Lab Leader: Ying Wang

Lab Name: Laboratory of T cell Dysfunction in Human Diseases

Lab Info：Research interest in my lab is the study on immunological mechanism and preventive strategies against lung-related diseases including infectious tuberculosis (TB), COVID-19 and lung cancer. In the investigations on TB, we have been working on the exploration of diagnostic biomarkers and development of novel preventive vaccines against TB and latent TB infection. We have screened panels of novel mycobaceterial antigens with high immunogenencity both in active TB patients and mice, which facilitates their further expectation for vaccine development and biomarker determination. In addition, some new-identified mycobacterial antigens were subjected to the study on the mechanisms of their immune regulatory function. Another interesting field lies in the screening the biomarkers for the checkpoint inhibitors against lung cancer. Multi-omics strategies has been used in this study to model the predictive and prognositic biomarkers for the clinical efficacy as well as resistance, which will be optional for the development of new immune-targets. Accordingly, new strategies are explored to improve the clinical efficacy of immune checkpoint inhibitors. During COVID-19 pandemics, we have investigated immune profiles of COVID-19 patients as well as in BBIBP-CorV vaccinees. In the last five years, we have successfully got more than 10 grants and published more than 30 publications. At present we have two faculty members, 5 graduate students and 1 post-doc. Prof Ying Wang has been selected in Shanghai Pujiang Talent program and Shanghai Academic Leader Program.

Lab Members: