个人简介：
2006年毕业于中国科学院上海生命科学研究院生物化学与细胞生物学研究所，获生物化学与分子生物学博士学位；2006-2020，中国科学院上海生命科学研究院，生物化学与细胞生物学研究所，期间聘任为副研究员。2020年3月加入欧洲杯竞猜平台公共卫生学院单细胞组学与疾病研究中心，任质谱平台负责人。2020年12月破格晋升为研究员。发表SCI研究论文22篇（Cancer Cell, Genomics, Proteomics & Bioinformatics, Cell Death Dis., J Mol Cell Biol., Cell Res., Nat Chem Biol.等），参与编撰国际系列丛书《Methods Mol Biol.》1部、专业书籍《蛋白质化学与蛋白质组学》1部。参与申请中国发明专利25项，其中12项获得授权。
社会任职/学术头衔：
担任Genomics, Proteomics & Bioinformatics、World Journal of Gastroenterology等期刊审稿人。入选浦东新区科学技术专家库、上海市科技专家库。
主要研究方向：
主要从事质谱技术的开发及其在癌症、疾病动物模型、心血管疾病和信号转导途径研究的应用，结直肠癌、胰腺癌、肺癌的蛋白质基因组学等多组学研究。
主要研究课题：
主持国家自然科学基金青年科学基金项目（1项）、上海生科院优秀青年人才领域前沿项目（1项）。参与科技部973计划（3项）、国家自然科学基金重大研究计划（2项）、国家自然科学基金面上项目（1项）、中国科学院战略性先导科技专项（1项）、国家重点研发计划重点专项项目（1项）。
获得荣誉称号：中国科学院院长优秀奖学金，第八届复旦大学谈家桢基金生命科学九源奖学金，赛诺菲—中国科学院上海生命科学研究院优秀青年人才。
主要研究成果 (#第一作者, *通讯作者) ：
1. Wu Y, Cao Y, Xu K, Zhu Y, Qiao Y, Wu Y, Chen J, Li C*, Zeng R*, Ge G*. Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis. Cell Death Dis. 2021, 12(2): 163. (IF= 6.304)
2. Sun Y#, Li C#, Pang S, Yao Q, Chen L*, Li Y*, Zeng R*. Kinase-substrate edge biomarkers provide a more accurate prognostic prediction in ER-negative breast cancer. Genomics, Proteomics & Bioinformatics. 2021. [in press] (IF=7.051)
3. Li C#, Sun Y#, Yu G#, Cui J#, Lou Z#, Zhang H, Huang Y, Bai C, Deng L, Liu P, Zheng K, Wang Y, Wang Q, Li Q, Wu Q, Liu Q, Shyr Y, Li Y, Chen L, Wu J*, Zhang W*, Zeng R*. Integrated Omics of Metastatic Colorectal Cancer. Cancer Cell. 2020 Nov 9;38(5):734-747. (IF=26.602)
4. Han J#, Yu M#, Bai Y#, Yu J#, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H*, Wu D*, Li L*. Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. Cancer Cell. 2020 Dec 14;38(6):844-856.
5. Tang Y#, He Y#, Li C# Mu W, Zou Y, Liu C, Qian S, Zhang F, Pan J, Wang Y, Huang H, Pan D, Yang P, Mei J*, Zeng R*, Tang QQ*. RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases. Cell Discov. 2018 Aug 21;4:52. (IF=4.600)
6. Li M#, Li C#, Liu W, Liu C, Cui J, Li Q, Ni H, Yang Y, Wu C, Chen C, Xing Z, Liu X, Zeng T, Zhao M, Chen L, Wu J*, Zeng R*, Chen L*. Dysfunction of PLA2G6 and CYP2C44 associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma. J Mol Cell Biol. 2017 Dec 1;9(6):489-503. (IF=5.595)
7. Zhu X, Yuan C, Tian C, Li C, Nie F, Song X, Zeng R, Wu D, Hao X, Li L*. The plant sesquiterpene lactone parthenoide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1. J Biol Chem. 2018 Apr 6;293(14):5335-5344.
8. He X#, Zhang W#, Yan C#, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W*, Hao X*, Li L*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discovery. 2017, 3, 17003.
9. Liang J#, Cao R#, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W, Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res. 2017 Mar;27(3):329-351.
10. Li F#, Fang Z#, Zhang J#, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H*.Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell Res. 2016 Oct;26(10):1149-1164.
11. Sheng Q#, Li R#, Dai J#, Li Q, Su Z, Guo Y, Li C, Shyr Y*, Zeng R*. Preprocessing significantly improves the peptide/protein identification sensitivity of high-resolution isobarically labeled tandem mass spectrometry data. Mol Cell Proteomics. 2015 Feb;14(2):405-17.
12. Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L*. Smurf1-mediated Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively regulates Wnt/β-catenin signaling. Mol Cell Biol. 2013, 33(20):4095-105.
13. Wang S#, Yin J#, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X*, Li L*. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.
14. Li C#, Ruan HQ#, Liu YS#, Xu MJ, Dai J, Sheng QH, Tan YX, Yao ZZ, Wang HY, Wu JR, Zeng R*. Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma. J Proteome Res. 2012 Feb 3;11(2):871-85. (IF=5.056)
15. Wu C#, Wei W#, Li C, Li Q, Sheng Q, Zeng R*. J Proteome Res. Delicate analysis of post-translational modifications on Dishevelled 3. 2012 Jul 6;11(7):3829-37.
16. Liu YS#, Luo XY#, Li QR, Li H, Li C, Ni H, Li RX, Wang R, Hu HC, Pan YJ, Chen HQ*, Zeng R*. Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer. J Mol Cell Biol. 2012 Oct;4(5):344-7.
17. Micutkova L, Diener T, Li C, Rogowska-Wrzesinska A, Mueck C, Huetter E, Weinberger B, Grubeck-Loebenstein B, Roepstorff P, Zeng R, Jansen-Duerr P*. Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts. Mech Ageing Dev. 2011 Oct;132(10):468-79.
18. Sun B, Guo S, Tang Q, Li C, Zeng R, Xiong Z, Zhong C, Ding J*. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. Cell Res. 2011 Aug;21(8):1262-6.
19. Liu Y#, Li C#, Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M*, Zeng R*. Proteomic mining in the dysplastic liver of WHV/c-myc mice--insights and indicators for early hepatocarcinogenesis. FEBS J. 2010 Oct;277(19):4039-53. (IF=3.129)
20. Li C, Hong Y, Tan YX, Ai JH, Zhou H, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*. Analysis of microdissected cells by two-dimensional LC-MS approaches. Methods Mol Biol. 2008;428:193-208.
21. Ding Y#, Xi Y#, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L*. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008 Sep 8;182(5):865-72.
22. Li C#, Tan YX#, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC, Wu JR, Wang HY*, Zeng R*. Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers. Proteomics. 2005 Mar;5(4):1125-39. (IF=6.088)
23. Li C, Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*, Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mol Cell Proteomics. 2004 Apr;3(4):399-409. (IF=9.624)
24. 屠成剑, 李辰, 第十三章, 样品的全息制备; 丁士健, 唐柳娅, 李辰, 第二十三章, 蛋白质组学在各领域中的应用; 曾嵘、夏其昌主编, 《蛋白质化学与蛋白质组学》, 1 ed. 北京: 科学出版社, 2004
25. 曾嵘,张卫,吴家睿,李辰,孙怡迪,于冠宇,崔静如,楼征,张杭,黄亚. 2020.8.28申请,申请号202010879274.8
26. 曾嵘,高笑静,李辰. 2019.1.21申请,申请号201910053299X
27. 曾嵘,高笑静,李辰. 2019.1.21申请,申请号2019100537705
28. 曾嵘,李辰,高笑静. 2019.1.21申请,申请号2019100532839
29. 曾嵘,吴家睿,李辰,李青润,袁亚俊. 2018.5.30申请,申请号201810538149.3
30. 曾嵘,吴家睿,李青润,李辰,袁亚俊. 2018.5.30申请,申请号201810538815.3
31. 曾嵘,吴家睿,袁亚俊,李辰,李青润. 2018.5.30申请,申请号201810538134.7
32. 曾嵘,吴家睿,金钢,李辰,郭世伟,袁亚俊. 2018.5.30申请,申请号201810538083.8
33. 金钢,曾嵘,吴家睿,郭世伟,李辰,袁亚俊. 2018.5.30申请,申请号201810538192.X
34. 曾嵘,陈海泉,吴庆庆,罗晓阳,李辰. 2017.7.14申请,申请号201710574961.7
35. 曾嵘, 陈洛南,王红阳,陈磊,李辰,李美仪,杨应成,刘伟鑫2017.6.5申请,申请号201710414593.X
36. 王红阳,陈磊,陈洛南,曾嵘, 杨应成,李美仪,李辰,刘伟鑫.2017.6.5申请,申请号201710413397.0
37. 陈洛南,曾嵘,王红阳,陈磊,李美仪,李辰,杨应成,刘伟鑫.2017.6.5申请,申请号201710414134.1
38. 曾嵘,阮宏强,徐孟杰,李辰,武祎. 2013.10授权,申请号ZL200910056784.9
39. 曾嵘,徐孟杰,李辰,武祎,阮宏强. 2013.10授权,申请号ZL200910056785.3
40. 曾嵘,王红阳,夏其昌,李辰,谈冶雄.2012.07授权,申请号ZL200410025465.9
41. 曾嵘,王红阳,夏其昌,李辰,谈冶雄. 2012.07授权,申请号ZL200410025464.4
42. 曾嵘,袁新雨,李辰,周晓. 2012.01授权,申请号ZL200510029160.X
43. 曾嵘,袁新雨,李辰,周晓. 2012.01授权,申请号ZL200510029165.2
44. 曾嵘,李辰,周晓,袁新雨. 2012.01授权,申请号ZL200510029155.9
45. 曾嵘,李辰,周晓,袁新雨. 2011.09授权,申请号ZL200510029158.2
46. 曾嵘,袁新雨,李辰,周晓. 2011.08授权,申请号ZL200510029167.1
47. 曾嵘,周晓,李辰,袁新雨. 2011.05授权,申请号ZL200610115883.6
48. 曾嵘,周晓,李辰,袁新雨. 2011.05授权,申请号ZL200610115885.5
49. 曾嵘,周晓,李辰,袁新雨. 2011.05授权,申请号ZL200610115888.9
