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师资队伍

研究生导师

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曹建平

作者：   发布时间 ：2020年10月28日

个人简介

 

姓名：曹建平               

性别: 男                  

出生年月：1964年10月 

学位/学历：博士            

职称：研究员、博士生导师                   

现任职务：中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）副所长、国家卫生健康委寄生虫病原与媒介生物学重点实验室副主任，《中国寄生虫学与寄生虫病杂志》主编，《疾病监测》副主编

电子邮件：caojpcdc@163.com   

办公地址：上海市黄浦区瑞金二路207号

办公电话：021-64735258，13651811278

传真：021-64376308

教育经历

1982年9月至1987年7月，南京欧洲杯竞猜平台，临床医疗专业，大学本科，学士学位

1989年9月至1992年7月，南京欧洲杯竞猜平台，基础医学专业，硕士研究生，硕士学位

1995年9月至1998年7月，中国预防医学科学院，病原生物学，博士研究生，博士学位

          

工作经历

1987年8月至1999年12月 镇江欧洲杯竞猜平台工作

2000年1月至今 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）工作

 

社会/学术任职和活动

任中华医学科技奖第二届和第三届评审委员会委员、上海科技发展重点领域技术预见专家、上海市寄生虫学会理事长、中华医学会热带病与寄生虫学分会副主任委员、中国微生物学会人兽共患病病原学专业委员会副主任委员、上海市免疫学会理事等

 

研究方向/主要研究内容

1.寄生虫与宿主相互作用机制

2.寄生虫感染免疫及其调控机制，疫苗研制

3.新发寄生虫病分子流行病学、致病机制与跨种传播、监测与风险评估关键技术研究

 

科研/教学研究项目

作为负责人先后承担科研课题26项，其中包括国家“863”计划、国家科技重大专项、国家科技攻关计划、国家自然科学基金和国家卫生行业科研专项等国家级课题16项

 

1. 日本血吸虫虫卵外泌体源microRNA-1促进肝脏纤维化的作用及其机制研究，No.81971969，2020-2023，国家自然科学基金面上项目

2. Vγ2γδT细胞促日本血吸虫感染小鼠肝纤维化作用机制研究，No.81772225，2018-2021，国家自然科学基金面上项目

3. 日本血吸虫感染晚期小鼠脾脏淋巴滤泡再形成及机制研究，No.81371841，2014-2017，国家自然科学基金面上项目

4. 日本血吸虫致宿主脾脏淋巴滤泡破坏相关虫源分子的研究，No.30872212，2009-2011，国家自然科学基金面上项目

5. 日本血吸虫免疫逃避机制相关分子的研究，No.30371262，2004-2006，国家自然科学基金

6. 肉源性、水源性寄生虫病监测和风险评估关键技术研究及应用，201502021，2016-2018，国家卫生行业科研专项

7. 我国未来病原体战略研究（寄生虫分课题），L1522033，2015-2017，中国工程院与国家自然基金委中长期发展战略研究

8. 日本血吸虫病基因工程多价疫苗的研究，2006AA02Z444，2006-2010，国家“863”计划

9. 日本血吸虫基因工程疫苗的研究，2001AA215151，2001-2003；2004AA215240，2004-2005，国家“863”计划

10. 日本血吸虫病基因工程多价疫苗和DNA疫苗的研究，2004AA2Z3520，2004-2005，国家科技重大专项

11. 隐孢子虫病快速检测方法及虫株鉴别的研究，2003BA712A03-06，2003-2005，国家科技攻关计划

12. 野生动物与媒介携带的病原微生物种群、分布特征及其发生规律研究（寄生虫课题），2016YFC1201900，2016-2019，国家重点研发计划

13. 隐孢子虫病的诊断，20131601，2013-2015，国家卫生行业标准

14. 自然疫源性传染病病原谱流行规律及变异研究（寄生虫子课题），2012ZX10004-201-004，2012-2015，国家传染病重大专项

15. 特殊传染病诊断试剂企业研发/产品评价用参考品的研制（寄生虫子课题），2013ZX10004-805，2012-2015，国家科技重大专项

16. 自然疫源性传染病病原谱流行规律及变异研究（寄生虫子课题），2009ZX10004-201-004，2009-2011，国家传染病重大专项

17. 寄生虫病与病媒控制，No.GWV-10.1-XK13，2020-2022，上海市公共卫生体系建设三年行动计划（2020-2022）重点学科项目

18. 重点学科-热带病学，15GWZK0101，2016-2019，上海市公共卫生体系建设三年行动计划重点学科项目

19. 日本血吸虫病基因工程疫苗临床前研究，064319026，2007-2009，上海市生物医药重点项目

20. 抗日本血吸虫雌雄虫合抱基因工程疫苗的研究，03DZ19231，2004-2006，上海市科技攻关重大计划

 

主要学术成果

期刊论文

发表学术论文200余篇，其中SCI论文100余篇。近5年部分论文：

1.      HuY,   Wang X, Wei Y, Liu H, Zhang J, Shen Y, Cao J*. Functional inhibition   of natural killer cells in a BALB/c mouse model of liver fibrosis induced by   Schistosoma japonicum infection. Front Cell Infect Microbiol. 2020;10:598987.

2.      Zhang   X, Gong W, Cao S, Yin J, Zhang J, Cao J*, Shen Y*. Comprehensive analysis   of non-coding RNA profiles of exosome-like vesicles from the protoscoleces   and hydatid cyst fluid of Echinococcus granulosus. Front Cell Infect   Microbiol. 2020;10:316.

3.      Xu   J, Wang X, Jing H, Cao S, Zhang X, Jiang Y, Yin J, Cao J*, Shen Y*.   Identification and genotyping of Enterocytozoon bieneusi in wild Himalayan   marmots (Marmota himalayana) and Alashan ground squirrels (Spermophilus   alashanicus) in the Qinghai-Tibetan Plateau area (QTPA) of Gansu Province,   China. Parasit Vectors. 2020;13(1):367.

4.      Sun   L, Gong W, Shen Y, Liang L, Zhang X, Li T, Chen TT, Hu Y*, Cao J*.   IL-17A-producing γδ T cells promote liver pathology in acute murine   schistosomiasis. Parasit Vectors. 2020;13(1):334.

5.      Khan   A, Ahmed H*, Simsek S, Liu H, Yin J, Wang Y, Shen Y, Cao J*. Molecular   characterization of human Echinococcus isolates and the first report of E.   canadensis (G6/G7) and E. multilocularis from the Punjab Province of Pakistan   using sequence analysis. BMC Infect Dis. 2020;20:262.

6.      Khan   A, Ahmed H*, Simsek S, Afzal MS, Cao J*. Spread of cystic   echinococcosis in Pakistan due to stray dogs and livestock slaughtering   habits: research priorities and public health importance. Front Public   Health. 2020;7:412.

7.      Liu   A*, Gong B, Liu X, Shen Y, Wu Y, Zhang W, Cao J*. A retrospective epidemiological   analysis of human Cryptosporidium infection in China during the past three   decades (1987-2018). PLoS Negl Trop Dis. 2020;14(3):e0008146.

8.      Shen   Y, Gong B, Liu X, Wu Y, Yang F, Xu J, Zhang X, Cao J*, Liu A*. First   identification and genotyping of Enterocytozoon bieneusi in humans in   Myanmar. BMC Microbiol. 2020;20(1):10.

9.      Xu   N, Liu H, Jiang Y, Yin J, Yuan Z, Shen Y*, Cao J*. First report of   Cryptosporidium viatorum and Cryptosporidium occultus in humans in China, and   of the unique novel C. viatorum subtype XVaA3h. BMC Infect Dis.   2020;20(1):16.

10.    Li   XH, Vance GM, Cartwright J, Cao JP*, Wilson RA*, Castro-Borges W.   Mapping the epitopes of Schistosoma japonicum esophageal gland proteins for   incorporation into vaccine constructs. PLoS One. 2020;15(2):e0229542.

11.    Cao   S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J*, Shen Y*. Prevalence   and genetic characterization of Cryptosporidium, Giardia and Enterocytozoon   in chickens from Ezhou, Hubei, China. Front Vet Sci. 2020;7:30.

12.    Wu   L, Xi C, Liu Y, Jiang X, Chen S*, Cao J*. Toxoplasma gondii Rhoptry   Protein 16 (ROP16) modifies apoptosis in human 293T cells. J Nanosci   Nanotechnol. 2020;20(1):24-30.

13.    Chen   TT, Peng S, Wang Y, Hu Y, Shen Y, Xu Y, Yin J, Liu C, Cao J*.   Improvement of mitochondrial activity and fibrosis by resveratrol treatment   in mice with Schistosoma japonicum infection. Biomolecules. 2019, 9, 658.

14.    Yin   K*, Zhao G, Xu C, Qiu X, Wen B, Sun H, Liu G, Liu Y, Zhao Q, Wei Q, Huang B,   Yan G, Cao J*. Prediction of Toxoplasma gondii virulence factor ROP18   competitive inhibitors by virtual screening. Parasit Vectors.2019;12:98.

15.    Wei   F, Gong W, Wang J, Yang Y, Liu J, Wang Y, Cao J*. Role of the lipoxin   A4 receptor in the development of neutrophil extracellular traps in   Leishmania infantum infection. Parasites & Vectors. 2019;12:275.

16.    Ugwu   CE#, Jiang YY#, Wu L Xu YX, Yin JH, Duan LP, Chen SX, Liu H, Pan W, Quan H,   Shen YJ*, Cao JP*. In vitro Screening of Ginkgolic Acids for   Antiparasitic Activity against Cryptosporidium andersoni. Biomed Environ Sci.   2019; 32(4): 143-147.

17.    Hua   Liu#, Ning Xu#, Jianhai Yin, Zhongying Yuan,Yujuan Shen*, Jianping Cao*.   Prevalence and multilocus genotyping of potentially zoonotic Giardia   duodenalis in pigs in Shanghai, China. Parasitology.   2019;146(9):1199-1205.

18.    Gong   W, Huang F, Sun L, Yu A, Zhang X, Xu Y, Shen Y, Cao J*. Toll-like   receptor-2 regulates macrophage polarization induced by excretory-secretory   antigens from Schistosoma japonicum eggs and promotes liver pathology in murine   schistosomiasis. PLoS Negl Trop Dis, 2018,12(12):e0007000.

19.    Yin   JH, Liu CH,, Yu AP, Yao JQ, Shen YJ*, Cao JP*. Pro-angiogenic activity   of monocytic-type myeloid-derived suppressor cells from Balb/C mice infected   with Echinococcus granulosus and the regulatory role of miRNAs. Cell Physiol   Biochem. 2018;51:1207-1220.

20.    Xu   M, Jiang Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J*,   Shen Y*. Altered gut microbiota compositionin subjects infected with   Clonorchis sinensis. Front Microbiol. 2018;9:2292.

21.    Yu   A, Wang Y, Yin J, Zhang J, Cao S, Cao J*, Shen Y*. Microarray analysis   of long non-coding RNA expression profiles in monocytic myeloid-derived   suppressor cells in Echinococcus granulosus-infected mice. Parasit Vectors.   2018 May;11(1):327.

22.    Jiang   Y, Yuan Z, Zang G, Li D, Wang Y, Zhang Y, Liu H, Cao J*, Shen Y*.   Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a   retrospective case study. Front Med. 2018;12(1):98-103.

23.    Yin   J, Liu C, Shen Y, Zhang H, Cao J*. Efficacy of ursolic acid against   Echinococcus granulosus in vitro and in a murine infection model. Parasit   Vectors. 2018;11(1):58.

24.    Yin   J, Shen Y, Yu A, Liu C, Yao J, Gong W, Cao J*. The proangiogenic role   of polymorphonuclear myeloid-derived suppressor cells in mice infected with   Echinococcus granulosus.  BioScience Trends. 2018; 12(3):338-341.

25.    Hu   Y, Sun L, Yuan Z, Xu Y, Cao J*. High throughput data analyses of the   immune characteristics of Microtus fortis infected with Schistosoma   japonicum. Sci Rep.2017;7(1):11311.

26.    Zheng   L, Hu Y, Wang Y, Huang X, Xu Y, Shen Y*, Cao J*. Recruitment of   neutrophils mediated by Vγ2 γδ T Cells deteriorates liver fibrosis induced by   Schistosoma japonicum infection in C57BL/6 mice. Infect   Immun. 2017,85(8):e01020-16.

27.    Pan   W, Hao WT, Shen YJ, Li XY, Wang YJ, Sun FF, Yin JH, Zhang J, Tang RX, Cao   JP*, Zheng KY*. The excretory-secretory products of Echinococcus   granulosus protoscoleces directly regulate the differentiation of B10, B17   and Th17 cells. Parasit Vectors, 2017,10(1) :384.

28.    Zhang   W, Ren G, Zhao W, Yang Z, Shen Y, Sun Y, Liu A*, Cao J*. Genotyping of   Enterocytozoon bieneusi and subtyping of Blastocystis in cancer patients:   relationship to diarrhea and assessment of zoonotic transmission. Front   Microbiol.2017;8:1835.

29.    Liu   H, Shen Y, Liu A, Yin J, Yuan Z, Jiang Y, Pan W, Zhang Y, Zhao W, Cao J*.   Occurrence and multilocus genotyping of Giardia duodenalis in pets and zoo   animals in Shanghai, China.  J Infect Dev Ctries 2017; 11(6):479-486.

30.    Liu   H, Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D, Shen Y*, Cao J*.   Infection by and genotype characteristics of Enterocytozoon bieneusi in   HIV/AIDS patients from Guangxi Zhuang autonomous region, China. BMC Infect   Dis, 2017,17:684.

31.    Huang   YL, Huang DN, Geng YJ, Fang SS, Yang F, Wu CL, Zhang HL, Wang M, Zhang R,   Wang X, Wu S, Cao JP*, Zhang RL*. An integrated control strategy takes   Clonorchis sinensis under control in an endemic area in south China.   Vector-Borne and Zoonotic Diseases,2017;17(12):791-798.

32.    Shi   M, Lin XD, Tian JH, Chen LJ, Chen X, Li CX, Qin XC, Li J, Cao JP*, Eden JS,   Buchmann J, Wang W, Xu JG, Holmes EC, Zhang YZ. Redefining the invertebrate   RNA virosphere. Nature. 2016;540(7634):539-543.

33.    Liu   Z, Yin L, Li Y, Yuan F, Zhang X, Ma J, Liu H, Wang Y, Zheng K*, Cao J*.   Intranasal immunization with recombinant Toxoplasma gondii actin   depolymerizing factor confers protective efficacy against toxoplasmosis in   mice. BMC Immunol. 2016;17(1):37.

34.    Zhang   Y, Wang Y*, Jiang Y, Pan W, Liu H, Yin J, Shen Y, Cao J*. T follicular   helper cells in patients with acute schistosomiasis. Parasit Vectors.   2016;9(1):321.

35.    Zheng   Y*, Guo X, He W, Shao Z, Zhang X, Yang J, Shen Y, Luo X, Cao J*.   Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage   RAW264.7 cells. Int Immunopharmacol. 2016,34:259-262.

36.    Liu   Z, Yuan F, Yang Y, Yin L, Liu Y, Wang Y, Zheng K*, Cao J*. Partial   protective immunity against toxoplasmosis in mice elicited byrecombinant   Toxoplasma gondii malate dehydrogenase. Vaccine 2016,34(7):989–994.

37.    Wu   L, Wang X, Li Y, Liu Y, Su D, Fu T, Guo F, Gu L, Jiang X, Chen S*, Cao J*.   Toxoplasma gondii ROP18: potential to manipulate host cell mitochondrial   apoptosis. Parasitol Res. 2016;115(6):2415-2422.

38.    Yang   Z, Zhao W, Shen Y, Zhang W, Shi Y, Ren G, Yang D, Ling H, Yang F, Liu A*, Cao   J*. Subtyping of Cryptosporidium cuniculus and genotyping of   Enterocytozoon bieneusi in rabbits in two farms in Heilongjiang Province,   China. Parasite 2016, 23, 52.

39.    Han   S, Tang Q, Lu X, Chen R, Li Y, Shu J, Zhang X*, Cao J*. Dysregulation   of hepatic microRNA expression profiles with Clonorchis sinensis infection.   BMC Infect Dis.2016;16(1):724.

 

著作

1.《临床微生物学手册》（第12版）共同主译，中华医学电子音像出版社，北京，2020，

2.《曼氏热带病》（第23版），副主译，上海科学技术出版社，上海，2020

3.《腹泻症候群病原学监测与检测技术》，副主编，中山大学出版社，广州，2016

4.《现代寄生虫病学》（第2版），副主编，人民军医出版社，北京，2015

 

专利

获授权国家发明专利5件，1件已转化

1.     沈玉娟，曹建平，刘华，袁忠英，姜岩岩，尹建海，王燕娟. 多重PCR检测肠道新发原虫试剂盒及检测方法，ZL   201510093500.9，   2017.2

2.     沈玉娟，陈盛霞，金红，李峰，潘雨青，孙启艳，吴亮，曹建平. 基于图像的寄生虫虫卵形状识别方法，ZL   201110022426.3，2012.10   已转化

3.     尹建海，曹建平，刘丛珊，张皓冰，沈玉娟. 熊果酸在制备抗包虫药物中的应用，ZL 2016 1 0517861.6，2019.4

4.     曹建平、Ugwu Chidiebere   Emmanuel、沈玉娟、姜岩岩、段李平、袁忠英. 银杏酸在抗隐孢子虫中的应用，

ZL   201310539693.7，2016.3

5.     曹建平，蔡辉霞，沈玉娟，韩秀敏，胡媛，王虎，卢潍媛，徐馀信，官亚宜. 诊断细粒棘球蚴病的重组抗原蛋白、其制备方法和用途，ZL 201010284913.2，2012.8

 

荣誉及奖项

作为第一完成人获医学科技奖4项，获国家卫生计生有突出贡献中青年专家、国家抗震救灾医药卫生先进个人、全国血防卫士、上海市职工创新工作室等

1. 我国重要新发肠道原虫病原和分子检测关键技术研究及应用，2019年，以第一完成人获中华医学科技奖二等奖（中华医学会）、上海市科技进步奖二等奖（上海市人民政府）和华夏医学科技奖三等奖（中国医疗保健国际促进交流会）

2. 我国隐孢子虫核酸检测和基因分型技术的研究及应用，以第一完成人获中华预防医学科技奖三等奖（中华预防医学会，2015）

 

开设课程

    讲授研究生课程包括《寄生虫感染免疫学》、《专业英语—免疫学》、《被忽视热带病》、《新发肠道原虫病流行与挑战》、《实验室生物安全管理》、《动物疾病与人类健康》等

 

Profile

 

 

 

曹建平

 

Name：Cao Jianping  

Gender: male               

Date of birth：14 Oct,1964   

Degree：Doctor        

Title：Professor, Doctoral Supervisor

Present Position：Deputy Director,   National Institute of Parasitic Diseases, Chinese Center for Disease Control   and Prevention (Chinese Center for Tropical Diseases Research); Deputy   Director,  NHC Key   Laboratory of Parasite and Vector Biology, China; Editor-in-chief, Chinese   Journal of Parasitology and Parasitic Diseases; Associate Editor, Disease   Surveillance.

Email：caojpcdc@163.com, caojp@yahoo.com

Address：No.207, Rui Jin 2nd   Road, Shanghai, China                 

Office Tel：+8621-64735258，+86 13651811278

Education

1982.9-1987.7   Nanjing Medical University, bachelor, clinical medicine

1989.9-1992.7   Nanjing Medical University, master, basic medicine

1995.9-1998.7   Chinese   Academy of Preventive Medicine, Ph.D.,Pathogen Biology

          

Appointments

Aug 1987   to Dec 1999 Zhenjiang   Medical College

Jan 2000   to present National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention (Chinese Center for Tropical Diseases Research)

 

Academic Participation and Activities

Member, Chinese Medical Science and Technology Award   Committee;

President, Shanghai Association for Parasitology;

Deputy President, Branch of Tropical Diseases   and Parasitology, Chinese Medical Association;

Deputy President, Committee on   Aetiology of Zoonoses, Chinese Society for Microbiology;

Member, Shanghai Immunology Association;

Expert, Technology Foresight in Key areas of Science   and Technology Development, Shanghai.

 

Research Interest

1. Mechanisms involved in the   interaction between parasite and the host

2. Infection and immunity, Development   of vaccine

3. Molecular   epidemiology, pathogenic mechanism, cross-species transmission, key   techniques for surveillance and risk assessment of emerging infectious parasitic   diseases

 

Projects

1. Study on the role and its mechanism of microRNA-1 of exosome from   Schistosoma japonicum egg in promoting liver fibrosis. National Natural   Science Foundation of China, No.81971969, 2020-2023,

2.Study on the mechanism of Vγ2γδT cells derived from mice   infected with Schistosoma japonicum facilicate the liver fibrosis. National   Natural Science Foundation of China, No.81772225, 2018-2021

3.Study on the mechanism of re-generated spleen lymphoid follicles   in mice during advanced schistosomiasis japonica. National Natural Science   Foundation of China, No.81371841, 2014-2017

4. Study on the destruction of the spleen’s lymphoid follicles   in mice infected with Schistosoma japonicum by the schistosome-derived   molecules. National Natural Science Foundation of China, No.30872212，2009-2011

5. Study on the molecular mechanism of immune evasion in mice   infected with Schistosoma japonicum. National Natural Science   Foundation of China, No.30371262，2004-2006

6. Study and application of the key technologies for monitoring   and risk assessment of meat-borne and water-borne parasitic diseases. Chinese   Special Program for Scientific Research of Public Health, 201502021,2016-2018

7. Study on genetic engineering polyvalent vaccine against   schistosomiasis japonica. National High Technology Research and Development   Programme of China (863 Programme), 2006AA02Z444, 2006-2010

8. Development of genetic engineering vaccine against Schistosoma   japonicum. National High Technology Research and Development Programme of   China (863 Programme), 2001AA215151, 2001-2003; 2004AA215240, 2004-2005

9. Development of geneticengineering polyvalent vaccine and DNA   vaccine against schistosomiasis japonica, National Science and Technology   Major Program of China, 2004AA2Z3520, 2004-2005

10. Study on rapid detection and identification techniques of Cryptosporidium.   National Programs for Science and Technology Development, 2003BA712A03-06, 2003-2005

11. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2012ZX10004-201-004, 2012-2015

12. Development of reference materials for special infectious   disease diagnostic reagent enterprise R & D/product evaluation. National   Science and Technology Major Program of China, 2013ZX10004-805, 2012-2015

13. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2009ZX10004-201-004, 2009-2011

14. Control of parasitic diseases and vectors. Key Discipline   Project of the Three-year Action Plan (2020-2022) for the Construction of   Shanghai Public Health System, No.GWV-10.1-XK13, 2020-2022

15. Tropical Medicine. Key Discipline Project of the Three-year Action   Plan for the Construction of Shanghai Public Health System, 15GWZK0101，2016-2019

17. Preclinical study of genetic engineering vaccine against   schistosomiasis japonica. Key Biomedical Project Shanghai, 064319026, 2007-2009

16. Development of genetic engineering vaccine against pairing   of female and male of Schistosoma japonicum. Shanghai Science and Technology   Major Program, 03DZ19231, 2004-2006

 

Publications

More than 200 papers published. Some of the papers published   in the past 5 years are as follows:

1.      HuY, Wang X, Wei Y, Liu H, Zhang J,   Shen Y, Cao J*. Functional inhibition of natural killer cells in a   BALB/c mouse model of liver fibrosis induced by Schistosoma japonicum   infection. Front Cell Infect Microbiol. 2020;10:598987.

2.      Zhang   X, Gong W, Cao S, Yin J, Zhang J, Cao J*, Shen Y*.   Comprehensive analysis of non-coding RNA profiles of exosome-like vesicles   from the protoscoleces and hydatid cyst fluid of Echinococcus granulosus.   Front Cell Infect Microbiol. 2020;10:316.

3.      Xu   J, Wang X, Jing H, Cao S, Zhang X, Jiang Y, Yin J, Cao J*, Shen Y*.   Identification and genotyping of Enterocytozoon bieneusi in wild   Himalayan marmots (Marmota himalayana) and Alashan ground squirrels (Spermophilus   alashanicus) in the Qinghai-Tibetan Plateau area (QTPA) of Gansu   Province, China. Parasit Vectors. 2020;13(1):367.

4.      Sun   L, Gong W, Shen Y, Liang L, Zhang X, Li T, Chen TT, Hu Y*, Cao J*.   IL-17A-producing γδ T cells promote liver pathology in acute murine   schistosomiasis. Parasit Vectors. 2020;13(1):334.

5.      Khan   A, Ahmed H*, Simsek S, Liu H, Yin J, Wang Y, Shen Y, Cao J*. Molecular   characterization of human Echinococcus isolates and the first report   of E. canadensis (G6/G7) and E. multilocularis from the Punjab   Province of Pakistan using sequence analysis. BMC Infect Dis. 2020;20:262.

6.      Khan   A, Ahmed H*, Simsek S, Afzal MS, Cao J*. Spread of cystic   echinococcosis in Pakistan due to stray dogs and livestock slaughtering   habits: research priorities and public health importance. Front Public   Health. 2020;7:412.

7.      Liu   A*, Gong B, Liu X, Shen Y, Wu Y, Zhang W, Cao J*. A retrospective   epidemiological analysis of human Cryptosporidium infection in China   during the past three decades (1987-2018). PLoS Negl Trop Dis.   2020;14(3):e0008146.

8.      Shen   Y, Gong B, Liu X, Wu Y, Yang F, Xu J, Zhang X, Cao J*, Liu A*. First   identification and genotyping of Enterocytozoon bieneusi in humans in   Myanmar. BMC Microbiol. 2020;20(1):10.

9.      Xu   N, Liu H, Jiang Y, Yin J, Yuan Z, Shen Y*, Cao J*. First report of Cryptosporidium   viatorum and Cryptosporidium occultus in humans in China, and of   the unique novel C. viatorum subtype XVaA3h. BMC Infect Dis.   2020;20(1):16.

10.    Li   XH, Vance GM, Cartwright J, Cao JP*, Wilson RA*, Castro-Borges W. Mapping   the epitopes of Schistosoma japonicum esophageal gland proteins for   incorporation into vaccine constructs. PLoS One. 2020;15(2):e0229542.

11.    Cao   S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J*, Shen Y*. Prevalence   and genetic characterization of Cryptosporidium, Giardia and Enterocytozoon   in chickens from Ezhou, Hubei, China. Front Vet Sci. 2020;7:30.

12.    Wu   L, Xi C, Liu Y, Jiang X, Chen S*, Cao J*. Toxoplasma gondii   Rhoptry Protein 16 (ROP16) modifies apoptosis in human 293T cells. J Nanosci   Nanotechnol. 2020;20(1):24-30.

13.    Chen   TT, Peng S, Wang Y, Hu Y, Shen Y, Xu Y, Yin J, Liu C, Cao J*.   Improvement of mitochondrial activity and fibrosis by resveratrol treatment   in mice with Schistosoma japonicum infection. Biomolecules. 2019, 9,   658.

14.    Yin   K*, Zhao G, Xu C, Qiu X, Wen B, Sun H, Liu G, Liu Y, Zhao Q, Wei Q, Huang B,   Yan G, Cao J*. Prediction of Toxoplasma gondii virulence factor   ROP18 competitive inhibitors by virtual screening. Parasit   Vectors.2019;12:98.

15.    Wei   F, Gong W, Wang J, Yang Y, Liu J, Wang Y, Cao J*. Role of the lipoxin   A4 receptor in the development of neutrophil extracellular traps in   Leishmania infantum infection. Parasites & Vectors. 2019;12:275.

16.    Ugwu CE#, Jiang YY#,   Wu L Xu YX, Yin JH, Duan LP, Chen SX, Liu H, Pan W, Quan H, Shen YJ*, Cao   JP*. In vitro Screening of Ginkgolic Acids for Antiparasitic
  Activity against Cryptosporidium andersoni. Biomed Environ Sci. 2019;   32(4): 143-147.

17.     Hua Liu#, Ning Xu#,   Jianhai Yin, Zhongying Yuan,Yujuan Shen*, Jianping Cao*. Prevalence   and multilocus genotyping of potentially zoonotic Giardia duodenalis in pigs   in Shanghai, China. Parasitology. 2019;146(9):1199-1205.

18.    Gong W, Huang F, Sun L, Yu A, Zhang X, Xu Y, Shen Y, Cao J*. Toll-like   receptor-2 regulates macrophage polarization induced by excretory-secretory   antigens from Schistosoma japonicum eggs and promotes liver pathology   in murine schistosomiasis. PLoS Negl Trop Dis, 2018,12(12):e0007000.

19.    Yin   JH, Liu CH,, Yu AP, Yao JQ, Shen YJ*,   Cao JP*.   Pro-angiogenic   activity of monocytic-type myeloid-derived suppressor cells from Balb/C mice   infected with Echinococcus granulosus and the regulatory role of   miRNAs. Cell Physiol Biochem. 2018;51:1207-1220.

20.    Xu   M, Jiang Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J*,   Shen Y*. Altered gut microbiota compositionin subjects infected with   Clonorchis sinensis. Front Microbiol. 2018;9:2292.

21.    Yu A, Wang Y, Yin J, Zhang J, Cao S, Cao J*, Shen Y*. Microarray analysis of   long non-coding RNA expression profiles in monocytic myeloid-derived   suppressor cells in Echinococcus granulosus-infected mice. Parasit   Vectors. 2018 May;11(1):327.

22.    Jiang   Y, Yuan Z, Zang G, Li D, Wang Y, Zhang Y, Liu H, Cao J*, Shen Y*.   Cyclospora cayetanensis infections among diarrheal outpatients in   Shanghai: a retrospective case study. Front Med. 2018;12(1):98-103.

23.    Yin   J, Liu C, Shen Y, Zhang H, Cao J*. Efficacy of ursolic acid against   Echinococcus granulosus in vitro and in a murine infection model. Parasit   Vectors. 2018;11(1):58.

24.    Yin   J, Shen Y, Yu A, Liu C, Yao J, Gong W, Cao J*. The proangiogenic role   of polymorphonuclear myeloid-derived suppressor cells in mice infected with   Echinococcus granulosus.  BioScience Trends. 2018; 12(3):338-341.

25.    Hu   Y, Sun L, Yuan Z, Xu Y, Cao J*. High throughput data analyses of the   immune characteristics of Microtus fortis infected with Schistosoma   japonicum. Sci Rep.2017;7(1):11311.

26.    Zheng   L, Hu Y, Wang Y, Huang X, Xu Y, Shen Y*, Cao J*. Recruitment of neutrophils   mediated by Vγ2 γδ T Cells deteriorates liver fibrosis induced by Schistosoma   japonicum infection in C57BL/6 mice. Infect   Immun. 2017,85(8):e01020-16.

27.    Pan   W, Hao WT, Shen YJ, Li XY, Wang YJ, Sun FF, Yin JH, Zhang J, Tang RX, Cao   JP*, Zheng KY*. The   excretory-secretory products of Echinococcus granulosus protoscoleces   directly regulate the differentiation of B10, B17 and Th17 cells. Parasit   Vectors, 2017,10(1) :384.

28.    Zhang W, Ren G, Zhao W, Yang Z, Shen Y, Sun Y, Liu A*, Cao J*.   Genotyping of Enterocytozoon bieneusi and subtyping of Blastocystis in   cancer patients: relationship to diarrhea and assessment of zoonotic   transmission. Front Microbiol.2017;8:1835.

29.    Liu H, Shen Y, Liu A, Yin J, Yuan Z, Jiang Y, Pan W, Zhang Y,   Zhao W, Cao J*. Occurrence and multilocus genotyping of Giardia   duodenalis in pets and zoo animals in Shanghai, China.  J Infect Dev   Ctries 2017; 11(6):479-486.

30.    Liu H, Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D, Shen Y*, Cao   J*. Infection by and genotype characteristics of Enterocytozoon   bieneusi in HIV/AIDS patients from Guangxi Zhuang autonomous region,   China. BMC Infect Dis, 2017,17:684.

31.    Huang YL, Huang DN, Geng YJ, Fang SS, Yang F, Wu CL, Zhang HL,   Wang M, Zhang R, Wang X, Wu S, Cao JP*, Zhang RL*. An integrated   control strategy takes Clonorchis sinensis under control in an endemic area   in south China. Vector-Borne and Zoonotic Diseases,2017;17(12):791-798.

32.    Shi   M, Lin XD, Tian JH, Chen LJ, Chen X, Li CX, Qin XC, Li J, Cao JP, Eden   JS,  Buchmann J, Wang W, Xu JG, Holmes EC, Zhang YZ. Redefining the   invertebrate RNA virosphere. Nature. 2016;540(7634):539-543.

33.    Liu   Z, Yin L, Li Y, Yuan F, Zhang X, Ma J, Liu H, Wang Y, Zheng K*,   Cao J*.   Intranasal immunization with recombinant Toxoplasma gondii actin   depolymerizing factor confers protective efficacy against toxoplasmosis in   mice. BMC Immunol. 2016;17(1):37.

34.    Zhang Y, Wang Y*, Jiang Y, Pan W, Liu H, Yin J, Shen Y, Cao J*. T follicular helper cells in patients with acute   schistosomiasis. Parasit Vectors. 2016;9(1):321.

35.    Zheng Y*, Guo X,   He W, Shao Z, Zhang X, Yang J, Shen Y, Luo X, Cao J*. Effects of Echinococcus   multilocularis miR-71 mimics on murine macrophage RAW264.7 cells. Int   Immunopharmacol. 2016,34:259-262.

36.    Liu Z, Yuan F,   Yang Y, Yin L, Liu Y, Wang Y, Zheng K*, Cao J*. Partial protective   immunity against toxoplasmosis in mice elicited byrecombinant Toxoplasma   gondii malate dehydrogenase. Vaccine 2016,34(7):989–994.

37.    Wu L, Wang X, Li   Y, Liu Y, Su D, Fu T, Guo F, Gu L, Jiang X, Chen S*, Cao J*. Toxoplasma   gondii ROP18: potential to manipulate host cell mitochondrial apoptosis.   Parasitol Res. 2016;115(6):2415-2422.

38.    Yang Z, Zhao W,   Shen Y, Zhang W, Shi Y, Ren G, Yang D, Ling H, Yang F, Liu A*, Cao J*. Subtyping of Cryptosporidium   cuniculus and genotyping of Enterocytozoon bieneusi in rabbits in   two farms in Heilongjiang Province, China. Parasite 2016, 23, 52.

39.    Han S, Tang Q, Lu   X, Chen R, Li Y, Shu J, Zhang X*, Cao J*. Dysregulation   of hepatic microRNA expression profiles with Clonorchis sinensis infection.   BMC Infect Dis.2016;16(1):724.

 

Books

1.《Manual of   Clinical Microbiology (12th Edition), Co-Chief-Translator, Chinese Medical Multimedia   Press, Beijing, 2020

2.《Manson’s   Tropical Diseases》(23rd   Edition), Deputy Chief-translator, Shanghai Science & Technology   Publishers, Shanghai, 2020

3.《Pathogen   Surveillance and Detection Techniques: Diarrhea Syndrome》,Associate   Editor, Sun Yat-sen University Press, Guangzhou, 2016

4.《Modern   Parasitology》(2nd Edition), Associate   Editor，People's   Military Medical Press, Beijing, 2015

 

Patents

1. Yujuan Shen，Jianping Cao，Hua Liu，Zhongyin Yuan，Yanyan Jiang，Jianhai Yin，Yanjuan Wang.   Multiplex PCR kit and detection method for detecting emerging intestinal protozoan. ZL   201510093500.9, 2017

2. Yujuan Shen，Shengxia Chen，Hong Jin，Feng Li，Yuqin Pan，Qiyan Sun，Liang Wu，Jianping Cao. Recognition   Method for Parasite Egg Based Shape Image. ZL 201110022426.3, 2012

3. Jianhai Yin，Jianping Cao，congshan Liu，Haobing Zhang，Yujuan Shen.   Application of ursolic acid in preparation of anti-hydatid drugs. ZL 2016 1   0517861.6, 2019.

4. Jianping Cao, Ugwu   Chidiebere Emmanuel, Yujuan Shen，Yanyan   Jiang，Liping Duan,   Zhongying Yuan. Application of ginkgo acid against cryptosporidium. ZL   201310539693.7, 2016

5. Jianping Cao, Huixia Cai,   Yujuan Shen，Xiumin Han，Yuan Hu，Hu Wang，Weiyuan Lu，Yuxin Xu，Yayi Guang.   Recombinant antigen protein for diagnosis of echinococcus granulosus, its   preparation method and application. ZL 201010284913.2, 2012

 

Honors and Awards

1. Study on the pathogens and key techniques of   molecular detection for important emerging intestinal protozoan and their   application in China. Second Prize of China Medical Science   and Technology Award, second Prize of Shanghai Science and Technology   Progress Award, and third Prize in the Huaxia Medical Technology Awards in 2019.

2. Establishment and application of   nucleic acid assays and genotyping techniques for Cryptosporidium in   China. Third prize of China Preventive Medicine Science and Technology Award   (2015)

 

Lectures

Parasitic   infection and immunity, Professional English -- Immunology, Neglected tropical   diseases, Epidemiology and challenges of emerging infectious parasitic   diseases, Laboratory Biosafety Management, Zoonotic parasitic diseases

 

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