免疫调节：

围绕免疫调节，聚焦“移植免疫耐受诱导和肿瘤免疫细胞生物治疗策略” 分为：1.中药天花粉蛋白（TCS）对免疫系统的负向调节机制及其应用的研究；2.CIITA对MHC分子及T细胞分化转录激活的表观遗传学调控方面的研究；3.B7-H1和调节性T细胞诱导（移植）免疫耐受的研究；4.肿瘤免疫治疗的转化研究 5.造血干细胞移植耐受及重建的机制研究。

1. 1. Zong An Chen, Zhen Gao, LingLing Xia, XiaoQing Wang, Li-Ming Lu* XiaoLi Wu *.Dysregulation of DPP4-CXCL12 balance by TGF-β1/SMAD pathway promotes CXCR4+ inflammatory cell infiltration in keloid scars. Journal of Inflammation Research.  2021 Aug 26; 14:4169-4180.

2. 2. Kai Wang, Man Zhang, Jiao Wang, Jizhuang Luo, Pan Sun, Haizhen Jing, Rong Li, Changqing Pan, Li-Ming Lu*. A systematic analysis identifies key regulators involved in cell proliferation and potential drugs for the treatment of human lung adenocarcinoma. Frontiers in Oncology-Thoracic Oncology.  2021 Sep 28;11:4-15

3. 3. Christopher D Nishimura, Marc C Pulanco, Wei Cui, Liming Lu, Xingxing Zang PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies. Trends Mol Med.2020 Nov 13;S1471-4914(20)30266-5.

4. 4. Duo Zhang; Di Tang; Yu Heng; Xiao-Ke Zhu; Liang Zhou; Lei Tao; Li-Ming Lu* Prognostic Impact of Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients. Laryngoscope. 2020 Oct 27. doi: 10.1002/lary.29196.

5. 5. Zhang Yu; Zhou Lin; Gu Xiang; Feng Xuan; Ding Ping; Xia Qiang; Li-Ming Lu* CXCL8high inflammatory B cells in the peripheral blood of patients with biliary atresia are involved in disease progression. Immunology & Cell Biology. 2020; 1–11

6. 6. Zhang, Na; Sun, Pan; Jin, Haizhen; Yang, Yuqin; Zhao, Qingya; Zhou, Lin; Guo, Lili; Yang, Xiaohua; Li-Ming Lu* Chidamide combined with paclitaxel effectively reverses the expression of histone deacetylase in lung cancer. Anti-Cancer Drugs. 2020 August; 31(7):702-708,

7. 7. Yi Xue , Di Tang , Sheng-Jie Li , Jian Zhou , Chi-Yao Hsueh , Dan-Dan Zhao , Yu Heng , Lei Tao, Li-Ming Lu* Link Between CIITA rs3087456 Polymorphism and the Risk of Laryngeal Squamous Cell Carcinoma in a Chinese Population. Pathol Res Pract. 2020 Jan;216(1):152793.

8. 8. Jian Zhou, Liang Zhou, Duo Zhang, Wei-Jing Tang, Di Tang, Xiao-Ling Shi, Yue Yang, Lin Zhou, Fei Liu, Yong Yu, Pentao Liu, Lei Tao, Li-Ming Lu*. BCL11A promotes the progression of laryngeal squamous cell carcinoma. Frontiers in Oncology. 2020 Mar 20;10:375.

9. 9. Gao, Xuefei; Nowak-Imialek, Monika; Chen, Xi; Chen, Dongsheng; Herrmann, Doris; Ruan, Degong; Chen, Andy Chun Hang; Eckersley-Maslin, Melanie A; Ahmad, Shakil; Lee, Yin Lau; Kobayashi, Toshihiro; Ryan, David; Zhong, Jixing; Zhu, Jiacheng; Wu, Jian; Lan, Guocheng; Petkov, Stoyan; Yang, Jian; Antunes, Liliana; Campos, Lia S; Fu, Beiyuan; Wang, Shengpeng; Yong, Yu; Wang, Xiaomin; Xue, Song-Guo; Ge, Liangpeng; Liu, Zuohua; Huang, Yong; Nie, Tao; Li, Peng; Wu, Donghai; Pei, Duanqing; Zhang, Yi; Lu, Liming; Yang, Fengtang; Kimber, Susan J; Reik, Wolf; Zou, Xiangang; Shang, Zhouchun; Lai, Liangxue; Surani, Azim; Tam, Patrick P L; Ahmed, Asif; Yeung, William Shu Biu; Teichmann, Sarah A; Niemann, Heiner; Liu, Pentao. Establishment of porcine and human expanded potential stem cells. Nature cell biology, 2019, 21(6): 687. Establishment of porcine and human expanded potential stem cells. Nature cell biology, 2019, 21(6): 687.

10. 10. Lin Ye, Yuqing Lou, Liming Lu* and Xiaohong Fan. Mesothelin-targeted second generation CAR-T cells inhibit growth of mesothelin-expressing tumors in vivo. Exp Ther Med. 2019 Jan;17(1):739-747.

11. 11. Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu* and Jun Liu*. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease. Journal of J Neuroinflammation. 2019;16(1):263.

12. 12. HeYu-Bin; GuoJiang-Hong; WangChong; Zhu Dan; Lu Li-Ming*. IL-33 promotes the progression of nonrheumatic aortic valve stenosis via inducing differential phenotypic transition in valvular interstitial cells. Journal of cardiology. 2019 Aug 12.

13. 13. Yi xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao and Li-ming Lu*. Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC. FRONTIERS IN ONCOLOGY , 2019 , Jul 2;9:588

14. 14. Guo-wei Tu ,Min-jie Ju, Yi-jun zheng, Guang-wei Hao,Guo-guang Ma, Jun-yi Hou, Xue-peng Zhang, Zhe Luo, Li-ming Lu*. CXCL16/CXCR6 Is Involved in LPS-induced Acute Lung Injury via P38 Signaling. Cell Physiol Biochem. 2019; 00; 1-10

15. 15. Jun Lu, Hua Zhong, Tianqing Chu, Xueyan Zhang, Rong Li, Jiayuan Sun, Runbo Zhong, Yuqin Yang, Mohammad Shah Alam, Yuqing Lou, Jianlin Xu, Yanwei Zhang, Jun Wu, Xiaowei Li, Xiaodong Zhao, Kai Li, Liming Lu*, Baohui Han. Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for non-small cell lung cancer therapy. European Respiratory Journal . 2019 Mar 1;53(3). pii: 1801562. doi: 10.1183/13993003.01562-2018

16. 16. Xiaoyan Yu, XiaoLu Teng, Feixiang Wang, Yuhan Zheng, Guojun Qu, Yan Zhou, Zhilin Hu, Zhongqiu Wu, Yuzhou Chang, Lei Chen,HuaBing Li, Bing Su, Liming Lu*, Zhiduo Liu, ShaoCong Sun, and Qiang Zou. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med . 2018 Sep 3;215(9):2463-2476. doi: 10.1084/jem.20180397 

17. 17. Yue Wang, Qing Li, Lin Zhou, Xueping Ding, Liming Lu .Peptede TK-PQ induces immunosuppression in skin allogeneic transplantation via increasing Foxp3+ Treg and impeding nuclear translocation of NF-κB .Molecular Immunology ,2018,101:597-607.  [Link]

18.  18. Xiao-yang Zhang, Lin Zhou, Zhen Guo, Ye Kong, Wei Zhang, Liming Lu*,Xin Li* .Regulatory T Cells may Play an Protection Role in Lung Injury after Operation in Rheumatic Heart Disease .Journal of Thoracic Disease ,2018 ,10(6):3196-3205 .  [Link]

19. 19. Weimin Fan, Yali Xu, Yue Liu, Zhengqing Zhang, Liming Lu and Zhide Ding.Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.Frontiers in Physiology , 2018 ,8:1117 .  [Link]

20. 20. ZongAn Chen, Lin Zhou, TaeHao Won, Zhen Gao, XiaoLi Wu,LiMing Lu.Characterization of CD45RO+ Memory T Lymphocytes in Keloid Disease .British Journal of Dermatology ,2018,178(4):940-950.  [Link]

21. 21. Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, G?ttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P .Establishment of mouse expanded potential stem cells .Nature ,2017,550（7676）.  [Link]

22. 22. 万建伟,周琳,赵丹丹,杨玉琴,路丽明 .联烯化合物PHPO 对肺癌细胞株A549 增殖及凋亡的影响 .欧洲杯竞猜平台学报（医学版） ,2017,37（10）：1433-1439 .  [Link]

23. 23. 张晓阳,路丽明,李 欣 .调节性T细胞和辅助性T细胞与体外循环后肺损伤相关性 的研究. 中国体外循环杂志 ,2017,15（2）：81-84 .  [Link]

24. 24. WEI JING TANG, LEI TAO, LI?MING LU , DI TANG,XIAO?LIN SHI.Role of T helper 17 cytokines in the tumour immune inflammation .ONCOLOGY LETTERS ,2017,14（1）: 561-568 .  [Link]

25. 25. Zhao AM, Xu HJ, Kang XM, Zhao AM, Lu LM .New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk .J Reprod Immunol ,2016,113:35-41 .  [Link]

26. 26. Yu Y, Tsang JC, Wang C, Clare S, Wang J, Chen X, Brandt C, Kane L, Campos LS, Lu L, Belz GT, McKenzie AN, Teichmann SA, Dougan G, Liu P .Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway.Nature ,2016,539(7627):102-106 .  [Link]

27. 27. 于浩然,张柳蕙,刘威,周琳,丁旭苹,蒋黎华,路丽明 .RBL教学对临床医学本科生综合能力培养的作用 .中华医学教育探索杂志,2016,15.10（2016）；1034-1038.  [Link]

28. 28. Zhou J, Zhang D, Zhou L, Yang Y, Liu F, Tao L, Lu LM .Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period .Acta Oto-Laryngologica ,2016,2016 Jun 14:1-7 .  [Link]

29. 29. Zhang D, Tang WJ, Tang D, Zhou J, Chou L, Tao L, Lu LM.The ratio of CD4/CD8 T-cells in human papillomavirus-positive laryngeal squamous cell carcinoma accounts for improved outcome.Acta Otolaryngol ,2016,136(8):826-33 .  [Link]

30. 30. Zhang D, Zhou J, Tang D, Zhou L, Chou L, Chou KY, Tao L, Lu LM.Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance.Clin Immunol ,2016,175:34-40 .  [Link]

31. 31. Zhou J, Yang Y, Zhang D, Zhou L, Liu F, Tao L, Lu LM.Association of the recurrence of vocal leukoplakia with MDM2-309 variants over a 2-year period: a prospective study.Acta Otolaryngol ,2016,136(1):95-9 .  [Link]

32. 32. Tang.D, W. J. Tang, X. L. Shi, W. P. Li, H. Zhou, Lu L*.Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma .Acta Otolaryngol ,2016,136, 806-11 .  [Link]

33. 33. 周琳,高文,路丽明.肺移植后闭塞性细支气管炎免疫学发病机制及治疗新策略 .现代免疫学,2016,36(1):67-71 .  [Link]

34. 34. Li Z, Yang N, Zhou L, Gu P, Wang H, Zhou Y, Zhou P, Lu L , Chou KY.A peptide tetramer Tk-tPN induces tolerance of cardiac allografting by conversion of type 1 to type 2 immune responses via the Toll-like receptor 2 signal-promoted activation of the MCP1 gene .Immunology ,2016,147(3):355–366.  [Link]

35. 35. Zhang D, Chen B, Zhou J, Zhou L, Li Q, Liu F, Chou KY, Tao L, Lu LM.Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c-Jun N-terminal protein kinase/mitogen-activated protein kinase activation .Mol Med Rep ,2015,11(1):349-56 .  [Link]

36. 36. Yang J, Wang W, Ooi J, Campos LS, Lu L , Liu P .Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells .Stem Cells,2015,33(5):1390-404.  [Link]

37. 37. Jason C. H. Tsang, Yong Yu, Shannon Burke, Florian Buettner, Cui Wang, Aleksandra A. Kolodziejczyk, Sarah A. Teichmann, Liming Lu, and Pentao Liu.Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.Genome Biology ,2015,16(1):178 .  [Link]

38. 38. Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S, Lu L, He D, Jenkins NA, Copeland NG, Dougan G, Liu P .The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development .J Exp Med ,2015 , 212(6):865-74 .  [Link]

39. 39. Zhou J, Zhang D, Chen B, Li Q, Zhou L, Liu F, Chou KY, Tao L, Lu LM.Association of interleukin-10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma .Oncol Lett ,2014,7(5):1721-1727.  [Link]

40. 40. Yang N, Li Z, Jiao Z, Gu P, Zhou Y, Lu L , Chou KY .A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8(+)CD28(-) Tregs.Clin Immunol.,2014,153(2):277-87 .  [Link]

41. 41. Jason CH Tsang, Xuefei Gao, Lu L , Pentao Liu .Cellular reprogramming by transcription factor engineering .Current Opinion in Genetics & Development,2014,28:1-9.  [Link]

42. 42. Xuefei Gao, Jason C.H. Tsang, Fortis Gaba, Donghai Wu, Lu. L , Pentao Liu .Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers .Nucleic Acids Research ,2014,42（20）：Pp. e155 .  [Link]

43. 43. Liu F, Pan X, Zhou L, Zhou J, Chen B, Shi J, Gao W, Lu L .Genetic polymorphisms and plasma levels of interleukin-22 contribute to the development of nonsmall cell lung cancer.DNA Cell Biol ,2014,33(10):705-14.  [Link]

44. 44. Chen B, Zhang D, Zhou J, Li Q, Zhou L, Li SM, Zhu L, Chou KY, Zhou L, Tao L, Lu LM .High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma .Oncol Rep ,2013,30(3):1380-90.  [Link]

45. 45. Guo-wei Tu; Min-jie Ju; Yi-jun Zheng, Guang-wei Hao; Guo-guang Ma; Jun-yi Hou; Xue-peng Zhang; Zhe Luo; Li-ming Lu.CXCL16/CXCR6 Is Involved in LPS-induced Acute Lung Injury via P38 Signaling.J Cell Mol Med,2019,00:1-10.  [Link]

46. 46. Yi xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao and Li-ming Lu*.Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC.FRONTIERS IN ONCOLOGY,2019,Accepted.  [Link]

47. 47. Xiaoyan Yu, XiaoLu Teng, Feixiang Wang, Yuhan Zheng, Guojun Qu, Yan?Zhou, Zhilin Hu, Zhongqiu Wu, Yuzhou Chang, Lei Chen,HuaBing Li, Bing Su, Liming Lu, Zhiduo Liu, ShaoCong Sun, and Qiang Zou.Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome .J Exp Med ,2018,Epub 2018 Aug 16 .  [Link]

48. 48. Jun Lu, Hua Zhong, Tianqing Chu, Xueyan Zhang, Rong Li, Jiayuan Sun, Runbo Zhong, Yuqin Yang, Mohammad Shah Alam, Yuqing Lou, Jianlin Xu, Yanwei Zhang, Jun Wu, Xiaowei Li, Xiaodong Zhao, Kai Li, Liming Lu*, Baohui Han.Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for non-small cell lung cancer therapy.European Respiratory Journal ,2019,53(3).  [Link]

49. 49. Gao, Xuefei; Nowak-Imialek, Monika; Chen, Xi; Chen, Dongsheng; Herrmann, Doris; Ruan, Degong; Chen, Andy Chun Hang; Eckersley-Maslin, Melanie A; Ahmad, Shakil; Lee, Yin Lau; Kobayashi, Toshihiro; Ryan, David; Zhong, Jixing; Zhu, Jiacheng; Wu, Jian; Lan, Guocheng; Petkov, Stoyan; Yang, Jian; Antunes, Liliana; Campos, Lia S; Fu, Beiyuan; Wang, Shengpeng; Yong, Yu; Wang, Xiaomin; Xue, Song-Guo; Ge, Liangpeng; Liu, Zuohua; Huang, Yong; Nie, Tao; Li, Peng; Wu, Donghai; Pei, Duanqing; Zhang, Yi; Lu, Liming; Yang, Fengtang; Kimber, Susan J; Reik, Wolf; Zou, Xiangang; Shang, Zhouchun; Lai, Liangxue; Surani, Azim; Tam, Patrick P L; Ahmed, Asif; Yeung, William Shu Biu; Teichmann, Sarah A; Niemann, Heiner; Liu, Pentao .Establishment of porcine and human expanded potential stem cells.Nature cell biology ,2019,21(6): 687-699.  [Link]

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