yin J, Zhang J, Cao J^*, Shen Y^*.Comprehensiveanalysis of non-coding RNA   profiles of exosome-like vesicles from theprotoscoleces and hydatid cyst   fluid of Echinococcus granulosus. Front Cell Infect Microbiol,   2020,10:316

6.        Liu   X^#, Wu Y^#, Yang F, Gong B, Jiang Y,Zhou K,Cao J, Zhang   W, LiuA* , ShenY*.Multilocus sequence typing ofEnterocytozoon   bieneusi isolates from various mammal and bird species and assessment of   population structure and substructure. Front Microbiol, 2020,11:1406. doi:   10.3389/fmicb.2020.01406 IF=4.193

7.        Shenkui   Cao, Wenci Gong, Xiaofan Zhang, Meng Xu, Ying Wang, Yuxin Xu,Jianping Cao, Yujuan   Shen*, Jiaxu Chen*. Arginase   promotesimmuneevasionof Echinococcus granulosus   in mice.Parasit Vectors,2020,13:49 

8.        Yujuan Shen^#,   Baiyan Gong^#, Xiaohua Liu, Yanchen Wu, Fengkun Yang, Jie Xu,   Xiaofan Zhang, Jianping Cao^*, and Aiqin Liu^*.First   identification and genotyping of Enterocytozoon bieneusi in humans in   Myanmar. BMC Microbiol. 2020,20:10 

9.      Ning Xu,   Hua Liu, Yanyan Jiang, Jianhai Yin, Zhongying Yuan, Yujuan Shen*,   Jianping Cao*. First   report of Cryptosporidium viatorum and Cryptosporidium occultus in   humans in China, and of the unique novel C. viatorum subtype XVaA3h.BMCInfect Dis,   2020,20:16

10.     Cao S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J^*, Shen Y^*.Prevalence and Genetic Characterization   of Cryptosporidium,Giardia and Enterocytozoon in   Chickens From Ezhou, Hubei, China. Front Vet Sci.2020,7:   30

11.   Wei Zhao, Huanhuan Zhou, Tianming Ma, Jianping Cao, Gang Lu^*, Yujuan Shen^*.   PCR-Based   Detection of Cryptosporidium spp. and Enterocytozoon bieneusi in   Farm-Raised and Free-Ranging Geese (Anser anser f. domestica) from   Hainan Province of China: Natural Infection Rate and the Species or Genotype   Distribution. Frontiers in Cellular and Infection   Microbiology. 2019, 9: 416  

12.       Baiyan   Gong^#, Yaming Yang^#, Xiaohua Liu, Jianping Cao, Meng   Xu, Ning Xu, Fengkun Yang, Fangwei Wu, Benfu Li, Aiqin Liu*, Yujuan Shen*.   First   survey of Enterocytozoon bieneusi anddominant genotype Peru6 among   ethnicminority groups in southwestern China’sYunnan Province and assessment   ofriskfactors. PLoS Negl Trop   Dis. 2019,13(5): e0007356

13.     Baiyan Gong, Xiaohua Liu, Yanchen Wu, Ning Xu, Meng Xu,   Fengkun Yang, Lei Tong, Kexin Zhou, Jianping Cao, Aiqin Liu*, Yujuan Shen*.Prevalence and subtype distribution of Blastocystis in   ethnic minority groups on both sides of the China–Myanmar border, and   assessment of risk factors. Parasite. 2019,26: 46

14.     UGWU   Chidiebere E^#, Yanyan Jiang^#, Liang Wu, Yuxin Yu,   Jianhai Yin, Liping Duan, Shengxia Chen, Hua Liu, Wei Pan, Hong Quan, Yujuan   Shen*, Jianping Cao*. In vitro Screening of Ginkgolic Acids   for AntiparasiticActivity against Cryptosporidiumandersoni. Biomed Environ Sci. 2019;32(4):300-303

15.     Hua   Liu^#, Ning Xu^#, Jianhai Yin, Zhongying Yuan,Yujuan   Shen*, Jianping Cao*. Prevalence and multilocus genotyping ofpotentially   zoonotic Giardia duodenalis inpigs in Shanghai, China. Parasitology. 2019, 1-7.   doi.org/10.1017/S0031182019000349 

16.       Jianhai   Yin , Congshan Liu, Aiping Yu, Jiaqing Yao, Yujuan Shen*,   Jianping Cao*. Pro-angiogenic activity of   monocytic-type myeloid-derived suppressor cells from Balb/C mice infected   with Echinococcus granulosus and the regulatory role of miRNAs. Cell   Physiol Biochem. 2018,51:1207-1220

17.       Meng Xu, Jiang Z, Huang W, Yin J, Ou S, Jiang Y,   Meng L, Cao S, Yu A, Cao J*, Shen Y*. Altered gut microbiota compositionin   subjects infected with Clonorchis sinensis.Fronit Microbiol. 2018, 9:2292.doi:   10.3389/fmicb.2018.02292

18.       Wei   Pan, Huiwen Xu, Wenting Hao, Fenfen Sun, Yanfang Qin, Shanshan Hao, Hua Liu,Jianping   Cao, Yujuan Shen*, Kuiyang Zheng*. The excretory-secretory products ofEchinococcus   granulosus protoscoleces stimulated IL-10 production in B cells viaTLR-2   signaling.BMC Immunol,   2018,19:29. doi.org/10.1186/s12865-018-0267-7

19.   Aiping   Yu,Yin Wang, Jianhai Yin, Jing Zhang, Shengkui Cao, Jianping Cao*, Yujuan   Shen*.Microarray analysis of long non-coding RNA expression profiles in   monocytic myeloid-derived suppressor cells in Echinococcus granulosus-infected   mice. Parasit Vectors,   2018,11(1):327

20.   Ziyin   Yang, Fengkun Yang, Jianguang Wang, Jianping Cao, Wei Zhao, Baiyan Gong,   Jiangrong Yan, Weizhe Zhang, Aiqin Liu*, Yujuan Shen*. Multilocus   sequence typing and population genetic structure of Cryptosporidium cuniculus   in rabbits in Heilongjiang Province,China. Infect Gent Evol,   2018,64:249-253 

21.   Yanyan   Jian,   Zhongying   Yuan,   Guoqin   Zang,   Dan   Li,   Ying   Wang,   Yi   Zhang,   Hua   Liu, Jianping   Cao,   Yujuan   Shen*. Cyclospora   cayetanensis infections among diarrheal outpatients in Shanghai: a   retrospective case study. Front   Med. 2018,12(1):98-103

22.   Liu H, Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D,Shen Y*,   Cao J*. Infection by and genotype characteristics of Enterocytozoon   bieneusi in HIV/AIDS patients from Guangxi Zhuang autonomous region,   China. BMC InfectDis. 2017, 17:684. doi: 10.1186/s12879-017-2787-9

23.   Li Zheng, Yuan Hu,Yanjuan Wang, Xibao Huang, Yuxin Xu, Yujuan   Shen*, Jianping Cao*. Recruitment of neutrophils mediated by Vγ2 γδ T   cells deteriorate liver fibrosis induced by Schistosoma japonicum   infection in C57BL/6 mice.Infect   Immun, 2017, 85(8): e01020-16

24.   Ying Wang, Hejun Zhou, Yujuan Shen*, Yanjuan Wang,   Weiping Wu, Haipeng Liu, Zhongying Yuan, Yuxin Xu, Yuan Hu, Jianping Cao*.Impairment of dendritic cell   function and induction of CD4⁺CD25⁺Foxp3⁺ T   cells by excretory-secretory   products: a potential mechanism of immune evasion adopted by Echinococcus   granulosus.BMC Immunol. 2015,11:119  doi: 10.1186/s12865   -015-0110-3

25.   Jiang Y, Ren J, Yuan Z, Liu A, Zhao H, Liu H, Chu L, Pan W,   Cao J, Lin Y, Shen Y*.Cryptosporidium andersoni   as a novel predominant Cryptosporidium species in outpatients with   diarrhea in Jiangsu Province, China. BMC Infect Dis.   2014,14:555. doi: 10.1186/s12879-014-0555-7

26.   Wei Pan, Yujuan Shen*, Xiuming Han, Ying Wang, Hua Liu, Yanyan Jiang, Yumei Zhang, Yanjuan Wang, Yuxin Xu, Jianping Cao*. Transcriptome profiles   of the protoscoleces of Echinococcus granulosus reveal that   excretory-secretory products are essential to metabolic adaptation. PLoS Negl   Trop Dis, 2014,8(12):e3392. doi:10.1371/journal.pntd.0003392 

27.   Hua   Liu, Yujuan Shen*, Jianhai Yin, Zhongying   Yuan, Yanyan Jiang, Yuxin Xu, Wei Pan, Yuan Hu, Jianping   Cao. Prevalence and genetic   characterization ofCryptosporidium, Enterocytozoon,Giardia and Cyclosporain   diarrheal outpatients in China. BMC Infect Dis, 2014, doi:10.1186/1471-2334-14-25

28.   Weizhe Zhang, Rongjun Wang, Fengkun Yang, Longxian Zhang,   Jianping Cao, Xiaoli Zhang, Hong Ling, Aiqin Liu, Yujuan Shen*.Distribution   and genetic characterizations of Cryptosporidium spp. in pre-weaned   dairy calves in Northeastern China's Heilongjiang Province. PLoS ONE,   2013, 8(1): e54857. doi:10.1371/journal. pone.0054857

29.   Jianhai Yin, Zhongying Yuan, Huixia Cai, Yujuan Shen*,   Yanyan Jiang, Jing Zhang, Yanjuan Wang, Jianping Cao. Age-related   infection of Cryptosporidium species and genotype in pigs in China. Biomed   Environ Sci, 2013,26(6):465-470

30.   Shen Yujuan, Yin Jianhai,Yuan   Zhongying, Lu Weiyuan, Xu Yuxin, Xiao Lihua, Cao Jianping. The identification of   the Cryptosporidium ubiquitum in pre-weaned ovines from Aba Tibetan   and Qiang autonomous prefecture in China. Biomed Environ Sci,   2011,24(3):315-320

31.   Jing Zhang, Yujuan Shen*(co-first author), Zhongying   Yuan, Jianhai Yin,  Wei Zang, Yuxin Xu, Weiyuan Lu, Yanjuan Wang, Ying   Wang, Jianping Cao. Primary   Analysis of the Expressed Sequence Tags in a Pentastomid Nymph cDNA   Library.PLoS ONE, 2013,8(2): e56511, doi:10.1371/journal.pone.0056511

32.   Jianhai Yin,Yujuan Shen(co-first author), Zhongying   Yuan, Weiyuan Lu, Yuxin Xu, Jianping Cao. Prevalence   of the Cryptosporidium Pig Genotype II in Pigs from the Yangtze River   delta, China. PLoS ONE, 2011,6(6):e20738.   doi:10.1371/ journal.pone. 0020738

33.   Weizhe Zhang, Yujuan Shen(co-first author), Rongjun   Wang, Aiqin Liu, Hong Ling, Yihong Li, Jianping Cao, Xiaoyun Zhang, Jing Shu,   Longxian Zhang.Cryptosporidium   cuniculus and Giardia duodenalis in Rabbits: Genetic Diversity and   Possible Zoonotic Transmission.PLoS ONE ,2012,7(2): e31262.   doi:10.1371/journal.pone. 0031262

专利

1.        沈玉娟，曹建平，刘华，袁忠英，姜岩岩，尹建海，王燕娟. 多重PCR检测肠道新发原虫试剂盒及检测方法，ZL   201510093500.9， 2017.2

2.      沈玉娟，陈盛霞，金红，李峰，潘雨青，孙启艳，吴亮，曹建平.   基于图像的寄生虫虫卵形状识别方法，ZL   201110022426.3，2012.10   已转化

3.      尹建海，曹建平，刘丛珊，张皓冰，沈玉娟.   熊果酸在制备抗包虫药物中的应用，ZL   2016 1 0517861.6，2019.4

4.      曹建平、Ugwu   Chidiebere Emmanuel、沈玉娟、姜岩岩、段李平、袁忠英. 银杏酸在抗隐孢子虫中的应用，

ZL   201310539693.7，2016.3

5.      曹建平，蔡辉霞，沈玉娟，韩秀敏，胡媛，王虎，卢潍媛，徐馀信，官亚宜.   诊断细粒棘球蚴病的重组抗原蛋白、其制备方法和用途，ZL   201010284913.2，2012.8

荣誉及奖项

1.      我国重要新发肠道原虫病原和分子检测关键技术研究及应用，上海市科技进步奖二等奖（2019）、中华医学科技奖二等奖（2019）、华夏医学科技奖三等奖（2019），排名第2

2.      我国隐孢子虫核酸检测和基因分型技术的研究及应用，中华预防医学科技奖三等奖（2015），排名第2

3.      P2017-2018年度上海市卫生健康系统三八红旗集体（团队负责人）

开设课程

《实验室生物安全实践》、《PCR实验》

Profile

Name：Yujuan Shen     

Gender:   Female         

Date   of birth： 10/1969

Degree：Master         

Title：Professor、postgraduate tutor

Present   Position：Vice director of Dept. of Pharmacology

Email：shenyj@nipd.chinacdc.cn; amyshyj12@163.com

Address：207   No.2 RuiJin Road, Shanghai   

Office   Tel：86-21-64723472

Education

9/1988-7/1992，Shanghai Jiaotong University School of Agricultural   and Biological，Veterinary，   Bachelor

9/2004-12/2007，Soochow   University，Pathogen Biology，Master

Appointments

7/1992-present    National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention(Chinese Center for Tropical Diseases Research)，Professor， postgraduate tutor

9/2014-8/2015    Creighton University, USA，   Visting Scholar

4/2015-3/2021    Key   Laboratory of Parasite and Vector Biology, MOH, National Institute of   Parasitic Diseases, Chinese Center for Disease Control and Prevention，Vice  director

3/2021-present    Dept. of Pharmacology, National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention(Chinese Center for Tropical Diseases Research)，Vice  director

Academic Participation and Activities

Member   of Public Health Branch of China Medical Women's   Association

Member of Travel Health Branch of Chinese Preventive   Medicial Association

Member of Zoonosis Branch of Chinese Society for   Microbiology

Member of Shanghai Immunology Society

Member of Infection and Immunology Branch of    Shanghai Immunology Society

Member of Biosafety of Shanghai laboratory animal   Society

Editoral Board Member of Chinese Journal of Zoonoses

Research   interest

1.   Immunity and pathogenic mechanism of echinococcosis

2. Emerging intestinal protozoa pathogen   , molecular epidemiology, high-throughput detection techniques, source track,   and risk assessment

Projects

1.     1/2021-12/2023，Study   on the role and mechanism of exosome-derived miR-4989 from Echinococcus   granulosus protoscoleces in promoting angiogenesis at the parasitic   sites, 82072307，National Natural Science Foundation

2.       1/2018-12/2021，Study   on the mechanism ofimmune down-regulation on MDSCs in infected mice oflncRNAs   from Echinococcus granulosus protoscolices-derived exosomes, 81772224，National   Natural Science Foundation

3.       1/2014-12/2017，Study   on the molecules associated with immunosuppression in Mo-MDSC derived from   mice infected by Echinococcus granulosus，81371842，National   Natural Science Foundation

4.       1/2008-12/2010， Study on   the molecules of male-femal worm pairing of Schistosoma japonicum，30771880，National   Natural Science Foundation

5.       1/2018-12/2021，   Study on the parasitic pathogen spectrum composition   and regularty of epidemic of natural focus infectiou diseases，2018ZX10713001-004，National   Science and Technology Major Program of China (sub subject）   

6.       11/2008-12/2011，Study   on strategy and source track of waterborne cryptosporidiosis in China，200802012，Chinese   Special Program for Scientific Research of Public Health

7.       6/2013-6/2015， Study on   the key technologies of detection, surveillance, risk assessment, and   forecasting and early warning on the safety of drinking water，201302004，   Chinese Special Program for Scientific Research of Public Health (sub subject）

8.       1/2012-12/2013，   Study on risk assessment and pathogen detection of the   emerging intestinal protozoa，GWDTR201214， Shanghai   Public Health Outstanding Academic Leader

9.       10/2008-6/2011,     Real-time   computer automatic identification system for microscopic images of key   parasite，2008ZX10004-002，National Science and   Technology Major Program of China   (sub subject）

Publications

1.        Wu   Y ^†, Gong B^†, Liu X, Jiang Y, Cao J, Yao L, Li H, Liu A^*, Shen Y^*. Identification of uncommon Cryptosporidium viatorum   (a novel subtype XVcA2G1c) and Cryptosporidium andersoni as well as   common Giardia duodenalis assemblages A and B in humans in Myanmar. Front   Cell Infect Microbiol, 2020,10:614053 

2.        ZhaoW, XuJ, XiaoM, CaoJ, JiangY, HuangH, Zheng B*, ShenY*.   Prevalence and Characterization of Cryptosporidium Species and   Genotypes in Four Farmed Deer Species in the Northeast of China. Front Vet   Sci,2020,7:430. doi: 10.3389/fvets.2020.00430

3.        Zheng M, Wang L, Jiang B, Ren X, Shen Y*, Liu H*. A case   report human thelaziasis from Zunyi, China. TheSoutheast   Asian Trop Med Public Health, 2020, 51(3):385-386

4.        Xu J, Wang X, Jing H, Cao S, Zhang X, Jiang Y, Yin J, Cao J*, Shen Y*.Identification   and genotyping of Enterocytozoon bieneusi in wild Himalayan marmots (Marmota   himalayana) and Alashan ground squirrels (Spermophilus alashanicus)   in the Qinghai-Tibetan Plateau area (QTPA) of Gansu Province, China. Parasit   Vectors, 2020,13:367

5.      Zhang X, Gong   W, Cao S, Yin J, Zhang J, Cao J^*, Shen Y^*.Comprehensiveanalysis   of non-coding RNA profiles of exosome-like vesicles from theprotoscoleces and   hydatid cyst fluid of Echinococcus granulosus. Front Cell Infect   Microbiol, 2020,10:316

6.        Liu   X^#, Wu Y^#, Yang F, Gong B, Jiang Y,Zhou K,Cao J, Zhang   W, LiuA* , ShenY*.Multilocus sequence typing ofEnterocytozoon   bieneusi isolates from various mammal and bird species and assessment of   population structure and substructure. Front Microbiol, 2020,11:1406. doi:   10.3389/fmicb.2020.01406 IF=4.193

7.        Shenkui   Cao, Wenci Gong, Xiaofan Zhang, Meng Xu, Ying Wang, Yuxin Xu,Jianping Cao, Yujuan   Shen*, Jiaxu Chen*. Arginase promotesimmuneevasionof Echinococcus granulosus   in mice.Parasit Vectors,2020,13:49 

8.        Yujuan Shen^#, Baiyan Gong^#,   Xiaohua Liu, Yanchen Wu, Fengkun Yang, Jie Xu, Xiaofan Zhang, Jianping Cao^*,   and Aiqin Liu^*.First identification and genotyping of Enterocytozoon   bieneusi in humans in Myanmar. BMC Microbiol. 2020,20:10 

