Research Field

• The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. Embryonic stem cells have the ability to differentiate into almost any kind of cell in the body; adult stem cells can form various cell types of source organs. Elucidating the regulatory signaling pathways of pluripotency and differentiation is a prerequisite for understanding the physiological functions and pathological mechanisms of stem cells. By using human and mouse stem cells, organoids as well as animal models, this lab applies genomics, epigenetics and bioinformatics to understand the regulatory mechanism of stem cell differentiation under physiological and pathological conditions, which will help speed the clinical application of stem cell therapy. The primary research interests focus on:

1. Study the early fate-determination mechanism of embryonic stem cell towards mesendoderm;

2. Identify key developmental regulators of mesendodermal organs and study the clinical applications of adult stem cells or progenitors.

Personal Introduction

Education & Work Experience

• 2018-         Principal Investigator，Professor

Shanghai Jiao Tong University, School of Medicine, Shanghai, China

• 2012-2018     Research Associate with Dr. Joan Massague

Memorial Sloan-Kettering Cancer Center, NY, USA

• 2010-2012     Research Fellow with Dr. Dirk Bohmann

University of Rochester, NY, USA

• 2005-2010     Ph.D. in Biomedical Genetics

University of Rochester, Rochester, NY, USA

• 2002-2005     Master of Medicine in Biochemistry and Molecular Biology

Shanghai Jiao Tong University School of Medicine, Shanghai, China

• 1997-2002     Bachelor of Medicine with highest honor in Clinical Medicine

University of South China, Hunan, China

Academic Awards

• 2019        Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

• 2017-2018     MSKCC Helena Johnson Hackley Society Scholar Prize, New York, NY, USA

• 2016        Geoffrey Beene Cancer Research Center Viewer Choice Award, New York, NY, USA

• 2014-2016     NYSTEM Postdoctoral Training Award, New York, NY, USA

• 2009 21^st     Genetics Day Poster Award, University of Rochester, Rochester, NY, USA

• 2008 20^th     Genetics Day Poster Award, University of Rochester, Rochester, NY, USA

Scientific Research Projects

• National Key R&D Program of China, 2021YFA1100400, 2021/12-2026/06，2,080,000 RMB out of 25,800,000 RMB

• National Natural Science Foundation of China，32070865，2021/01-2024/12，580,000 RMB

• Shanghai Committee of Science and Technology, China;，20ZR1430400，2020/07-2023/06，200,000 RMB

• The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning，2019/11-2022/10，1,000,000 RMB

• National Natural Science Foundation of China，31771512,2018/01-2021/12，630,000 RMB

Publications

1. Wang Q., Zou Y., Nowotschin S., Kim S., Li Q. V., Soh C.-L., Su J., Zhang C., Shu W., Xi Q., Huangfu D., Hadjantonakis A.-K., and Massagué, J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017; 20: 70-86 (with Preview)

2. Aragón E.#, Wang Q.#, Zou Y.#, Morgani S., Ruiz L., Kaczmarska Z., Su J., Torner C., Tian L., Hu J., Shu W., Agrawal S., Gomes T., Márquez J., Hadjantonakis A., Macias M., and Massagué J. Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes & Development. 2019; 33, 1506-1524 (# co-first author)

3. Wang Q., Uhlirova M., and Bohmann D. Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis. Developmental Cell. 2010; 18: 157–164 (Cover article)

4. Ma Shuangyu, Zhao Bingnan, Wang Q., The development and application of pancreatic organoid technology. Chinese Journal of Cell Biology. 2021, 43(6): 1166-1173 (Invited Review)

5. Su J., Morgani S.M., David C.J., Wang Q., Er E.E., Huang Y.H., Basnet H., Zou Y., Shu W., Soni R.K., Hendrickson R.C., Hadjantonakis A.K. & Massague J. TGF-beta orchestrates fibrogenic and developmental EMTs via the ras effector RREB1. Nature. 2020; 577, 566-571

6. Li Q., Dixon G., Verma N., Rosen B., Gordillo M., Luo R., Xu C., Wang Q., Soh C., Xiang Q., Leonardo T., Evan T., Massague J., Garippa R., Huangfu D. Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature Genetics. 2019; 51, 999–1010

7. Martin-Malpartida P., Batet M., Kaczmarska Z., Freier R., Gomes T., Aragón  Eric, Zou Y., Wang Q., Xi Q., Ruiz L., Vea A., Márquez J., Massagué J. & Macias M. Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors. Nature Communications. 2017; 8(1): 2070-84

8. Wang X., Wang P., Pan Y., Wang Q.*, Yin M*. Effect and mechanism of phenotypic transformation of vascular smooth muscle cells regulated by TGF-β2 on the venous thrombus wall remodeling. Medical Journal of Chinese People’s Liberation Army. 2020; 45, 791-797 (* co-correspondence)

9. Gao F.H., Wang Q., Wu Y.L., Li X., Zhao K.W., Chen G.Q. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochemical and Biophysical Research Communications. 2007; 356: 505–511

10. Li X., Xu Y.B., Wang Q., Lu Y., Zheng Y., Wang Y.C., Lubbert M., Zhao K.W., Chen G.Q. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: The role in AML1-ETO-induced growth arrest in leukemic cells. Journal of Cellular Physiology. 2006; 208(3): 594 – 01

11. Song M.G., Gao S.M., Du K.M., Xu M., Yu Y., Zhou Y.H., Wang Q., Chen Z., Zhu Y.S. and Chen G.Q. Nanomolar Level of NSC606985, a camptothecin analogue, induces leukemic cell apoptosis by protein kinase C-dependent mechanisms. BLOOD. 2005; 105(9): 3714-21

12. 12.Chen G.Q., Wang Q., Yan H. and Chen Z. Arsenic trioxide and leukemia: from bedside to bench. (Chapter 11, p251-272) Natural Products: Drug Discovery and Therapeutic Medicine. 2005; Eds Humana Press Inc. 999, Totowa, NJ 0751