Lab Leader: Yang Wen

Lab Name: Laboratory of Mitochondrial Metabolism and Aging

Lab Info：Study of molecular mechanisms of mitochondria and aging, using proteomic approaches to study the dynamic changes of mitochondrial proteins and their relationship with aging and related diseases. The main focus is on the effects of mitochondrial protein level modifications (including acetylation, succinylation and oxidation) on the regulation of mitochondrial function and reverse signaling in aging and related diseases. At this stage, the main subject directions include the following.

1. Mitochondrial peroxide-mediated reverse signaling in senescence and cell death

2. The function of ketoglutarate dehydrogenase-specific chaperonin proteins in related disease

3. Protein networks of mitochondria-organelle interactions

4. Mitochondrial metabolism and cancer drug resistance

Lab Members: