Lab Leader: Dachuan Zhang

Lab Name: Laboratory of Regulatory Networks of the Hematopoietic and Immune Systems

Lab Info：Our lab is dedicated to investigation of the regulatory networks for hematopoietic stem cells and innate immune cells, and the key roles of the microbiota and peripheral nervous system in homeostasis and pathophysiology. Our previous studies have found that the microbiota plays important roles in regulating neutrophil functional activity, inflammatory disease progression, and hematopoietic stem cell fate decision. In addition, the peripheral nervous system plays key roles in regulating hematopoietic stem cell mobilization, homing, and the microenvironment. Our lab is supported by NSFC funding, and previous studies have been published in top journals including Nature, Cell Stem Cell, and Blood. Our research directions include: (1) The roles of microbiota and microenvironment in regulating hematopoietic stem cell and leukemia pathogenesis; (2) Isolation, manipulation, and application of gut commensals in hematopoietic and inflammatory diseases; (3) The roles of peripheral nervous system in the homeostasis, migration and activation of hematopoietic stem cell and innate immune cells.

Lab Members:

The Zhang lab is affiliated with the Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, which provides a first-class research platform and superb cross-disciplinary environment. We are now actively recruiting Research Associate and Postdoctoral Fellows. The candidates with genuine interest and enthusiasm for our scientific directions are welcome to apply!