Research

  • Name:Xiaodong Yang

  • Office Location:Room 1006, Building 5, 280 South Chongqing Road, Huangpu District, Shanghai 200025

  • Telephone:86-021-54610176

  • Email:xdyang@shsmu.edu.cn

Education


2001.09-2005.07 Tsinghua University Ph.D.
1994.09-1998.07 China Agricultural University B.S.
1998.09-2001.07 China Agricultural University M.S.
2006.01-2010.02 University of Illinois at Urbana-Champaign Postdoc
2010.02-2011.11 University of Texas Southwestern Medical Center Postdoc
2014.12-2015.05 MD Anderson Cancer Center Visiting Scholar

Career

2011.12-2014.08 University of Texas Southwestern Medical Center      Instructor
2014.11-present Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Co-PI

Research Interests

Protein ubiquitination plays critical roles in the immune and inflammatory responses. However the underlying mechanisms remains largely unclear while a wide array of ubiquitin editing enzymes (E2s, E3s, and DUBs) have been identified in these processes. Our research investigates how these protein ubiquitination enzymes are regulated and how they regulate downstream events in immune signaling pathways, with emphasis on the NF-kB pathway. Specifically, we employ a combination of approaches including biochemistry, molecular biology, and mouse genetics to identify upstream regulators and downstream substrates of these enzymes and characterize their functions in health and diseases using mouse models and human patient samples. Understanding the regulatory roles of protein ubiquitination in the immune and inflammatory responses would provide new insights into immune regulation and more therapeutic options for immune and inflammatory diseases.


1.  Yang XD, Karhadkar T, Medina J, Robertson SM, Lin R..The β-catenin WRM-1 is a multifunctional regulatory subunit in the LIT-1 MAP kinase complex.Proc Natl Acad Sci U S A,2015,112(2):E137-146.   [Link]

2.  Yang XD, Sun SC..Targeting signaling factors for degradation, an emerging mechanism for TRAF functions.Immunological Reviews,2015,266(1):56-71.   [Link]

3.  Yang XD, Lo MC, Huang S, Mizumoto K, Sawa H, Xu W, Robertson SM, Lin R.Distinct and mutually inhibitory binding by two diverged beta-catenins coordinates TCF levels and activity in C. elegans.Development,2011,138(19): 4255-4265.   [Link]

4.  Yang XD, Chen LF.Talking to histone: methylated RelA serves as a messenger.Cell Research ,2011,21(4):561-563.   [Link]

5.  Yang XD, Tajkhorshid E, Chen L.Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-kappaB.Mol Cell Biol,2010,30(9): 2170-2180.   [Link]

6.  Huang B*, Yang XD*, Lamb A, Chen LF.Posttranslational modifications of NF-kappaB: Another layer of regulation for NF-kappaB signaling pathway.Cell Signal,2010,22(9): 1282-1290.   [Link]

7.  Yang XD, Huang B, Li M, Lamb A, Kelleher NL, Chen LF..Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.EMBO J,2009,28(8): 1055-1066.   [Link]

8.  Yang XD, Lamb A, Chen LF. .Lysine methylation, a new epigenetic mark for protein stability.Epigenetics,2009,4(7): 429-433.   [Link]

9.  Lamb A, Yang XD, Tsang YH, Li JD, Higashi H, Hatakeyama M, Peek RM, Blanke SR, Chen LF..Helicobacter pylori CagA stimulates NF-kB by targeting TAK1 for TRAF6-mediated K63-ubiquitination.EMBO Rep,2009,10(11): 1242-1249.   [Link]

10.  Huang B, Yang XD, Zhou MM, Ozato K, Chen LF.Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.Mol Cell Biol,2009,29(5): 1375-1387.   [Link]
                 

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