姓名:吴文郁 职称:中级
联系方式:
办公室地址:上海市黄浦区重庆南路280号老红楼407
办公室电话:021-63846590转776428
邮箱:wenyuWu@sjtu.edu.cn
教育经历(从本科开始)
2011年-2015年 中国农业大学 动物科学学士
2015年-2018年 中国科学院大学 生物工程硕士
2018年-2023年 欧洲杯竞猜平台 生物学博士
工作经历
社会/学术任职和活动
科研方向/主要研究内容
急性髓系白血病的基础和临床转化研究。全健康科学/人兽共患病。
科研项目
项目编号 |
项目类型 |
项目名称 |
起止年月 |
备注 |
20JC1410600 |
上海市科学技术委员会 |
以PML核体亚细胞器为核心的抗肿瘤新策略研究 |
2021.01-2023.12 |
主要参与 |
81970132 |
国家自然科学基金 |
急性B淋巴细胞白血病致癌蛋白MEF2D-fusion的发病机制研究 |
2020.01-2023.12 |
参与 |
20152504-2 |
上海市教委 |
上海市教委高峰高原计划 (第二期) |
2019.01-2021.12 |
参与 |
81770142 |
国家自然科学基金 |
DUX4-IGH融合蛋白诱导急性B淋巴细胞白血病的发病机制研究 |
2018.01-2021.12 |
参与 |
82100153 |
国家自然科学基金 |
PML基因的砷剂耐药突变对PML核体组装的影响及机制研究 |
2021.01-2024.12 |
主要参与 |
82104582 |
国家自然科学基金 |
雄黄的主要活性分子——硫化砷靶向结合PML蛋白的分子机制研究 |
2021.01-2024.12 |
主要参与 |
发表论文(格式:国标GB/T7714-2015)
[1] Wu W, Tan Y, Yin H, Yin H, Jiang M, et al. Phase separation is required for PML nuclear body biogenesis and function[J].FASEB journal : official publication of the Federation of American Societies for Experimental Biology.2023,37(6):e22986.
[2] Chen Z, Wang Q, Zhang H, Ma X, Wu W, et al. Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex[J].Protein expression and purification.2021,179:105788.
[3] Li Y, Ma X, Wu W, Chen Z, Meng G. PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy[J].Trends in cancer.2020,6(10):889-906.
[4] Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, et al.B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis[J].Nature communications.2019,10(1):3789
[5] Wu W, Zhen X, Shi N. DNA-binding domain of myelin-gene regulatory factor: purification, crystallization and X-ray analysis[J].Acta crystallographica Section F, Structural biology communications.2017,73(Pt 7):393-7.
Name:WenyuWu
Degree:PhD
Title:
Email Address: wenyuWu@sjtu.edu.cn
Office Address: Room 407, Building 1, 280 South Chongqing Road, Shanghai
Office Tel: 021-63846590*776428
Education:2011. 09-2015. 07,Chinese Agriculture University, Bachelor, Animal Science
2015. 09-2018. 07,University of Chinese Academy of Sciences, Master, Biological Engineering
2018. 09-2023. 07 Shanghai Jiao Tong University School, Ph.D, Biology
Appointments:
Academic Participation and Activities:
[1] Wu W, Tan Y, Yin H, Yin H, Jiang M, et al. Phase separation is required for PML nuclear body biogenesis and function[J].FASEB journal : official publication of the Federation of American Societies for Experimental Biology.2023,37(6):e22986.
[2] Chen Z, Wang Q, Zhang H, Ma X, Wu W, et al. Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex[J].Protein expression and purification.2021,179:105788.
[3] Li Y, Ma X, Wu W, Chen Z, Meng G. PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy[J].Trends in cancer.2020,6(10):889-906.
[4] Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, et al.B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis[J].Nature communications.2019,10(1):3789
[5] Wu W, Zhen X, Shi N. DNA-binding domain of myelin-gene regulatory factor: purification, crystallization and X-ray analysis[J].Acta crystallographica Section F, Structural biology communications.2017,73(Pt 7):393-7.
ResearchInterest:
Dr. Wenyu Wu’s research focuses on the study of PML NBs and the pathogenesis of acute myeloid leukemia. Whole Health Sciences/Zoonoses.