个人简介
2003-2007年毕业于英国爱丁堡大学，获生物技术学士学位；2008-2009年毕业于英国剑桥大学，获生物信息学硕士学位；2012-2016年毕业于英国剑桥大学，获生物信息学博士学位。期间曾在辉瑞制药，桑格基因研究所，剑桥大学血液系工作实习。2016-2020年于英国剑桥大学干细胞所Bertie Gottgens教授实验室任博士后，主要负责生物大数据分析、分析流程的构建以及相关算法的优化和开发。特别是利用单细胞多组学测序技术，研究心脏早期发育、心脏损伤修复以及血液分化和各种血液疾病模型，通过生物信息学方法揭示细胞异质性，并开发新的细胞分化途径算法，以阐明底层的分子调控机制。共发表论文15篇，其中近5年发表Science 1篇（2018，IF 41.845，共同一作第二位），Nature Communications 1篇（2020，IF 12.124，共同一作第二位），OncoImmunology 1 篇（2021，IF 5.869，一作），Development 1篇（2020，IF 5.843，共同一作第二位）。
主要研究方向
通过单细胞多组学测序，从造血角度，在细胞和分子层面解读心血管疾病，特别是动脉粥样硬化的发生与发展。相关结果将为未来医疗转化提供一个新的视角，可以通过调控造血的方式，来防范动脉粥样硬化和/或减轻疾病症状。
主要研究成果
1. Wang X, Peticone C, Kotsopoulou E, Gottgens B, Calero-Nieto FJ. Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures. OncoImmunology. 2021 Jan 06;10(1): 1866287. doi:10.1080/2162402X.2020.1866287
2. Koth J*, Wang X*, Killen AC*, Stockdale WT, Potts HG, Jefferson A, Bonkhofer F, Riley PR, Patient RK, Göttgens B, Mommersteeg MTM. Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development. 2020 Apr 27;147(8):dev186569. doi: 10.1242/dev.186569.
3. Basilico S*, Wang X*, Kennedy A, Tzelepis K, Giotopoulos G, Kinston SJ, Quiros PM, Wong K, Adams DJ, Carnevalli LS, Huntly BJP, Vassiliou GS, Calero-Nieto FJ, Göttgens B. Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML. Nat Commun. 2020 Mar 16;11(1):1407. doi: 10.1038/s41467-020-15220-0.
4. Lescroart F*, Wang X*, Lin X*, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C. Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq. Science. 2018 Mar 9;359(6380):1177-1181.
5. Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E. Myeloid progenitor cluster formation drives emergency and leukaemicmyelopoiesis. Nature. 2017 Apr 6;544(7648):53-58.
6. Wilson NK1, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010 Oct 8;7(4):532-44.
1. Hamey FK, Lau WWY, Kucinski I, Wang X, Diamanti E, Wilson NK, Göttgens B, Dahlin JS. Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development. Allergy. 2020 Oct 20. doi: 10.1111/all.14633.
2. Vink CS, Calero-Nieto FJ, Wang X, Maglitto A, Mariani SA, Jawaid W, Göttgens B, Dzierzak E. Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells. Cell Rep. 2020 May 12;31(6):107627. doi: 10.1016/j.celrep.2020.107627.
3. Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9.
4. Castaño J, Aranda S, Bueno C, Calero-Nieto FJ, Mejia-Ramirez E, Mosquera JL, Blanco E, Wang X, Prieto C, Zabaleta L, Mereu E, Rovira M, Jiménez-Delgado S, Matson DR, Heyn H, Bresnick EH, Göttgens B, Di Croce L, Menendez P, Raya A, Giorgetti A. GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm. Stem Cell Reports. 2019 Sep 10;13(3):515-529. doi: 10.1016/j.stemcr.2019.07.009. Epub 2019 Aug 8
5. Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambile D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P. Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions. Haematologica. 2019 Jan 24.
6. Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E. Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors. Nat Commun. 2018 Oct 5;9(1):4100.
7. Gracia T, Wang X, Su Y, Norgett EE, Williams TL, Moreno P, Micklem G, Frankl FE. Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney. Sci Rep. 2017 Jan 17;7:40601.
8. Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Göttgens B, Kouzarides T. Three distinct patterns of histone H3Y41 phosphorylation mark active genes. Cell Rep. 2012 Sep 27;2(3):470-7.
9. Tijssen MR1, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH, Göttgens B. Ouwehandand Berthold Göttgens. Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators. Dev Cell. 2011 May 17;20(5):597-609.
10. Joshi N., Wang X, Montgomery, L., Elfick, A., and French, C. Novel approaches to biosensors for detection of arsenic in drinking water. Desalination 2010. 252, 100-106.
11. Wang X, Burrows J. Assessment of Dry Powder Lactose Formulation Characteristics for Delivery to Rat Airways. DDL17, 2006.
