Lab Leader: Youqiong Ye

Lab Name: Laboratory of Tumor Multiomics and Immunotherapy

Lab Info：The research in my laboratory focuses on tumor microenvironment (TME) and immunotherapy. We take full advantage of the multi-omics data in human cancer, combine with innovative bioinformatics methods, basic experiments, clinical cohorts and other multi-scale methods to build an immunotherapy efficacy prediction model, to explore the regulatory roles of tumor (boundary) microenvironment on tumor progression and immune escape, providing new potential therapeutic strategies for immunotherapy (Cancer Cell, 2020; Nature Metabolism, 2019; Nature Immunology, 2019; Nature Communications, 2020, 2022; etc.). The main research contents as follows: 1) combining multi-scale data such as spatial transcriptomics, single-cell multi-omics, pathological images, etc., to construct approaches to accurately study the regulation roles of tumor boundary microenvironment in tumor immune microenvironment subtypes, metastasis, and immunotherapy resistance, and to develop new therapeutic strategies based on the targets in tumor boundary microevironment; 2) single-cell and other omics based clinical cohorts reveal tumor microenvironment-related characteristics to assist tumor immunotherapy.

Lab Members: