Lab Leader: Hou Zhaoyuan

Lab Name: Laboratory of Gene Expression Regulation

Lab Info：Our research group includes 1 principal investigator (PI), 2 teachers, and 1 technician. The main research direction of our group is the expression and regulation of gene networks in epithelial-mesenchymal transition (EMT) and tumor metastasis. The specific research object is the molecular mechanism of transcription factor Snail inhibiting gene transcription. Snail belongs to a family of zinc-finger proteins containing SNAG domains. SNAG is located at the amino terminus of Snail molecule and has the function of inhibiting gene transcription. During embryonic development and tumor metastasis, Snail is a key factor in inducing EMT and a central molecule connecting various signaling pathways that promote tumor metastasis. Therefore, studying the mechanism of Snail's action in cells not only helps us to understand the mechanism of tumor metastasis in theory, but also provides new targets for drug design and effective treatment in clinical practice.

Lab Members: