Name: Ying Wang

Title： Professor

Email: Ywangssmu@shsmu.edu.cn

Tel: 0086-02163846590

Research Interests

Research interest in my lab is the study on immunological mechanism and preventive strategies against lung-related diseases including infectious tuberculosis (TB) and lung cancer. In the investigations on TB, I have been working on the exploration of diagnostic biomarkers and development of novel preventive vaccines against TB and latent TB infection. We have screened panels of novel mycobaceterial antigens with high immunogenencity both in active TB patients and mice, which facilitates their further expectation for vaccine development and biomarker determination. In addition, some new-identified mycobacterial antigens were subjected to the study on the mechanisms of their immune regulatory function. Another interesting field lies in the screening the biomarkers for the checkpoint inhibitors against lung cancer. Multi-omics strategies has been used in this study to model the predictive and prognositic biomarkers for the clinical efficacy as well as resistance, which will be optional for the development of new immune-targets. Relevant mechanism will be investigated simultaneously.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1.Sam IK, Chen YY, Ma J, Li SY, Ying RY, Li LX, Ji P, Wang SJ, Xu J, Bao YJ, Zhao GP, Zheng HJ, Wang J*, Sha W*, Wang Y*. TB-QUICK: CRISPR-Cas12b-assisted rapid and sensitive detection of Mycobacterium tuberculosis  J Infect. 2021 Jul;83(1):54-60. doi: 10.1016/j.jinf.2021.04.032.

2.Lai YD, Chen YY, Sun JP, Ling Y, Xu J, Ye YQ, Shen L, Lu HZ∗, Su S∗ and Wang Y∗. Immune profiles of a COVID-19 adolescent with mild symptoms and anti-viral antibody deficiency.  Fundamental Research (2021) 1:117–123

3.Yang QY#, Zhang YT#, Xiao JN, Liang YS, Ji P, Wang SJ, Wang Y* and Chen YY*. Age-related immunoreactivity profiles to diverse mycobacterial antigens in BCG vaccinated Chinese population. Front. Immunol. (2021) 11: 608220

4.Bao YJ #, Ling Y #, Chen YY #, Tian D, Zhao GP, Zhang XH, Hang H, Li Y, Su B, Lu HZ*, Xu J* and Wang Y*. Dynamic Anti-Spike Protein Antibody Profiles in COVID-19 Patients. Int J Infect Dis. (2021) 103:540–548

5.Tian Y #, Lian CY #, Chen YY #, Wei D, Zhang XX, Ling Y, Wang Y* and Yeap LS*. Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays. Cell Discovery. (2020) 6:75. doi: 10.1038/s41421-020-00224-3. eCollection 2020

6.Chen YY#, Xiao JN#, Li Y#, Xiao YJ#, Xiong YQ, Liu Y, Wang SJ, Ji P, Zhao GP, Shen H, Lu SH, Fan XY* and Wang Y*, Mycobacterial lipoprotein Z triggers efficient innate and adaptive immunity for protection against Mycobacterium tuberculosis infection. Front. Immunol., (2019) 9:3190.

7.Yuan-yong Liu#, Wei Sha#, Shi-qiang Xu, Xu-Wei Gui, Li-liang Xia, Ping Ji, Shu-jun Wang, Guo-ping Zhao, Xiao Zhang*, Yingying Chen* and Ying Wang. Identification of HLA-A2-restricted mycobacterial lipoprotein Z peptides recognized by T Cells from patients with active tuberculosis infection, Front. Microbiol., (2018) 9:3131.

8.Xiao JN, XiongYQ, Chen YY, Xiao YJ, Ji P, Li Y, Wang SJ, Zhao GP, Cheng QJ, Lu SH* and Wang Y*. Determination of Lipoprotein Z-specific IgA in tuberculosis and latent tuberculosis infection. Front Cell Infect Mcrobiol. (2017) Nov 30; 7; 495. doi: 10.3389/fcimb.2017.00495

9.Yang X, Wu JB, Liu Y, Xiong Y, Ji P, Wang SJ, Chen Y, Zhao GP, Lu SH, Wang Y*. Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection. Tuberculosis (Edinb). 2017 Dec;107:119-125. doi: 10.1016/j.tube.2017.08.005. Epub 2017 Aug 31.

10.Xiao XJ, Sha W, Tian ZF, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H* and Wang Y*. Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis. J Mol Med 2016 Jul;94(7):823-34/ [Epub 2016 Feb 23.]