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Geng Y, Li L, Yan J, Liu K, Yang A, Zhang L, Shen Y, Gao H, Wu X, Noth I, Huang Y, Liu J, Fan X. PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis. Nat Commun. 2022 Nov 19;13(1):7114. PMID: 36402779

Xiang H, Tao Y, Jiang Z, Huang X, Wang H, Cao W, Li J, Ding R, Shen M, Feng R, Li L, Guan C, Liu J, Ni J, Chen L, Wang Z, Ye Y, Zhong Q, Liu J, Zou Q, Wu X*. Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation. Cell Rep. 2022 Jun 14;39(11):110943. PMID: 35705052.  

Wang D#, Yuan T#, Liu J#, Wen Z, Shen Y, Tang J, Wang Z*, Wu X*. ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. Eur J Immunol. 2022 Apr 15. PMID: 35426127

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Ni J, Guan C, Liu H, Huang X, Yue J, Xiang H, Jiang Z, Tao Y, Cao W, Liu J, Wang Z, Wang Y*, Wu X*. Ubc13 promotes K63-linked poly-ubiquitination of NLRP3 to activate inflammasome. Journal of Immunology 2021; 206(10):2376-2385. PMID: 33893171

Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J*, Cheng J*, Wu X*. SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation. Theranostics 2021; 11(8):3981-3995. PMID: 33664876

Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y. TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination. J Exp Med. 217(7):e20192083. (2020). PMID: 32324863

Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 39 (2):e102201. (2020) PMID: 31762063

Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 22; 75(4):823-834 (2019). PMID: 31302001

Huang X, Zuo Y, Wang X, Wu X, Tan H, Fan Q, Dong B, Xue W, Chen GQ, Cheng J. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Res. 79(15):3891-3902. (2019). PMID: 31186231

Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 9(1):3157. (2018) PMID: 30089837

Todoric J#, Antonucci L#, Di Caro G#, Li N#, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 32(6):824-839.e8. (2017) PMID: 29153842

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3Kγ is a molecular switch that controls immune suppression. Nature 2016 Sep 19. doi: 10.1038/nature19834. [Epub ahead of print] PMID: 27642729

Wu X, M Karin. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 266(1):161-74. (2015) PMID: 26085214

Jo M, Schmidt J, Zhou T, Wu X, Crosby J, Brand E, Kim Y, and Macleod R. Strong pharmacological activity of locally administered next-generation antisense oligonucleotides (ASOs) in orthotopic lung cancer mouse models. Journal of Thoracic Oncology. 11(25): S26 (2015). DOI: http://dx.doi.org/10.1016/j.jtho.2015.12.043

Inokuchi-Shimizu S, EJ Park, YS Roh, L Yang, B Zhang, J Song, S Liang, M Pimienta, K Taniguchi, X Wu, K Asahina, W Lagakos, MR Mackey, S Akira, MH Ellisman, DD Sears, JM Olefsky, M Karin, DA Brenner, E Seki. TAK1-Mediated Autophagy and Fatty Acid Oxidation Prevent Hepatosteatosis and Tumorigenesis. J Clin Invest. 124(8):3566-78. (2014) PMID: 24983318

Charlaftis N, Suddason T, X Wu, M Karin and E Gallagher. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 33(21):2581-96. (2014) PMID: 25260751

Zhang H, H Hu, N Greeley, J Jin, A Matthews, E Ohashi, M Caetano, H Li, X Wu, P Mandel, J McMurray, SJ Moghaddam, S-C Sun, S. Watowich. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nature Communications 2014 Dec 15; 5:5798. doi: 10.1038/ncomms6798. (2014) PMID: 25503582

Wu X, W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin. Ubiqutin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade. PNAS (2014) 111(38): 13870-5. PMID: 25189770 Highlighted in International, National and Regional Media including Union-Tribute San Diego Sept 7, 2014; and Science Signaling Editors’ Choice 7 (345), ec264.

Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 123(5):2231-43. (2013) PMID: 23563314

Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1. Cancer Cell. 23(5):647-59. (2013) PMID: 23602409

Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 32(6):816-28. (2013) PMID: 23422957

Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 13: 481-490 (2012) PMID: 22484734

Wu X#, Zhang M# and Sun S-C. Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax. Cell & Bioscience 2011 Aug 8; 1(1):27. PMID: 21824392

Hu H#, Wu X#, Jin W, Chang M, Cheng X and Sun S-C. Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. PNAS 2011 Aug 2; 108(31):12827-32. Epub 2011 Jul 18. [* co-first author] PMID: 21768353

Zhang M, Lee AJ, Wu X, Sun SC. Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol. 8(6):502-4 (2011). PMID: 21946435

Xu G, Y-C Lo, Q Li, G Napolitano, Wu X, X Jiang, Karin M and Wu H. Crystal structure of the inhibitor of κB kinase β (IKKβ). Nature 472 (7343):325-30 (2011). PMID: 21423167

Lee A#, Wu X#, H Cheng, X Zhou, X Cheng, and S-C Sun. CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling. J. Biol Chem. 2010 Mar25. 285(21): 15696-703 (2010). PMID: 20233721

Wu X, M Yamamoto, S Akira, and S-C Sun. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. PNAS 106 (49): 20836-41 (2009). PMID: 19926860

Zhang M#, Wu X#, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun. Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem. 283(27): 8621-6 (2008). PMID: 18467330

Wu X, S-C Sun. Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association. EMBO Rep. 8(5): 510-5 (2007). PMID: 17363973

Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med. 204(6): 1475-85 (2007). PMID: 17548520

Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M, Sun SC. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem. 282(21): 15884-93 (2007). PMID: 17392286

Babu G, Waterfield M, Chang M, Wu X, Sun SC. Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem. 281(20): 14041-7 (2006). PMID: 16565081

Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC. Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim Biophys Acta. 1763(2): 174-81 (2006). PMID: 16448710

Reiley W, M Zhang, Wu X, E Granger, and S-C Sun. Regulation of the deubiquitinating enzyme CYLD by IKKγ-dependent phosphorylation. Mol. Cell. Biol. 25(10): 3886-95 (2005). PMID: 15870263

Abdul-Kareem AR, Sheng C, Shi, M, An C, Wu X, Li D and Du R. Isolation and Characterization of a Salt-induced Transcript from Halophyte Spartina Anglica Using DDRT-PCR. Acta Scientiarum Naturalium Universitatis Nankaiensis (Natural Science Edition) 36 (2) 8-14 (2003).

Ye M, Sheng C, Shi M, An C, Ji J, Wu X, Du R and Li D. Detection of Potato Spindle Tuber Viroid by Single-enzyme RT-PCR. Acta Agriculturae Boreali-Sinica 17 (1) 41-45 (2002).

Ji J, Sheng C, Shi M, An C, Wu X, Li D and Du R. A Study on the Transformation of Wheat with Salt-tolerant Gene HVA1 by Method Deflating Pollen Tube. Journal of Triticeae Crops 22(2): 10-13 (2002).