Shanghai Institute of Immunology & Department of Immunology and Microbiology
Shanghai Institute of Immunology & Department of Immunology and Microbiology

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LI Bin

E-mail: binli@@shsmu.edu.cn

Tel: +86 18019287551

Laboratory of Molecular Immunology Laboratory

Research Field: FOXP3+ Treg and their clinical applications

Personal Introduction

Dr. Bin Li obtained his Ph.D. degree from Peking University in 2001 and did his postdoctoral training in Immunology at the University of Pennsylvania School of Medicine. He joined Institut Pasteur of Shanghai, CAS with CAS 100-Talent Program in 2009. Currently, he is the senior Principal Investigator and vice director for academic affairs at Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine.

Prof. Li’s research focuses on FOXP3+ Regulatory T cells (Treg) in inflammatory diseases, as well as their therapeutical applications. Li is a leading scientist in the field of posttranslational modification of FOXP3 and Treg stability in China and worldwide. Li serves as Associate Editor of Science Bulletin since 2018, and an Executive Committee member and Associate Editor of European Journal of Immunology since 2020. His work on Treg has been supported by a number of major grants including one National Science Fund for Distinguished Young Scholars, three NSFC Key Grants and two NSFC international collaborative grants.

Scientific Research Projects

  • Current

  • 01/01/2022-12/31/2024

  • National Natural Science Foundation of China (Key Program), ¥3,180,200, 32130041

  • Systematic characterizations of adipose Treg subsets and their physiological function

  • Role: Principal Investigator

  • 01/01/2020-12/31/2024

  • National Key Research and Development Project, ¥4,340,000, 2019YFA0906102

  • Construction and functional study of engineered CAR-T cells resistant to Treg inhibition

  • Role: Subject leader

  • 07/01/2019-06/31/2022

  • International Cooperation and Exchanges NSFC, ¥1,400,000, 31961133011

  • New approaches to characterize Th17/Treg cell balance contributing to anti-tumor immune response

  • Role: Principal Investigator

  • 01/01/2019-12/31/2023

  • National Natural Science Foundation of China (Key Program), ¥2,940,000, 81810051

  • To develop new immunotherapies against autoimmune diseases by modulating Th17/Treg balance

  • Role: Principal Investigator

Publications

  1. Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab. 2022 May 23. doi: 10.1038/s42255-022-00575-z.

  2. Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Sep;22(9):1175-1185.

  3. Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021 Aug;161(2):575-591.e16.

  4. Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J, Zang YS, Li B. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+-Induced Regulatory T Cells. J Immunol. 2020 Sep 15;205(6):1497-1502.

  5. Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H, Pan F, Li B. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep. 2020 Sep 3;21(9):e50308.

  6. Yi G, Zhao Y, Xie F, Zhu F, Wan Z, Wang J, Wang X, Gao X, Cao L, Li X, Chen C, Kuang Y, Qiu X, Yang H, Wang J, Su B, Chen L, Zhang W, Hou Y, Xu X, He Y, Tsun A, Liu X, Li B, Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin, 2020, 65(13):1114-1124.

  7. Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G, Li B. Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma. Science Bulletin, 2018,63(15):972-981.

  8. Fang, S. Huang, Y. Wang, N. Zhang, S. Zhong, S. Li, Y. Sun, J. Liu, X. Wang, Y. Gu, P. Li, B. Zhou, H. Fan, X. Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab., 2018, doi: 10.1210.

  9. Fang S, Huang Y, Zhong S, Li Y, Zhang Y, Li Y, Sun J, Liu X, Wang Y, Zhang S, Xu T, Sun X, Gu P, Li D, Zhou H, Li B, Fan X. Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy. J Clin Endocrinol Metab., 2017,102(11):4273-4283.

  10. Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X, Li B. IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO. J Clin Endocrinol Metab., 2016,101(8):2955-65.

  11. Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog., 2017,13(12):e1006773.

  12. 12.Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem., 2013,288(49):35093-103.

  13. 13.Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B. Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. J Biol Chem., 2016,291(3):1201.

  14. Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun., 2016,7: 13559.

  15. Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A., 2015,112(25): E3246-54.

  16. 16.Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B. Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt. J Immunol. 2015 May 1;194(9):4094-7.

  17. Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression. J Biol Chem., 2015,290(48):29086-94.

  18. Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem., 2014,289(39):26872-81.

  19. Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells. J Biol Chem., 2014,289(37):25546-55.

  20. Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013 May 31;288(22):15537-46.

  21. Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem. 2013 Mar 29;288(13):9373-82.

  22. Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity, 2013,39(2):272-85.

Patent

  • [Bin Li, Zhiyuan Li, Fang Lin] (2013), “Application of phosphorylation pathway-related factors in regulatory T cell function”, PCT/CN2013/070769; ZL 201310021575.7

  • [Bin Li, Zuojia Chen, Fang Lin] (2010), “Negative regulators of FOXP3 and regulatory T cells and their applications”, PCT/CN2011/077032; ZL 201110192414; 13/809,267; 11803163.2

  • [Bin Li, Jing Yang, Lei Han] (2014), “Application of ubiquitination pathway-related factors in regulating helper T cell function”, PCT/CN2015/084078; CN2014103536434

  • [Bin Li, Shuying Yin] (2014), “Identification and application of downstream signaling factors of GDF15 receptor”, CN201410107938.3

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