1. 脂肪组织代谢稳态的免疫调控

2. 天然淋巴细胞发育及功能的调控机制及其与炎症性疾病的关系

1. Xu Y, Zhang H, Wu S, Liu J, Liu H, Wang D, Zhang Y, Niu H, Su X, Sun J, Shen L*. PLZF restricts intestinal ILC3 function in gut defense. Cell Mol Immunol (2023). https://doi.org/10.1038/s41423-023-00975-5
   

2. Zhou J, Zhang J, Tao L,Peng K, Zhang Q, Yan K, Luan J, Pan J, Su X, Sun J, Zhang Z, Shen L*. Up-regulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cell activation in psoriasis. Proceedings of the National Academy of Sciences of the United States of America, 2022,119(44):e2117523119.

3. Zhang J，Qiu J, Zhou W, Cao J, Hu X, Mi W, Su B, He B, Qiu J, Shen L*. Neuropilin-1 mediates lung tissue-specific control of ILC2s function in type 2 immunity. Nature Immunology (2022). https://doi.org/10.1038/s41590-021-01097-8

4. ChenZ，XieX，JiangN,Li J, Shen L*, Zhang Y*. CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest. Cell Death Dis.2021 Feb 15;12(2):184. doi: 10.1038/s41419-021-03464-7.

5. Shen L,Ye Y, Sun H,Su B. ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy. Cancer Cell. 2021 Aug 13:S1535-6108(21)00442-6. doi: 10.1016/j.ccell.2021.08.002.

6. Qi J, Crinier A, Escalière B, Ye Y, Wang Z, Zhang T, Batista L, Liu H, Hong L, Wu N, Zhang M, Chen L, Liu Y, Shen L*, Narni-Mancinelli E*, Vivier E*, Su B*. Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. Cell Rep Med. 2021 Jul 27;2(8):100353. doi: 10.1016/j.xcrm.2021.100353. PMID: 34467243; PMCID: PMC8385246.

7. Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H*, Shen L*, Qiu J*. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol. 2021 Aug 4. doi: 10.1038/s41385-021-00431-5. Epub ahead of print. PMID: 34349237.

8. Li C, Liu J, Pan J, Wang Y, Shen L*, Xu Y*. ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients. Front Immunol. 2021 Jul 26;12:708678. doi: 10.3389/fimmu.2021.708678. PMID: 34381457; PMCID: PMC8350136.

9. Ji Z, Wu S, Xu Y, Qi J, Su X, Shen L*.Obesity promotes EAE through IL-6 and CCL-2-mediated T cells infiltration. .Frontiers in Immunology,2019,8（10））.  [Link]

10. Cai T, Qiu J, Ji Y, Li W, Ding Z, Suo C, Chang J, Wang J, He R, Qian Y, Guo X, Zhou L, Sheng H, Shen L*, Qiu J*.IL-17-producing ST2+ group 2 Innate Lymphoid Cells play a pathogenic role in lung inflammation. .J Allergy Clin Immunol,2019,143(1):229-244.  [Link]

11. Wang H, Shen L, Sun X, Liu F, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D, Bi Y.Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity.Nat Commun.,2019,10(1):3254.  [Link]

12. Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J.SENP1 regulates IFN-g-STAT1 signaling through STAT3-SOCS3 negative feedback loop..J Mol Cell Biol. ,2017,9(2):144-153.  [Link]

13.  McLaughlin T, Ackerman SE, Shen L, Engleman E.Role of innate and adaptive immunity in obesity-associated metabolic disease..J Clin Invest,2017,127(1): 5-13..  [Link]

14. Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, E.B-1a Lymphocytes Attenuate Insulin Resistance.Diabetes,2015,64(2):593-603.  [Link]

15. Shen L, Zhang H, Caimol M, Benike CJ, Chakravar.Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production..Eur J Immunol.,2015,45(2):612-623.  [Link]

16. McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E..T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans..Arterioscler Thromb Vasc Biol. ,2014,34(12):2637-43.  [Link]

17. Winer DA, Winer S, Chng MH, Shen L, Engleman EG..B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance..Cell Mol Life Sci.,2014,71(6):1033-43.  [Link]

18. Winer D* Winer S*, Shen L*, Wadia P, Yantha J, Paltser G, Tsui H, Wu P, Davidson M, Alonso M, Leong H, Glassford A, Caimol M, Tedder T, McLaughlin T, Miklos D, Dosch HM, Engleman EG..B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies..Nature Medicine,2011,17(5):610-7.  [Link]

19.  Shen L, Evel-Kabler K, Strube R, Chen SY..Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity..Nature Biotechnology,2004,22:1546-1553.  [Link]

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