Lab Leader: Huang Chuanxin

Lab Name: Laboratory of B cell Response and Tumor

Lab Info：In response to antigens such as vaccines B cells are activated and form germinal center B cells in lymphatic follicles, and eventually differentiate into plasma cells that can produce a large number of protective antibodies to eliminate pathogenic bacteria. The germinal center response leads to the formation of immune memory and production of high-affinity antibodies, and is critical for the effective role of the vaccine. Deficient B cell response can easily lead to low immune function and even immunodeficiency. Deregulated B cell differentiation within germinal center is associated with many human diseases, including autoimmune, allergic diseases, and B-cell lymphoma. We use a variety of genetic, cell biological and high-throughput sequencing technologies to reveal the transcriptional network underlying B cell responses. The goal is to better understand how B cells are programmed to produce antibodies via cell-intrinsic mechanisms and environmental clues, helping to develop new vaccine and therapeutic strategies for human B cell-related diseases.

Lab Members: