Research

    

  • Name:Huihui Zhang

  • Office Location:280 South Chongqing Road, Room 1011, West #5 Building, Shanghai, China 200025

  • Telephone:86-021-63846590-776629

  • Email:huizha@shsmu.edu.cn


Education


2000.09-2004.07 Inner Mongolia University B.S.
2004.09-2009.07 University of Chinese Academy of Sciences Ph.D



Career

2009.9-2013.8 Karolinska Institutet     Postdoctoral Fellow
2014.5- Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Associate Investigator

Research Interests

1. Fcγ receptors functions and regulatory mechanisms
2. Redox regulation of Innate and adaptive immunity



1.  Zhang, H., Du, Y., Zhang, X., Lu, J., and Holmgren A. .Glutaredoxin2 Reduces both Thioredoxin2 and Thioredoxin1 and Protects Cells from Apoptosis Induced by Auranofin and 4-Hydroxynonenal.Antioxid. Redox Signal.,2014,21,669-81.   [Link]

2.  Du, Y., Zhang, H., Montano, S., Hegestam, J., Ekberg, N. R., Holmgren, A., Brismar, K., and Ungerstedt, J. S..Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes.Acta diabetologica,2014,51,225-32.   [Link]

3.  Du, Y., Zhang, H., Zhang, X., Lu, J., and Holmgren, A..Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by glutaredoxin system.J. Biol. Chem.,2013,288, 32241-7.   [Link]

4.  Du, Y., Zhang, H., Lu, J., and Holmgren, A..Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.J. Biol. Chem.,2012,287, 38210-9.   [Link]

5.  Ungerstedt, J., Du, Y., Zhang, H., Nair, D., and Holmgren, A..In vivo redox state of human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).Free Radic. Biol. Med.,2012,53, 2002-7.   [Link]

6.  Zhang, H., Cao, D. , Cui, W., Ji, M., Qian, X., and Zhong, L..Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.Free Radic. Biol. Med.,2010,49, 2010-8.   [Link]

7.  Zhang, H., and Zhong, L..Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.Eur. J. Pharmacol.,2010,626, 276-82 .   [Link]

8.  Cao, D., Zhang, Y., Zhang, H., Zhong, L., and Qian, X..Systematic Characterization of the Covalent Interactions between (-)-Epigallocatechin Gallate and Peptides at Physiological Conditions by Mass Spectrometry.Rapid Commun. Mass Spectrom.,2009,23, 1147-57.   [Link]

9.  Du, Y., Wu, Y., Cao, X., Cui, W., Zhang, H., Tian, W., Ji, M., Holmgren, A., and Zhong, L..Inhibition of mammalian thioredoxin reductase by black tea and its constituents: Implications for anticancer actions.Biochimie,2009,91, 434-4.   [Link]

10.  Wang, Y., Zhang, H., Holmgren, A., Tian, W., and Zhong, L. .Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.Oncol. Rep.,2008,20, 1479-87.   [Link]


                 

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