实验室主要关注一种特殊的左手螺旋核酸—Z型核酸，这种特殊构象核酸在人体的功能直到2017年才引起广泛关注。

已知病毒感染可以导致Z型核酸的形成，在肠炎、皮炎等自身免疫疾病中也发现内源的Z型核酸可以诱导炎症反应。

但是该领域还有大量未知的问题等待被探索，课题组围绕Z型核酸的研究方向包括：

1、Z型核酸在病原微生物感染中的产生和功能 

2、Z型核酸在疾病中的功能

3、进化上Z型核酸的调控

同时课题组还涵盖了其他研究方向，包括：

干细胞技术在肿瘤免疫治疗中的应用等。

1. Qiannan Tang; Rachel E. Rigby; George R. Young; Astrid Korning Hvidt; Tanja Davis; Tiong Kit Tan; Anne Bridgeman; Alain R. Townsend; George Kassiotis; Jan Rehwinkel; Adenosine-to-inosine editing of endogenous Z-form RNA by the 

deaminase ADAR1 prevents spontaneous MAVS- dependent type I interferon responses, Immunity, 2021, 54(9): 1961-1975.e5

2. Qiannan Tang; Xinlu Wang; Guangxia Gao; The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1, Journal of Virology, 2017, 2(91): e01909-16

3. Qiannan Tang; Z-nucleic acids: Uncovering the functions from past to present, European Journal of Immunology, 2022, 52(11): 1700-1711

4. Le Qin; Yuanbin Cui; Tingjie Yuan; Dongmei Chen; Ruocong Zhao; Shanglin Li; Zhiwu Jiang; Qiting Wu; Youguo Long; Suna Wang; Zhaoyang Tang; Huixia Pan; Xiaoping Li; Wei Wei; Jie Yang; Xuequn Luo; Zhenfeng Zhang; Qiannan Tang; 

Pentao Liu; Robert Weinkove; Yao Yao; Dajiang Qin; Jean Paul Thiery; Peng Li; Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis, Nature Communications, 2022, 13(1): 6051

5. Shanglin Li; Ruocong Zhao; Diwei Zheng; Le Qin; Yuanbin Cui; Yao Li; Zhiwu Jiang; Mengjun Zhong; Jingxuan Shi; Ming Li; Xindong Wang; Zhaoyang Tang; Qiting Wu; Youguo Long; Duo Hu; Suna Wang; Yao Yao; Shuang Liu; Li-Hua Yang; 

Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Yangqiu Li; Peng Li; DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D, Molecular Therapy - Oncolytics, 2022, 26: 15-26

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实验室地址：上海市黄浦区重庆南路280号 欧洲杯竞猜平台西五楼 10楼

邮箱：qiannan.tang@sjtu.edu.cn