Personal Introduction

Dr. Bing Su obtained his B.S. degree from Peking University in 1984 and his Ph.D. degree from Yale University in 1991. He did his postdoctoral training with Dr. Michael Karin at the University of California San Diego before starting his academic career in 1995 as an Assistant Professor at the University of Texas M. D. Anderson Cancer Center where he was promoted to a tenured full Professor in 2006. He moved to Yale University in 2006 as a tenured faculty at the Department of Immunobiology until 2014 when he relocated to SJTU in China. Dr. Bing Su is now the Director of Shanghai Institute of Immunology and Chair of Department of Immunology and Microbiology at , Co-Founding Director of -Yale University Institute for Immune Metabolism (SYIIM) and an Adjunct Professor at Department of Immunobiology at Yale University School of Medicine. Dr. Su also holds a KC Wong Chair Professorship at Shanghai JiaoTong University

Dr. Su’s research focuses on the intracellular signal transduction pathways controlled by the mammalian target of rapamycin (mTOR) and the mitogen activated protein kinases (MAPKs). He studies the roles of these intracellular signaling cascades in immune regulation and vascular function. Dr. Su has published over 110 peer-reviewed papers, many of which were in high-impact journals such as Nature, Cell, Nature Genetics, Nature Immunology, Immunity, Molecular Cell, EMBO J, etc., with citation over 15000. His research has been supported from grants awarded by Ministry of National Scinece and Technology (Chief Scientist), as well as National Natural Science Foundation of China (NSFC) and Shanghai Science and Technology Commission.

Dr. Su is a member of Chinese Biological Investigator Society and a member of Society of Chinese Bioscientists in America (SCBA). He served on many review committees including NIH Study Sections, the Review Committee for the Key Programs of NSFC, etc.  He is also the editor-in-chief of Current Immunology, and the associate editor of Journal of Molecular Cell Biology and Current Research in Immunology.

Scientific Research Projects

• Project Number: 2021YFA1301400

• Principal Investigator: Bing Su

• Funding Source: Ministry of Science and Technology of China

• Title of Project: 呼吸道病毒感染免疫应答的全景研究

• Dates of Approved Project: 2021.12~2026.11

• Total Costs: ¥ 21000,000

• Project Number: 31930035

• Principal Investigator: Bing Su

• Funding Source: National Natural Science Foundation of China

• Title of Project (Subproject): Modulation of gut immune homeostasis by innate lymphoid cells in health and diseases

• Dates of Approved Project: 2020-01~2024-12

• Total Costs: ¥ 3080,000

• Project Number: 91942311

• Principal Investigator: Bing Su

• Funding Source: National Natural Science Foundation of China (重大研究计划）

  Modulation of gut immune homeostasis by the novel subsets of gut stromal cells

• Dates of Approved Project: 2020-01~2022-12

• Total Costs: ¥ 2500,000

• Project Number: 20410714000

• Principal Investigator: Bing Su

• Funding Source: Shanghai Science and Technology Committee

• Title of Project (Subproject): The role of novel coronavirus protein in mediating pneumonia and cellular molecular mechanism

• Dates of Approved Project: 2020-06~2023-5

• Total Costs: ¥ 450,000

• Project Number: 32061143028

• Principal Investigator: Bing Su

• Funding Source: National Natural Science Foundation of China

• Title of Project (Subproject): Ontogeny,  plasticity and function of two emerging populations of mesenchymal cells in gut homeostasis and damage repair

• Dates of Approved Project: 2020.10~2023.5

• Total Costs: ¥ 1980,000

Scientific Research Projects

1. Su B, Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. JNK mediates signal integration during costimulation of T lymphocytes. Cell 77:727-736, 1994.

2. Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, and Su B. Essential role of MEKK3 in early embryonic cardiovascular development. Nature Genetics, 24(3):309-13, 2000.

3. Yang J, Lin Y, Guo Z, Borem M, Huang H, Liao, Chen Z, Liu ZG* and Su B*. Essential role of MEKK3 in TNF-induced NF-kB activation. Nat Immunol. 2001 Jul;2(7):620-4.

4. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B. Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.Nat Immunol. 2004 Jan;5(1):98-103.

5. Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways. EMBO J. 2006 Jan 11;25(1):97-107.

6. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J*, Su B*. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 127(1):125-37. 2006.

7. Facchinetti V*, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B*, Jacinto E*. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23;27(14):1932-43.

8. Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells. Mol. Cell. 2010. Aug 13;39(3):433-43.

9. Xing Chang, Fang Liu, Xiaofang Wang, and Su B. MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation. Immunity. 34: 201-212, 2011.

10. Zhang F, Lazorchak AS, Liu D, Chen F*, Su B*. Inhibition of the mTORC2 and chaperone pathways to treat leukemia. Blood. 2012 Jun 21;119(25):6080-8.

11. Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ*, Su B.* Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015 Aug 3; 6:7937.

12. Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B* and Wu ZB*. Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors . Nature Communications,2018, 9:4624.

13. Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F*, Su B*. Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation. Cell Mol Immunol. 2019 Sep;16(9):757-769.

14. Ouyang X, Han Y, Qu G, Li M, Wu N, Liu H, Arojo O, Sun H, Liu X, Liu D, Chen L, Zou Q*, Su B*. Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. J Mol Cell Biol. 2019 Feb 1;11(2):93-106.

15. Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B*, Ginhoux F*. Fate mapping via Ms4a3 expression history traces monocyte-derived cells. Cell. 2019 Sep 5;178(6):1509-1525.

16. Yang XD*, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B*. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39(2):e102201

17. Wu N, Chen D, Sun H, Tan J, Zhang Y, Zhang T, Han Y, Liu H, Ouyang X, Yang XD, Niu X, Zhong J, Wang Z*, Su B*, MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis. SCIENCE CHINA Life Sciences.2020 Jul 28.doi: 10.1007/s11427-020-1720-9.

18. Qi J, Crinier A, Escalière B, Ye Y, Wang Z, Zhang T, Batista L, Liu H, Hong L, Wu N, Zhang M, Chen L, Liu Y, Shen L, Narni-Mancinelli E, Vivier E, Su B*. Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. Cell Rep Med. 2021 Jul 27;2(8):100353.

19. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature. 2021 Apr;592(7855):606-610.

20. Qi J, Sun H, Zhang Y, Wang Z, Xun Z, Li Z, Ding X, Bao R, Hong L, Jia W, Fang F, Liu H, Chen L, Zhong J, Zou D, Liu L, Han L, Ginhoux F, Liu Y, Ye Y, Su B*. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat Commun. 2022 Apr 1;13(1):1742.

Patent

• “Screening for modulators of MEKK2 and MEKK3”, International Application Number: PCT/US2004/040699, International Publication Number: WO 2005/0526825 A1.