Lab Leader: Yujie Tang

Lab Name: Laboratory of Oncogenic Mechanisms & Targeted Diagnostics and Therapeutics of Pediatric Solid Tumors

Lab Info：Our lab performs basic medical research of pediatric solid tumors, focusing on epigenetic mechanisms of oncogenesis and targeted diagnostic and therapeutic strategies. We are collaborating with clinicians from pediatric solid tumor related clinical departments of many affiliated hospitals, to study various types of pediatric solid tumor including DIPG, medulloblastoma, neuroblastoma, hepatoblastoma, Ewing sarcoma, osteosarcoma, and chondroblastoma. We are building tumor tissue bank and patient-derived primary tumor model bank, performing multi-omics profiling together with functional genomic screening and small molecule screening, to systematically dissect and illustrate novel oncogenic mechanisms and targeted diagnostic and therapeutic strategies. Our research has been published on various prestigious journals including Cancer Cell, PNAS, Cancer Research, Oncogene, Cell Death & Disease and Journal of Experimental & Clinical Cancer Research. We have also obtained many fundings and supports including The Recruitment Program of Global Experts of China (National 1000-Youth Talents Program), The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Shanghai Rising-Star Program, the general program of National Natural Science Foundation of China.

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