姓名：朱泳璋  职称：副教授  硕/博士生导师

所在院系：欧洲杯竞猜平台全球健康学院动物健康与食品安全系

联系方式

办公室地址：上海市黄浦区重庆南路280号老红楼412

办公室电话：021-63846590-776974

邮箱：yzhzhu@sjtu.edu.cn

教育经历（从本科开始）

1998年-2002年  云南大学生命科学学院 国家生物学基地班  微生物学 学士

2002年-2007年  清华大学北京协和欧洲杯竞猜平台 医学生物学研究所  硕博连读 遗传学博士

工作经历

2007.09-2009.09  微生物与免疫学系, 欧洲杯竞猜平台  病原生物学博士后

2011.03-2017.07  微生物与免疫学系, 欧洲杯竞猜平台   讲师、副教授

2014.11-2015.11  兽欧洲杯竞猜平台, 康奈尔大学,  访问学者

2017.08-2019.07  抗生素研究所, 复旦大学附属华山医院,  讲师、副教授

2020.06-2020.11  P3实验室, 广州海关技术中心,  检验副主任技师

2020.12-至今    动物健康与食品安全系, 欧洲杯竞猜平台全球健康学院  副教授

社会/学术任职和活动

中国微生物学会人兽共患病病原学专业委员会委员

中国微生物学会医学微生物学与免疫学专委会青年学组委员

上海预防医学会微生态学专业委员会委员

上海微生物学会微生物组专业委员会委员

科研方向/主要研究内容

研究方向：病原组学与耐药控制

研究内容：重点关注重要人畜共患病原菌和重要耐药基因在人-动物-环境的交叉界面流行和传播模式和相互作用机制。以项目负责人主持国家自然科学青年基金、省自然科学基金和国家博士后基金等多项省部级课题，近五年来以第一作者或通讯作者发表包括8篇中科院一区文章在内的SCI论文20余篇，影响因子超过10分以上有9篇，影响因子超过100，包括Emerging Microbes & infections, Infectious Disease of Poverty, Sci Total Environ，mSystems和PLOS NTD等。

发表文章列表：

1) Min Li, Haoran Zhang, Wengang Zhang, Ying Cao, Bingqing Sun, et al, Xiaokui Guo, Jun Shang*, Shixin Huang*, Zhu YZ *(corresponding author). One global disseminated 193 kb high-risk hybrid plasmid harboring tet(X4), mcr or blaNDM threatening public health. Sci Total Environ 2023 Mar 14;876:162807.

2) Chang C, Guo W, Yu X, Guo C, Zhou N, Guo X, Huang RL*, Li Q*, Zhu Y*(corresponding author). Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy. Mater Today Bio 2023 Mar 24;20:100612.

3) Chao Lv, Jun Shang, Wengang Zhang, Bingqing Sun, Min Li, Chaoyi Guo, Nan Zhou, Xiaokui Guo*, Shixin Huang*,   Zhu YZ *(corresponding author). Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island, Shanghai. Infect Dis Poverty 2022 Sep 16;11(1):98.

4) Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yung-Fu Chang, Sheng Chen, Xiaokui Guo*, Xiao-Nong Zhou*, Min Li*,  Zhu YZ *(corresponding author). Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 2022 Aug 23;11(1):92.

5) Zhu Y, Shi L, Zeng Y, Piao D, Xie Y, Du J, Gao M, Gao W, Tian J, Yue J, Li M, Guo X, Yao Y, Kang Y. Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China. Infect Dis Poverty 2022 Jun 4;11(1):63.

6)  Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun*, Yufeng Yao*,  Zhu YZ *(corresponding author). Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients. Infect Dis Poverty. 2022 Feb 2;11(1):15.

7) Tinghua Lia, Lin Lyua, Yan Zhang, Ke Donga, Qingtian Li*, Xiaokui Guo*, Zhu YZ *(corresponding author).  A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI.  Genomics 2020 Sep 18;S0888-7543(20)30206-8.

8) Tinghua Li, Yan Zhang, Ke Dong, Chih-Jung Kuo, Chong Li, Yong-Qiang Zhu, Jinhong Qin, Qing-Tian Li, Yung-Fu Chang*, Xiaokui Guo*, Zhu YZ *(corresponding author). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020 May 5;5(3):e00017-20.

9) Cuicai Zhang, Jianmin Xu, Tinglan Zhang, Haiyan Qiu, Zhenpeng Li, Enmin Zhang, Shijun Li, Yung-Fu Chang, Xiaokui Guo*, Xiugao Jiang*, Zhu YZ *(corresponding author). Genetic Characteristics of Pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015.   PLOS Neglected Tropical Diseases. June 24, 2019  10.1371/journal.pntd.0007513

10) Xu-ming Li, Yao-xia Kang1, Liang Lin, En-Hou Jia, Dong-Ri Piao, Hai Jiang, Cui-Cai Zhang, Jin He, Yung-Fu Chang*, Xiao-Kui Guo* and Zhu YZ *(corresponding author). Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus. Front. Microbiol, 03 May 2019.

11) Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang*, Bruce Thorley*, Zhu YZ *(corresponding author). The Emergence and Spread of One Coxsackievirus A16 Genogroup D Novel Recombinant Strain Causing a Clustering HFMD Outbreak in Shanghai, China, 2016.  Emerg Microbes Infect. 2018 Jul 18;7(1):131.

12) Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo*, Xi Zhang*, Zhu YZ *(corresponding author).  Epidemiological and Serological Surveillance of Hand-Foot-and-Mouth Disease in Shanghai, China, 2012- 2016.  Emerg Microbes Infect. 2018 Jan 24;7(1):8.

Name：YongZhang Zhu

Degree：Ph.D                  

Title：  Associate Professor

Email Address: yzhzhu@sjtu.edu.cn

Office Address: No.412 room in laohong lou building

Office Tel: 021-63846590-776694

Education：

1998.09-2002.07 YunNan University School of life science National biology base class

2002.09-2007.07 Tsinghua University & Peking Union Medical College, Genetics Ph.D

Appointments：

2007.09-2009.09  Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine  Postdoc

2011.03-2017.07  Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine,  Associate Professor

2014.11-2015.11  Veterinary School, Cornell University, Visiting Scholar

2017.08-2019.07  Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University,  Associate Professor

2020.06-2020.11   Pathogen NGS sequencing platform of P3 lab, Guangzhou Customs District Technology Center,  Associate Professor

2020.12-Present   School of Global Health, Shanghai Jiao Tong University School of Medicine,  Associate Professor

Supporting  Grants：

Time： 2010.01-2012.12  Title： Virulence evolution mechanism of serovar icterohaemorrhagiae  virulent  and Virulence-attenuated strains in Pathogenic Leptospira Interrogans  Grant Number：30900051 Source： National Natural Science Foundation of China

Time：2010.11-2013.10 Title：Genomic and Proteomic-based novel approach for screening  vaccine antigens of Bordetella pertussis  Grant Number：BK2010158  Source：Provincial Natural Science Foundation

Time：2008.09-2010.08 Title： Comparative Genomics of Serovar Autumns hypervirulent and Attenuated strains in Pathogenic Leptospira Interrogans  Grant Number：20080430655   Source：Chinese Postdoctoral Science Foundation

Research Interest：

Pathogen Genomics and AMR control

Selected Publications

1) Min Li, Haoran Zhang, Wengang Zhang, Ying Cao, Bingqing Sun, et al, Xiaokui Guo, Jun Shang*, Shixin Huang*, Zhu YZ *(corresponding author). One global disseminated 193 kb high-risk hybrid plasmid harboring tet(X4), mcr or blaNDM threatening public health. Sci Total Environ 2023 Mar 14;876:162807.

2) Chang C, Guo W, Yu X, Guo C, Zhou N, Guo X, Huang RL*, Li Q*, Zhu Y*(corresponding author). Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy. Mater Today Bio 2023 Mar 24;20:100612.

3) Chao Lv, Jun Shang, Wengang Zhang, Bingqing Sun, Min Li, Chaoyi Guo, Nan Zhou, Xiaokui Guo*, Shixin Huang*, Zhu YZ *(corresponding author). Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island, Shanghai. Infect Dis Poverty 2022 Sep 16;11(1):98.

4) Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yung-Fu Chang, Sheng Chen, Xiaokui Guo*, Xiao-Nong Zhou*, Min Li*,  Zhu YZ *(corresponding author). Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 2022 Aug 23;11(1):92.

5) Zhu Y, Shi L, Zeng Y, Piao D, Xie Y, Du J, Gao M, Gao W, Tian J, Yue J, Li M, Guo X, Yao Y, Kang Y. Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China. Infect Dis Poverty 2022 Jun 4;11(1):63.

6)  Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun*, Yufeng Yao*, Zhu YZ *(corresponding author). Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients. Infect Dis Poverty. 2022 Feb 2;11(1):15.

7) Tinghua Lia, Lin Lyua, Yan Zhang, Ke Donga, Qingtian Li*, Xiaokui Guo*, Zhu YZ *(corresponding author).  A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI.  Genomics 2020 Sep 18;S0888-7543(20)30206-8.

8) Tinghua Li, Yan Zhang, Ke Dong, Chih-Jung Kuo, Chong Li, Yong-Qiang Zhu, Jinhong Qin, Qing-Tian Li, Yung-Fu Chang*, Xiaokui Guo*, Zhu YZ *(corresponding author). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020 May 5;5(3):e00017-20.

9) Cuicai Zhang, Jianmin Xu, Tinglan Zhang, Haiyan Qiu, Zhenpeng Li, Enmin Zhang, Shijun Li, Yung-Fu Chang, Xiaokui Guo*, Xiugao Jiang*, Zhu YZ *(corresponding author). Genetic Characteristics of Pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015.   PLOS Neglected Tropical Diseases. June 24, 2019  10.1371/journal.pntd.0007513

10) Xu-ming Li, Yao-xia Kang1, Liang Lin, En-Hou Jia, Dong-Ri Piao, Hai Jiang, Cui-Cai Zhang, Jin He, Yung-Fu Chang*, Xiao-Kui Guo*, Zhu YZ *(corresponding author). Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus. Front. Microbiol, 03 May 2019.

11) Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang*, Bruce Thorley*, Zhu YZ *(corresponding author). The Emergence and Spread of One Coxsackievirus A16 Genogroup D Novel Recombinant Strain Causing a Clustering HFMD Outbreak in Shanghai, China, 2016.  Emerg Microbes Infect. 2018 Jul 18;7(1):131.

12) Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo*, Xi Zhang*, Zhu YZ *(corresponding author).  Epidemiological and Serological Surveillance of Hand-Foot-and-Mouth Disease in Shanghai, China, 2012- 2016.  Emerg Microbes Infect. 2018 Jan 24;7(1):8.