食品安全与毒理学系

王慧/ 职称：二级教授/博士生导师

学历学位：博士 研究生

Email: huiwang@shsmu.edu.cn

个人简介

王慧，欧洲杯竞猜平台特聘教授，博士生导师，欧洲杯竞猜平台公共卫生学院院长，欧洲杯竞猜平台数字医学研究院执行院长，欧洲杯竞猜平台单细胞组学与疾病研究中心中方主任，上海市黄浦区侨联主席，国家杰出青年科学基金获得者，国家百千万人才工程入选者，中国青年女科学家奖获得者，享受国务院特殊津贴专家，中科院百人计划，上海市三八红旗手、五一劳动奖章获得者，上海市优秀学术带头人，上海市领军人才，国务院食品安全委员会专家委员会委员，上海市毒理学会理事长，Elsevier高被引学者，中国侨联第九届“侨界贡献奖”一等奖获得者，科技部重点专项首席科学家。长期从事主动健康与慢病防控、营养与食品安全、健康教育与健康传播的基础和应用研究，创立基于主动健康指数的数字化全生命周期的健康管理体系在全国多地应用示范。在Nature、JAMA、Nature Microbiol、Lancet Digit Health、Lancet Psychiatry、Gut、Nat Commun等国际杂志发表SCI 论文170余篇，主编专著9部，申请专利56项，成果转化7项，形成国家、行业标准25项，获计算机软件著作权登记4项，3项视频著作权，3个系列中英文电子出版，牵头国家全民数字素养与技能培训基地、上海市营养创新平台数字营养中心、上海市病媒生物预防控制实训基地、上海市学生（青少年）科创教育基地等建设，服务2500万上海市民。

研究领域

  1. 肿瘤分子靶点和营养药学的应用基础研究：发现肿瘤人群易感标志物和诊断治疗新靶点，研究靶点功能及其分子调控和信号转导，探索以膳食营养素、天然植物活性成份、化学小分子探针等靶向干预和治疗肿瘤的新机制和新方法。

  2. 营养和食品安全的基础和应用研究：营养成分安全性评价及毒理学研究，营养素和营养素物质的安全剂量，过量时的毒理作用以及机制；食物中有毒有害物质代谢途径和致病机理，食品安全风险评估、预防控制和检测新技术研究。

研究队伍

巴 乾 副研究员, Co-PI

李晓光 副研究员, Co-PI

近期论文

  1. Yao W, Ba Q, Li X, Li H, Zhang S, Yuan Y, Wang F, Duan X, Li J, Zhang W, Wang H*. A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer. EBioMedicine. 2017 Aug;22:58-67. Epub 2017 Jul 18. (*Corresponding author)

  2. Huang C, Sun M, Yang Y, Wang F, Ma X, Li J, Wang Y, Ding Q, Ying H, Song H, Wu Y, Jiang Y, Jia X, Ba Q, Wang H*. Titanium dioxide nanoparticles prime a specific activation state of macrophages. Nanotoxicology. 2017 Jul 15:1-14. [Epub ahead of print] (*Corresponding author)

  3. Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H*. BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. J Mol Cell Biol. 2017 May 16. [Epub ahead of print] (*Corresponding author)

  4. Li C, Chen P, Duan X, Wang J, Shu B, Li X, Ba Q, Li J, Wang Y,Wang H*.Bioavailable 25(OH)D but not total 25(OH)D is an independent determinant for bone mineral density in Chinese postmenopausal women.Ebiomedicine.2016, in press.

  5. Li X, Zhou Y, Liu Y, Zhang X, Chen T, Chen K, Ba Q, Li J, Liu H,Wang H*.Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for Ovarian Cancer.Ebiomedicine2016, in press.

  6. Ba Q, Li M, Chen P, Huang C, Duan X, Lu L, Li J, Chu R, Xie D, Song H, Wu Y, Ying H, Jia X,Wang H*.Gender-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice.Environ Health Perspect.2016 Sep 16. [Epub ahead of print] (*Corresponding author)

  7. Chen P, Duan X, Li M, Huang C, Li J, Chu R, Ying H, Song H, Jia X, Ba Q,Wang H*.Systematic network assessment of the carcinogenic activities of cadmium.Toxicol Appl Pharmacol.2016 Sep 12. [Epub ahead of print] (*Corresponding author)

  8. Chen P, Li M, Duan X, Jia J, Li J, Chu R, Yu C, Han J,Wang H*.Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3.Acta Pharmacol Sin.2016 Aug 29. [Epub ahead of print] (*Corresponding author)

  9. Chen P, Li B, Zhu Y, Chen W, Liu X, Li M, Duan X, Yi B, Wang J, Liu C, Luo X, Li X, Li J, Liang J, Yin X,Wang H*, Jiang X. Establishment and Validation of a Prognostic Nomogram for Patients with Resectable Perihilar Cholangiocarcinoma.Oncotarget.2016 Apr 29. doi: 10.18632/oncotarget.9104. [Epub ahead of print] (*Corresponding author)

  10. Ba Q, Huang C, Fu Y, Li J, Li J, Chu R, Jia X,Wang H*. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells.Toxicology Research. 2016;5:107-115. (*Corresponding author)

  11. Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X,Wang H*. Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.Gut. 2015 Oct 9. (*Corresponding author)

  12. Zhang X, Ba Q, Gu Z, Guo D, Zhou Y, Xu Y,Wang H*, Ye D, Liu H. Fluorescent Coumarin–Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities.Chemistry. 2015 Nov 23;21(48):17415-21. (*Corresponding author)

  13. Ba Q, Li J, Huang C, Qiu H, Li J, Chu R,Zhang W, Xie D, Wu Y,Wang H*. Cumulative benzo(a)pyrene exposure promotes humanhepatocellular carcinoma angiogenesis and metastasis via NF-κB pathway.Environ Health Perspect. 2015 Mar;123(3):246-54. (*Corresponding author)

  14. Ba Q, Li J, Huang C, Li J, Chu R, Wu Y,Wang H*. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene.Toxicol Appl Pharmacol. 2015 Mar 1;283(2):83-91. (*Corresponding author)

  15. Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, Liu C, Shen B, Wang XA, Wu W, Zhou D, Zhang D, Wang T, Liu B, Qu K, Ding Q, Weng H, Ding Q, Mu J, Shu Y, Bao R, Cao Y, Chen P, Liu T, Jiang L, Hu Y, Dong P, Gu J, Lu W, Shi W, Lu J, Gong W, Tang Z, Zhang Y, Wang X, Chin YE, Weng X, Zhang H, Tang W, Zheng Y, He L,Wang H*, Liu Y, Liu Y. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway.Nat Genet. 2014 Aug;46(8):872-6. (*Corresponding author)

  16. Li M, Chen P, Li J, Chu R, Xie D,Wang H*. The Impacts of Circulating 25-Hydroxyvitamin D Levels on Cancer Patient Outcomes: a Systematic Review and Meta-Analysis.J Clin Endocrinol Metab. 2014 Jul;99(7):2327-36. (*Corresponding author)

  17. Chen P, Li C, Li X, Li J, Chu R,Wang H*. Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis.Br J Cancer. 2014 Apr 29;110(9):2327-38. (*Corresponding author)

  18. Li C, Chen P, Hu P, Li M, Li X, Guo H, Li J, Chu R, Zhang W,Wang H*. Folate intake and MTHFR polymorphism C677T is not associated with ovarian cancer risk: evidence from the meta-analysis.Mol Biol Rep. 2013 Dec;40(12):6547-60. (*Corresponding author)

  19. Huang C, Ba Q, Yue Q, Li J, Li J, Chu R,Wang H*. Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction.Mol Biosyst. 2013 Dec 29;9(12):3091-100. (*Corresponding author)

  20. Li J, Ba Q, Yin J, Wu S, Zhuan F, Xu S, Li J, Salazar JK, Zhang W,Wang H*. Surface Display of Recombinant Drosophila melanogaster Acetylcholinesterase for Detection of Organic Phosphorus and Carbamate Pesticides.PLoS ONE. 2013 Sep 9;8(9):e72986. (*Corresponding author)

  21. Liu Y, Li C, Chen P, Li X, Li M, Guo H, Li J, Chu R,Wang H*. Polymorphisms in the vitamin D receptor (VDR) and the risk of ovarian cancer: a meta-analysis.PLoS ONE. 2013 Jun 24;8(6):e66716. (*Corresponding author)

  22. Li M, Chen PZ, Yue QX, Li JQ, Chu RA, Zhang W,Wang H*. Pungent ginger components modulates human cytochrome P450 enzymes in vitro.Acta Pharmacol Sin. 2013 Sep 5;34(9):1237-42. (*Corresponding author)

  23. Hou W, Qin X, Zhu X, Fei M, Liu P, Liu L, Moon H, Zhang P, Greshock J, Bachman KE, Ye BC,Wang H*, Zang CY. Lapatinib inhibits the growth of esophageal squamous cell carcinoma and synergistically interacts with 5-fluorouracil in patient-derived xenograft models.Oncol Rep. 2013 Aug;30(2):707-14. (*Corresponding author)

  24. Ba Q, Duan J, Tian JQ, Wang ZL, Chen T, Li XG, Chen PZ, Wu SJ, Xiang L, Li JQ, Chu RA,Wang H*. Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish.Acta Pharmacol Sin. 2013 Aug;34(8):1101-7. (*Corresponding author)

  25. Li X, Yang X, Liu Y, Gong N, Yao W, Chen P, Qin J, Jin H, Li J, Chu R, Shan L, Zhang R, Zhang W,Wang H*. Japonicone A suppresses growth of Burkitt’s lymphoma cells through its effect on NF-κB.Clin Cancer Res. 2013 Jun 1;19(11):2917-28. (*Corresponding author)

  26. Li X ,Chen T, Lin S, Zhao J, Chen P, Ba Q, Guo H, Liu Y, Li J, Chu R, Shan L , Zhang W andWang H*. Valeriana jatamansi Constituent IVHD-valtrate As a Novel Therapeutic Agent to Human Ovarian Cancer: in vitro and in vivo Activities and Mechanisms.Curr Cancer Drug Targets. 2013 May 1;13(4):472-83. (*Corresponding author)

  27. Chen P, Li M, Gu X, Liu Y, Li X, Li C, Wang Y, Xie D, Wang F, Yu C, Li J, Chen X, Chu R, Zhu J, Ou Z,Wang H*. Higher Blood 25(OH)D Level May Reduce the Breast Cancer Risk: Evidence from a Chinese Population Based Case-Control Study and Meta-Analysis of the Observational Studies.PLoS ONE. 2013;8(1):e49312. (*Corresponding author)

  28. Lin S, Zhang ZX, Chen T, Ye J, Dai WX, Shan L, Su J, Shen YH, Li HL, Liu RH, Xu XK,Wang H*, Zhang WD. Characterization of chlorinated valepotriates from Valeriana jatamansi.Phytochemistry. 2013 Jan;85:185-93. (*Corresponding author)

  29. Ba Q, Zhou N, Duan J, Chen T, Hao M, Yang X, Li J, Yin J, Chu R,Wang H*. Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1.PLoS ONE. 2012;7(8):e42703. (*Corresponding author)

  30. Ba Q, Hao M, Huang H, Hou J, Ge S, Zhang Z, Yin J, Chu R, Jiang H, Wang F, Chen K, Liu H andWang H*. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies.Clin Cancer Res. 2011 Dec 15;17(24):7625-33. (*Corresponding author)

  31. Chen T, Xu Y, Guo H, Liu Y, Hu P, Yang X, Li X, Ge S, Velu S, Nadkarni D, Wang W, Zhang R andWang H*. Experimental therapy of ovarian cancer with synthetic Makaluvamine Analog: In vitro and in vivo anticancer activity and molecular mechanisms of action.PLoS ONE. 2011;6(6):e20729. (*Corresponding author)

  32. Duan J, Ba Q, Wang Z, Hao M, Hu P, Li X, Zhang D, Zhang R andWang H*. Knockdown of Ribosomal Protein S7 Causes Developmental Abnormalities via p53 Dependent and Independent Pathways in Zebrafish.Int J Biochem Cell Biol. 2011 Aug;43(8):1218-27. (*Corresponding author)

  33. Guo D, Chen T, Ye D, Xu j, Jiang H, Chen K,Wang H*and Liu H. Cell-permeable Iminocoumarine-based Fluorescent Dyes for Mitochondria.Org Lett. 2011 Jun 3;13(11):2884-7. (*Corresponding author)

  34. Li M, Zhou Y, Chen P, Yang H, Yuan X, Tajima K, Cao J andWang H*. Genetic Variants on Chromosome 8q24 and Colorectal Neoplasia Risk: A Case-control Study in China and a Meta-analysis of the Published Literature.PLoS ONE. 2011 Mar; 6(3):e18251. (*Corresponding author)

  35. Hao M, Wang W, Zhao Y, Zhang R andWang H*. Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors.Eur J Drug Metab Pharmacokinet. 2011 Jan;35(3-4):109-13. (*Corresponding author)

  36. Hao M, Ba Q, Yin J, Li J, Zhao Y andWang H*. Deglycosylated ginsenosides are more potent inducers of CYP1A1, CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides.Drug Metabolism and Pharmacokinetics. 2011;26(2):201-5. (*Corresponding author)

  37. Liang J, Chen P, Hu Z, Shen H, Wang F, Chen L, Li M, Tang J,Wang H*and Shen H. Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population.Breast Cancer Res Treat. 2010 Nov;124(1):237-41. (*Corresponding author)

  38. Feng Y, Ding X, Chen T, Chen L, Liu F, Jia X, Luo X, Shen X, Chen K, Jiang H,Wang H*, Liu H, Liu D. Design, synthesis and interaction study of quinazoline-2(1H)-thione derivatives as potential novel Bcl-xL Inhibitors.J Med Chem. 2010 May 13;53(9):3465-79. (*Corresponding author)

  39. Lin S, Chen T, Liu XH, Shen YH, Li HL, Shan L, Liu RH, Xu XK, Zhang WD,Wang H*. Iridoids and Lignans from Valeriana jatamansi.J Nat Prod. 2010 Apr 23;73(4):632-8. (*Corresponding author)

  40. Chen P, Hu P, Xie D, Qin Y, Wang F, andWang H*. Meta-analysis of Vitamin D, Calcium and the Prevention of Breast Cancer.Breast Cancer Res Treat. 2010 Jun;121(2):469-77. (*Corresponding author)

  41. Chen T, Li M, Zhang R, andWang H*. Dihydroartemisinin Induces Apoptosis and Sensitizes Human Ovarian Cancer Cells to Carboplatin Therapy.J Cell Mol Med. 2009 Jul;13(7):1358-70. (*Corresponding author)

  42. Lin S, Shen YH, Li HL, Yang XW, Chen T, Lu LH, Huang ZS, Liu RH, Xu XK, Zhang WD,Wang H*. Acylated iridoids with cytotoxicity from Valeriana jatamansi.J Nat Prod. 2009 Apr;72(4):650-5. (*Corresponding author)

  43. Liang J, Chen P, Hu Z, Zhou X, Chen L, Li M, Wang Y, Tang J,Wang H*and Shen H. Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women.Carcinogenesis. 2008 Dec;29(12):2341-6. (*Corresponding author)

  44. Chen P, Liang J, Wang Z, Zhou X, Chen L, Li M, Xie D, Hu Z, Shen H, andWang H*. Association of Common PALB2 Polymorphisms with Breast Cancer Risk: a Case-Control Study.Clin Cancer Res. 2008. Sep 15; 14 (8): 5931-37. (* Corresponding author)

  45. Hou J, Wang D, Zhang R, andWang H*. Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action.Clin Cancer Res. 2008 Sep 1; 14(17):5519-30. (* Corresponding author)