Lab Leader: Yingli Wu

Lab Name: Laboratory of Deubiquitinating Enzymes and Targeted Therapies

Lab Info：Deubiquitinating enzymes (DUBs) regulate protein degradation, localization and protein interaction by removing ubiquitination modifications of proteins, thereby participating in various biological processes such as DNA damage repair, cell survival, cell cycle, immune response, and angiogenesis. Accumulating evidence show that DUBs are an emerging class of anti-tumor targets. In recent years, our group has focused on DUBs related studies, mainly including: revealing the role and mechanism of DUBs in tumors; identifying the corresponding DUBs of various important oncoproteins or tumor suppressors; and using DUBs as the target to develop its inhibitors or agonists and envaluate their efficacy in vitro and in vitro. The results have been published in Nature communications, Signal transduction & targeted therapy, Science China Life Sciences and other journals. These studies will provide new mechanisms for the occurrence and development of tumors, and provide new targets and drugs for the treatment of tumors.

Lab Members: