张 涛 研究员

邮箱：tzhang7@yeah.net

电话：021-67722485

研究方向：细胞死亡和炎症与神经退行性疾病的发生发展

教育经历

2007-2013 中国科学院上海有机化学研究所，博士

2003-2007 复旦大学化学系，学士

工作经历

2023.05- 至 今 欧洲杯竞猜平台松江研究院，研究员

2015.12-2023.04 美国哈佛欧洲杯竞猜平台，博士后

2013.01-2015.11 中国科学院上海有机化学研究所，助理研究员

研究概述

课题组长简介：

张涛，独立PI，研究员，博士生导师。2007年7月毕业于复旦大学化学系，获理学学士学位。2013年1月毕业于中国科学院上海有机化学研究所，获理学博士学位。2013年1月-2015年11月，任中国科学院上海有机化学研究所助理研究员。2015年12月-2023年4月在美国哈佛大学欧洲杯竞猜平台进行博士后训练。2023年5月入职欧洲杯竞猜平台松江研究院。张涛博士从事研究RIPK1的调控机制及其生理病理功能，相关成果以第一作者发表在Science,Nature Cell Biology,Nature Communications和eLife等期刊。

研究方向介绍

细胞死亡和炎症是神经退行性疾病发生和发展的两个极为重要的因素，而受体互作蛋白RIPK1是调控细胞死亡和炎症的关键激酶。RIPK1的激活是促进细胞程序性坏死（Necroptosis）和 RIPK1激酶依赖性凋亡(RIPK1-dependent apoptosis) 以及炎症发生的重要上游机制。近年来的多项研究表明RIPK1介导的细胞死亡和炎症在人类疾病中发挥着重要作用，尤其在神经退行性疾病中发现RIPK1的活化与神经细胞死亡、神经炎症发生及病理变化密切相关。课题组将综合利用包括细胞生物学，遗传学，结构生物学等各种实验手段，和各种疾病小鼠模型进一步探究RIPK1的调控机制及其生理病理功能。

代表性论文(#表示共同第一作者, *表示通讯作者)

1. Tao Zhang^#, Daichao Xu^#,^*, Elijah Trefts^#, Mingming Lv^#, Jianping Liu, Min Liu, Chen Chu, Min Wang, Huibin Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Cong Jiang, Xiaoming Dai, Yu-Ru Lee, Hiroyuki Inuzuka, Emily Erickson, Alissandra L. Hillis, Christian C. Dibble, Ji Miao, John M. Asara, Gyongy Szabo, Piotr Sicinski, Lifeng Pan^*, Reuben J. Shaw^*, Junying Yuan^*, and Wenyi Wei^*. Metabolic orchestration of cell death and inflammation through AMPK-mediated phosphorylation of RIPK1.Science, in press,2023.

2. Tao Zhang^#, Daichao Xu^#,^*, Jianping Liu^#, Min Wang^#,Li-Juan Duan, Mingming Lv, Huyan Meng, Min Liu, Yuan Zhuang, Yu-Ru Lee, Huibin Wang, Linyu Shi, Rui Guo, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Cong Jiang, Xiaoming Dai, Zhengyi Zhang, Gewei Lian, Ji Miao, Gyongy Szabo, Guo-Hua Fong, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan^* and Wenyi Wei^*. Oxygen-sensitive prolyl hydroxylation of RIPK1 suppresses its activation.Nature Cell Biology, in press,2023.

3. Tao Zhang^#, Na Zhang^#, Jing Xing^#, Shuhua Zhang^#, Yulu Chen^#, Daichao Xu^*, and Jinyang Gu^*. UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis.Nature Communications 14,2715,2023.

4. Lingjie Yan^#,Tao Zhang^# , Kai Wang^#, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang , Yedan Zhong, Nan Liu, Jinyang Gu, Daichao Xu*. SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.Nature Communications vol. 13,1 7153.2022.

5. Tao Zhang^#, Kangyun Dong^#, Wei Liang^#, Daichao Xu^#, Hongguang Xia^#, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu and Junying Yuan^*. G-protein Coupled Receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of adaptor protein Atg14L.eLife, 4, e06734,2015.

6. Tao Zhang^#, Yingnan Wang^#, Hiroyuki Inuzuka, Wenyi Wei^*. Necroptosis pathways in tumorigenesis.Seminars in Cancer Biology vol. 86,Pt 3 (2022): 32-40.

7. Fabin Dang^#, Cong Jiang^#,Tao Zhang^*, Hiroyuki Inuzuka^*, Wenyi Wei^*. PCAF and SIRT1 modulate βTrCP1 protein stability in an acetylation-dependent manner.J Genet Genomics. 2021; 48(7):652-655.

8. Yuanxin Yang^#, Xingyan Li^#, Tao Zhang^#, and Daichao Xu*. RIP kinases and necroptosis in aging and aging-related diseases. Life Medicine, lnac003, https://doi.org/10.1093/lifemedi/lnac003.

9. Cong Jiang^#, Xiaoming Dai^#, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu,Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao*, and Wenyi Wei*. Ring domains are essential for GATOR2-dependent mTORC1 activation.Molecular Cell, S1097-2765(22)01134-0.

10. Xiaoming Dai^#, Cong Jiang^#, Qiwei Jiang, Lan Fang, Haihong Yu, Jinhe Guo, Peiqiang Yan, Fangtao Chi,Tao Zhang, Hiroyuki Inuzuka, John M. Asara, Ping Wang, Jianping Guo^*, Wenyi Wei*. AMPK-dependent phosphorylation of GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation.Nature Metabolism, vol. 5,2 (2023):265-276

11. Fabin Dang^#, Li Nie^#, Jin Zhou^#, Kouhei Shimizu, Chen Chu, Zhong Wu, Anne Fassl, Shizhong Ke, Yuangao Wang, Jinfang Zhang,Tao Zhang, Zhenbo Tu, Hiroyuki Inuzuka, Piotr Sicinski, Adam J Bass, Wenyi Wei*. Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer. Nature communications. 2021;12(1):5386.

12. Ji Cheng, Brian J North,Tao Zhang, Xiangpeng Dai, Kaixiong Tao, Jianping Guo, Wenyi Wei*. The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease. Aging Cell. 2018;17(5):e12801.

13. Ji Cheng,Tao Zhang, Hongbin Ji, Kaixiong Tao, Jianping Guo and Wenyi Wei*. Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.Biochim Biophys Acta. 2016 ,1866(2): 232–251

14. Daichao Xu, Bing Shan^#, Byung-Hoon Lee^#, Kezhou Zhu^#, Tao Zhang^#, Huawang Sun, Min Liu , Linyu Shi, Wei Liang, Lihui Qian ,Juan Xiao, Lili Wang , Lifeng Pan , Daniel Finley ,Junying Yuan*. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system.eLife, 4, e10510. 2015.

15. Hong-guang Xia, Ayaz Najafov^#, Jiefei Geng^#, Lorena Galan-Acosta^#, Xuemei Han^#, Yuan Guo, Bing Shan, Yaoyang Zhang, Erik Norberg,Tao Zhang, Lifeng Pan, Junli Liu, Jonathan L. Coloff, Dimitry Ofengeim, Hong Zhu, Kejia Wu, Yu Cai, John R. Yates, Zhengjiang Zhu, Junying Yuan*, and Helin Vakifahmetoglu-Norberg. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.Journal of Cell Biology, 2015, 210(5):705-16.

16. Daichao Xu,Tao Zhang^#, Juan Xiao^#, Kezhou Zhu, Ran Wei, Zheming Wu, Huyan Meng, Ying Li and Junying Yuan*. DeISGylation of Beclin1 by USP18 regulates type I interferon controlled autophagy.Autophagy, 2015.11:4, 1--12.

17. Juan Xiao,Tao Zhang^#, Daichao Xu^#, Huibing Wang, Yu Cai, Taijie Jin, Ming Liu, Mingzhi Jin, Kejia Wu and Junying Yuan*. FBXL20 mediated Vps34 ubiquitination as a p53controlled checkpoint in regulating autophagy and receptor degradation.Genes & Development, 2014, 29: 184-196.

18. Junli Liu^#, Hongguang Xia^#, Minsu Kim, Lihua Xu, Ying Li, Lihong Zhang, Yu Cai, Helin Vakifahmetoglu Norberg, Tao Zhang, Tsuyoshi Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Augustine Choi, Hengming Ke, Dawei Ma, and Junying Yuan*. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.Cell, 2011,147: 223–234

19. Hong-guang Xia, Lihong Zhang, Gang Chen^#,Tao Zhang^#, Junli Liu, Mingzhi Jin, Xiuquan Ma, Dawei Ma, and JunyingYuan*. Control of basal autophagy by calpain1 mediated cleavage of ATG5.Autophagy. 2010, 6(1): 61–66.