Name: Fubin Li

Title： PI

Email: Fubin.li@sjtu.edu.cn

Tel: +86-21-54592183

Research Interests

The lab is mainly interested in two research subjects: (1) how the in vivo activities of cancer immunotherapeutic antibodies are regulated and can be optimized; (2) how B cell development and differentiation are regulated.

Among several ongoing research projects in the lab, we are studying how the interaction between agonistic anti-tumor antibodies and Fcγ receptors impacts on their in vivo activities. Fcγ receptors have complex interplay with immunoglobulins and regulate both afferent and efferent immune responses. Fcγ receptors are also critical mediators and regulators of therapeutic antibodies’ activities. The research of the lab is focused on the function of Fcγ receptors in immunoregulation and immunotherapy and the underlying molecular mechanism, such as their regulation on B cell response, and on the activities of different classes of antibodies including agonistic antibodies.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1. Da Chen, Yingjie Zhao, Mingyu Li, Hang Shang, Na Li, Fan Li, Wei Wang, Yuan Wang, Ruina Jin, Shiyu Liu, Xun Li, Shan Gao, Yujie Tian, Ruonan Li, Huanhuan Li, Yongyan Zhang, Mingjuan Du, Youjia Cao, Yan Zhang, Xin Li, Yi Huang, Liaoyuan A. Hu#, Fubin Li*, Hongkai Zhang*. 2021. A general Fc engineering platform for the next generation of antibody therapeutics. Theranostics 11(4):1901-1917

2. Rongqing Zhao, Huihui Zhang, Yan Zhang, Dan Li, Chuanxin Huang, Fubin Li. 2020. In Vivo Screen Identifies Zdhhc2 As a Critical Regulator of Germinal Center B Cell Differentiation. Frontiers in Immunology 11:1025

3. Xiaobo Liu#, Yingjie Zhao#, Huan Shi#, Yan Zhang, Xueying Yin, Mingdong Liu, Huihui Zhang, Yongning He, Boxun Lu, Tengchuan Jin, Fubin Li. 2019. Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nature Communications  10(1): 4206.

4. Wenqian Zhang#, Huihui Zhang#, Shujun Liu, Fucan Xia, Zijian Kang, Yan Zhang, Yaoyang Liu, Hui Xiao, Lei Chen, Chuanxin Huang, Nan Shen, Huji Xu, Fubin Li. 2019. Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus. Proceedings of the National Academy of Sciences of the United States of America 116(37):18550-18560.

5. Li M#, Lazorchak AS#, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li, F*, Su, B*, 2019 Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation. Cellular & Molecular Immunology 16(9):757-769

6. Li, F*., P. Smith, and J. V. Ravetch*. 2014. Inhibitory Fcgamma Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms. Journal of immunology 192:3021-8 (#corresponding author)

7. Li, F*., and J. V. Ravetch*. 2013. Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. Proceedings of the National Academy of Sciences of the United States of America 110: 19501-19506.

8. Li, F., and J. V. Ravetch. 2012. Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement. Proceedings of the National Academy of Sciences of the United States of America 109: 10966-10971.

9. Li, F., and J.V. Ravetch. 2011. Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333:1030-1034.

10. Li, F., and L.A. Eckhardt. 2009. A role for the IgH intronic enhancer E mu in enforcing allelic exclusion. The Journal of experimental medicine 206:153-167.