A subset of Kupffer cells regulates metabolism through the expression of CD36. Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Mohd Kairi MF, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Jinmiao Chen JM, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, and Ginhoux F, Immunity 2021 September 14 54, 1–16; doi: 10.1016/j.immuni.2021.08.006

Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S,  Ficht X, De Ponti FF, Bono EB, Giustini L, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Rava M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Florent Ginhoux F and Iannacone M, Immunity 2021 September 14 54, 1–12; doi: 10.1016/j.immuni.2021.05.005

Microbial exposure during early human development primes fetal immune cells. Mishra A, Lai GC, Yao LJ, Aung TT, Shental N, Rotter-Maskowitz A, Shepherdson E, Naranjan Singh G, Pai R, Shanti A, Men Men Wong R, Lee A, Khyriem C, Dutertre CA, Chakarov S, Srinivasan KG, Binte Shadan N, Zhang XM, Khalilnezhad S, Cottier F, Shin Min Tan A, Low G, Chen P, Fan Y, Xiang Hor P, Khoo May Lee A, Choolani M, Vermijlen D, Ankur Sharma A, Fuks G, Straussman R, Pavelka N, Malleret B, McGovern N, Albani S, Kok Yen Chan J, Ginhoux G, Cell 2021 June 24 184, 3394–3409; doi:10.1016/j.cell.2021.04.039

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinom. Sharma A, Seow J, Dutertre CA, Pai R, Blériot C, Mishra A, Wong R, Singh G, Sudhagar S, Khalilnezhad S, Erdal S, Teo HM, Khalilnezhad A, Chakarov S, Kiat Hon Lim T, Chung Yaw Fui A, Kow Wei Chieh A, Cheow Peng Chung CP, Bonney G, Goh Kim Poh B, Chan J, Chow P, Ginhoux F, DasGupta R, Cell 2020 Oct 15 183, 1–18; doi: 10.1016/j.cell.2020.08.040

Determinants of resident tissue macrophage form and function. Bleriot C, Chakarov S, Ginhoux F, Immunity 2020 Jun 16 52, 957-970; doi: 10.1016/j.immuni.2020.05.014

Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B, Ginhoux F. Cell. 2019 Sep 5 178, 1509-1525; doi:10.1016/j.cell.2019.08.009

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung. Schyns J, Bai O, Ruscitti C, Radermecker C, De Schepper S, Chakarov S, Farnir F, Pirottin D, Ginhoux F, Boeckxstaens G, Bureau F, Marichal T. Nat Commun. 2019 Sep 3; 10:3964; doi: 10.1038/s41467-019-11843-0

Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen. Fujita K, Chakarov S, Kobayashi T, Sakamoto K, Voisin B, Duan K, Nakagawa T, Horiuchi K, Amagai M, Ginhoux F, Nagao K PNAS. 2019 Jul 16;116(29):14714-14723; doi: 10.1073/pnas.1818907116

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches.Chakarov S, Lim HY, Tan L, Lim SY, See P, Lum J, Zhang XM, Foo S, Nakamizo S, Duan K, Kong WT, Gentek R, Balachander A, Carbajo D, Bleriot C, Malleret B, Tam JKC, Baig S, Shabeer M, Toh SES, Schlitzer A, Larbi A, Marichal T, Malissen B, Chen J, Poidinger M, Kabashima K, Bajenoff M, Ng LG, Angeli V, Ginhoux F. Science. 2019 Mar 15;363(6432). pii: eaau0964; doi: 10.1126/science.aau0964.

Hyaluronan receptor lyve-1-expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen. Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley ER, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V Immunity. 2018 Aug 21;49(2):326-341.e7; doi: 10.1016/j.immuni.2018.06.008.

Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function. Takata K, Kozaki T, Lee CZW, Thion MS, Otsuka M, Lim S, Utami KH, Fidan K, Park DS, Malleret B, Chakarov S, See P, Low D, Low G, Garcia-Miralles M, Zeng R, Zhang J, Goh CC, Gul A, Hubert S, Lee B, Chen J, Low I, Shadan NB, Lum J, Wei TS, Mok E, Kawanishi S, Kitamura Y, Larbi A, Poidinger M, Renia L, Ng LG, Wolf Y, Jung S, Önder T, Newell E, Huber T, Ashihara E, Garel S, Pouladi MA, Ginhoux F. Immunity. 2017 Jul 18;47(1):183-198.e6; doi: 10.1016/j.immuni.2017.06.017.

Exposure to bacterial CpG DNA protects from airway allergic inflammation by expanding regulatory lung interstitial macrophages. Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T, Bureau F Immunity. 2017 Mar 21;46(3):457-473; doi: 10.1016/j.immuni.2017.02.016.

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossm E, Bogen B, Choolani M, Chan JKY, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B, Ginhoux F. Immunity. 2016 Sep 20;45(3):669-684; doi:10.1016/j.immuni.2016.08.015. Epub 2016 Sep13.

Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development. Chen J, Schlitzer A, Chakarov S, Ginhoux F, Poidinger M Nat Commun. 2016 Jun 30; 7:11988; doi:10.1038/ncomms11988.

Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, Casanova-Acebes M, Khudoynazarova M, Agudo J, Tung N, Chakarov S, Rivera C, Hogstad B, Bosenberg M, Hashimoto D, Gnjatic S, Bhardwaj N, Palucka AK, Brown BD, Brody J, Ginhoux F, Merad M. Immunity. 2016 Apr 19;44(4):924-38; doi:10.1016/j.immuni.2016.03.012.

Tracking by flow cytometry antigen-specific follicular helper T cells in wild-type animals after protein vaccination. Chakarov S & Fazilleau N Methods Mol Biol. 2015 1291:39-47; doi: 10.1007/978-1-4939-2498-1_4.

Monocyte-derived dendritic cells promote T follicular helper cell differentiation. Chakarov S & Fazilleau N EMBO Mol Med. 2014 May;6(5):590-603; doi: 10.1002/emmm.201403841.