课题组致力于通过前沿的单细胞测序技术和经典的遗传学谱系示踪技术研究免疫细胞的发育和功能。

科研项目：

1.中组部万人计划“青年拔尖人才” (2022)；

2.国家自然科学基金 面上项目“III型树突状细胞的发育”(2022)32270916；

3.国家自然科学基金 面上项目“组织巨噬细胞的胚胎起源”(2020)32070880；

4.国家自然科学基金 青年项目“利用单核细胞示踪模型研究组织巨噬细胞的来源和更新” (2019)31900630；

5.上海市青年科技启明星 (2020)上海市科学技术委员会20QA1408500；

6.上海市人才发展资金(2020)上海市人力资源和社会保障部；

7.欧洲杯竞猜平台“交大2030计划”(2022)；

8.欧洲杯竞猜平台“前瞻布局”(2021)。

发表文章

1. Liu, Z., H. Wang, Z. Li, R. J. Dress, Y. Zhu, S. Zhang, D. De Feo, W. T. Kong, P. Cai, A. Shin, C. Piot, J. Yu, Y. Gu, M. Zhang, C. Gao, L. Chen, H. Wang, M. Vetillard, P. Guermonprez, I. Kwok, L. G. Ng, S. Chakarov, A. Schlitzer, B. Becher, C. A. Dutertre, B. Su and F. Ginhoux (2023). "Dendritic cell type 3 arises from Ly6C(+) monocyte-dendritic cell progenitors." Immunity.

2. Liu, Z., Y. Gu, S. Chakarov, C. Bleriot, I. Kwok, X. Chen, A. Shin, W. Huang, R. J. Dress, C. A. Dutertre, A. Schlitzer, J. Chen, L. G. Ng, H. Wang, Z. Liu, B. Su and F. Ginhoux (2019). "Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells." Cell 178(6): 1509-1525 e1519.

3. Liu, Z., Y. Gu, A. Shin, S. Zhang and F. Ginhoux (2020). "Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry." STAR Protoc 1(1): 100029.

4. Cansever, D., E. Petrova, S. Krishnarajah, C. Mussak, C. A. Welsh, W. Mildenberger, K. Mulder, V. Kreiner, E. Roussel, S. A. Stifter, M. Andreadou, P. Zwicky, N. P. Jurado, H. Rehrauer, G. Tan, Z. Liu, C. Bleriot, F. Ronchi, A. J. Macpherson, F. Ginhoux, G. Natalucci, B. Becher and M. Greter (2023). "Lactation-associated macrophages exist in murine mammary tissue and human milk." Nat Immunol 24(7): 1098-1109.

5. Li, L., L. Cui, P. Lin, Z. Liu, S. Bao, X. Ma, H. Nan, W. Zhu, J. Cen, Y. Mao, X. Ma, L. Jiang, Y. Nie, F. Ginhoux, Y. Li, H. Li and L. Hui (2023). "Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers." Cell Stem Cell 30(3): 283-299 e289.

6. Miao, N., Z. Wang, Q. Wang, H. Xie, N. Yang, Y. Wang, J. Wang, H. Kang, W. Bai, Y. Wang, R. He, K. Yan, Y. Wang, Q. Hu, Z. Liu, F. Li, F. Wang, F. Ginhoux, X. Zhang, J. Yin, L. Lu and J. Wang (2023). "Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus." Nat Commun 14(1): 872.

7. Ng, L. G., Z. Liu, I. Kwok and F. Ginhoux (2023). "Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils." Annu Rev Immunol 41: 375-404.

8. Tadepalli, S., D. R. Clements, S. Saravanan, R. Arroyo Hornero, A. Ludtke, B. Blackmore, J. A. Paulo, A. Gottfried-Blackmore, D. Seong, S. Park, L. Chan, B. J. Kopecky, Z. Liu, F. Ginhoux, K. J. Lavine, J. P. Murphy, M. Mack, E. E. Graves and J. Idoyaga (2023). "Rapid recruitment and IFN-I-mediated activation of monocytes dictate focal radiotherapy efficacy." Sci Immunol 8(84): eadd7446.

9. Vanneste, D., Q. Bai, S. Hasan, W. Peng, D. Pirottin, J. Schyns, P. Marechal, C. Ruscitti, M. Meunier, Z. Liu, C. Legrand, L. Fievez, F. Ginhoux, C. Radermecker, F. Bureau and T. Marichal (2023). "MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation." Nat Immunol.

10. Viola, M. F., M. Chavero-Pieres, E. Modave, M. Delfini, N. Stakenborg, M. C. Estevez, N. Fabre, I. Appeltans, T. Martens, K. Vandereyken, H. Theobald, J. Van Herck, P. Petry, S. Verheijden, S. De Schepper, A. Sifrim, Z. Liu, F. Ginhoux, M. Azhar, A. Schlitzer, G. Matteoli, K. Kierdorf, M. Prinz, P. Vanden Berghe, T. Voet and G. Boeckxstaens (2023). "Dedicated macrophages organize and maintain the enteric nervous system." Nature 618(7966): 818-826.

11. Zheng, X., X. Wang, X. Cheng, Z. Liu, Y. Yin, X. Li, Z. Huang, Z. Wang, W. Guo, F. Ginhoux, Z. Li, Z. Zhang and X. Wang (2023). "Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer." Nat Cancer 4(8): 1138-1156.

12. Amorim, A., D. De Feo, E. Friebel, F. Ingelfinger, C. D. Anderfuhren, S. Krishnarajah, M. Andreadou, C. A. Welsh, Z. Liu, F. Ginhoux, M. Greter and B. Becher (2022). "IFNgamma and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation." Nat Immunol.

13. Rebejac, J., E. Eme-Scolan, L. Arnaud Paroutaud, S. Kharbouche, M. Teleman, L. Spinelli, E. Gallo, A. Roussel-Queval, A. Zarubica, A. Sansoni, Q. Bardin, P. Hoest, M. C. Michallet, C. Brousse, K. Crozat, M. Manglani, Z. Liu, F. Ginhoux, D. B. McGavern, M. Dalod, B. Malissen, T. Lawrence and R. Rua (2022). "Meningeal macrophages protect against viral neuroinfection." Immunity 55(11): 2103-2117 e2110.

14. Silvin, A., S. Uderhardt, C. Piot, S. Da Mesquita, K. Yang, L. Geirsdottir, K. Mulder, D. Eyal, Z. Liu, C. Bridlance, M. S. Thion, X. M. Zhang, W. T. Kong, M. Deloger, V. Fontes, A. Weiner, R. Ee, R. Dress, J. W. Hang, A. Balachander, S. Chakarov, B. Malleret, G. Dunsmore, O. Cexus, J. Chen, S. Garel, C. A. Dutertre, I. Amit, J. Kipnis and F. Ginhoux (2022). "Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration." Immunity 55(8): 1448-1465 e1446.

15. Zhou, H., F. Lou, J. Bai, Y. Sun, W. Cai, L. Sun, Z. Xu, Z. Liu, L. Zhang, Q. Yin, J. Zhang, Y. Gao, Z. Wang, L. Niu, X. Cai, S. Deng, H. Wang, L. Xia, F. Ginhoux, Q. Li and H. Wang (2022). "A peptide encoded by pri-miRNA-31 represses autoimmunity by promoting T(reg) differentiation." EMBO Rep 23(5): e53475.

16. Bleriot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., Wan, G., Gessain, G., Khalilnezhad, A., Zhang, X. M., Ang, N., Chen, P., Morgantini, C., Azzimato, V., Kong, W. T., Liu, Z., Pai, R., Lum, J., Shihui, F., Low, I., Xu, C., Malleret, B., Kairi, M. F. M., Balachander, A., Cexus, O., Larbi, A., Lee, B., Newell, E. W., Ng, L. G., Phoo, W. W., Sobota, R. M., Sharma, A., Howland, S. W., Chen, J., Bajenoff, M., Yvan-Charvet, L., Venteclef, N., Iannacone, M., Aouadi, M. and Ginhoux, F (2021). A subset of Kupffer cells regulates metabolism through the expression of CD36. Immunity.

17. Bleriot, C., Z. Liu and F. Ginhoux (2021). "Water quality check: macrophages setting the standards." Cell Res 31(1): 3-4.

18. Jin, H., K. Liu, J. Tang, X. Huang, H. Wang, Q. Zhang, H. Zhu, Y. Li, W. Pu, H. Zhao, L. He, Y. Li, S. Zhang, Z. Zhang, Y. Zhao, Y. Qin, S. Pflanz, K. E. I. Kasmi, W. Zhang, Z. Liu, F. Ginhoux, Y. Ji, B. He, L. Wang and B. Zhou (2021). "Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury." Nat Commun 12(1): 2863.

19. Wang, M., Y. Yang, D. Cansever, Y. Wang, C. Kantores, S. Messiaen, D. Moison, G. Livera, S. Chakarov, T. Weinberger, C. Stremmel, M. Fijak, B. Klein, C. Pleuger, Z. Lian, W. Ma, Q. Liu, K. Klee, K. Handler, T. Ulas, A. Schlitzer, J. L. Schultze, B. Becher, M. Greter, Z. Liu, F. Ginhoux, S. Epelman, C. Schulz, A. Meinhardt and S. Bhushan (2021). "Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis." Proc Natl Acad Sci U S A 118(1).

20. Wu, N., H. Sun, X. Zhao, Y. Zhang, J. Tan, Y. Qi, Q. Wang, M. Ng, Z. Liu, L. He, X. Niu, L. Chen, Z. Liu, H. B. Li, Y. A. Zeng, M. Roulis, D. Liu, J. Cheng, B. Zhou, L. G. Ng, D. Zou, Y. Ye, R. A. Flavell, F. Ginhoux and B. Su (2021). "MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche." Nature.

21. Dawson, C. A., B. Pal, F. Vaillant, L. C. Gandolfo, Z. Liu, C. Bleriot, F. Ginhoux, G. K. Smyth, G. J. Lindeman, S. N. Mueller, A. C. Rios and J. E. Visvader (2020). "Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling." Nat Cell Biol 22(5): 546-558.

22. Dress, R. J., Z. Liu and F. Ginhoux (2020). "Towards the better understanding of myelopoiesis using single-cell technologies." Mol Immunol 122: 186-192.

23. Kwok, I., E. Becht, Y. Xia, M. Ng, Y. C. Teh, L. Tan, M. Evrard, J. L. Y. Li, H. T. N. Tran, Y. Tan, D. Liu, A. Mishra, K. H. Liong, K. Leong, Y. Zhang, A. Olsson, C. K. Mantri, P. Shyamsunder, Z. Liu, C. Piot, C. A. Dutertre, H. Cheng, S. Bari, N. Ang, S. K. Biswas, H. P. Koeffler, H. L. Tey, A. Larbi, I. H. Su, B. Lee, A. St John, J. K. Y. Chan, W. Y. K. Hwang, J. Chen, N. Salomonis, S. Z. Chong, H. L. Grimes, B. Liu, A. Hidalgo, E. W. Newell, T. Cheng, F. Ginhoux and L. G. Ng (2020). "Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor." Immunity.

24. Niu, L. M., F. Z. Lou, Y. Sun, L. B. Sun, X. J. Cai, Z. Y. Liu, H. Zhou, H. Wang, Z. K. Wang, J. Bai, Q. Q. Yin, J. X. Zhang, L. J. Chen, D. H. Peng, Z. Y. Xu, Y. Y. Gao, S. B. Tang, L. Fan and H. L. Wang (2020). "A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation." Science Advances 6(21).

25. Lou, F., Y. Sun, Z. Xu, L. Niu, Z. Wang, S. Deng, Z. Liu, H. Zhou, J. Bai, Q. Yin, X. Cai, L. Sun, H. Wang, Q. Li, Z. Wu, X. Chen, J. Gu, Y. L. Shi, W. Tao, F. Ginhoux and H. Wang (2020). "Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis." Immunity.

26. Msallam, R., J. Balla, A. P. S. Rathore, H. Kared, B. Malleret, W. A. A. Saron, Z. Liu, J. W. Hang, C. A. Dutertre, A. Larbi, J. K. Y. Chan, A. L. St John and F. Ginhoux (2020). "Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE." Science.

27. Jaitin, D. A., L. Adlung, C. A. Thaiss, A. Weiner, B. Li, H. Descamps, P. Lundgren, C. Bleriot, Z. Liu, A. Deczkowska, H. Keren-Shaul, E. David, N. Zmora, S. M. Eldar, N. Lubezky, O. Shibolet, D. A. Hill, M. A. Lazar, M. Colonna, F. Ginhoux, H. Shapiro, E. Elinav and I. Amit (2019). "Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner." Cell 178(3): 686-698 e614.

实验室地址：上海市黄浦区重庆南路280号 欧洲杯竞猜平台西五楼 10楼

邮箱：zhaoyuan_liu@sjtu.edu.cn