Research Field

The pathophysiological mechanism of aging and metabolism-related diseases. The research group mainly focuses on the role of protein modification in aging, liver metabolic diseases and tumorigenesis. Our research interests include: Mechanism in which glucose and lipid metabolic remodeling determines the fate of different hepatic cells and its pathophysiological role in ALD, NAFLD and HCC; Mechanism of inter-organ communication during aging and metabolic remodeling; Research and development the corresponding biomarker and targeted therapies.

Personal Introduction

He Ming, Professor, Doctoral Supervisor, PI in Department of Pathophysiology. Recipient of "Shanghai May 1st Labor Medal", "Shanghai Youth May 4th Medal", "Shanghai Pujiang Program", "Shanghai Teaching Expert", "Huangpu District Youth Post Expert", "Shanghai Jiaotong University Teaching and Education Award", "Shanghai Jiaotong University Teaching Expert", Shanghai Jiaotong University Medical School "Shangyao Xinglin Talent Award", "Jiulong Medical Excellent Young Talent Award", "Excellent Young Teachers" "Excellent Instructor of the Innovation Training Program for College Students"; Winner of "Outstanding Member of the Communist Party of China", "Outstanding Employee (2017 and 2018)" and "RBL Excellent Instructor" of College of Basic Medical Science; He was selected into the "The National 10000 Excellent iInnovation and Entrepreneurship Tutors Talent Pool" of the Ministry of Education; Winner of the second prize of "National Young Teachers' Teaching Competition in Colleges and Universities" and the special prize of "Shanghai Young Teachers' Teaching Competition in Colleges and Universities". Professor He Ming has long been engaged in the molecular mechanism and translational research of Aging and Metabolism. He has successively obtained over 5 National Natural Science Foundation and 4 Shanghai Projects. He has published more than 40 papers in international journals such as Cell Metabolism, Cell Discovery, Cell Death & Differentiation, Cell Reports, etc.

Education

• 2002–2007    Ph.D.

  Department of Physiology and Pathophysiology

  Fudan University Shanghai Medical College, Shanghai, China

• 1997–2002    Bachelor of Medicine

 Taishan Medical University, Shandong, China

Professional Experience

• Dec 2017-Present    Professor

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,

• Jun 2012-Jan 2015   Research Specialist, Senior Scientist

Department of Nutritional Science and Toxicology, Molecular and Cell Biology, University of California, Berkeley, USA

• Dec 2009-Nov 2017   Associate Professor

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,

• Jul 2007-Nov 2009   Lecturer

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,

• Sep 2017-Aug 2022   Adjunct Professor

Department of Innovation in Medical Education, Faculty of Medicine, University of Ottawa, Canada

Scientific Research Projects

• Mechanism and roles of cholesterol metabolism regulation in NAFLD-HCC progression. Grant of National Natural Science Foundation of China (No. 92057118); ¥780,000 (Principal Investigator)

• Investigation for SIRT2 to protect against alcoholic liver disease and its molecular mechanisms. Grant of National Natural Science Foundation of China (No. 82070603); ¥550,000 (Principal Investigator)

• Mechanism of SIRT7 in preventing the development of nonalcoholic fatty liver disease in mice. Grant of National Natural Science Foundation of China (No. 81470841); ¥730,000 (Principal Investigator)

• The roles of microRNA in Hypoxia-inducible factor-1 аlpha-induced differentiation of myeloid leukemic cells. Grant of National Natural Science Foundation of China (No. 81170505); ¥600,000 (Principal Investigator)

• Role of temperature-sensitive transient receptor potential (TRP) channels in phenotypic changes of airway smooth muscle cells in a rat model of asthma. Grant of National Natural Science Foundation of China (No.30800380); ¥200,000 (Principal Investigator)

Publications

• Wo L, Zhang X, Ma C, Zhou C, Li J, Hu Z, Gong X, Zhan M, He M#, Zhao Q#. LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening. Cell Death Discov. 2022;8(1):171. doi: 10.1038/s41420-022-00917-6.

• Zhang Y, Long X, Ruan X, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q#, He M#. SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury. Cell Discov. 2021; 7 (9). doi: 10.1038/s41421-021-00326-6.

• Ma C*, Wo L*, Wang D, Zhou C, Li J, Zhang X, Gong X, Wang C, Chen G, He M#, Zhao Q#. (2021) Hypoxia activated long non-coding RNA HABON regulates the growth and proliferation of hepatocarcinoma cells by binding to and antagonizing HIF-1 alpha. RNA Biol. doi: 10.1080/15476286.2020.1871215.

• Wei Q, Zhang Y, Lin L, He E, He Y, Su Y, Duan C, Wang S, Zhao Q, Zhao Q, He M#. Haptoglobin suppresses hepatocyte ferroptosis via inhibition of the ERK1/2 signaling pathway. Journal of Shanghai Jiaotong University (Medical Science). 2021 (8):  999-1008.  doi: 10.3969/j.issn.1674-8115.2021.08.002.

• He M#, Zhang Y, Wei Q, Ruan X, An X, Sun Y. LPS induces acute liver injury by down-regulating SIRT2 in hepatocyte. Current Immunology. 2021; 41(1):8-13;55.

• Wang CL, Li JC, Zhou CX, Ma CN, Wang DF, Wo LL, He M, Yin Q, He JR, Zhao Q. Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein. Breast Cancer Res Treat. 2021;189(3):607-619. doi: 10.1007/s10549-021-06286-5.

• He M#, Wei Q, Zhang Y. Research progress on the mechanism of ferroptosis and its role in liver related diseases. Journal of Shanghai Jiaotong University (Medical Science). 2020, 40(12): 1519-1523.

• He M*, Chiang H*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu W, Zhao S, Wu H, Chen D. (2020) An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance. Cell Metab. 31(3): 580-591.e5. doi: 10.1016/j.cmet.2020.01.009.

• Ruan X, Zhang Y, Han K, Lin L, Chen C, Yue M, Wang C, Sun Y, Zhao Q, He M#. (2019) SIRT7 protects hepatocytes from LPS or D-GalN/LPS-induced apoptosis by attenuating endoplasmic reticulum stress via inactivation of GRP78. Journal of Shanghai Jiaotong University (Medical Science). 39(8):928-935.

• Peng Y, Han K, Ruan X, Zhang Y, Wei Q, Zhao Y, An X, He M#. (2019) Expression of p53, TGFβ1 and inflammatory cytokines in a novel alcoholic renal injury mouse model.Current Immunology. 39(5):26-31.

• Zhang Y, Wu Y, He M#. (2019) Application of CD229 in immunophenotyping of plasma cell diseases. Laboratory Medicine.34(7):605-609.

• Lin S, Xing H, Zang T, Ruan X, Wo L, He M#. (2018)  Sirtuins in mitochondrial stress: indispensable helpers behind the scenes. Ageing Res Rev. 44:22-32. doi: 10.1016/j.arr.2018.03.006.

• Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018). MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

• Gong X, Yu A, Tang J, Wang C, He J, Chen G, Zhao Q, He M#, Zhou C#. (2018) MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res. 362(2):378-385. doi: 10.1016/j.yexcr.2017.11.039.

• Han K, Ruan X, He M#. (2018) The roles of SIRT2 in the tumorigenesis and development of hepatocellular carcinoma. Journal of Shanghai Jiaotong University (Medical Science). 10:1247-1251.

• Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018) MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

• Zang T, Liu H, Wo L, Lin S, Xing H, He M#. (2017) Roles of SIRT2 in glucose lipid metabolism. Sheng Li Ke Xue Jin Zhan. 48(6): 458-462.

• Zhang L, An X, Ruan X, Huang D, Zhou L, Xue H, Lu L#, He M#. (2017) Inhibition of (pro)renin receptor contributes to renoprotective effects of angiotensin II type 1 receptor blockade in diabetic nephropathy. Front. Physiol. 8:758. doi: 10.3389/fphys.2017.00758. eCollection 2017.

• An X, Zhang L, Yuan Y, Wang B, Yao Q, Li L, Zhang J#, He M#, Zhang J#. (2017) Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression. Sci Rep. 7(1):6413. doi: 10.1038/s41598-017-06844-2.

• An X, Zhang L, Yao Q, Li L, Wang B, Zhang J#, He M#, Zhang J#. (2017) The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway. Mol Cell Endocrinol. 470:14-25. doi: 10.1016/j.mce.2017.05.004.

• Huang D, Wo L, Ruan X, Xu Y, Gong Y, Yang L, Li X, Kang Y, He M#. (2017) Construction of a new alcoholic liver disease mouse model. Journal of Shanghai Jiaotong University (Medical Science). 37(7):906-913.

• Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ, Zhao Q. (2017). Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis. 6(10):e387. doi: 10.1038/oncsis.2017.85.

• Zhan MN, Yu XT, Tang J, Zhou CX, Wang CL, Yin QQ, Gong XF, He M, He JR, Chen GQ, Zhao Q. (2017) MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Cell Death Dis. 8(1):e2529. doi: 10.1038/cddis.2016.440.

• Zhang L, An XF, Wang QY, He M#. (2016) Activation of cold-sensitive channels TRPM8 and TRPA1 inhibits the proliferative airway smooth muscle cell phenotype. Lung. 194(4):595-603. doi: 10.1007/s00408-016-9901-4.

• Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, Zhao Q. (2016) MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 7(2):1288-99. doi: 10.18632/oncotarget.6339.

• Zhang L, He M#. (2015) Roles of Sirtuins in occurrence and development of chronic kidney disease. Journal of Shanghai Jiaotong University (Medical Science). 35(4):594-600.

• He M*, Wang QY*, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ, Zhao Q. (2013) HIF-1 down-regulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 20(3):408-418. doi: 10.1038/cdd.2012.130.

• Shin J*, He M*, Liu Y*, Paredes S*, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. (2013) SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 5(3): 654-665. doi: 10.1016/j.celrep.2013.10.007.

• Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q. (2013). MiR-124 targets slug to regulate epithelial-to-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34(3):713-722. doi: 10.1093/carcin/bgs383.

• Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q. (2011). MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett. 585(9):1363-1367. doi: 10.1016/j.febslet.2011.04.018.

• Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q. (2011) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis. 32(1):2-9. doi: 10.1093/carcin/bgq209.

• Ten SC, Gu SY, Niu YF, An XF, Yan M, He M. (2010) Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocr Res. 35(3):128-136.

• Han X, Yan M, An XF, He M, Yu JY. (2010) Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats. Acta Pharmacol Sin. 31(2):145-149.

• He M, Zhang L, Shao Y, Zhou L, Wang XF, Yao T, Lu LM. (2010) Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal renin/prorenin receptor expression. Mol Cell Endocrinol. 315(1-2):188-194. doi: 10.1016/j.mce.2009.10.008.

• He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L. (2009) Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 606(1-3):155-161. doi: 10.1016/j.ejphar.2008.12.050.

• Chen L, He M, Wang WQ. (2009) High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis. Acta Physiologica Sinica. 61(6):559-566.

• An XF, He M, Feng Y, Feng H, Yu JY. (2009) Central administration of Orphanin FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats. Neurosci Bull. 25(1):1-6.

• Shao Y, He M, Zhou L, Yao T, Lu LM. (2008) Chronic Angiotensin (1-7) injection accelerated STZ-induced diabetic renal injure. Acta Pharmacol Sin. 29(7):829-837.

• An XF, Niu YF, Ten SC, Liu JS, Feng H, He M, Shen XJ. (2008) Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats. Neurosci Lett. 440(2):109-112. doi: 10.1016/j.neulet.2008.05.059.

• He M, Huang YL, Zhang L, Yao T, Lu LM. (2008). Expression of renin/prorenin receptor in rat kidney and cultured mesangial cells. Acta Physiologica Sinica. 59 (6): 796-804.

• He M, Lu LM, Yao T. (2004). Effects of renin-angiotensin system on the regulation of renal function and chronic renal insufficiency. Sheng Li Ke Xue Jin Zhan. 35(2):188-192.