9.      Ning Xu, Hua Liu, Yanyan Jiang, Jianhai Yin, Zhongying Yuan, Yujuan   Shen*, Jianping Cao*. First report of Cryptosporidium   viatorum and Cryptosporidium occultus in humans in China, and of   the unique novel C. viatorum subtype XVaA3h.BMCInfect Dis, 2020,20:16

10.     Cao S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J^*,   Shen Y^*.Prevalence and Genetic Characterization of Cryptosporidium,Giardia   and Enterocytozoon in Chickens From Ezhou, Hubei, China. Front Vet   Sci.2020,7: 30

11.   Wei   Zhao, Huanhuan Zhou, Tianming Ma, Jianping Cao, Gang Lu^*, Yujuan   Shen^*. PCR-Based   Detection of Cryptosporidium spp. and Enterocytozoon bieneusi in   Farm-Raised and Free-Ranging Geese (Anser anser f. domestica) from   Hainan Province of China: Natural Infection Rate and the Species or Genotype   Distribution. Frontiers in Cellular and Infection   Microbiology. 2019, 9: 416  

12.   Baiyan Gong^#,   Yaming Yang^#, Xiaohua Liu, Jianping Cao, Meng Xu, Ning Xu, Fengkun   Yang, Fangwei Wu, Benfu Li, Aiqin Liu*, Yujuan Shen*. First survey of   Enterocytozoon bieneusi anddominant genotype Peru6 among ethnicminority   groups in southwestern China’sYunnan Province and assessment ofriskfactors.   PLoS Negl Trop Dis. 2019,13(5): e0007356

13.     Baiyan Gong, Xiaohua Liu, Yanchen Wu, Ning Xu, Meng Xu,   Fengkun Yang, Lei Tong, Kexin Zhou, Jianping Cao, Aiqin Liu*, Yujuan Shen*.Prevalence   and subtype distribution of Blastocystis in ethnic minority groups on   both sides of the China–Myanmar border, and assessment of risk factors.   Parasite. 2019,26: 46

14.     UGWU   Chidiebere E^#, Yanyan Jiang^#, Liang Wu, Yuxin Yu,   Jianhai Yin, Liping Duan, Shengxia Chen, Hua Liu, Wei Pan, Hong Quan, Yujuan   Shen*, Jianping Cao*. In   vitro Screening of Ginkgolic Acids for AntiparasiticActivity against Cryptosporidiumandersoni.   Biomed Environ Sci. 2019;32(4):300-303 

15.     Hua   Liu^#, Ning Xu^#, Jianhai Yin, Zhongying Yuan,Yujuan   Shen*, Jianping Cao*. Prevalence and multilocus genotyping ofpotentially   zoonotic Giardia duodenalis inpigs in Shanghai, China. Parasitology. 2019,   1-7. doi.org/10.1017/S0031182019000349 

16.   Jianhai Yin , Congshan   Liu, Aiping Yu, Jiaqing Yao, Yujuan Shen*, Jianping Cao*. Pro-angiogenic   activity of monocytic-type myeloid-derived suppressor cells from Balb/C mice   infected with Echinococcus granulosus and the regulatory role of   miRNAs. Cell Physiol Biochem. 2018,51:1207-1220

17.   Meng   Xu, Jiang   Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J*, Shen Y*.   Altered gut microbiota compositionin subjects infected with Clonorchis   sinensis. Fronit Microbiol. 2018, 9:2292.doi: 10.3389/fmicb.2018.02292

18.     Wei   Pan, Huiwen Xu, Wenting Hao, Fenfen Sun, Yanfang Qin, Shanshan Hao, Hua   Liu,Jianping Cao, Yujuan Shen*, Kuiyang Zheng*. The excretory-secretory   products ofEchinococcus granulosus protoscoleces stimulated IL-10   production in B cells viaTLR-2 signaling. BMC Immunol, 2018,19:29.   doi.org/10.1186/s12865-018-0267-7

19.   Aiping Yu,Yin Wang,   Jianhai Yin, Jing Zhang, Shengkui Cao, Jianping Cao*, Yujuan Shen*.Microarray   analysis of long non-coding RNA expression profiles in monocytic   myeloid-derived suppressor cells in Echinococcus granulosus-infected   mice. Parasit   Vectors,   2018,11(1):327

20.   Ziyin Yang, Fengkun   Yang, Jianguang Wang, Jianping Cao, Wei Zhao, Baiyan Gong, Jiangrong Yan,   Weizhe Zhang, Aiqin Liu*, Yujuan Shen*. Multilocus sequence typing and   population genetic structure of Cryptosporidium cuniculus in rabbits in   Heilongjiang Province,China.   Infect   Gent Evol, 2018,64:249-253 

21.   Yanyan Jian,   Zhongying Yuan, Guoqin Zang, Dan Li, Ying Wang, Yi Zhang, Hua   Liu, Jianping Cao, Yujuan Shen*. Cyclospora cayetanensis   infections among diarrheal outpatients in Shanghai: a retrospective case   study. Front Med. 2018,12(1):98-103

22.   Liu H,   Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D,Shen Y*, Cao J*. Infection   by and genotype characteristics of Enterocytozoon bieneusi in HIV/AIDS   patients from Guangxi Zhuang autonomous region, China. BMC InfectDis. 2017,   17:684. doi: 10.1186/s12879-017-2787-9

23.   Li   Zheng, Yuan Hu,Yanjuan Wang, Xibao Huang, Yuxin Xu, Yujuan Shen*,   Jianping Cao*. Recruitment of neutrophils mediated by Vγ2 γδ T cells   deteriorate liver fibrosis induced by Schistosoma japonicum infection   in C57BL/6 mice.Infect Immun, 2017, 85(8): e01020-16

24.   Ying   Wang, Hejun Zhou, Yujuan Shen*, Yanjuan Wang, Weiping Wu, Haipeng Liu,   Zhongying Yuan, Yuxin Xu, Yuan Hu, Jianping Cao*. Impairment of dendritic   cell function and induction of CD4⁺CD25⁺Foxp3⁺   T cells by excretory-secretory products: a potential mechanism of immune   evasion adopted by Echinococcus granulosus. BMC Immunol.   2015,11:119  doi: 10.1186/s12865 -015-0110-3

25.   Jiang Y,   Ren J, Yuan Z, Liu A, Zhao H, Liu H, Chu L, Pan W, Cao J, Lin Y, Shen Y*.Cryptosporidium   andersoni as a novel predominant Cryptosporidium species in   outpatients with diarrhea in Jiangsu Province, China. BMC Infect Dis. 2014,14:555.   doi: 10.1186/s12879-014-0555-7

26.   Wei Pan, Yujuan Shen*, Xiuming Han, Ying Wang, Hua Liu, Yanyan Jiang, Yumei Zhang, Yanjuan Wang, Yuxin Xu, Jianping Cao*. Transcriptome profiles   of the protoscoleces of Echinococcus granulosus reveal that   excretory-secretory products are essential to metabolic adaptation. PLoS Negl   Trop Dis, 2014,8(12):e3392. doi:10.1371/journal.pntd.0003392 

27.   Hua Liu, Yujuan   Shen*, Jianhai Yin, Zhongying Yuan, Yanyan   Jiang, Yuxin Xu, Wei Pan, Yuan Hu, Jianping Cao.   Prevalence and genetic characterization of Cryptosporidium, Enterocytozoon,Giardia and Cyclosporain   diarrheal outpatients in China. BMC Infect Dis, 2014,   doi:10.1186/1471-2334-14-25

28.   Weizhe   Zhang, Rongjun Wang, Fengkun Yang, Longxian Zhang, Jianping Cao, Xiaoli   Zhang, Hong Ling, Aiqin Liu, Yujuan Shen*.Distribution and genetic   characterizations of Cryptosporidium spp. in pre-weaned dairy calves   in Northeastern China's Heilongjiang Province. PLoS ONE, 2013, 8(1): e54857.   doi:10.1371/journal. pone.0054857

29.   Jianhai   Yin, Zhongying Yuan, Huixia Cai, Yujuan Shen*, Yanyan Jiang, Jing   Zhang, Yanjuan Wang, Jianping Cao. Age-related infection of Cryptosporidium   species and genotype in pigs in China. Biomed Environ Sci, 2013,26(6):465-470

30.   Shen   Yujuan, Yin Jianhai,Yuan Zhongying, Lu Weiyuan, Xu Yuxin, Xiao   Lihua, Cao Jianping. The identification of the Cryptosporidium ubiquitum in   pre-weaned ovines from Aba Tibetan and Qiang autonomous prefecture in China.   Biomed Environ Sci,   2011,24(3):315-320

31.   Jing   Zhang, Yujuan Shen*(co-first author), Zhongying Yuan, Jianhai   Yin,  Wei Zang, Yuxin Xu, Weiyuan Lu, Yanjuan Wang, Ying Wang, Jianping   Cao. Primary Analysis of the Expressed Sequence Tags in a Pentastomid   Nymph cDNA Library.PLoS ONE, 2013,8(2): e56511,   doi:10.1371/journal.pone.0056511

32.   Jianhai   Yin,Yujuan Shen(co-first author), Zhongying Yuan, Weiyuan Lu, Yuxin   Xu, Jianping Cao. Prevalence   of the Cryptosporidium Pig Genotype II in Pigs from the Yangtze River   delta, China. PLoS ONE, 2011,6(6):e20738.   doi:10.1371/ journal.pone. 0020738

33.   Weizhe   Zhang, Yujuan Shen(co-first author), Rongjun Wang, Aiqin Liu, Hong   Ling, Yihong Li, Jianping Cao, Xiaoyun Zhang, Jing Shu, Longxian Zhang.Cryptosporidium   cuniculus and Giardia duodenalis in Rabbits: Genetic Diversity and   Possible Zoonotic Transmission.PLoS ONE ,2012,7(2): e31262.   doi:10.1371/journal.pone. 0031262

Patents

1. Yujuan Shen, Jianping   Cao, Hua Liu, Yanyan Jiang, Jianhai Yin, Yanjuan Wang.  Multiplex   PCR kit and detection method for detecting intestinal protozoa.  ZL   201510093500.9，2/2017

2. Yujuan Shen,   Shengxia Chen, Hong Jin, Feng Li, Yuqing Pan, Qiyan Sun, Liang Wu, Jiangping   Cao.  Identification method   for parasite egg via image.  ZL   201110022426.3，10/2012   (transformed)

3. Jianhai Yin,   Jianping Cao, Congshan Liu, Haobing Zhang, Yujuan Shen.  Application   of ursolic acid in preparing anti-hydatid   drugs.  ZL 2016 1 0517861.6，4/2019

4. Jianping Cao, Ugwu Chidiebere Emmanuel,Yujuan Shen,   Yanyan Jiang, Liping Duan, Zhongying Yuan. Function of Ginkgolic   Acids for against Cryptosporidium.    ZL 201310539693.7,  3/2016

5. Jianping Cao, Huixia   Cai, Yujuan Shen, Xiumin Han, Yuan Hu, Hu Wang, Weiyuan Lu, Yuxin Xu, Yayi   Guan. Recombinant antigen for diagnosis of Echinococcus   granulosus, which   application and preparation   method.  ZL 201010284913.2，8/2012

Honors   and Awards

1. Application   and   research on   pathogen and molecular identification of key emerging   intestinal   protozoa    in   China.    Shanghai   Science and Technology Progress Award, the second   prize, 2019;  Chinese Medical Science and Technology   Award,    the second prize, 2019; Huaxia Medical Science and Technology   Award,    the third prize, 2019

2. Application   and   research on nucleic   acid detection and molecular identification   of Cryptosporidium in China.  Chinese   Preventive Medical Science and Technology Award,  the   third prize, 2015

3.   Shanghai health systm, three, eight red flag group,  2017-2018(PI)

Lectures

Laboratory biosafety   practices， PCR test