Shanghai Institute of Immunology & Department of Immunology and Microbiology
Shanghai Institute of Immunology & Department of Immunology and Microbiology

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LI Huabing

Email: huabing.li@shsmu.edu.cn

Tel: 86-021-63846590-776794

Laboratory of RNA Epigenetics &Immunity

Research Field: RNA Epigenetics &Immunity

Personal Introduction

  • I was trained with Dr. Richard Flavell for T cell immunology at Yale Medical School for my Postdoc work, and did my Ph.D. thesis on Drosophila epigenetics with Dr. Vincenzo Pirrotta at Rutgers University. The Li lab is using mouse disease models to reveal the novel functions of RNA modifications in cancer immunology and autoimmune disease.

Education & Experience

EDUCATION

  • B.S., Nankai University, Tianjin, China                          2002

  • M.S., Nankai University, Tianjin, China (Mentor: Wenqin Song)       2005

  • Ph.D., Rutgers-the State University of New Jersey, New Jersey, USA (Mentor: Vincenzo Pirrotta) 2011

ACADEMIC POSITIONS/EMPLOYMENT/EXPERIENCE

  • 2011 – 2012 Postdoctoral Associate, Rutgers University, USA. （Mentor: Vincenzo Pirrotta）

  • 2012 – 2017 Postdoctoral Fellow, Yale University, USA. （Mentor: Richard A. Flavell）

  • 2017 – Present    Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

  • 2018 – present Assistant Professor Adjunct, Department of Immunobiology, Yale University

Scientific Research Projects

  • Funding Source: NSFC, Grant Number: 91753141, 2018/01-2020/12

  • Funding Source: Shanghai Education department, Grant Number: none, 2017/11-2020/10

  • Funding Source: Organization Department of Central Government, Grant Number: none, 2019-2021

  • Funding Source: Shanghai Science and Technology Commission. Grant Number：201409005500, 2020/06-2023/05

  • Funding Source: Shanghai Science and Technology Commission. Grant Number：20JC1417400, 2020/10-2023/09

  • Funding Source: NSFC, Grant Number: 32070917, 2021.1 - 2024.12

  • Funding Source: NSFC, Grant Number: 82030042, 2021.1-2025.12

  • Funding Source: NSFC, Grant Number: 82111540277, 2022.1-2023.12

  • Funding Source: National Key R&D Program of China, Grant Number: SQ2021YFA1100349, 2022.1-2026.12

Publications

  1. Li HB, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, and Pirrotta V. (2011) Insulators, not Polycomb Response Elements, are required for long-range interactions between Polycomb targets in Drosophila. Molecular and Cellular Biology，31(4):616-25. doi: 10.1128/MCB.00849-10. PMID: 21135119 IF: 4.272

  2. Li HB, Ohno K, Gui H, and Pirrotta V. (2013) Insulators target active genes to transcription factories and Polycomb-repressed genes to PcG bodies. PLoS Genetics, 9(4):e1003436. doi: 10.1371/journal.pgen.1003436. PMID: 23637616 (Highlighted by Cell: 153(5), p935) IF: 5.917

  3. Hu B#, Jin C#, Li HB#, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. (2016) The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science, 354 (6313): 765-768. DOI: 10.1126/science.aaf7532. PMID: 27846608 (# equal contribution) IF: 47.728

  4. Li HB#*, Tong J#, Zhu S#, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z*, Flavell RA*. (2017) m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature, 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9.. PMID: 28792938 (# equal contribution, * co-corresponding) IF: 49.962

  5. Tong J#, Cao G#, Zhang T#, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA*, Li HB*. (2018) m6A mRNA methylation sustains Treg suppressive functions. Cell Research, 28(2): 253-256. doi:10.1038/cr.2018.7. PMID: 29303144 (*co-corresponding) IF: 25.617

  6. Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB*, Huang C*, Yi J* , Zou Q*. (2018) SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications, 2018 Aug 8;9(1):3157. doi: 10.1038/s41467-018-05676-6. PMID: 30089837 (* co-corresponding) IF: 14.919

  7. Tong J, Flavell RA*, Li HB*. (2018) RNA m6A modification and its functions in diseases. Frontiers of Medicine, 2018 Aug;12(4):481-489. doi: 10.1007/s11684-018-0654-8. PMID: 30097961 (* co-corresponding) IF: 4.592

  8. Liu Y, Li HB*, Flavell RA*. (2018) cGAS activation in phased droplets. Cell Research, 2018 Oct;28(10):967-968. doi: 10.1038/s41422-018-0087-6. PMID: 30218060 (* co-corresponding) IF: 25.617

  9. Wang J, Flavell RA*, Li HB*. (2019) Antiviral immunity: a link to bile acids. Cell Research, 2019 Mar;29(3):177-178. doi: 10.1038/s41422-019-0148-5. PMID: 30778178  (* co-corresponding) IF: 25.617

  10. Zhang X, Flavell RA*, Li HB*. (2019) hnRNPA2B1: a nuclear DNA sensor in antiviral immunity. Cell Research, 2019 Nov;29(11):879-880. doi: 10.1038/s41422-019-0226-8. IF: 25.617

  11. Gao Y*#, Vasic R#, Song Y#, Teng R, Gbyli R, Biancon G, Nelakanti R, Liu C, Kudo E, Lobben K, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA*, Li HB*, Tebaldi T*, Halene S*. (2020) Activation of Double-Stranded RNA Innate Immune Response and Hematopoietic Failure upon Loss of METTL3-Mediated m6A RNA Modification. Immunity, 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. PMID: 32497523 (* co-corresponding) IF: 31.745

  12. Xu C*, Li HB*, Flavell RA*. (2020) A special collection of reviews on frontiers in immunology. Cell Research, Oct;30(10):827-828. doi: 10.1038/s41422-020-00403-7. (* co-corresponding, Editorial) IF: 25.617

  13. Wang Y#, He K#, Sheng B#, Lei X, Tao WE, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H*, Li HB*, Flavell RA*, Zhu S*. (2021) The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells. PNAS., 118 (4) e2017432118  (* co-corresponding) IF: 11.205

  14. Chen H#, Yao J#, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y*, Li HB*. (2021) Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer. Molecular Cancer, 20(1):29. doi: 10.1186/s12943-021-01322-w. PMID: 33557837  (* co-corresponding) IF: 27.401

  15. Tong J#, Wang X#, Liu Y#, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q*, Flavell RA*, Zhu S*, Li HB*. (2021) Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advances, 2021 Apr 28; 7(18):eabd4742. doi: 10.1126/sciadv.abd4742. PMID: 33910903 (* co-corresponding) IF: 14.136

  16. Chao Y, Li HB*, Zhou J*. (2021) Multiple Functions of RNA Methylation in T Cells: A Review. Frontiers in Immunology, 2021 Apr 12;12:627455. doi: 10.3389/fimmu.2021.627455. eCollection 2021. PMID: 33912158 (* co-corresponding) IF: 7.561

  17. Zhou J#, Zhang X#, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA*, Li HB*. (2021) m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity. Science Advances, 2021 Jun 16;7(25):eabg0470. doi: 10.1126/sciadv.abg0470. PMID: 34134995 (*co-corresponding) IF: 14.136

  18. Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA*, Li HB*, Ouyang X*. (2021) m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Reports, 2021 Nov 9;37(6):109968. doi: 10.1016/j.celrep.2021.109968. PMID: 34758326 (* co-corresponding) IF: 9.423

  19. Zhang T#, Ding C#*, Chen H# Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*. (2022) m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway. Science Advances, 8, eabl5723, 2022 March 25 IF: 14.136

  20. Chen B#, Hu J#, Chen H, Bao R, Zhou Y, Zhan M*, Ye Y*, Li H*, Li HB*. (2022) DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications , 2022 April 19 IF: 14.919

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