Lab Leader: Aiwu Zhou

Lab Name: Laboratory of Structural Mechanism of Diseases

Lab Info：The research group mainly focuses on the structural mechanism of protein complexes related to cardiovascular diseases and tumors immunotherapy. Through biochemical and structural biology techniques including crystallography and cryo-electron microscopy, we aim to reveal the regulatory mechanisms of proteins, explore the relationship between their conformational changes and onset of diseases, and attempt to intervene these conformational changes for disease treatment through rational drug design. Our research group has published about 40 research papers as correspondence or co-corresponding authors in journals such as NATURE (2010, 2019), BLOOD (2009, 2012, 2022), Science Advance (2020) and JBC. Currently, the research group has 1 associate professor, 1 research assistant, 1 postdoctoral fellow, 2 master students and 2 doctoral students.

Lab Members: