欧洲杯竞猜平台-百度百科

Name:Feng Wang
Office Location:Room 807, No.5 Bldg., 280 South Chongqing Rd.,Shanghai
Telephone:86-21-53594658
Email:wangfeng16@sjtu.edu.cn

Biography & Research Interests
Publications
Lab Members

Education

2001-2005

Beijing Normal University

B.S. Biology

2005-2010

National Institute of Biological Sciences (NIBS) and Beijing Normal University

Ph.D. Biochemistry and Molecular Biology

Career

2010-2013

Stanford University School of Medicine, Advisor: Prof. Mark M. Davis Postdoctoral Research Fellow

2013-2016

Stanford University School of Medicine, Advisor: Prof. Mark M. Davis Research Associate

2016-present

Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine Principal Investigator

Research Interests

The research in my laboratory focuses on the mechanism of antigen recognition, signaling transduction and metabolic regulation of T lymphocytes. Three research directions include: (1) Regulation of immune cell signaling by naturally occurring metabolites; (2) The role of TCR signaling and repertoire in anti-tumor immune response; (3) The mechanism of anti-tumor immunity and autoimmunity induced by immune checkpoint blockade.

1. Liang W, Yi R, Wang W, Shi Y, Zhang J, Xu X, Wang Q, Liu M, Wang F#. Enhancing the antitumor immunity of T cells by engineering the lipid-regulatory site of the TCR/CD3 complex. Cancer Immunology Research, 2022 In press.

2. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F#. Disulfiram bolsters T cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO Journal, 2022; e110636. doi: 10.15252/embj.2022110636.

3. Zhao X, Liang W, Wang Y, Yi R, Luo L, Wang W, Sun N, Yu M, Xu W, Sheng Q, Lu L, Pang J, Lv Z#, Wang F#. Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis. Cell & Bioscience, 2022.

4. Wang Y, Jin H, Wang Y, Yao Y, Yang C, Meng J, Tan X, Nie Y, Xue L, Xu B, Zhao H, Wang F#. Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics, 2021; 11(20):10074-10090. doi:10.7150/thno.61646.

5. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F#. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery, 2021，28;7(1):89. doi: 10.1038/s41421-021-00321-x.

6. Qian Y, Yu W, Grzeskowiak C, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, Boehmer L, Metzner T, Leppert J, Chien Y, Kuo C, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor infiltrating T cells with broad antigen specificities. PNAS, 2021, doi.org/10.1073/pnas.2016168118.

7. Zhao X, Luo X, Sun R, Wang F#, and Sun X#. The interaction between microglia and macroglia in glaucoma, Frontiers in Neuroscience, 2021, doi: 10.3389/fnins.2021.610788.

8. Wang Y, Zhao X, Gao M, Wan X, Guo Y, Qu Y, Chen Y, Li T, Liu H, Jiang M, Wang F#, and Sun X#. Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment. Cell Death & Disease, 2021, DOI:10.21203/rs.3.rs-80015/v1.

9. Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F#, and Sun X#. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in Cell and Developmental Biology, 2021, Doi: 10.3389/fcell.2021.639851.

10. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Chen J, Liang J, Li Y, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu S, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zou Z, Bai F, Huang X, Zhou P#, Jiang Q#, Huang Z#, Bei J#, Wei L#, Bian X#, Liu X#, Cheng T#, Li X#, Zhao P#, Wang F#, Wang H#, Su B#, Zhang Z#, Qu K#, Wang X#, Chen J#, Jin R#, Zhang Z#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell, 2021, DOI: 10.1016/j.cell.2021.01.053.

11. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM#, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

12. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

13. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

14. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

15. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

16. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

17. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

18. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

19. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

20. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

21. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

22. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

23. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

24. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

25. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.